Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Neurobiology of Disease

Volumn 16, Issue 1, 2004, Pages 21-28

  Bang, Oh Young ^a   Hong, Hyun Seok ^b   Kim, Dong Hyun ^b   Kim, Hee ^b   Boo, Jung Hyun ^b   Huh, Kyoon ^a,b   Mook Jung, Inhee ^b,c  

^a Department of Neurology ^*  (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Alzheimer's disease; Beta amyloid; Cell death; Estrogen; Estrogen receptor; Genistein

Indexed keywords

AMYLOID BETA PROTEIN; ANTIESTROGEN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR BETA; FULVESTRANT; GENISTEIN;

ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; ENDOMETRIUM CELL; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING;

AMYLOID BETA-PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIUM; FEMALE; GENISTEIN; HUMANS; NEUROPROTECTIVE AGENTS; RECEPTORS, ESTROGEN;

EID: 2342635931     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2003.12.017     Document Type: Article

References (38)

1. Adlercruetz C.H.T., Goldin B.R., Gorbach S.L., Hockerstedt K.A.V., Watanabe S., Hamalainen E.K., Markkanen M.H., Makela T.H., Wahala K.T., Hase T.A., Fotsis T. Soybean phytoestrogen intake and cancer risk. J. Nutr. 125:1995;757S-770S
2. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:1987;5592-5595
3. Alves da Costa C., Paitel E., Mattson M.P., Amson R., Telerman A., Ancolio K., Checler F., Mattson M.P. Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons. Proc. Natl. Acad. Sci. U. S. A. 99:2002;4043-4048
4. An J., Tzagarakis-Foster C., Scharschmidt T.C., Lomri N., Leitman D.C. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J. Biol. Chem. 276:2001;17808-17814
5. Behl C., Skutella T., Lezoualc'h F., Post A., Widmann M., Newton C.J., Holsboer F. Neuroprotection against oxidative stress by estrogen: structure-activity relationship. Mol. Pharmacol. 51:1997;535-541
6. Beresford S.A.A., Weiss N.S., McKnight B. Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet. 349:1997;458-461
7. Black L., Berenbaum M.C. Factors affecting the dye exclusion test for cell viability. Exp. Cell Res. 35:1964;9-13
8. Bottenstein J.E., Sato G.H. Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl. Acad. Sci. U. S. A. 76:1979;514-517
9. Breinholt V., Hossaini A., Svendsen G.W., Brouwer C., Nielsen S.E. Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. Food Chem. Toxicol. 38:2000;555-564
10. Clinical Synthesis Panel on HRT Hormone replacement therapy. Lancet. 354:1999;152-155
11. Collaborative Group on Hormonal Factors in Breast Cancer Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52, 705 women with breast cancer and 108, 411 women without breast cancer. Lancet. 350:1997;1047-1059
12. Dotzlaw H., Leygue E., Watson P.H., Murphy L.C. Expression of estrogen receptor-beta in human breast tumors. J. Clin. Endocrinol. Metab. 82:1997;2371-2374
13. Enmark E., Pelto-Huikko M., Grandien K., Lagercrantz S., Lagercrantz J., Fried G., Nordenskjold M., Gustafsson J.A. Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. J. Clin. Endocrinol. Metab. 82:1997;4258-4265
14. Gillardon F., Skutell T., Uhlmann E., Holsboer F., Zimmermann M., Behl C. Activation of c-Fos contributes to amyloid beta-peptide-induced neurotoxicity. Brain Res. 706:1996;169-172
15. Gridley K.E., Green P.S., Simpkins J.W. A novel, synergistic interaction between 17 beta-estradiol and glutathione in the protection of neurons against beta-amyloid 25-35-induced toxicity in vitro. Mol. Pharmacol. 54:1998;874-880
16. 1-42 peptide is cell type dependent. J. Neurochem. 65:1995;292-300
17. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297:2002;353-356
18. Ishimi Y., Arai N., Wang X., Wu J., Umegaki K., Miyaura C., Takeda A., Ikegami S. Difference in effective dosage of genistein on bone and uterus in ovariectamized mice. Biochem. Biophys. Res. Commun. 274:2000;697-701
19. Kawas C., Resnick S., Morrison A., Brookmeyer R., Corrada M., Zonderman A., Bacal C., Lingle D.D., Metter E. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology. 48:1997;1517-1521
20. Kim H., Bang O.Y., Jung M.W., Ha S.D., Hong H.S., Huh K., Kim S.U., Mook-Jung I. Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells. Neurosci. Lett. 302:2001;58-62
21. Kuiper G.G., Enmark E., Pelto-Huikko M., Nilsson S., Guastafsson J.A. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U. S. A. 93:1996;5925-5930
22. Kuiper G.G., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J.A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β Endocrinology. 138:1997;863-870
23. Lautenschlager N.T., Cupples L.A., Rao V.S., Auerbach S.A., Becker R., Burke J., Chui H., Duara R., Foley E.J., Glatt S.L., Green R.C., Jones R., Karlinsky H., Kukull W.A., Kurz A., Larson E.B., Martelli K., Sadovnick A.D., Volicer L., Waring S.C., Growdon J.H., Farrer L.A. Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: what is in store for the oldest old? Neurology. 46:1996;641-650
24. Lawrence D.S., Niu J. Protein kinase inhibitors: the tyrosine specific protein kinases. Pharmacol. Ther. 77:1998;81-114
25. Liu J., Shigenaga M.K., Mori A., Ames B.N. Free radicals and neurodegenerative disease: stress and oxidative damage. Packer L., Hiramatsu M., Yoshikawa T. Free Radicals in Brain Physiology and Disorders. 1996;403-437 Academic Press, San Diego
26. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewics A.J., Cotman C.W. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U. S. A. 90:1993;7951-7955
27. Moreno-Manzano V., Ishikawa Y., Lucio-Czana J., Kitamura M. Selective involvement of superoxide anion, but not downstream compounds hydrogen peroxide and peroxynitrite, in tumor-necrosis factor-α-induced apoptosis of rat mesangial cells. J. Biol. Chem. 275:2000;12684-12691
28. Pagliacci M.C., Smacchia M., Migliorati G., Grignani F., Riccardi C., Nicoletti I. Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells. Eur. J. Cancer. 30A:1994;1675-1682
29. Pike C.J. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease. J. Neurochem. 72:1999;1552-1563
30. Potter S.M., Baum J.A., Teng H., Stillman R.J., Shay N.F., Erdman J.W. Jr. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 68:1998;1375S-1379S
31. Ravnikar V.A. Compliance with hormone replacement therapy: are women receiving the full impact of hormone replacement therapy preventive heath benefits? Women Health Issues. 2:1992;75-80
32. Shughrue P.J., Lane M.V., Merchenthaler I. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J. Comp. Neurol. 388:1997;507-525
33. Small G.W., La Rue A., Komo S., Kaplan A., Mandelkern M.A. Predictors of cognitive change in middle-aged and older adults with memory loss. Am. J. Psychiatry. 152:1995;1757-1764
34. Spinozzi F., Pagliacci M.C., Migliorati G., Moraca R., Grignani F., Riccardi C., Nicoletti I. The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leuk. Res. 18:1994;431-439
35. Svensson A.L., Nordberg A. Beta-estradiol attenuates amyloid beta-peptide toxicity via nicotinic receptors. NeuroReport. 10:1999;3485-3489
36. Yaffe K., Sawaya G., Lieberburg I., Grady D. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. J. Am. Med. Assoc. 279:1998;688-695
37. Zava D.T., Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr. Cancer. 27:1997;31-40
38. Zhao L., Chen Q., Brinton R.D. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp. Biol. Med. 227:2002;509-519