Computational protein design suggests that human PCNA-partner interactions are not optimized for affinity

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 2, 2013, Pages 341-348

  Fridman, Yearit ^a,b   Gur, Eyal ^a   Fleishman, Sarel J ^b   Aharoni, Amir ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Computational biology; DNA replication; Protein design

Indexed keywords

CYCLINE; MUTANT PROTEIN;

ANISOTROPY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN INTERACTION; PROTEIN PURIFICATION; WILD TYPE;

COMPUTATIONAL BIOLOGY; DNA REPLICATION; HUMANS; MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEINS; REPRODUCIBILITY OF RESULTS;

EUKARYOTA;

EID: 84872620083     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24190     Document Type: Article

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