-
1
-
-
2442646665
-
A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group
-
ALS CNTF Treatment Study Group,: 10.1212/wnl.46.5.1244
-
ALS CNTF Treatment Study Group. (1996). A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46, 1244-1249. doi: 10.1212/wnl.46.5.1244
-
(1996)
Neurology
, vol.46
, pp. 1244-1249
-
-
-
2
-
-
0028951044
-
Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease
-
doi: 10.1038/nm0295-168
-
Anand, P., Parrett, A., Martin, J., Zeman, S., Foley, P., Swash, M., et al. (1995). Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease. Nat. Med. 1, 168-172. doi: 10.1038/nm0295-168
-
(1995)
Nat. Med
, vol.1
, pp. 168-172
-
-
Anand, P.1
Parrett, A.2
Martin, J.3
Zeman, S.4
Foley, P.5
Swash, M.6
-
3
-
-
2642526164
-
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
-
doi: 10.1038/nature02544
-
Azzouz, M., Ralph, G. S., Storkebaum, E., Walmsley, L. E., Mitrophanous, K. A., Kingsman, S. M., et al. (2004). VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429, 413-417. doi: 10.1038/nature02544
-
(2004)
Nature
, vol.429
, pp. 413-417
-
-
Azzouz, M.1
Ralph, G.S.2
Storkebaum, E.3
Walmsley, L.E.4
Mitrophanous, K.A.5
Kingsman, S.M.6
-
4
-
-
0037109762
-
Motoneuron- derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons
-
Bechade, C., Mallecourt, C., Sedel, F., Vyas, S., and Triller, A. (2002). Motoneuron- derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons. J. Neurosci. 22, 8779-8784.
-
(2002)
J. Neurosci
, vol.22
, pp. 8779-8784
-
-
Bechade, C.1
Mallecourt, C.2
Sedel, F.3
Vyas, S.4
Triller, A.5
-
5
-
-
77956395029
-
Amyotrophic lateral sclerosis: Current practice and future treatments
-
doi: 10.1097/wco. 0b013e32833c7ac2
-
Bedlack, R. S. (2010). Amyotrophic lateral sclerosis: current practice and future treatments. Curr. Opin. Neurol. 23, 524-529. doi: 10.1097/wco. 0b013e32833c7ac2
-
(2010)
Curr. Opin. Neurol
, vol.23
, pp. 524-529
-
-
Bedlack, R.S.1
-
6
-
-
84872197429
-
Recombinant human insulin-like growth factor I (rhIGF-I) for the treatment of amyotrophic lateral sclerosis/motor neuron disease
-
doi: 10.1002/14651858.CD002064.pub3
-
Beauverd, M., Mitchell, J. D., Wokke, J. H., and Borasio, G. D. (2012). Recombinant human insulin-like growth factor I (rhIGF-I) for the treatment of amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst. Rev. 11:CD002064. doi: 10.1002/14651858.CD002064.pub3
-
(2012)
Cochrane Database Syst. Rev
, vol.11
-
-
Beauverd, M.1
Mitchell, J.D.2
Wokke, J.H.3
Borasio, G.D.4
-
7
-
-
0035886428
-
Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity
-
doi: 10.1016/s0022- 510x(01)00627-x
-
Bendotti, C., Calvaresi, N., Chiveri, L., Prelle, A., Moggio, M., Braga, M., et al. (2001). Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity. J. Neurol. Sci. 191, 25-33 doi: 10.1016/s0022- 510x(01)00627-x
-
(2001)
J. Neurol. Sci
, vol.191
, pp. 25-33
-
-
Bendotti, C.1
Calvaresi, N.2
Chiveri, L.3
Prelle, A.4
Moggio, M.5
Braga, M.6
-
8
-
-
0033062724
-
Apoptosis in neuronal development and transplantation: Role of caspases and trophic factors
-
doi: 10.1006/exnr.1999.7056
-
Boonman, Z., and Isacson, O. (1999). Apoptosis in neuronal development and transplantation: role of caspases and trophic factors. Exp. Neurol. 156, 1-15. doi: 10.1006/exnr.1999.7056
-
(1999)
Exp. Neurol
, vol.156
, pp. 1-15
-
-
Boonman, Z.1
Isacson, O.2
-
9
-
-
0031722582
-
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group
-
doi: 10.1212/wnl.51.2.583
-
Borasio, G. D., Robberecht, W., Leigh, P. N., Emile, J., Guiloff, R. J., Jerusalem, F., et al. (1998). A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group. Neurology 51, 583-586. doi: 10.1212/wnl.51.2.583
-
(1998)
Neurology
, vol.51
, pp. 583-586
-
-
Borasio, G.D.1
Robberecht, W.2
Leigh, P.N.3
Emile, J.4
Guiloff, R.J.5
Jerusalem, F.6
-
10
-
-
34248569426
-
Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis
-
doi: 10.1186/1471-2350-8-23
-
Brockington, A., Wokke, B., Nixon, H., Hartley, J., and Shaw, P. J. (2007). Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis. BMC Med. Genet. 8:23. doi: 10.1186/1471-2350-8-23
-
(2007)
BMC Med. Genet
, vol.8
, pp. 23
-
-
Brockington, A.1
Wokke, B.2
Nixon, H.3
Hartley, J.4
Shaw, P.J.5
-
11
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
doi: 10.1016/s0896-6273(00)80272-x
-
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., et al. (1997). ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 18, 327-338. doi: 10.1016/s0896-6273(00)80272-x
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
-
12
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
doi: 10.1126/science.282.5392.1318
-
Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., et al. (1998). Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321. doi: 10.1126/science.282.5392.1318
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
-
13
-
-
78149352586
-
Neurotrophic factors improve muscle reinnervation from embryonic neurons
-
doi: 10.1002/mus.21757
-
Casella, G. T., Almeida, V. W., Grumbles, R. M., Liu, Y., and Thomas, C. K. (2010). Neurotrophic factors improve muscle reinnervation from embryonic neurons. Muscle Nerve 42, 788-797. doi: 10.1002/mus.21757
-
(2010)
Muscle Nerve
, vol.42
, pp. 788-797
-
-
Casella, G.T.1
Almeida, V.W.2
Grumbles, R.M.3
Liu, Y.4
Thomas, C.K.5
-
14
-
-
0028933344
-
Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD and in mice overexpressing wild type human SOD: A model of familial amyotrophic lateral sclerosis (FALS)
-
doi: 10.1016/0006-8993(95)00063-V
-
Dal Canto, M. C., and Gurney, M. E. (1995). Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res. 676, 25-40. doi: 10.1016/0006-8993(95)00063-V
-
(1995)
Brain Res
, vol.676
, pp. 25-40
-
-
Dal Canto, M.C.1
Gurney, M.E.2
-
15
-
-
0028788476
-
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
-
doi: 10. 1016/0092-8674(95)90172-8
-
DeChiara, T. M., Vejsada, R., Poueymirou, W. T., Acheson, A., Suri, C., Conover, J. C., et al. (1995). Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83, 313-322. doi: 10. 1016/0092-8674(95)90172-8
-
(1995)
Cell
, vol.83
, pp. 313-322
-
-
Dechiara, T.M.1
Vejsada, R.2
Poueymirou, W.T.3
Acheson, A.4
Suri, C.5
Conover, J.C.6
-
16
-
-
77952932485
-
FUS-immunoreactive inclusions are a common feature in sporadic and non- SOD1 familial amyotrophic lateral sclerosis
-
doi: 10. 1002/ana.22051
-
Deng, H. X., Zhai, H., Bigio, E. H., Yan, J., Fecto, F., Ajroud, K., et al. (2010). FUS-immunoreactive inclusions are a common feature in sporadic and non- SOD1 familial amyotrophic lateral sclerosis. Ann. Neurol. 67, 739-748. doi: 10. 1002/ana.22051
-
(2010)
Ann. Neurol
, vol.67
, pp. 739-748
-
-
Deng, H.X.1
Zhai, H.2
Bigio, E.H.3
Yan, J.4
Fecto, F.5
Ajroud, K.6
-
17
-
-
2942627907
-
Low levels of the vascular endothelial growth factor in CSF from early ALS patients
-
doi: 10.1212/01.wnl.0000129913. 44351.a3
-
Devos, D., Moreau, C., Lassalle, P., Perez, T., De Seze, J., Brunaud-Danel, V., et al. (2004). Low levels of the vascular endothelial growth factor in CSF from early ALS patients. Neurology 62, 2127-2129. doi: 10.1212/01.wnl.0000129913. 44351.a3
-
(2004)
Neurology
, vol.62
, pp. 2127-2129
-
-
Devos, D.1
Moreau, C.2
Lassalle, P.3
Perez, T.4
de Seze, J.5
Brunaud-Danel, V.6
-
18
-
-
34147131311
-
Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death
-
doi: 10.1016/j.nbd.2006.12.023
-
Dewil, M., Dela Cruz, V. F., Van Den Bosch, L., and Robberecht, W. (2007). Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death. Neurobiol. Dis. 26, 332-341. doi: 10.1016/j.nbd.2006.12.023
-
(2007)
Neurobiol. Dis
, vol.26
, pp. 332-341
-
-
Dewil, M.1
Dela Cruz, V.F.2
Van Den Bosch, L.3
Robberecht, W.4
-
19
-
-
44349162407
-
Delivery ofAAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity
-
doi: 10. 1038/mt.2008.60
-
Dodge, J. C., Haidet, A. M., Yang, W., Passini, M. A., Hester, M., Clarke, J., et al. (2008). Delivery ofAAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity. Mol. Ther. 16, 1056-1064. doi: 10. 1038/mt.2008.60
-
(2008)
Mol. Ther
, vol.16
, pp. 1056-1064
-
-
Dodge, J.C.1
Haidet, A.M.2
Yang, W.3
Passini, M.A.4
Hester, M.5
Clarke, J.6
-
20
-
-
51149107212
-
A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinalmotor neurons
-
doi: 10.1523/jneurosci. 2010-08.2008
-
Dugas, J. C., Mandemakers, W., Rogers, M., Ibrahim, A., Daneman, R., and Barres, B. A. (2008). A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinalmotor neurons. J. Neurosci. 28, 8294-8305. doi: 10.1523/jneurosci. 2010-08.2008
-
(2008)
J. Neurosci
, vol.28
, pp. 8294-8305
-
-
Dugas, J.C.1
Mandemakers, W.2
Rogers, M.3
Ibrahim, A.4
Daneman, R.5
Barres, B.A.6
-
21
-
-
0028274040
-
Mice lacking brain-derived neu- rotrophic factor develop with sensory deficits
-
doi: 10. 1038/368147a0
-
Ernfors, P., Lee, K. F., and Jaenisch, R. (1994a). Mice lacking brain-derived neu- rotrophic factor develop with sensory deficits. Nature 368, 147-150. doi: 10. 1038/368147a0
-
(1994)
Nature
, vol.368
, pp. 147-150
-
-
Ernfors, P.1
Lee, K.F.2
Jaenisch, R.3
-
22
-
-
0028291238
-
Lack of neurotrophin- 3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
-
doi: 10.1016/0092-8674(94)90 213-5
-
Ernfors, P., Lee, K. F., Kucera, J., and Jaenisch, R. (1994b). Lack of neurotrophin- 3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77, 503-512. doi: 10.1016/0092-8674(94)90 213-5
-
(1994)
Cell
, vol.77
, pp. 503-512
-
-
Ernfors, P.1
Lee, K.F.2
Kucera, J.3
Jaenisch, R.4
-
23
-
-
0141529994
-
Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo
-
Forger, N. G., Prevette, D., Delapeyriere, O., De Bovis, B., Wang, S., Bartlett, P., et al. (2003). Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. J. Neurosci. 23, 8854-8858.
-
(2003)
J. Neurosci
, vol.23
, pp. 8854-8858
-
-
Forger, N.G.1
Prevette, D.2
Delapeyriere, O.3
de Bovis, B.4
Wang, S.5
Bartlett, P.6
-
24
-
-
0033977281
-
Brain-derived neurotrophic factor induces excitotoxic sensitivityin cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway
-
doi: 10. 1046/j.1471-4159.2000.740582.x
-
Fryer, H. J., Wolf, D. H., Knox, R. J., Strittmatter, S. M., Pennica, D., O'leary, R. M., et al. (2000). Brain-derived neurotrophic factor induces excitotoxic sensitivityin cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway. J. Neurochem. 74, 582-595. doi: 10. 1046/j.1471-4159.2000.740582.x
-
(2000)
J. Neurochem
, vol.74
, pp. 582-595
-
-
Fryer, H.J.1
Wolf, D.H.2
Knox, R.J.3
Strittmatter, S.M.4
Pennica, D.5
O'Leary, R.M.6
-
25
-
-
17344367099
-
The neuroprotective function of vascular endothelial growth factor (VEGF)
-
Gora-Kupilas, K., and Josko, J. (2005). The neuroprotective function of vascular endothelial growth factor (VEGF). Folia Neuropathol. 43, 31-39.
-
(2005)
Folia Neuropathol
, vol.43
, pp. 31-39
-
-
Gora-Kupilas, K.1
Josko, J.2
-
26
-
-
84895807660
-
Amyotrophic lateral sclerosis: An update for 2013 clinical features, pathophysiology, management and therapeutic trials
-
doi: 10.14336/ad.2013.0400295
-
Gordon, P. H. (2013). Amyotrophic lateral sclerosis: an update for 2013 clinical features, pathophysiology, management and therapeutic trials. Aging Dis. 4, 295-310. doi: 10.14336/ad.2013.0400295
-
(2013)
Aging Dis
, vol.4
, pp. 295-310
-
-
Gordon, P.H.1
-
27
-
-
39849108398
-
The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
-
doi: 10.1523/jneurosci.5185-07.2008
-
Gould, T. W., Yonemura, S., Oppenheim, R. W., Ohmori, S., and Enomoto, H. (2008). The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J. Neurosci. 28, 2131-2146. doi: 10.1523/jneurosci.5185-07.2008
-
(2008)
J. Neurosci
, vol.28
, pp. 2131-2146
-
-
Gould, T.W.1
Yonemura, S.2
Oppenheim, R.W.3
Ohmori, S.4
Enomoto, H.5
-
28
-
-
0032523802
-
Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuronloss
-
doi: 10.1006/dbio.1997.8859
-
Grieshammer, U., Lewandoski, M., Prevette, D., Oppenheim, R. W., and Martin, G. R. (1998). Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuronloss. Dev. Biol. 197, 234-247. doi: 10.1006/dbio.1997.8859
-
(1998)
Dev. Biol
, vol.197
, pp. 234-247
-
-
Grieshammer, U.1
Lewandoski, M.2
Prevette, D.3
Oppenheim, R.W.4
Martin, G.R.5
-
29
-
-
0344012211
-
Absence of mutations in the hypoxia response element ofVEGF in ALS
-
doi: 10.1002/mus.10498
-
Gros-Louis, F., Laurent, S., Lopes, A. A., Khoris, J., Meininger, V., Camu, W., et al. (2003). Absence of mutations in the hypoxia response element ofVEGF in ALS. Muscle Nerve 28, 774-775. doi: 10.1002/mus.10498
-
(2003)
Muscle Nerve
, vol.28
, pp. 774-775
-
-
Gros-Louis, F.1
Laurent, S.2
Lopes, A.A.3
Khoris, J.4
Meininger, V.5
Camu, W.6
-
30
-
-
0033556587
-
Increased expression of glial cell line-derived neu- rotrophic factor mRNA in muscle biopsies from patients with amyotrophic lateral sclerosis
-
doi: 10.1016/s0022-510x(98) 00333-5
-
Grundstrom, E., Askmark, H., Lindeberg, J., Nygren, I., Ebendal, T., and Aquilonius, S. M. (1999). Increased expression of glial cell line-derived neu- rotrophic factor mRNA in muscle biopsies from patients with amyotrophic lateral sclerosis. J. Neurol. Sci. 162, 169-173. doi: 10.1016/s0022-510x(98) 00333-5
-
(1999)
J. Neurol. Sci
, vol.162
, pp. 169-173
-
-
Grundstrom, E.1
Askmark, H.2
Lindeberg, J.3
Nygren, I.4
Ebendal, T.5
Aquilonius, S.M.6
-
31
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
-
doi: 10. 1126/science.8209258
-
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., et al. (1994). Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-1775. doi: 10. 1126/science.8209258
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
-
32
-
-
0037194898
-
GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools
-
doi: 10. 1016/s0896-6273(02)00864-4
-
Haase, G., Dessaud, E., Garces, A., De Bovis, B., Birling, M., Filippi, P., et al. (2002). GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Neuron 35, 893-905. doi: 10. 1016/s0896-6273(02)00864-4
-
(2002)
Neuron
, vol.35
, pp. 893-905
-
-
Haase, G.1
Dessaud, E.2
Garces, A.3
de Bovis, B.4
Birling, M.5
Filippi, P.6
-
33
-
-
84863029363
-
An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury
-
doi: 10.1089/scd.2011.0596
-
Hawryluk, G. W., Mothe, A., Wang, J., Wang, S., Tator, C., and Fehlings, M. G. (2012). An in vivo characterization of trophic factor production following neural precursor cell or bone marrow stromal cell transplantation for spinal cord injury. Stem Cells Dev. 21, 2222-2238. doi: 10.1089/scd.2011.0596
-
(2012)
Stem Cells Dev
, vol.21
, pp. 2222-2238
-
-
Hawryluk, G.W.1
Mothe, A.2
Wang, J.3
Wang, S.4
Tator, C.5
Fehlings, M.G.6
-
34
-
-
19444374567
-
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice
-
doi: 10.1016/j.brainres.2005.03.037
-
Holasek, S. S., Wengenack, T. M., Kandimalla, K. K., Montano, C., Gregor, D. M., Curran, G. L., et al. (2005). Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res. 1045, 185-198. doi: 10.1016/j.brainres.2005.03.037
-
(2005)
Brain Res
, vol.1045
, pp. 185-198
-
-
Holasek, S.S.1
Wengenack, T.M.2
Kandimalla, K.K.3
Montano, C.4
Gregor, D.M.5
Curran, G.L.6
-
35
-
-
48949091215
-
Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration
-
doi: 10.1016/s1937-6448(08)00603-5
-
Hou, S. T., Jiang, S. X., and Smith, R. A. (2008). Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration. Int. Rev. Cell Mol. Biol. 267, 125-181. doi: 10.1016/s1937-6448(08)00603-5
-
(2008)
Int. Rev. Cell Mol. Biol
, vol.267
, pp. 125-181
-
-
Hou, S.T.1
Jiang, S.X.2
Smith, R.A.3
-
36
-
-
0034862169
-
Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord
-
Ikeda, O., Murakami, M., Ino, H., Yamazaki, M., Nemoto, T., Koda, M., et al. (2001). Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord. Acta Neuropathol. 102, 239-245.
-
(2001)
Acta Neuropathol
, vol.102
, pp. 239-245
-
-
Ikeda, O.1
Murakami, M.2
Ino, H.3
Yamazaki, M.4
Nemoto, T.5
Koda, M.6
-
37
-
-
0028351190
-
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
-
doi: 10.1016/0092- 8674(94)90377-8
-
Jones, K. R., Farinas, I., Backus, C., and Reichardt, L. F. (1994). Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76, 989-999. doi: 10.1016/0092- 8674(94)90377-8
-
(1994)
Cell
, vol.76
, pp. 989-999
-
-
Jones, K.R.1
Farinas, I.2
Backus, C.3
Reichardt, L.F.4
-
38
-
-
0033120177
-
Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain
-
doi: 10.1006/dbio.1998.9184
-
Kablar, B., and Rudnicki, M. A. (1999). Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain. Dev. Biol. 208, 93-109. doi: 10.1006/dbio.1998.9184
-
(1999)
Dev. Biol
, vol.208
, pp. 93-109
-
-
Kablar, B.1
Rudnicki, M.A.2
-
39
-
-
0042528664
-
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
-
doi: 10.1126/science.1086137
-
Kaspar, B. K., Llado, J., Sherkat, N., Rothstein, J. D., and Gage, F. H. (2003). Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 301, 839-842. doi: 10.1126/science.1086137
-
(2003)
Science
, vol.301
, pp. 839-842
-
-
Kaspar, B.K.1
Llado, J.2
Sherkat, N.3
Rothstein, J.D.4
Gage, F.H.5
-
40
-
-
33845242529
-
Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
-
doi: 10.1523/jneurosci.0434-06.2006
-
Kilic, U., Kilic, E., Jarve, A., Guo, Z., Spudich, A., Bieber, K., et al. (2006). Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J. Neurosci. 26, 12439-12446. doi: 10.1523/jneurosci.0434-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 12439-12446
-
-
Kilic, U.1
Kilic, E.2
Jarve, A.3
Guo, Z.4
Spudich, A.5
Bieber, K.6
-
41
-
-
0037049644
-
Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation ofNADPH oxidase
-
doi: 10.1083/jcb.200112131
-
Kim, S. H., Won, S. J., Sohn, S., Kwon, H. J., Lee, J. Y., Park, J. H., et al. (2002). Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation ofNADPH oxidase. J. Cell Biol. 159, 821-831. doi: 10.1083/jcb.200112131
-
(2002)
J. Cell Biol
, vol.159
, pp. 821-831
-
-
Kim, S.H.1
Won, S.J.2
Sohn, S.3
Kwon, H.J.4
Lee, J.Y.5
Park, J.H.6
-
42
-
-
23944442778
-
Phos- phatidylinositol 3-kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
-
doi: 10.1016/j.tox.2005.05.009
-
Koh, S. H., Roh, H., Lee, S. M., Kim, H. J., Kim, M., Lee, K. W., et al. (2005). Phos- phatidylinositol 3-kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene. Toxicology 213, 45-55. doi: 10.1016/j.tox.2005.05.009
-
(2005)
Toxicology
, vol.213
, pp. 45-55
-
-
Koh, S.H.1
Roh, H.2
Lee, S.M.3
Kim, H.J.4
Kim, M.5
Lee, K.W.6
-
43
-
-
0027195615
-
The neurotrophicfactor concept:Areexamination
-
Korsching, S. (1993). The neurotrophicfactor concept:areexamination. J. Neurosci. 13, 2739-2748.
-
(1993)
J. Neurosci
, vol.13
, pp. 2739-2748
-
-
Korsching, S.1
-
44
-
-
33644823299
-
Expectations and challenges in the therapeutic use of neurotrophic factors
-
doi: 10. 1002/ana.20794
-
Kotzbauer, P. T., and Holtzman, D. M. (2006). Expectations and challenges in the therapeutic use of neurotrophic factors. Ann. Neurol. 59, 444-447. doi: 10. 1002/ana.20794
-
(2006)
Ann. Neurol
, vol.59
, pp. 444-447
-
-
Kotzbauer, P.T.1
Holtzman, D.M.2
-
45
-
-
84881313291
-
Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial als rat model
-
doi: 10.1038/mt. 2013.108
-
Krakora, D., Mulcrone, P., Meyer, M., Lewis, C., Bernau, K., Gowing, G., et al. (2013). Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial als rat model. Mol. Ther. 21, 1602-1610. doi: 10.1038/mt. 2013.108
-
(2013)
Mol. Ther
, vol.21
, pp. 1602-1610
-
-
Krakora, D.1
Mulcrone, P.2
Meyer, M.3
Lewis, C.4
Bernau, K.5
Gowing, G.6
-
46
-
-
33646493863
-
Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor- axon pathway selection in the limb
-
doi: 10.1016/j.neuron. 2006.02.020
-
Kramer, E. R., Knott, L., Su, F., Dessaud, E., Krull, C. E., Helmbacher, F., et al. (2006). Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor- axon pathway selection in the limb. Neuron 50, 35-47. doi: 10.1016/j.neuron. 2006.02.020
-
(2006)
Neuron
, vol.50
, pp. 35-47
-
-
Kramer, E.R.1
Knott, L.2
Su, F.3
Dessaud, E.4
Krull, C.E.5
Helmbacher, F.6
-
47
-
-
41049090255
-
Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset
-
doi: 10.1111/j.1468-1331.2008.02080.x
-
Laaksovirta, H., Soinila, S., Hukkanen, V., Roytta, M., and Soilu-Hanninen, M. (2008). Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset. Eur. J. Neurol. 15, 355-359. doi: 10.1111/j.1468-1331.2008.02080.x
-
(2008)
Eur. J. Neurol
, vol.15
, pp. 355-359
-
-
Laaksovirta, H.1
Soinila, S.2
Hukkanen, V.3
Roytta, M.4
Soilu-Hanninen, M.5
-
48
-
-
6844266272
-
Effect of recombinant human insulin-like growth factor-I on progression ofALS. A placebo-controlled study. The North America ALS/IGF-I Study Group
-
doi: 10.1212/wnl.49.6.1621
-
Lai, E. C., Felice, K. J., Festoff, B. W., Gawel, M. J., Gelinas, D. F., Kratz, R., et al. (1997). Effect of recombinant human insulin-like growth factor-I on progression ofALS. A placebo-controlled study. The North America ALS/IGF-I Study Group. Neurology 49, 1621-1630. doi: 10.1212/wnl.49.6.1621
-
(1997)
Neurology
, vol.49
, pp. 1621-1630
-
-
Lai, E.C.1
Felice, K.J.2
Festoff, B.W.3
Gawel, M.J.4
Gelinas, D.F.5
Kratz, R.6
-
49
-
-
72749106555
-
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: Increased susceptibility in male carriers of the -2578AA genotype
-
doi: 10.1136/jmg. 2008.058222
-
Lambrechts, D., Poesen, K., Fernandez-Santiago, R., Al-Chalabi, A., Del Bo, R., Van Vught, P. W., et al. (2009). Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype. J. Med. Genet. 46, 840-846. doi: 10.1136/jmg. 2008.058222
-
(2009)
J. Med. Genet
, vol.46
, pp. 840-846
-
-
Lambrechts, D.1
Poesen, K.2
Fernandez-Santiago, R.3
Al-Chalabi, A.4
Del Bo, R.5
van Vught, P.W.6
-
50
-
-
0033232984
-
Analysis of the retrograde transport of glial cell line-derived neurotrophic factor (GDNF), neurturin, and persephin suggests that in vivo signaling for the GDNF family is GFRalpha coreceptor-specific
-
Leitner, M. L., Molliver, D. C., Osborne, P. A., Vejsada, R., Golden, J. P., Lampe, P. A., et al. (1999). Analysis of the retrograde transport of glial cell line-derived neurotrophic factor (GDNF), neurturin, and persephin suggests that in vivo signaling for the GDNF family is GFRalpha coreceptor-specific. J. Neurosci. 19, 9322-9331.
-
(1999)
J. Neurosci
, vol.19
, pp. 9322-9331
-
-
Leitner, M.L.1
Molliver, D.C.2
Osborne, P.A.3
Vejsada, R.4
Golden, J.P.5
Lampe, P.A.6
-
51
-
-
0037451069
-
VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death
-
doi: 10.1016/s0169- 328x(03)00025-1
-
Li, B., Xu, W., Luo, C., Gozal, D., and Liu, R. (2003). VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. Brain Res. Mol. Brain Res. 111, 155-164. doi: 10.1016/s0169- 328x(03)00025-1
-
(2003)
Brain Res. Mol. Brain Res
, vol.111
, pp. 155-164
-
-
Li, B.1
Xu, W.2
Luo, C.3
Gozal, D.4
Liu, R.5
-
52
-
-
84863845583
-
Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model ofALS
-
doi: 10.1016/j.expneurol.2012. 06.011
-
Liao, B., Zhao, W., Beers, D. R., Henkel, J. S., and Appel, S. H. (2012). Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model ofALS. Exp. Neurol. 237, 147-152. doi: 10.1016/j.expneurol.2012. 06.011
-
(2012)
Exp. Neurol
, vol.237
, pp. 147-152
-
-
Liao, B.1
Zhao, W.2
Beers, D.R.3
Henkel, J.S.4
Appel, S.H.5
-
53
-
-
84855833419
-
Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients
-
doi: 10. 1002/mus.22288
-
Lunetta, C., Serafini, M., Prelle, A., Magni, P., Dozio, E., Ruscica, M., et al. (2012). Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients. Muscle Nerve 45, 200-208. doi: 10. 1002/mus.22288
-
(2012)
Muscle Nerve
, vol.45
, pp. 200-208
-
-
Lunetta, C.1
Serafini, M.2
Prelle, A.3
Magni, P.4
Dozio, E.5
Ruscica, M.6
-
54
-
-
0027484249
-
Disruption of the CNTF gene results in motor neuron degeneration
-
doi: 10.1038/365027a0
-
Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G., and Thoenen, H. (1993). Disruption of the CNTF gene results in motor neuron degeneration. Nature 365, 27-32. doi: 10.1038/365027a0
-
(1993)
Nature
, vol.365
, pp. 27-32
-
-
Masu, Y.1
Wolf, E.2
Holtmann, B.3
Sendtner, M.4
Brem, G.5
Thoenen, H.6
-
55
-
-
0035344017
-
Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades
-
doi: 10.1096/fj.00-0495fje
-
Matsuzaki, H., Tamatani, M., Yamaguchi, A., Namikawa, K., Kiyama, H., Vitek, M. P., et al. (2001). Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J. 15, 1218-1220. doi: 10.1096/fj.00-0495fje
-
(2001)
FASEB J
, vol.15
, pp. 1218-1220
-
-
Matsuzaki, H.1
Tamatani, M.2
Yamaguchi, A.3
Namikawa, K.4
Kiyama, H.5
Vitek, M.P.6
-
56
-
-
0028095440
-
The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
-
doi: 10. 1002/ana.410360205
-
Mitsumoto, H., Ikeda, K., Holmlund, T., Greene, T., Cedarbaum, J. M., Wong, V., et al. (1994). The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann. Neurol. 36, 142-148. doi: 10. 1002/ana.410360205
-
(1994)
Ann. Neurol
, vol.36
, pp. 142-148
-
-
Mitsumoto, H.1
Ikeda, K.2
Holmlund, T.3
Greene, T.4
Cedarbaum, J.M.5
Wong, V.6
-
57
-
-
0033587480
-
Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis
-
doi: 10. 1089/10430349950017536
-
Mohajeri, M. H., Figlewicz, D. A., and Bohn, M. C. (1999). Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis. Hum. Gene Ther. 10, 1853-1866. doi: 10. 1089/10430349950017536
-
(1999)
Hum. Gene Ther
, vol.10
, pp. 1853-1866
-
-
Mohajeri, M.H.1
Figlewicz, D.A.2
Bohn, M.C.3
-
58
-
-
78650721472
-
Deregulation of the hypoxia inducible factor-1alpha pathway in monocytes from sporadic amyotrophic lateral sclerosis patients
-
doi: 10.1016/j.neuroscience.2010.10.040
-
Moreau, C., Gosset, P., Kluza, J., Brunaud-Danel, V., Lassalle, P., Marchetti, P., et al. (2011). Deregulation of the hypoxia inducible factor-1alpha pathway in monocytes from sporadic amyotrophic lateral sclerosis patients. Neuroscience 172, 110-117. doi: 10.1016/j.neuroscience.2010.10.040
-
(2011)
Neuroscience
, vol.172
, pp. 110-117
-
-
Moreau, C.1
Gosset, P.2
Kluza, J.3
Brunaud-Danel, V.4
Lassalle, P.5
Marchetti, P.6
-
59
-
-
0032472831
-
Time course of neuropathology in the spinal cord of G86R superoxide dis- mutase transgenic mice
-
doi: 10.1002/(sici)1096- 9861(19980202)391:1<64::aid-cne6>3.0.co;2-p
-
Morrison, B. M., Janssen, W. G., Gordon, J. W., and Morrison, J. H. (1998). Time course of neuropathology in the spinal cord of G86R superoxide dis- mutase transgenic mice. J. Comp. Neurol. 391, 64-77. doi: 10.1002/(sici)1096- 9861(19980202)391:1<64::aid-cne6>3.0.co;2-p
-
(1998)
J. Comp. Neurol
, vol.391
, pp. 64-77
-
-
Morrison, B.M.1
Janssen, W.G.2
Gordon, J.W.3
Morrison, J.H.4
-
60
-
-
33747333574
-
Growth hormone secretion is impaired in amyotrophic lateral sclerosis
-
doi: 10.1111/j.1365-2265.2006.02609.x
-
Morselli, L. L., Bongioanni, P., Genovesi, M., Licitra, R., Rossi, B., Murri, L., et al. (2006). Growth hormone secretion is impaired in amyotrophic lateral sclerosis. Clin. Endocrinol. (Oxf) 65, 385-388. doi: 10.1111/j.1365-2265.2006.02609.x
-
(2006)
Clin. Endocrinol. (Oxf)
, vol.65
, pp. 385-388
-
-
Morselli, L.L.1
Bongioanni, P.2
Genovesi, M.3
Licitra, R.4
Rossi, B.5
Murri, L.6
-
61
-
-
67651240342
-
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
-
doi: 10.1007/s00702-009-0207-z
-
Mudò, G., Bonomo, A., Di Liberto, V., Frinchi, M., Fuxe, K., and Belluardo, N. (2009). The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain. J. Neural Transm. 116, 995-1005. doi: 10.1007/s00702-009-0207-z
-
(2009)
J. Neural Transm
, vol.116
, pp. 995-1005
-
-
Mudò, G.1
Bonomo, A.2
Di Liberto, V.3
Frinchi, M.4
Fuxe, K.5
Belluardo, N.6
-
62
-
-
27244455282
-
Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis
-
doi: 10. 1179/016164105x39860
-
Nagano, I., Shiote, M., Murakami, T., Kamada, H., Hamakawa, Y., Matsubara, E., et al. (2005). Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis. Neurol. Res. 27, 768-772. doi: 10. 1179/016164105x39860
-
(2005)
Neurol. Res
, vol.27
, pp. 768-772
-
-
Nagano, I.1
Shiote, M.2
Murakami, T.3
Kamada, H.4
Hamakawa, Y.5
Matsubara, E.6
-
63
-
-
84882287457
-
Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor- 1alpha in amyotrophic lateral sclerosis
-
doi: 10. 1111/bpa.12040
-
Nagara, Y., Tateishi, T., Yamasaki, R., Hayashi, S., Kawamura, M., Kikuchi, H., et al. (2013). Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor- 1alpha in amyotrophic lateral sclerosis. Brain Pathol. 23, 534-546. doi: 10. 1111/bpa.12040
-
(2013)
Brain Pathol
, vol.23
, pp. 534-546
-
-
Nagara, Y.1
Tateishi, T.2
Yamasaki, R.3
Hayashi, S.4
Kawamura, M.5
Kikuchi, H.6
-
64
-
-
0034655803
-
Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration
-
Namikawa, K., Honma, M., Abe, K., Takeda, M., Mansur, K., Obata, T., et al. (2000). Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J. Neurosci. 20, 2875-2886.
-
(2000)
J. Neurosci
, vol.20
, pp. 2875-2886
-
-
Namikawa, K.1
Honma, M.2
Abe, K.3
Takeda, M.4
Mansur, K.5
Obata, T.6
-
65
-
-
0032513319
-
Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle
-
doi: 10.1126/science.279.5357.1725
-
Nguyen, Q. T., Parsadanian, A. S., Snider, W. D., and Lichtman, J. W. (1998). Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle. Science 279, 1725-1729. doi: 10.1126/science.279.5357.1725
-
(1998)
Science
, vol.279
, pp. 1725-1729
-
-
Nguyen, Q.T.1
Parsadanian, A.S.2
Snider, W.D.3
Lichtman, J.W.4
-
66
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
doi: 10.1038/88842
-
Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., et al. (2001). Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 28, 131-138. doi: 10.1038/88842
-
(2001)
Nat. Genet
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Storkebaum, E.3
Beck, H.4
Nuyens, D.5
Brusselmans, K.6
-
67
-
-
0026058318
-
Cell death during development of the nervous system
-
doi: 10.1146/annurev.neuro.14.1.453
-
Oppenheim, R. W. (1991). Cell death during development of the nervous system. Annu. Rev. Neurosci. 14, 453-501. doi: 10.1146/annurev.neuro.14.1.453
-
(1991)
Annu. Rev. Neurosci
, vol.14
, pp. 453-501
-
-
Oppenheim, R.W.1
-
68
-
-
0023881779
-
Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor
-
doi: 10.1126/science. 3363373
-
Oppenheim, R. W., Haverkamp, L. J., Prevette, D., Mcmanaman, J. L., and Appel, S. H. (1988). Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor. Science 240, 919-922. doi: 10.1126/science. 3363373
-
(1988)
Science
, vol.240
, pp. 919-922
-
-
Oppenheim, R.W.1
Haverkamp, L.J.2
Prevette, D.3
McManaman, J.L.4
Appel, S.H.5
-
69
-
-
0035866059
-
Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons
-
Oppenheim, R. W., Wiese, S., Prevette, D., Armanini, M., Wang, S., Houenou, L. J., et al. (2001). Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons. J. Neurosci. 21, 1283-1291.
-
(2001)
J. Neurosci
, vol.21
, pp. 1283-1291
-
-
Oppenheim, R.W.1
Wiese, S.2
Prevette, D.3
Armanini, M.4
Wang, S.5
Houenou, L.J.6
-
70
-
-
33645822300
-
Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
-
doi: 10.1073/pnas.0508774103
-
Raoul, C., Buhler, E., Sadeghi, C., Jacquier, A., Aebischer, P., Pettmann, B., et al. (2006). Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Proc. Natl. Acad. Sci. USA 103, 6007-6012. doi: 10.1073/pnas.0508774103
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6007-6012
-
-
Raoul, C.1
Buhler, E.2
Sadeghi, C.3
Jacquier, A.4
Aebischer, P.5
Pettmann, B.6
-
71
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
doi: 10.1038/ 362059a0
-
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., et al. (1993). Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62. doi: 10.1038/ 362059a0
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
-
72
-
-
84856701376
-
A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: Clinical, neuroimaging, and hormonal results
-
doi: 10.1007/s00415-011-6146-2
-
Saccà, F., Quarantelli, M., Rinaldi, C., Tucci, T., Piro, R., Perrotta, G., et al. (2012). A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results. J. Neurol. 259, 132-138. doi: 10.1007/s00415-011-6146-2
-
(2012)
J. Neurol
, vol.259
, pp. 132-138
-
-
Saccà, F.1
Quarantelli, M.2
Rinaldi, C.3
Tucci, T.4
Piro, R.5
Perrotta, G.6
-
73
-
-
84865501729
-
Impaired response of hypoxic sensor protein HIF-1alpha and its downstream proteins in the spinal motor neurons of ALS model mice
-
doi: 10.1016/j.brainres.2012.07.040
-
Sato, K., Morimoto, N., Kurata, T., Mimoto, T., Miyazaki, K., Ikeda, Y., et al. (2012). Impaired response of hypoxic sensor protein HIF-1alpha and its downstream proteins in the spinal motor neurons of ALS model mice. Brain Res. 1473, 55-62. doi: 10.1016/j.brainres.2012.07.040
-
(2012)
Brain Res
, vol.1473
, pp. 55-62
-
-
Sato, K.1
Morimoto, N.2
Kurata, T.3
Mimoto, T.4
Miyazaki, K.5
Ikeda, Y.6
-
74
-
-
0026749255
-
Ciliaryneurotrophicfactor prevents degeneration ofmotor neurons in mouse mutant progressive motor neuronopathy
-
doi: 10.1038/358502a0
-
Sendtner, M., Schmalbruch, H., Stockli, K. A., Carroll, P., Kreutzberg, G. W., and Thoenen, H. (1992). Ciliaryneurotrophicfactor prevents degeneration ofmotor neurons in mouse mutant progressive motor neuronopathy. Nature 358, 502-504. doi: 10.1038/358502a0
-
(1992)
Nature
, vol.358
, pp. 502-504
-
-
Sendtner, M.1
Schmalbruch, H.2
Stockli, K.A.3
Carroll, P.4
Kreutzberg, G.W.5
Thoenen, H.6
-
75
-
-
60849106964
-
Racing against the clock: Recognizing, differentiating, diagnosing and referring the amyotrophic lateral sclerosis patient
-
doi: 10.1002/ana.21545
-
Shook, S. J., and Pioro, E. P. (2009). Racing against the clock: recognizing, differentiating, diagnosing and referring the amyotrophic lateral sclerosis patient. Ann. Neurol. 65(Suppl. 1), S10-S16. doi: 10.1002/ana.21545
-
(2009)
Ann. Neurol
, vol.65
, Issue.SUPPL. 1
-
-
Shook, S.J.1
Pioro, E.P.2
-
76
-
-
77954344953
-
Clinical trials for neuroprotection in ALS
-
doi: 10.2174/187152710791292648
-
Siciliano, G., Carlesi, C., Pasquali, L., Piazza, S., Pietracupa, S., Fornai, F., et al. (2010). Clinical trials for neuroprotection in ALS. CNS Neurol. Disord. Drug Targets 9, 305-313. doi: 10.2174/187152710791292648
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 305-313
-
-
Siciliano, G.1
Carlesi, C.2
Pasquali, L.3
Piazza, S.4
Pietracupa, S.5
Fornai, F.6
-
77
-
-
84885608405
-
Amyotrophic lateral sclerosis: Problems and prospects
-
doi: 10.1002/ana.24012
-
Sreedharan, J., and Brown, R. H. Jr. (2013). Amyotrophic lateral sclerosis: problems and prospects. Ann. Neurol. 74, 309-316. doi: 10.1002/ana.24012
-
(2013)
Ann. Neurol
, vol.74
, pp. 309-316
-
-
Sreedharan, J.1
Brown Jr., R.H.2
-
78
-
-
33646082251
-
Widespread loss of neuronal populations in the spinal ventral horn in sporadic motor neuron disease. A morphometric study
-
doi: 10.1016/j.jns.2005.12.003
-
Stephens, B., Guiloff, R. J., Navarrete, R., Newman, P., Nikhar, N., and Lewis, P. (2006). Widespread loss of neuronal populations in the spinal ventral horn in sporadic motor neuron disease. A morphometric study. J. Neurol. Sci. 244, 41-58. doi: 10.1016/j.jns.2005.12.003
-
(2006)
J. Neurol. Sci
, vol.244
, pp. 41-58
-
-
Stephens, B.1
Guiloff, R.J.2
Navarrete, R.3
Newman, P.4
Nikhar, N.5
Lewis, P.6
-
79
-
-
16644382257
-
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
-
doi: 10.1038/nn1360
-
Storkebaum, E., Lambrechts, D., Dewerchin, M., Moreno-Murciano, M. P., Appelmans, S., Oh, H., et al. (2005). Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 8, 85-92. doi: 10.1038/nn1360
-
(2005)
Nat. Neurosci
, vol.8
, pp. 85-92
-
-
Storkebaum, E.1
Lambrechts, D.2
Dewerchin, M.3
Moreno-Murciano, M.P.4
Appelmans, S.5
Oh, H.6
-
80
-
-
59849127305
-
Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult
-
doi: 10.1089/neu.2008.0656
-
Su, H., Zhang, W., Guo, J., Guo, A., Yuan, Q., and Wu, W. (2009). Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult rats. J. Neurotrauma 26, 67-80. doi: 10.1089/neu.2008.0656
-
(2009)
Rats. J. Neurotrauma
, vol.26
, pp. 67-80
-
-
Su, H.1
Zhang, W.2
Guo, J.3
Guo, A.4
Yuan, Q.5
Wu, W.6
-
81
-
-
41249086987
-
Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis
-
doi: 10. 1016/j.tins.2008.01.006
-
Suzuki, M., and Svendsen, C. N. (2008). Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci. 31, 192-198. doi: 10. 1016/j.tins.2008.01.006
-
(2008)
Trends Neurosci
, vol.31
, pp. 192-198
-
-
Suzuki, M.1
Svendsen, C.N.2
-
82
-
-
56749154435
-
Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS
-
doi: 10.1038/mt.2008.197
-
Suzuki, M., Mchugh, J., Tork, C., Shelley, B., Hayes, A., Bellantuono, I., et al. (2008). Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol. Ther. 16, 2002-2010. doi: 10.1038/mt.2008.197
-
(2008)
Mol. Ther
, vol.16
, pp. 2002-2010
-
-
Suzuki, M.1
McHugh, J.2
Tork, C.3
Shelley, B.4
Hayes, A.5
Bellantuono, I.6
-
83
-
-
37549065020
-
GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS
-
doi: 10.1371/journal.pone.0000689
-
Suzuki, M., Mchugh, J., Tork, C., Shelley, B., Klein, S. M., Aebischer, P., et al. (2007). GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS One 2:e689. doi: 10.1371/journal.pone.0000689
-
(2007)
PLoS One
, vol.2
-
-
Suzuki, M.1
McHugh, J.2
Tork, C.3
Shelley, B.4
Klein, S.M.5
Aebischer, P.6
-
84
-
-
0344076149
-
A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF study group (phase III)
-
The BDNF Study Group,: 10.1212/WNL.52.7.1427
-
The BDNF Study Group. (1999). A controlled trial of recombinant methionyl human BDNF in ALS: the BDNF study group (phase III). Neurology 52, 1427-1433. doi: 10.1212/WNL.52.7.1427
-
(1999)
Neurology
, vol.52
, pp. 1427-1433
-
-
-
85
-
-
1442303850
-
The spinal GDNF level is increased after transient spinal cord ischemia in the rat
-
doi: 10.1007/978-3-7091-0651-8_50
-
Tokumine, J., Sugahara, K., Kakinohana, O., and Marsala, M. (2003). The spinal GDNF level is increased after transient spinal cord ischemia in the rat. Acta Neurochir. Suppl. 86, 231-234. doi: 10.1007/978-3-7091-0651-8_50
-
(2003)
Acta Neurochir. Suppl
, vol.86
, pp. 231-234
-
-
Tokumine, J.1
Sugahara, K.2
Kakinohana, O.3
Marsala, M.4
-
86
-
-
42549127816
-
Vascular endothelial growth factor protects spinal cord motoneurons against glutamate- induced excitotoxicity via phosphatidylinositol 3-kinase
-
doi: 10.1111/j.1471-4159.2007.05206.x
-
Tolosa, L., Mir, M., Asensio, V. J., Olmos, G., and Llado, J. (2008). Vascular endothelial growth factor protects spinal cord motoneurons against glutamate- induced excitotoxicity via phosphatidylinositol 3-kinase. J. Neurochem. 105, 1080-1090. doi: 10.1111/j.1471-4159.2007.05206.x
-
(2008)
J. Neurochem
, vol.105
, pp. 1080-1090
-
-
Tolosa, L.1
Mir, M.2
Asensio, V.J.3
Olmos, G.4
Llado, J.5
-
87
-
-
60349086984
-
Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition
-
doi: 10.1016/j.neuroscience. 2008.10.060
-
Tolosa, L., Mir, M., Olmos, G., and Llado, J. (2009). Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition. Neuroscience 158, 1348-1355. doi: 10.1016/j.neuroscience. 2008.10.060
-
(2009)
Neuroscience
, vol.158
, pp. 1348-1355
-
-
Tolosa, L.1
Mir, M.2
Olmos, G.3
Llado, J.4
-
88
-
-
0038383029
-
Persistent activation of p38 mitogen-activated protein kinase inamouse model of familial amyotrophic lateral sclerosis correlates with disease progression
-
doi: 10.1016/s1044-7431(03)00022-8
-
Tortarolo, M., Veglianese, P., Calvaresi, N., Botturi, A., Rossi, C., Giorgini, A., et al. (2003). Persistent activation of p38 mitogen-activated protein kinase inamouse model of familial amyotrophic lateral sclerosis correlates with disease progression. Mol. Cell. Neurosci. 23, 180-192. doi: 10.1016/s1044-7431(03)00022-8
-
(2003)
Mol. Cell. Neurosci
, vol.23
, pp. 180-192
-
-
Tortarolo, M.1
Veglianese, P.2
Calvaresi, N.3
Botturi, A.4
Rossi, C.5
Giorgini, A.6
-
89
-
-
78149277977
-
VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo byactivation ofPI3-K pathway and inhibition of p38MAPK
-
doi: 10.1111/j. 1471-4159.2010.06766.x
-
Tovar-Y-Romo, L. B., and Tapia, R. (2010). VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo byactivation ofPI3-K pathway and inhibition of p38MAPK. J. Neurochem. 115, 1090-1101. doi: 10.1111/j. 1471-4159.2010.06766.x
-
(2010)
J. Neurochem
, vol.115
, pp. 1090-1101
-
-
Tovar-Y-Romo, L.B.1
Tapia, R.2
-
90
-
-
84859032386
-
Delayed administration ofVEGF rescues spinal motor neurons from death with a short effective time frame in excito- toxic experimental models in vivo
-
doi: 10.1042/an201 10057
-
Tovar-Y-Romo, L. B., and Tapia, R. (2012). Delayed administration ofVEGF rescues spinal motor neurons from death with a short effective time frame in excito- toxic experimental models in vivo. ASNNeuro 4, 121-129. doi: 10.1042/an201 10057
-
(2012)
ASNNeuro
, vol.4
, pp. 121-129
-
-
Tovar-Y-Romo, L.B.1
Tapia, R.2
-
91
-
-
34948909599
-
Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration
-
doi: 10. 1097/nen.0b013e3181567c16
-
Tovar-Y-Romo, L. B., Zepeda, A., and Tapia, R. (2007). Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration. J. Neuropathol. Exp. Neurol. 66, 913-922. doi: 10. 1097/nen.0b013e3181567c16
-
(2007)
J. Neuropathol. Exp. Neurol
, vol.66
, pp. 913-922
-
-
Tovar-Y-Romo, L.B.1
Zepeda, A.2
Tapia, R.3
-
92
-
-
32244441514
-
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS
-
doi: 10.1016/j.mcn.2005.09.009
-
Veglianese, P., Lo Coco, D., Bao Cutrona, M., Magnoni, R., Pennacchini, D., Pozzi, B., et al. (2006). Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS. Mol. Cell. Neurosci. 31, 218-231. doi: 10.1016/j.mcn.2005.09.009
-
(2006)
Mol. Cell. Neurosci
, vol.31
, pp. 218-231
-
-
Veglianese, P.1
Lo Coco, D.2
Bao Cutrona, M.3
Magnoni, R.4
Pennacchini, D.5
Pozzi, B.6
-
93
-
-
11244356796
-
Mice lacking IGF-I and LIF have motoneuron deficits in brain stem nuclei
-
Vicario-Abejon, C., Fernandez-Moreno, C., Pichel, J. G., and De Pablo, F. (2004). Mice lacking IGF-I and LIF have motoneuron deficits in brain stem nuclei. Neuroreport 15, 2769-2772.
-
(2004)
Neuroreport
, vol.15
, pp. 2769-2772
-
-
Vicario-Abejon, C.1
Fernandez-Moreno, C.2
Pichel, J.G.3
de Pablo, F.4
-
94
-
-
0037104725
-
Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis
-
Wang, L. J., Lu, Y. Y., Muramatsu, S., Ikeguchi, K., Fujimoto, K., Okada, T., et al. (2002). Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J. Neurosci. 22, 6920-6928.
-
(2002)
J. Neurosci
, vol.22
, pp. 6920-6928
-
-
Wang, L.J.1
Lu, Y.Y.2
Muramatsu, S.3
Ikeguchi, K.4
Fujimoto, K.5
Okada, T.6
-
95
-
-
33846221802
-
Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
-
doi: 10.1523/jneurosci.4433-06.2007
-
Wang, Y., Mao, X. O., Xie, L., Banwait, S., Marti, H. H., Greenberg, D. A., et al. (2007). Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J. Neurosci. 27, 304-307. doi: 10.1523/jneurosci.4433-06.2007
-
(2007)
J. Neurosci
, vol.27
, pp. 304-307
-
-
Wang, Y.1
Mao, X.O.2
Xie, L.3
Banwait, S.4
Marti, H.H.5
Greenberg, D.A.6
-
96
-
-
33747047814
-
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
-
doi: 10.1073/pnas.0603670103
-
Wu, D. C., Re, D. B., Nagai, M., Ischiropoulos, H., and Przedborski, S. (2006). The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc. Natl. Acad. Sci. U S A 103, 12132-12137. doi: 10.1073/pnas.0603670103
-
(2006)
Proc. Natl. Acad. Sci. U S A
, vol.103
, pp. 12132-12137
-
-
Wu, D.C.1
Re, D.B.2
Nagai, M.3
Ischiropoulos, H.4
Przedborski, S.5
-
97
-
-
84862992874
-
Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis
-
doi: 10. 1371/journal.pone.0039946
-
Yanpallewar, S. U., Barrick, C. A., Buckley, H., Becker, J., and Tessarollo, L. (2012). Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis. PLoS One 7:e39946. doi: 10. 1371/journal.pone.0039946
-
(2012)
PLoS One
, vol.7
-
-
Yanpallewar, S.U.1
Barrick, C.A.2
Buckley, H.3
Becker, J.4
Tessarollo, L.5
-
98
-
-
26944431588
-
Akt/Bad signaling and motor neuron survival after spinal cord injury
-
doi: 10.1016/j.nbd.2005.04.004
-
Yu, F., Sugawara, T., Maier, C. M., Hsieh, L. B., and Chan, P. H. (2005). Akt/Bad signaling and motor neuron survival after spinal cord injury. Neurobiol. Dis. 20, 491-499. doi: 10.1016/j.nbd.2005.04.004
-
(2005)
Neurobiol. Dis
, vol.20
, pp. 491-499
-
-
Yu, F.1
Sugawara, T.2
Maier, C.M.3
Hsieh, L.B.4
Chan, P.H.5
-
99
-
-
27844508565
-
Neuroprotective role of vascular endothelial growth factor: Signalling mechanisms, biological function and therapeutic potential
-
doi: 10.1159/000088637
-
Zachary, I. (2005). Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function and therapeutic potential. Neurosignals 14, 207-221. doi: 10.1159/000088637
-
(2005)
Neurosignals
, vol.14
, pp. 207-221
-
-
Zachary, I.1
-
100
-
-
4844227301
-
Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS
-
doi: 10.1002/ana.20223
-
Zheng, C., Nennesmo, I., Fadeel, B., and Henter, J. I. (2004). Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS. Ann. Neurol. 56, 564-567. doi: 10.1002/ana.20223
-
(2004)
Ann. Neurol
, vol.56
, pp. 564-567
-
-
Zheng, C.1
Nennesmo, I.2
Fadeel, B.3
Henter, J.I.4
|