Synthesis and antimicrobial activities of 7-O-modified genistein derivatives

European Journal of Medicinal Chemistry

Volumn 43, Issue 7, 2008, Pages 1543-1551

  Zhang, Li Na ^a   Cao, Ping ^a   Tan, Shu Hua ^a   Gu, Wen ^a   Shi, Lei ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antibacterial activity; Antifungal activity; Genistein; Heterocyclic moieties; Structure modifications; Structure activity relationship

Indexed keywords

5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (2 (4 METHYLPIPERAZIN 1 YL)ETHOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (2 (PIPERAZIN 1 YL)ETHOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (2 (PIPERIDIN 1 YL)ETHOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (2 (PYRROLIDIN 1 YL)ETHOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (2 MORPHOLINOETHOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (3 (PIPERAZIN 1 YL)PROPOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (3 (PIPERIDIN 1 YL)PROPOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (3 (PYRROLIDIN 1 YL)PROPOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (3 MORPHOLINOPROPOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (4 (4 METHYLPIPERAZIN 1 YL)BUTOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (4 (PIPERAZIN 1 YL)BUTOXY) 4H CHROMEN 4 ONE; 5 HYDROXY 3 (4 HYDROXYPHENYL) 7 (4 MORPHOLINOBUTOXY) 4H CHROMEN 4 ONE; 7 (2 (1H BENZIMIDAZOLIUM 1 YL)ETHOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (2 (1H IMIDAZOL 1 YL)ETHOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (2 (DIBUTYLAMINO)ETHOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (2 (DIPROPYLAMINO)ETHOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (2 (FURAN 2 YL METHYLAMINO)ETHOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (2 BROMOETHOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (3 (DIBUTYLAMINO)PROPOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (3 (DIPROPYLAMINO)PROPOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (3 BROMOPROPOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 (1H BENZIMIDAZOLIUM 1 YL)BUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 (1H IMIDAZOL 1 YL)BUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 (DIBUTYLAMINO)BUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 (DIPROPYLAMINO)BUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 (FURAN 2 YL METHYLAMINO)BUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 (4 BROMOBUTOXY) 5 HYDROXY 3 (4 HYDROXYPHENYL) 4H CHROMEN 4 ONE; 7 O GENISTEIN DERIVATIVE; GENISTEIN; UNINDEXED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; PSEUDOMONAS FLUORESCENS; STAPHYLOCOCCUS AUREUS; TRICHOPHYTON RUBRUM;

ANTI-BACTERIAL AGENTS; GENISTEIN; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 45849085792     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.09.008     Document Type: Article

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