Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

Cell Death and Disease

Volumn 5, Issue 3, 2014, Pages

  Kim, S Y ^a   Shim, M S ^a   Kim, K Y ^b   Weinreb, R N ^a   Wheeler, L A ^c   Ju, W K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALLERGAN INC   (United States)

Author keywords

Cyclophilin D; Cyclosporin A; Mitochondrial DNA; Mitochondrial transcription factor A; Retinal ganglion cell; Retinal ischemia

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CASPASE 3; CYCLOPHILIN D; CYCLOSPORIN A; MITOCHONDRIAL DNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PROTEIN BCL XL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RETINA GANGLION CELL; RETINA INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; CASPASE 3; CELL SURVIVAL; CYCLOPHILINS; CYCLOSPORINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; FEMALE; HIGH MOBILITY GROUP PROTEINS; INTRAOCULAR PRESSURE; ISCHEMIA; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEUROPROTECTIVE AGENTS; OCULAR HYPERTENSION; PHOSPHORYLATION; RETINAL DISEASES; RETINAL GANGLION CELLS; TIME FACTORS;

EID: 84897415969     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.80     Document Type: Article

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