VEGF protects spinal motor neurons against chronic excitotoxic degeneration in vivo by activation of PI3-K pathway and inhibition of p38MAPK

Journal of Neurochemistry

Volumn 115, Issue 5, 2010, Pages 1090-1101

  Tovar y Romo, Luis B ^a,b   Tapia, Ricardo ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE GERIATRÍA   (Mexico)

Author keywords

Amyotrophic lateral sclerosis; Motor neuron degeneration; P38 mitogen activated protein kinase; Phosphatidyl inositol 3 kinase; Spinal cord; Vascular endothelial growth factor

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; IN VIVO STUDY; MALE; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL CORD MOTONEURON;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANALYSIS OF VARIANCE; ANIMALS; CHOLINE O-ACETYLTRANSFERASE; CHROMONES; CINNAMATES; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; IMIDAZOLES; INFUSION PUMPS, IMPLANTABLE; MALE; MORPHOLINES; MOTOR ACTIVITY; MOTOR NEURONS; NERVE DEGENERATION; NEUROTOXICITY SYNDROMES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PYRIDINES; RATS; RATS, WISTAR; SPINAL CORD; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

RATTUS;

EID: 78149277977     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06766.x     Document Type: Article

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