Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 36, 2012, Pages 14646-14651

  Cheah, Christine S ^a   Yu, Frank H ^a,c   Westenbroek, Ruth E ^a   Kalume, Franck K ^a   Oakley, John C ^b   Potter, Gregory B ^d   Rubenstein, John L ^d   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Seoul National University   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; SODIUM CHANNEL NAV1.1; SCN1A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DEATH; ENHANCER REGION; FOREBRAIN; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; INTERNEURON; MOUSE; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SODIUM CURRENT; TONIC CLONIC SEIZURE; ANIMAL; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; MYOCLONUS EPILEPSY; PATHOLOGY; PLASMID; TRANSGENIC MOUSE;

ANIMALS; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; EPILEPSIES, MYOCLONIC; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MICE; MICE, TRANSGENIC; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; PLASMIDS; PROSENCEPHALON;

EID: 84871686984     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211591109     Document Type: Article

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