Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway

Journal of Neurochemistry

Volumn 74, Issue 2, 2000, Pages 582-595

  Fryer, Hugh J L ^a   Wolf, Daniel H ^a   Knox, Ronald J ^a   Strittmatter, Stephen M ^a   Pennica, Diane ^b   O'Leary, Rhona M ^b   Russell, David S ^a   Kalb, Robert G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

Author keywords

Excitotoxicity; Ionotropic glutamate receptors; Low affinity neurotrophin receptor; Motor neurons; Phosphatidylinositol 3 kinase; TrkB

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM ION; CARDIOTROPHIN 1; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; IONOTROPIC RECEPTOR; MESSENGER RNA; NEUROTROPHIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; ENZYME ACTIVATION; HERPES SIMPLEX VIRUS; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RNA SYNTHESIS; SPINAL CORD MOTONEURON;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM; CELLS, CULTURED; DRUG SYNERGISM; ENZYME ACTIVATION; GLUTAMIC ACID; MOTOR NEURONS; NEUROTOXINS; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKB; RNA, MESSENGER; SPINAL CORD;

EID: 0033977281     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.740582.x     Document Type: Article

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