Acetylcholinesterase inhibitors from plants

Phytomedicine

Volumn 14, Issue 4, 2007, Pages 289-300

  Mukherjee, Pulok K ^a,b   Kumar, Venkatesan ^b   Mal, Mainak ^b   Houghton, Peter J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b JADAVPUR UNIVERSITY   (India)

Author keywords

Acetylcholine; Acetylcholinesterase inhibition; Alzheimer's disease; Botanicals; Plants

Indexed keywords

ABUTILON INDICUM EXTRACT; ACANTHUS EBRACTEATUS EXTRACT; ACETYLCHOLINE; AEGLE MARMELOS EXTRACT; ALBIZIA PROCERA EXTRACT; BACOPA MONNIERI EXTRACT; BLACK PEPPER EXTRACT; BUTEA SUPERBA EXTRACT; BUXUS SEMPERVIRENS EXTRACT; CARTHAMUS TINCTORIUS EXTRACT; CASSIA FISTULA EXTRACT; CHOLINESTERASE INHIBITOR; CORYDALIS SOLIDA EXTRACT; CYPERUS ROTUNDUS EXTRACT; EUPHORBIA EXTRACT; FUMARIA EXTRACT; GINKGO BILOBA EXTRACT; LYCOPODIUM CLAVATUM EXTRACT; MAMMEA HARMANDII EXTRACT; MELISSA OFFICINALIS EXTRACT; MICHELIA CHAMPACA EXTRACT; MIMOSA PUDICA EXTRACT; MIMUSOPS ELENGI EXTRACT; MUSA SAPIENTUM EXTRACT; MYRICARIA ELEGANS EXTRACT; NELUMBO NUCIFERA EXTRACT; PLANT EXTRACT; RHODIOLA EXTRACT; SALVIA OFFICINALIS EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABUTILON INDICUM; ACANTHACEAE; ACANTHUS EBRACTEATUS; AEGLE MARMELOS; ALBIZIA PROCERA; ALZHEIMER DISEASE; ANGIOSPERM; ARTICLE; ATAXIA; BACOPA MONNIERI; BANANA; BLACK PEPPER; BUTEA; BUTEA SUPERBA; BUXUS; BUXUS SEMPERVIRENS; CASSIA FISTULA; CORYDALIS SOLIDA; CYPERUS; ENZYME INHIBITION; EUPHORBIA; FUMARIA; GINKGO BILOBA; LEGUME; LYCOPODIUM; MAGNOLIACEAE; MAMMEA; MELISSA OFFICINALIS; MICHELIA CHAMPACA; MIMOSA; MIMUSOPS; MYASTHENIA GRAVIS; MYRICARIA ELEGANS; NELUMBO; PAPAVERACEAE; PRIORITY JOURNAL; RHODIOLA; RUTACEAE; SAFFLOWER; SALVIA OFFICINALIS; SENILE DEMENTIA; TAMARICACEAE;

ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 33947206537     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2007.02.002     Document Type: Article

References (59)

1. Ahmad W., Ahmad B., Ahmad M., Iqbal Z., Nisar M., and Ahmad M. In vitro inhibition of acetylcholinesterase, butyrylcholinesterase and lipoxygenase by crude extract of Myricaria elegans Royle. J. Biol. Sci. 3 (2003) 1046-1049
2. Andrade M.T., Lima J.A., Pinto A.C., Rezende C.M., Carvalho M.P., and Epifanio R.A. Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme. Bioorg. Med. Chem. 13 (2005) 4092-4095
3. 50) by a direct high performance liquid chromatographic method on an immobilized acetylcholinesterase column. J. Chromatogr. B 753 (2001) 375-383
4. Anonymous. Compendium of Pharmaceuticals and Specialties. 25th ed (2000), Canadian Pharmacists Association, Toronto, Canada
5. Ashani Y., Grunwald J., Kronman C., Velan B., and Shafferman A. Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. Mol. Pharmacol. 45 (1994) 555-560
6. Brenner G.M. Pharmacology (2000), W.B. Saunders Company, Philadelphia
7. Brlihlmann C., Marston A., Hostettmann K., Carrupt P.A., and Testa B. Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors. Chem. Biodivers. 1 (2004) 819-829
8. Chung Y.K., Heo H.J., Kim E.K., Kim H.K., Huh T.L., Lim Y., Kim S.K., and Shin D.H. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol. Cells 11 (2001) 137-143
9. Das A., Shanker G., Nath C., Pal R., Singh S., and Singh H.K. A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba anticholinesterase and cognitive enhancing activities. Pharmacol. Biochem. Behav. 73 (2002) 893-900
10. Davies P., and Maloney A.J. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2 (1976) 1403
11. Da-Yuan Z., Dong-Lu B., and Xi-Can T. Recent studies on traditional Chinese medicinal plants. Drug Dev. Res. 39 (1996) 147-157
12. DeKosky S.T., Harbaugh R.E., Schmitt F.A., Bakay R.A., Chui H.C., and Knopman D.S. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological and cognitive correlations. Ann. Neurol. 32 (1992) 625-632
13. Ellman G.L., Courtney K.D., Andres V., and Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 88-95
14. Enz A., Amstutz R., Boddeke H., Gmelin G., and Malanowski J. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease. Prog. Brain Res. 98 (1993) 431-438
15. Erkinjuntti T., Kurz A., Gauthier S., Bullock R., Lilienfeld S., and Damaraju CV. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet 359 (2002) 1283-1290
16. Foye W.O., Lemke T.L., and Williams D.A. Principles of Medicinal Chemistry. fourth ed (1995), Williams and Wilkins, USA
17. Giacobini E. Long term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer's disease. J. Neural Transmission Suppl (2002) 181-187
18. Gottwald M.D., and Rozanski R.I. Rivastigmine a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status. Expert Opin. Invest. Drugs 8 (1999) 1673-1682
19. Hillhouse B.J., Ming D.S., French C.J., and Neil Towers G.H. Acetylcholine esterase inhibitors in Rhodiola rosea. Pharm. Biol. 42 (2004) 68-72
20. Howes M.J., and Houghton P.J. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function Pharmacology. Biochem. Behav. 75 (2003) 513-527
21. Howes M.R., Perry N.S.L., and Houghton P.J. Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother. Res. 17 (2003) 1-18
22. Ingkaninan K., Best D., Heijden V.D., Hofte A.J.P., Karabatak B., Irth H., Tjaden U.R., Greef V.D., and Verpoorte R. High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products. J. Chromatogr. A 872 (2000) 61-73
23. Ingkaninan K., Temkitthawon P., Chuenchom K., Yuyaem T., and Thongnoi W. Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies. J. Ethnopharmacol. 89 (2003) 261-264
24. Karczmar A. Invited review: anticholinesterases: dramatic aspects of their use and misuse. Neurochem. Int. 32 (1998) 401-411
25. Kasa P., Rakonczay Z., and Gulya K. The cholinergic system in Alzheimer's disease. Prog. Neurobiol. 52 (1997) 511-535
26. Kelly C.A., Harvey R.J., and Cayton H. Drug treatments for Alzheimer's disease. Br. Med. J. 314 (1997) 693-694
27. Khalid A., Haq Z.U., Ghayur M.N., Feroz F., Rahman A.U., Gilani A.H., and Choudhary M.I. Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids. J. Steroid Biochem. Mol. Biol. 92 (2004) 477-484
28. Kim D.K. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch. Pharm. Res. 25 (2002) 817-819
29. Kim D.K., Lim J.P., Yang J.H., Eom D.O., Eun J.S., and Leem K.H. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch. Pharm. Res. 25 (2002) 856-859
30. Kim D.K., Lee K.T., Baek N.I., Kim S.H., Park H.W., Lim J.P., Shin T.Y., Eom D.O., Yang J.H., and Eun J.S. Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. Arch. Pharm. Res. 27 (2004) 1127-1131
31. Kishnani P.S., Sullivan J.A., Walter B.K., Spiridigliozzi G.A., Doraiswamy P.M., and Krishnan K.R.R. Cholinergic therapy for Down's syndrome. Lancet 353 (1999) 1064-1065
32. Lee K.Y., Sung S.H., and Kim Y.C. New acetylcholinesterase-inhibitory pregnane glycosides of Cynanchum atratum roots. Helvetica Chim. Acta 86 (2003) 474-483
33. Lopez S., Bastida J., Viladomat F., and Codina C. Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts. Life Sci. 71 (2002) 2521-2529
34. Marston A., Kissling J., and Hostettmann K. A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants. Phytochem. Anal. 13 (2002) 51-54
35. Melzer D. New drug treatment for Alzheimer's diseases: lessons for healthcare policy. BMJ 316 (1998) 762-764
36. Mukherjee P.K. Evaluation of Indian traditional medicine. Drug Inf. J. 35 (2001) 620-623
37. Oh M.H., Houghton P.J., Whang W.K., and Cho J.H. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 11 (2004) 544-548
38. Orhan I., Sener B., Choudhary M.I., and Khalid A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J. Ethnopharmacol. 91 (2004) 57-60
39. Perry E.K., Haroutunian V., and Davis K.L. Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease. Neuroreport 5 (1994) 747-749
40. Perry E.K., Pickering A.T., Wang W.W., Houghton P.J., and Perry N.S.L. Medicinal plants and Alzheimer's disease: integrating ethnobotanical and contemporary scientific evidence. J. Altern. Complem. Med. 4 (1998) 419-428
41. Perry N., Court G., Bidet N., Court J., and Perry E. European herbs with cholinergic activities: potential in dementia therapy. Int. J. Geriatric Psychiatry 11 (1996) 1063-1069
42. Perry N.S.L., Houghton P.G., Theolad A.E., Jenner P., and Perry E.K. In vitro inhibition of human erythrocyte acetylcholinesterase by Salvia lavandulaefolia essential oil and constituent terpenes. J. Pharm. Pharmacol. 52 (2000) 895-902
43. Perry N.S.L., Houghton P.G., Sampson J., Theolad A.E., Hart S., Lis-balchin M., Hoult J.R.S., Evans P., Jenner P., Milligan S., and Perry E.K. In vitro activities of Salvia lavandulaefolia (Spanish Sage) relevant to treatment of Alzheimer's disease. J. Pharm. Pharmacol. 53 (2001) 1347-1356
44. Price D.L. New perspectives on Alzheimer's disease. Neuroscience 9 (1986) 489-512
45. Rahman A.U., and Choudhary M.I. Bioactive natural products as a potential source of new pharmacophores a theory of memory. Pure Appl. Chem. 73 (2001) 555-560
46. Raves M.L., Harel M., Pang Y.P., Silman I., Kozikowski A.P., and Sussman J.L. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat. Struct. Biol. 4 (1997) 57-63
47. Rhee I.K., Meent M.V., Ingkaninan K., and Verpoorte R. Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. J. Chromatogr. A 915 (2001) 217-223
48. Rizzi A., Schuh R., Bruckner A., Cvitkovich B., Kremser L., Jordis U., Frohlich J., Kuenburg B., and Czollner L. Enantiomeric resolution of galantamine and related drugs used in anti-Alzheimer therapy by means of capillary zone electrophoresis employing derivatized cyclodextrin selectors. J. Chromatogr. B 730 (1999) 167-175
49. Roddick J.G. The acetylcholinesterase inhibitory activity of steroidal glycoalkaloids and their aglycones. Phytochemistry 28 (1989) 2631-2634
50. Scott L.J., and Goa K.L. Galantamine: a review of its use in Alzheimer's disease. Drugs 60 (2000) 1095-1122
51. Schulz V. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trial and guidelines fail to consider. Phytomedicine 10 (2003) 74-79
52. Siddiqui M.F., and Levey A.I. Cholinergic therapies in Alzheimer's disease. Drugs of Future 24 (1999) 417-444
53. Sims N.R., Bowen D.M., Allen S.J., Smith C.C., Neary D., and Thomas D.J. Presynaptic cholinergic dysfunction in patients with dementia. J. Neurochem. 40 (1983) 503-509
54. Siqueira I.R., Fochesatto C., Lourenco da Silva A., Nunes D.S., Battastini A.M., Netto C.A., and Elisabetsky E. Ptychopetalum olacoides, a traditional Amazonian nerve tonic possesses anticholinesterase activity. Pharmacol. Biochem. Behav. 75 (2003) 645-650
55. Sung S.H., Kang S.Y., Lee K.Y., Park M.J., Kim J.H., Park J.H., Kim Y.C., Kim J., and Kim Y.C. (+)-α-Viniferin, a stilbene trimer from Caragana chamlague inhibits acetylcholinesterase. Biol. Pharm. Bull. 25 (2002) 125-127
56. Tang X.C., Kindel G.H., Kozikowski A.P., and Hanin I. Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo. J. Ethnopharmacol. 44 (1994) 147-155
57. Urbain A., Marston A., Queiroz E.F., Ndjoko K., and Hostettmann K. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 70 (2004) 1011-1014
58. Wang T., and Tang X.C. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur. J. Pharmacol. 349 (1998) 137-142
59. Whitehouse P.J. Cholinergic therapy in dementia. Acta Neurol. 149 (1993) 42-45