Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Yuen, Chun Man ^a   Sun, Cheuk Kwan ^b   Lin, Yu Chun ^b   Chang, Li Teh ^c   Kao, Ying Hsien ^b   Yen, Chia Hung ^d   Chen, Yung Lung ^a   Tsai, Tzu Hsien ^a   Chua, Sarah ^a   Shao, Pei Lin ^e   Leu, Steve ^a   Yip, Hon Kan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c MEIHO UNIVERSITY   (Taiwan)

^d NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; CASPASE 3; CYCLOSPORIN; CYTOCHROME C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ERYTHROPOIETIN; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; PPARGC1A PROTEIN, RAT; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; IMMUNOFLUORESCENCE; INTERNAL CAROTID ARTERY OCCLUSION; MALE; MORTALITY; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SENSORIMOTOR FUNCTION; WESTERN BLOTTING; ANIMAL; BRAIN INFARCTION; CELL NUCLEUS; CONVALESCENCE; DRUG COMBINATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; STROKE;

ANIMALS; APOPTOSIS; AQUAPORIN 4; BRAIN INFARCTION; CELL NUCLEUS; CYCLOSPORINE; CYTOCHROMES C; DRUG THERAPY, COMBINATION; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; IN SITU NICK-END LABELING; INFLAMMATION; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RNA, MESSENGER; RNA-BINDING PROTEINS; STROKE; TRANSCRIPTION FACTORS;

EID: 80052026949     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-141     Document Type: Article

References (34)

1. Hankey GJ. Stroke: how large a public health problem, and how can the neurologist help?. Arch Neurol 1999, 56:748-754. 10.1001/archneur.56.6.748, 10369318.
2. Organization WH World Health Report 1999-Making a Difference 1999, Geneva, Switzerland: World Health Organization, Organization WH.
3. Association AH Stroke Statistics 2002, Dallas, Dallas, TX: American Heart Association, Association AH.
4. Bacigaluppi M, Pluchino S, Martino G, Kilic E, Hermann DM. Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci 2008, 265:73-77. 10.1016/j.jns.2007.06.012, 17610905.
5. Andres RH, Choi R, Steinberg GK, Guzman R. Potential of adult neural stem cells in stroke therapy. Regen Med 2008, 3:893-905. 10.2217/17460751.3.6.893, 18947311.
6. Wardlaw JM, Murray V, Berge E, Del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2009, CD000213.
7. Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Kuelkens S, Larrue V, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007, 369:275-282. 10.1016/S0140-6736(07)60149-4, 17258667.
8. Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007, 38:1655-1711. 10.1161/STROKEAHA.107.181486, 17431204.
9. Bravata DM. Intravenous thrombolysis in acute ischaemic stroke: optimising its use in routine clinical practice. CNS Drugs 2005, 19:295-302. 10.2165/00023210-200519040-00002, 15813643.
10. Sandercock P, Berge E, Dennis M, Forbes J, Hand P, Kwan J, Lewis S, Lindley R, Neilson A, Wardlaw J. Cost-effectiveness of thrombolysis with recombinant tissue plasminogen activator for acute ischemic stroke assessed by a model based on UK NHS costs. Stroke 2004, 35:1490-1497. 10.1161/01.STR.0000126871.98801.6E, 15105519.
11. Thomalla G, Sobesky J, Kohrmann M, Fiebach JB, Fiehler J, Zaro Weber O, Kruetzelmann A, Kucinski T, Rosenkranz M, Rother J, Schellinger PD. Two tales: hemorrhagic transformation but not parenchymal hemorrhage after thrombolysis is related to severity and duration of ischemia: MRI study of acute stroke patients treated with intravenous tissue plasminogen activator within 6 hours. Stroke 2007, 38:313-318. 10.1161/01.STR.0000254565.51807.22, 17204683.
12. Calvillo L, Latini R, Kajstura J, Leri A, Anversa P, Ghezzi P, Salio M, Cerami A, Brines M. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci USA 2003, 100:4802-4806. 10.1073/pnas.0630444100, 153636, 12663857.
13. Moon C, Krawczyk M, Ahn D, Ahmet I, Paik D, Lakatta EG, Talan MI. Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats. Proc Natl Acad Sci USA 2003, 100:11612-11617. 10.1073/pnas.1930406100, 208806, 14500913.
14. Hirata A, Minamino T, Asanuma H, Fujita M, Wakeno M, Myoishi M, Tsukamoto O, Okada K, Koyama H, Komamura K, et al. Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs. J Am Coll Cardiol 2006, 48:176-184. 10.1016/j.jacc.2006.04.008, 16814664.
15. Chua S, Leu S, Lin YC, Sheu JJ, Sun CK, Chung SY, Chai HT, Lee FY, Kao YH, Wu CJ, et al. Early Erythropoietin Therapy Attenuates Remodeling and Preserves Function of Left Ventricle in Porcine Myocardial Infarction. J Investig Med 2011, 59:574-586.
16. Yuen CM, Leu S, Lee FY, Yen CH, Lin YC, Chua S, Chung SY, Chai HT, Sheu JJ, Ko SF, et al. Erythropoietin markedly attenuates brain infarct size and improves neurological function in the rat. J Investig Med 2010, 58:893-904.
17. Yip HK, Tsai TH, Lin HS, Chen SF, Sun CK, Leu S, Yuen CM, Tan TY, Lan MY, Liou CW, et al. Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke. Crit Care 2011, 15:R40. 10.1186/cc10002, 21269484.
18. Argaud L, Gateau-Roesch O, Muntean D, Chalabreysse L, Loufouat J, Robert D, Ovize M. Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J Mol Cell Cardiol 2005, 38:367-374. 10.1016/j.yjmcc.2004.12.001, 15698843.
19. Kim JS, Jin Y, Lemasters JJ. Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2006, 290:H2024-2034. 10.1152/ajpheart.00683.2005, 16399872.
20. Argaud L, Gateau-Roesch O, Chalabreysse L, Gomez L, Loufouat J, Thivolet-Bejui F, Robert D, Ovize M. Preconditioning delays Ca2+-induced mitochondrial permeability transition. Cardiovasc Res 2004, 61:115-122. 10.1016/j.cardiores.2003.11.003, 14732208.
21. Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008, 359:473-481. 10.1056/NEJMoa071142, 18669426.
22. Sheu JJ, Chua S, Sun CK, Chang LT, Yen CH, Wu CJ, Fu M, Yip HK. Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction. Int J Cardiol 2011, 147:79-87. 10.1016/j.ijcard.2009.08.008, 19751953.
23. Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK. Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. J Transl Med 2010, 8:63. 10.1186/1479-5876-8-63, 2913939, 20584315.
24. Wang L, Zhang Z, Wang Y, Zhang R, Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 2004, 35:1732-1737. 10.1161/01.STR.0000132196.49028.a4, 15178821.
25. Matsumoto S, Isshiki A, Watanabe Y, Wieloch T. Restricted clinical efficacy of cyclosporin A on rat transient middle cerebral artery occlusion. Life Sci 2002, 72:591-600. 10.1016/S0024-3205(02)02267-1, 12467900.
26. Leu S, Kao YH, Sun CK, Lin YC, Tsai TH, Chang LT, Chua S, Yeh KH, Wu CJ, Fu M, Yip HK. Myocardium-derived conditioned medium improves left ventricular function in rodent acute myocardial infarction. J Transl Med 2011, 9:11. 10.1186/1479-5876-9-11, 3033820, 21244680.
27. Wu L, Shen F, Lin L, Zhang X, Bruce IC, Xia Q. The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore. Neurosci Lett 2006, 402:184-189. 10.1016/j.neulet.2006.04.001, 16678347.
28. Leger PL, De Paulis D, Branco S, Bonnin P, Couture-Lepetit E, Baud O, Renolleau S, Ovize M, Gharib A, Charriaut-Marlangue C. Evaluation of cyclosporine A in a stroke model in the immature rat brain. Exp Neurol 2010,
29. Ehrenreich H, Weissenborn K, Prange H, Schneider D, Weimar C, Wartenberg K, Schellinger PD, Bohn M, Becker H, Wegrzyn M, et al. Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke 2009, 40:e647-656. 10.1161/STROKEAHA.109.564872, 19834012.
30. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 2002, 53:31-47. 10.1016/S0008-6363(01)00434-5, 11744011.
31. Lambert JM, Lopez EF, Lindsey ML. Macrophage roles following myocardial infarction. Int J Cardiol 2008, 130:147-158. 10.1016/j.ijcard.2008.04.059, 2857604, 18656272.
32. Kerschensteiner M, Meinl E, Hohlfeld R. Neuro-immune crosstalk in CNS diseases. Neuroscience 2009, 158:1122-1132. 10.1016/j.neuroscience.2008.09.009, 18848864.
33. McColl BW, Allan SM, Rothwell NJ. Systemic infection, inflammation and acute ischemic stroke. Neuroscience 2009, 158:1049-1061. 10.1016/j.neuroscience.2008.08.019, 18789376.
34. Jerndal M, Forsberg K, Sena ES, Macleod MR, O'Collins VE, Linden T, Nilsson M, Howells DW. A systematic review and meta-analysis of erythropoietin in experimental stroke. J Cereb Blood Flow Metab 2010, 30:961-968. 10.1038/jcbfm.2009.267, 2949185, 20040929.