Brimonidine Blocks Glutamate Excitotoxicity-Induced Oxidative Stress and Preserves Mitochondrial Transcription Factor A in Ischemic Retinal Injury

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Lee, Dongwook ^a,b   Kim, Keun Young ^a   Noh, You Hyun ^a   Chai, Stephen ^a   Lindsey, James D ^a   Ellisman, Mark H ^a   Weinreb, Robert N ^a   Ju, Won Kyu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; BRIMONIDINE; CYTOCHROME C OXIDASE; GLUTAMIC ACID; MITOCHONDRIAL TRANSCRIPTION FACTOR A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PROTEIN BAX; PROTEIN BCL XL; PROTEIN SOD2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; EXCITOTOXICITY; FEMALE; IMMUNOREACTIVITY; INTRAOCULAR HYPERTENSION; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; RETINA GANGLION CELL; RETINA ISCHEMIA;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; DNA-BINDING PROTEINS; GLUTAMIC ACID; ISCHEMIA; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; QUINOXALINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, N-METHYL-D-ASPARTATE; RETINA; RETINAL DISEASES; RETINAL GANGLION CELLS; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 84867295552     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047098     Document Type: Article

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