Essential oil from lemon peels inhibit key enzymes linked to neurodegenerative conditions and pro-oxidant induced lipid peroxidation

Journal of Oleo Science

Volumn 63, Issue 4, 2014, Pages 373-381

  Oboh, Ganiyu ^a   Olasehinde, Tosin A ^a   Ademosun, Ayokunle O ^a  

^a FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Essential oil; Lemon peels; Neurodegeneration

Indexed keywords

CITRUS FRUITS; GAS CHROMATOGRAPHY; LIPIDS; MONOTERPENES; OXIDANTS; OXIDATIVE STRESS;

ACETYLCHOLINESTERASE; ANTI-OXIDANT ACTIVITIES; ANTIOXIDANT PROPERTIES; BUTYRYLCHOLINESTERASE; CONCENTRATION-DEPENDENT MANNERS; LEMON PEEL; NEURODEGENERATION; POSSIBLE MECHANISMS;

ESSENTIAL OILS;

ACETYLCHOLINESTERASE; ANTIOXIDANT; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; ESSENTIAL OIL; LEMON OIL; VEGETABLE OIL;

ANIMAL; ARTICLE; BRAIN; CHEMISTRY; CITRUS; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; ISOLATION AND PURIFICATION; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; RAT; WISTAR RAT;

ACETYLCHOLINESTERASE; ANIMALS; ANTIOXIDANTS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CITRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPID PEROXIDATION; MALE; NEURODEGENERATIVE DISEASES; OILS, VOLATILE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT OILS; RATS; RATS, WISTAR;

EID: 84897083054     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.ess13166     Document Type: Article

References (56)

1. Abd El-aal, H. A.; Halaweish, F. T. Food preservative activity of phenolic compounds in orange peel extracts (Citrus sinensis L.). Lucrari stiintifice. Seria Zootehnie-Universitatea de Stiinte Agricole si Medicina Veterinara Ion Ionescu de la Brad. 53, 233-240 (2010).
2. Oboh, G.; Ademosun, A. O. Phenolic extracts from Grapefruit Peels(Citrus paradisi)Inhibit Key Enzymes Linked to Type-2 Diabetes and Hypertension. J. Food Biochem. 35, 1703-1709(2011).
3. Oboh, G.; Ademosun A. O. Shaddock Peels(Citrus maxima)Phenolic Extracts Inhibit α-amylase, α-glucosidase and Angiotensin-I Converting Enzyme Activities: A Nutraceutical Approach to Diabetes Management. Diabetes Metab. Synd: Clin. Res. Rev. 5, 148-52(2011).
4. Oboh, G.; Ademosun A. O. Characterization of the an-tioxidant properties of phenolic extracts from some citrus peels. J. Food Sci. Technol. 49, 729-736(2012).
5. Siddique, S.; Shafique, Z.; Parveen, S.; Khan, Khanum, R. Volatile components, antioxidant and antimicrobial activity of Citrus Aurantiumvar bitter orange peel oil. Pharmacol. online. 2, 499-507(2011).
6. Odeh, F.; Rahmo, A.; Alnori, A. S.; Chaty, M. E. The cytotoxic effect of essential oils citrus aurantium peels on human colorectal carcinoma cell line(LIM1863). J. Microbiol. Biotechnol. Food Sci. 1, 1476-1487 (2012).
7. Rao, A.; Agarwal, S. Role of antioxidant lycopene in cancer and heart disease. J. Ame. Coll. Nutr. 19, 563-569(2000).
8. Small, G. W.; Robins, R. V.; Barry, P. P.; Buckholts, N. S.; Dekosky, S. T.; Ferris, S. H.; Finkel, S. I.; Gwyther, L. P.; Khachaturian, Z. S.; Lebowitz, B. D.; McRae, T. D.; Morris, J. O.; Oakley, F.; Schneider, L. S.; Streim, J. E.; Sunderland, T.; Teri, L. A.; Tune, L. E. Diagnosis and treatment of Alzheimer's disease and related disorder. JAMA. 278, 1363-1371(1997).
9. Melzer, D. New drug treatment for Alzheimer's disease: lessons for healthcare policy. Br. Med. J. 316, 762-764(1998).
10. Yoon, N. Y.; Chung, H. Y.; Kim, H. R.; Choi, J. S. Acetyland butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera. Fish Sci. 74, 200-207(2008).
11. 2+ induced lipid peroxidation in rat brain in vitro by some citrus fruit juices. J. Med. Food. 15, 428-434(2012).
12. Ferreira, A.; Proença, C.; Serralheiro, M. L. M.; Araújo, M. E. M. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J. Epidemiol. 108, 31-37 (2006).
13. Mukherjee, P. K.; Kumar, V.; Mal M.; Houghton, P. J. Acetylchol inesterase inhibi tors f rom plants. Phytomed. 14, 289-300(2007).
14. Gandhi, S.; Abramov, A. Y. Mechanism of Oxidative Stress in Neurodegeneration. Oxidative Medicine and Cellular Longevity. doi: 10. 1155/2012/428010(2012).
15. European Pharmacopoeia. 3rd Ed. Strasbourg: Council of Europep. 121-122(1997).
16. Bhuiyan, M. N. I.; Begum, J.; Sardar, P. K.; Rahman, M. S. Constituents of Peel and Leaf Essential Oils of Citrus medica L. J. Sci. Res. 1, 387-392(2009).
17. Atti-Santos, A. C.; Rossato, M.; Serafini, L. A.; Cassel, E.; Moyna. P. Extraction of Essential Oils from Lime (Citrus latifolia Tanaka)by Hydrodistillation and Supercritical Carbon Dioxide. Brazil Arch. Biol. Technol. 48, 155-160(2005).
18. Kamal, G. M.; Anwar, F.; Hussain, A. I.; Sarri, N.; Ashraf, M. Y. Yield and chemical composition of Citrus essential oils as affected by drying pretreatment of peels. I. Food Res. J. 18, 1275-1282(2011).
19. Singleton, V. L.; Orthofor, R.; Lamuela-Raventos, R. M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocaltau reagent. Method. Enzymol. 299, 152-178(1999).
20. Meda, A.; Lamie, C.; Romito, M.; Millogo, J.; Nacoulma, O. Determination of the total phenolic, flavonoid and proline contents in Burkina Faso honey, as well as their radical scavenging activity. Food Chem. 91, 571-577(2005).
21. Perry, N. S.; Houghton, P. J.; Theobald, A.; Jenner, P.; Perry, E. K. In vitro activity of Slavandulaefolia (Spanish sage)relevant to treatment of Alzheimer's disease. J. Pharmacol. 52, 895-902(2000).
22. Belle, N.; Dalmolin, G.; Fonini, G.; Rubim, M.; Rocha, J. Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain Res. 1008, 245-251 (2004).
23. Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358(1979).
24. Gyamfi, M. A.; Yonamine, M.; Aniya, Y. Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally induced liver injuries. Gen. Pharmacol. 32, 661-667(1999).
25. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorisation assay. Free Rad. Biol. Med. 26, 1231-1237(1999).
26. Oyaizu, M. Studies on products of browning reaction: antioxidative activity of products of browning reaction prepared from glucosamine. Jpn. J. Nutr. 44, 307-315 (1986).
27. Susanta K.; Chakraborty, G.; Gupta, M.; Mazumder, U. In vitro antioxidant activity of Dispyro. s malabarica kostel bark. India J. Exp. Biol. 44, 39-44(2006).
28. 2+-dependent lipid peroxidation. Free Rad. Biol. Med. 3, 379-387(1987).
29. Puntel, R. L.; Nogueira, C. W.; Rocha, J. B. T. Krebs cycle intermediates modulate thiobarbituric reactive species(TBARS)production in rat brain in vitro. Neurochem. Res. 30, 225-235(2005).
30. Halliwell, B.; Gutteridge, J. M. C. Formation of a thiobarbituric-acid reactive substance from deoxyribose in the presence of iron salts. FEBS Lett. 128, 347-352 (1981).
31. Zar, J. H. Biostatistical Analysis. Prentice-Hall, Inc., Upper Saddle River, NJ p. 620(1984).
32. Howes, M.; Perry, N.; Houghton, P. Plants with traditional uses and activities relevant to the management of Alzheimer's disease and other cognitive disorders. Phytotherap. Res. 17, 1-18(2003).
33. Weinstock, M. Selectivity of cholinesterase inhibition. Clinical implications for the treatment of Alzheimer's disease. CNS Drugs 12, 307-313(1999).
34. Ballard, C. Advances in the treatment of Alzheimer's disease benefits of dual cholinesterase inhibition. Eur. Neurol. 47, 64-70(2002).
35. Benamar, H.; Rached, W.; Derdour, A.; Marouf, A. Screening of algerian medicinal plants for acetylcholinesterase inhibitory activity. J. Biol. Sci. 10, 100-109 (2010).
36. Perry, N. S. L.; Bollen, C.; Perry, E. K; Ballard, C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol. Biochem. Behav. 75, 651-659(2003).
37. Savelev, S.; Okello, E.; Perry, N. S. L.; Wilkins, R. M.; Perry, E. K. Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil. Pharmacol. Biochem. Behav. 75, 661-668(2003).
38. Santos, H. S.; Furtado, E. F.; Bertini, L. M.; Bandeira, P. N.; Ribeiro Albuquerque, M. R. J; Alencar Menezes, J. E. S.; Trevisan, M. T. S.; Lemos, T. L. G. Chemical Composition And Cholinesterase Inhibition Of Essential Oils Of Three Chemotypes From Croton Zehntneri. Revista Lationoamericana de Química. 38, 45-51 (2010).
39. 2+-induced lipid peroxidation in brain in vitro. Food Chem. 102, 178-185(2007).
40. Hazel, J.; Williams, E. The role of alterations in membrane lipid compositions in enabling physiological adaptation of organisms to their physical environment. Prog. Lipid Res. 26, 167-227(1990).
41. Floyd, R.; Carney, J. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32, 22-27(1992).
42. Evan Gelder, W.; Huijskes-Heins, M.; Cleton-Soeteman, M.; van Dijk, J.; van Ejik, H. Iron uptake in blood-brain barrier endothelial cells cultured in iron-depleted and iron-enriched media. J. Neurochem. Res. 71, 1134-1140(1998).
43. Bayi{dotless}r, H.; Kochanek, P. M.; Kagan, V. E. Oxidative stress in immature brain after traumatic brain injury. Dev. Neurosci. 28, 420-431(2006).
44. Pláteník, J.; Stopka, P.; Vejrazka, M.; Stípek, S. Quinolinic acid-iron(ii)complexes: slow autoxidation, but enhanced hydroxyl radical production in the Fenton reaction. Free Rad. Res. 34, 445-459(2001).
45. Myint, A. M. Kynurenines: from the perspective of major psychiatric disorders. FEBS J. 279, 1375-1385 (2012).
46. Chen, Y.; Guillemin, G. J. Kynurenine pathway metabolites in humans: disease and healthy states. I. J. Tryptophan Res. 2, 1-19(2009).
47. Sadeghnia, H. R.; Kamkar, M.; Assadpour, E.; Boroushaki, M. T.; Ghorbani, A. Protective effect of safranal, a constituent of Crocus sativus, on quinolinic acid-induced oxidative damage in rat hippocampus. Iran J. Basic Med. Sci. 16, 73-82(2013).
48. Braidy, N.; Grant, R.; Adams, S.; Brew, B.; Guillemin, G. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotoxicol. Res. 16, 77-86 (2009).
49. Tanyildizi, S.; Servi, K.; Ciftci. O. Protective effects of d-limonene and linalool on female rats intoxicated with 7, 12 dimethylbenz(a)anthracene(DMBA). Revue de Médecine Vétérinaire 160, 221-225(2009).
50. Mastelić, J.; Jerković, I.; Blažević, I.; Poljak-Blaži, M.; Borović, S.; Ivančić-Baće, I.; Smrečki, V.; Zarcović, N.; Brčić-Kostić, K.; Vikić-Topić, D.; Müller, N. Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives. J. Agric. Food Chem. 56, 3989-1996(2008).
51. Aazza, S.; Lyoussi, B.; Miguel, M. G. Antioxidant and Antiacetylcholinesterase Activities of Some Commercial Essential Oils and Their Major Compounds. Mol. 16, 7672-7690(2011).
52. Reed, T. T.; Owen, J.; Pierce, W. M.; Sebastian, A.; Sullivan, P. G.; Butterfield, D. A. Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated post injury with gamma-glutamylcysteine ethyl ester: insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain injury. J. Neurosci. Res. 87, 408-417(2009).
53. Crichton, R. R.; Dexter, D. T.; Ward, R. J. Brain Iron metabolism and its perturbation in neurological diseases. J. Neural. Transm. 118, 301-314(2011).
54. Lindsay, R. C. Food additives In: Fennema OR(Ed), Food Chemistry Marcel Dekker Inc, New York 778-780 (1996).
55. Yuan, Y. V.; Bone, D. E.; Carrington, M. F. Antioxidant activity of dulse(Palmaria palmata)extract evaluated in vitro. Food Chem. 91, 485-494(2005).
56. Gulcin, I.; Bursal, E.; Sehitoglu, M. H.; Bilsel, M.; Goren, A. C. Polyohenol contents and antioxidant activity of lypholysed aqueous extracts of propolis from Erzurm, Turkey. Food Chem. Toxicol. 48, 2227-2238 (2010).