Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Michan, Shaday ^a   Juan, Aimee M ^b   Hurst, Christian G ^b   Cui, Zhenghao ^b   Evans, Lucy P ^b   Hatton, Colman J ^b   Pei, Dorothy T ^b   Ju, Meihua ^b   Sinclair, David A ^c,d   Smith, Lois E H ^b   Chen, Jing ^b  

^a INSTITUTO NACIONAL DE GERIATRÍA   (Mexico)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; CRE RECOMBINASE; NESTIN; OXYGEN; RESVERATROL; SIRTUIN 1; SRT 1720; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; GENE OVEREXPRESSION; MACROPHAGE; MONOCYTE; MOUSE; NERVE CELL DEGENERATION; NEWBORN; NONHUMAN; OXYGEN INDUCED PROLIFERATIVE RETINOPATHY; PROLIFERATIVE RETINOPATHY; PROTEIN EXPRESSION; RETINA BLOOD VESSEL; RETINA NEOVASCULARIZATION; RETINA NERVE CELL; RETINAL THICKNESS; TRANSGENIC MOUSE; UPREGULATION; VASCULAR ENDOTHELIUM; WILD TYPE;

ANIMALS; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENE EXPRESSION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INTEGRASES; MACROPHAGES; MICE; NEOVASCULARIZATION, PATHOLOGIC; NERVE DEGENERATION; NESTIN; NEURONS; OXYGEN; RECEPTOR, TIE-2; RETINA; RETINAL DEGENERATION; SIRTUIN 1; STILBENES;

EID: 84896989132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085031     Document Type: Article

References (53)

1. Chen J, Smith LE (2007) Retinopathy of prematurity. Angiogenesis 10: 133-140. (Pubitemid 46440629)
2. Antonetti DA, Klein R, Gardner TW (2012) Diabetic retinopathy. N Engl J Med 366: 1227-1239.
3. Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, et al. (1995) Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A 92: 10457-10461.
4. Chen J, Connor KM, Aderman CM, Smith LE (2008) Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest 118: 526-533. (Pubitemid 351206543)
5. Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, et al. (2009) Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci 50: 1329-1335.
6. Watanabe D, Suzuma K, Matsui S, Kurimoto M, Kiryu J, et al. (2005) Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med 353: 782-792. (Pubitemid 41215487)
7. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, et al. (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480-1487. (Pubitemid 24356306)
8. Chen J, Stahl A, Hellstrom A, Smith LE (2011) Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr 23: 173-178.
9. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, et al. (2011) Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood 117: 6024-6035.
10. Sapieha P (2012) Eyeing central neurons in vascular growth and reparative angiogenesis. Blood 120: 2182-2194.
11. Fulton AB, Hansen RM, Moskowitz A, Akula JD (2009) The neurovascular retina in retinopathy of prematurity. Prog Retin Eye Res 28: 452-482.
12. Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, et al. (2013) Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis Aug 4. [Epub ahead of print].
13. Smith LE, Wesolowski E, McLellan A, Kostyk SK, D'Amato R, et al. (1994) Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 35: 101-111. (Pubitemid 24046832)
14. Guarente L (2011) Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. N Engl J Med 364: 2235-2244.
15. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, et al. (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458: 1056-1060.
16. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015. (Pubitemid 38393275)
17. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118. (Pubitemid 40349395)
18. Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, et al. (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324: 1289-1293.
19. Michan S (2013) Acetylome Regulation By Sirtuins In The Brain:From Normal Physiology To Aging And Pathology. Curr Pharm Des.
20. Michan S, Li Y, Chou MM, Parrella E, Ge H, et al. (2010) SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci 30: 9695-9707.
21. Donmez G, Wang D, Cohen DE, Guarente L (2010) SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142: 320-332.
22. Jiang M, Wang J, Fu J, Du L, Jeong H, et al. (2012) Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med 18: 153-158.
23. Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, et al. (2012) SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. J Neurosci 32: 124-132.
24. Guarani V, Deflorian G, Franco CA, Kruger M, Phng LK, et al. (2011) Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 473: 234-238.
25. Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, et al. (2007) SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21: 2644-2658. (Pubitemid 47607673)
26. Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, et al. (2011) SRT1720 improves survival and healthspan of obese mice. Sci Rep 1: 70.
27. Hubbard BP, Gomes AP, Dai H, Li J, Case AW, et al. (2013) Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 339: 1216-1219.
28. Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, et al. (2009) Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc 4: 1565-1573.
29. Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, et al. (2010) The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci 51: 2813-2826.
30. Stahl A, Connor KM, Sapieha P, Willett KL, Krah NM, et al. (2009) Computer-aided quantification of retinal neovascularization. Angiogenesis 12: 297-301.
31. Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, et al. (2011) Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation 124: 1871-1881.
32. Libert S, Pointer K, Bell EL, Das A, Cohen DE, et al. (2011) SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 147: 1459-1472.
33. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109-1122. (Pubitemid 44894520)
34. Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, et al. (2012) SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood.
35. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342. (Pubitemid 44764104)
36. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716. (Pubitemid 350207685)
37. Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, et al. (2007) Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100: 1512-1521. (Pubitemid 46834764)
38. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, et al. (2008) SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135: 907-918.
39. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, et al. (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3: e2020.
40. Kadiyala CS, Zheng L, Du Y, Yohannes E, Kao HY, et al. (2012) Acetylation of retinal histones in diabetes increases inflammatory proteins; effects of minocycline and manipulation of histone acetyl transferase (HAT) and histone deacetylase (HDAC). J Biol Chem.
41. Chen B, Cepko CL (2009) HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323: 256-259.
42. Baur JA (2010) Biochemical effects of SIRT1 activators. Biochim Biophys Acta 1804: 1626-1634.
43. Smoliga JM, Baur JA, Hausenblas HA (2011) Resveratrol and health-a comprehensive review of human clinical trials. Mol Nutr Food Res 55: 1129-1141.
44. Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, et al. (2010) Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation. Am J Pathol 177: 1725-1731.
45. King RE, Kent KD, Bomser JA (2005) Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact 151: 143-149. (Pubitemid 40208564)
46. Kim WT, Suh ES (2010) Retinal protective effects of resveratrol via modulation of nitric oxide synthase on oxygen-induced retinopathy. Korean J Ophthalmol 24: 108-118.
47. Hua J, Guerin KI, Chen J, Michan S, Stahl A, et al. (2011) Resveratrol Inhibits Pathological Retinal Neovascularization in Vldlr-/- Mice. Invest Ophthalmol Vis Sci.
48. Khan AA, Dace DS, Ryazanov AG, Kelly J, Apte RS (2010) Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol 177: 481-492.
49. Wiejak J, Dunlop J, Mackay SP, Yarwood SJ (2013) Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. Biochem J 454: 283-293.
50. Ichikawa T, Hayashi R, Suzuki K, Imanishi S, Kambara K, et al. (2013) Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma. Respirology 18: 332-339.
51. Suzuki K, Hayashi R, Ichikawa T, Imanishi S, Yamada T, et al. (2012) SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncol Rep 27: 1726-1732.
52. Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, et al. (2010) Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol 30: 328-339.
53. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, et al. (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285: 8340-8351.