Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients

Neuroscience

Volumn 172, Issue , 2011, Pages 110-117

  Moreau, C ^a   Gosset, P ^b   Kluza, J ^c   Brunaud Danel, V ^a   Lassalle, P ^b   Marchetti, P ^c   Defebvre, L ^a   Destee A ^a   Devos, D ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b INSERM U1019   (France)

^c INSERM   (France)

Author keywords

ALS; HIF 1 ; Hypoxemia; PGE 2; PHD 2; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROSTAGLANDIN E2; VASCULOTROPIN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; BLOOD GAS ANALYSIS; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROXYLATION; MALE; MICROGLIA; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANOXIA; DOWN-REGULATION; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICROGLIA; MIDDLE AGED; MONOCYTES; SIGNAL TRANSDUCTION;

EID: 78650721472     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.10.040     Document Type: Article

References (31)

1. Almer G., Guegan C., Teismann P., Naini A., et al. Increased expression of the pro inflammatory enzyme cyclooxygenase 2 in amyotrophic lateral sclerosis. Ann Neurol 2001, 49:176-185.
2. Azari M.F., Profyris C., Le Grande M.R., Lopes E.C., et al. Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS. Eur J Neurol 2005, 12:357-364.
3. Berra E., Benizri E., Ginouves A., Volmat V., Roux D., Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady state levels of HIF-1α in normoxia. EMBO J 2003, 22:4082-4090.
4. Chavez J.C., Baranova O., Lin J., Pichiule P. The transcriptional activator hypoxia inducible factor-2 (HIF-2/EPAS) regulates the oxygen dependent expression of erythropoietin in cortical astrocytes. J Neurosci 2006, 37:9471-9481.
5. Cudkowicz M.E., Shefner J.M., Schoenfeld D.A., Zhang H., et al. Trial of celecoxib in amyotrophic lateral sclerosis. Ann Neurol 2006, 60:22-31.
6. Curti D., Malaspina A., Facchetti G., Camana C., et al. ALS: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes. Neurology 1996, 47:1060-1064.
7. Devos D., Moreau C., Lassalle P., Perez T., et al. Low levels of VEGF 165 in CSF from early ALS patients. Neurology 2004, 62:2127-2129.
8. Epstein A., Mac Geadle J., McNeil L., Hewiston K., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by rpolyl hydroxylation. Cell 2001, 107:43-54.
9. Felbecker A., Camu W., Valdmanis P., Dorte-Sperfed A., et al. Four familial ALS pedigrees discordant for 2 SOD-1 mutations: are all SOD61 mutations pathogenic. J Neurol Neurosurg Psychiatry 2010, 81:572-577.
10. Ginouves A., Ilc K., Macias N., Pouyssegur J., Berra E. PHDs overactivation during chronic hypoxia "desensitizes" HIF-1 and protects cells from necrosis. Proc Natl Acad Sci U S A 2008, 105(12):4745-4750.
11. Greenberg H., Ye X., Wilson D., Htoo A.K., et al. Chronic intermittent hypoxia activates nuclear factor κB in cardiovascular tissues in vivo. Biochem Biophys Res Commun 2006, 343:591-596.
12. Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
13. Hayashi T., Sakurai M., Abe K., Sadahiro M., et al. Expression of angiogenic factors in rabbit spinal cord after transient ischaemia. Neuropathol Appl Neurobiol 1999, 25:63-71.
14. Henkel J.S., Engelhardt J.I., Siklós L., Simpson E.P., et al. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol 2004, 55:221-235.
15. Iłzecka J. Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis. Clin Neurol Neurosurg 2004, 106:289-293.
16. Jewell U., Kvietikova I., Scheid A., Bauer A., et al. Induction of HIF-1α in response to hypoxia is instantaneous. FASEB J 2001, 15:1312-1314.
17. Just N., Moreau C., Lassalle P., Gosset P., et al. High erythropoietin and low levels of VEGF 165 in CSF from ALS patients suggest an abnormal response to hypoxia. Neuromuscul Disord 2007, 17:169-173.
18. Kawamata T., Akiyama H., Yamada T., McGeer P.L. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 1992, 140:691-707.
19. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19:312-318.
20. Lambrechts D., Storkebaum E., Morimoto M., et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 2003, 34:383-394.
21. 165 expression in retinal cells by hypoxia. Invest Ophtalmol Vis Sci 2003, 44:4163-4170.
22. Lyall R.A., Donaldson N., Polkey M.I., Leigh P.N., et al. Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis. Brain 2001, 124:2000-2013.
23. Moreau C., Devos D., Brunaud-Danel V., Defebvre L., et al. Elevated levels of IL-6 in CSF from sporadic ALS patients: inflammation or hypoxia?. Neurology 2005, 65:1958-1960.
24. 165 expression in CSF to hypoxia in ALS patients. J Neurol Neurosurg Psychiatry 2006, 77:255-257.
25. Moreau C., Devos D., Gosset P., Brunaud-Danel V., Tonnel A.B., Lassalle P., Defebvre L., Destée A. Mechanisms of deregulated response to hypoxia in sporadic amyotrophic lateral sclerosis: a clinical study. Rev Neurol (Paris) 2010, 166:279-283.
26. Moreau C., Gosset P., Brunaud-Danel V., Lassalle P., et al. CSF profiles of angiogenic and inflammatory factors depend on the respiratory status of ALS patients. Amyotroph Lateral Scler 2009, 10:175-181.
27. Nygren I., Larsson A., Johansson A., Askmark H. VEGF is increased in serum but not in spinal cord from patients with amyotrophic lateral sclerosis. Neuroreport 2002, 13:2199-2201.
28. Oosthuyse B., Moons L., Storkebaum E., et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001, 28:131-138.
29. Semenza G.L. Hypoxia inducible factor-1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998, 8:588-594.
30. Wang Y., Mao X.O., Xie L., Banwait S., et al. Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J Neurosci 2007, 27:304-307.
31. Yiangou Y., Facer P., Durrenberger P., Chessell I.P., et al. COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol 2006, 6:12.