Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6692-6698

  Sheng, Rong ^a   Lin, Xiao ^a   Zhang, Jing ^a   Chol, Kim Sun ^b   Huang, Wenhai ^a   Yang, Bo ^a   He, Qiaojun ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Department of Chemistry   (South Korea)

Author keywords

AChE inhibitor; Flavonoid derivatives; Synthesis

Indexed keywords

6,7 DIMETHOXY 3 [4 (PYRROLIDIN 1 YLMETHYL)PHENYL] 4H CHROMEN 4 ONE; CHOLINESTERASE INHIBITOR; DONEPEZIL; FLAVONOID; ISOFLAVONE DERIVATIVE; RIVASTIGMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; FLAVONOIDS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENYLCARBAMATES; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69249148311     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.072     Document Type: Article

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