Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice

Journal of Neuroscience

Volumn 19, Issue 16, 1999, Pages 6733-6739

  Ferraro, Thomas N ^a   Golden, Gregory T ^a,b   Smith, George G ^a,b   Jean, Pamela St ^c   Schork, Nicholas J ^c,d,e,f   Mulholland, Nicole ^a   Ballas, Christos ^a   Schill, Jörg ^a   Buono, Russell J ^a   Berrettini, Wade H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD UNIVERSITY   (United States)

^f JACKSON LABORATORY   (United States)

Author keywords

Epilepsy; Genetics; Mice; Pentylenetetrazol; Quantitative trait loci; Seizure

Indexed keywords

PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLONUS; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE LOCUS; GENE MAPPING; GENOTYPE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; REGRESSION ANALYSIS; SCORING SYSTEM; SEIZURE; STATISTICAL ANALYSIS;

EID: 0033567071     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-16-06733.1999     Document Type: Article

References (48)

1. Beck-Mannagetta G, Janz D, Hoffmeister U (1989) Morbidity for seizures and epilepsy in offspring of patients with epilepsy. In:Genetics of the epilepsies (Beck-Mannagetta G, Anderson VE, Doose H, eds), pp 119-126. Berlin:Springer.
2. Berkovic SF, McIntosh A, Howell, RA, Mitchell A, Sheffield LJ, Hopper JL (1996) Familial temporal lobe epilepsy:a common disorder identified in twins. Ann Neurol 40:227-235.
3. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK (1998) A potassium channel mutation in neonatal human epilepsy. Science 279:403-406.
4. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP (1996) Altered neuronal and microglial responses to excitotoxic and schemic brain injury in mice lacking TNF receptors. Nat Med 2:788-794.
5. Buck KJ, Metten P, Belknap J Crabbe JC (1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 17:3946-3955.
6. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, Leppert M (1998) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18:53-55.
7. Dietrich W, Miller J, Steen R, Merchant M, Damron-Boles D, Husain Z, Dredge R, Daly M, Ingalls K, O'Connor T, Evans C, DeAngelis M, Levinson D, Kruglyak L, Goodman N, Copeland N, Jenkins N, Hawkins T, Lincoln S, Page D, Lander E (1996) A comprehensive genetic map of the mouse genome. Nature 380:149-152.
8. Engstrom F, Woodbury DM (1988) Seizure susceptibility in DBA and C57 mice:the effects of various convulsants. Epilepsia 29:389-395.
9. Erickson JC, Clegg KE, Palmiter RD (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-418.
10. Ferraro TN, Buono RJ (1999) The genetics of epilepsy:mouse and human studies. In:Handbook of genetic influences on the nervous system (Pfaff DW, Maxson SC, Berretini WH, Joh TH, eds), pp 117-145. Boca Raton, FL:CRC.
11. Ferraro TN, Golden GT, Smith GG, Berrettini WH (1995) Differential susceptibility to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice. Epilepsia 36:301-307.
12. Ferraro TN, Golden GT, Smith GG, Schork NJ, St. Jean P, Ballas C, Choi H, Berrettini WH (1997) Mapping murine loci for seizure response to kainic acid. Mamm Genome 8:200-208.
13. Ferraro TN, Golden GT, Snyder R, Laibinis M, Smith GG, Buono RJ, Berrettini WH (1998a) Genetic influences on electrical seizure threshold. Brain Res 813:207-210.
14. Ferraro TN, Schill JF, Ballas C, Mulholland N, Golden GT, Smith GG, Buono RJ, Berrettini WB (1998b) Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining:application to quantitative trait loci analysis of seizure susceptibility in mice. Psychiatr Genet 8:227-233.
15. Ferraro TN, Golden GT, Laibinis M, Smith GG, Longman RE, Mulholland N, Zamboni D, Buono RJ, Berrettini WH (1998c) Quantitative trait locus (QTL) for maximal electroshock seizure threshold (MEST) in C57BL/6J (B6) and DBA/2J (D2) mice maps to distal chromosome 1. Soc Neurosci Abstr 24:777.
16. Frankel WN, Taylor BA, Noebels JL, Lutz CM (1994) Genetics epilepsy model derived from common inbred mouse strains. Genetics 138:1-9.
17. Frankel WN, Valenzuela A, Lutz CM, Johnson EW, Dietrich WF, Coffin JM (1995) New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mamm Genome 6:830-838.
18. Freund RK, Marley RJ, Wehner JM (1987) Differential sensitivity to bicuculline in three inbred mouse strains. Brain Res Bull 18:657-662.
19. Hall CS (1947) Genetic differences in fatal audiogenic seizures between two inbred strains of house mice. J Hered 38:2-6.
20. Kosobud AE, Crabbe JC (1990) Genetic correlations among inbred strain sensitivities to convulsions induced by 9 convulsant drugs. Brain Res 526:8-16.
21. Krugylak L, Lander ES (1995) A nonparametric approach for mapping quantitative trait loci. Genetics 139:1421-1428.
22. Lahiri DK, Nurnberger JI (1991) A rapid non-enzymatic method for the preparation of high molecular weight DNA from blood for RFLP studies. Nucleic Acids Res 19:5444.
23. Lander ES, Botstein D (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
24. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
25. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newburg L (1987) MAPMAKER:An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174-181.
26. Lehejoski AE, Koskiniemi M, Sistonen P, Miao J, Hastbacka J, Norio R, de la Chapelle A (1991) Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22. Proc Natl Acad Sci USA 88:3696-3699.
27. Leppert M, Anderson VE, Quattlebaum T, Stauffer D, O'Connell P, Nakamura Y, Laloulel JM, White R (1989) Benign neonatal familial convulsions linked to genetic markers on chromosome 20. Nature 337:647-648.
28. Lewis TB, Leach RJ, Ward K, O'Connell P, Ryan SG (1993) Genetic heterogeneity in benign neonatal familial convulsions:identification of a new locus on chromosome 8q. Am J Hum Genet 53:670-675.
29. Liu AW, Delgado-Escueta AV, Serratosa JM, Alonso ME, Medina MT, Gee MN, Cordova S, Zhao HZ, Spellman JM, Ramos Peek JR, Donnadieu FR, Sparkes RS (1995) Juvenile myoclonic epilepsy locus in chromosome 6p21.2-p11:linkage to convulsions and electroencephalograghy trait. Am J Hum Genet 57:368-381.
30. Marley RJ, Gaffney D, Wehner JM (1986) Genetic influences on GABA-related seizures. Pharmacol Biochem Behav 24:665-672.
31. Martin B, Clement Y, Venault P, Chapouthier G (1995) Mouse chromosomes 4 and 13 are involved in B-carboline-induced seizures. J Hered 86:274-279.
32. Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, Minowa O, Kuno J, Sakakibara S, Yamada M, Yoneshima H, Miyawaki A, Fukuuchi Y, Furuichi T, Okano H, Mikoshiba K, Noda T (1996) Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379:168-171.
33. McAleer MA, Reifsnyder P, Palmer SM, Prochazka M, Love JM, Copeman JB, Powell EE, Rodrigues NR, Prins JB, Serreze DV, DeLarato NH, Wicker LS, Peterson LB, Schork NJ, Todd JA, Leiter EH (1995) Crosses of NOD mice with the related NON strain. Diabetes 44:1186-1195.
34. Neumann PE, Collins RL (1991) Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proc Natl Acad Sci USA 88:5408-5412.
35. Neumann PE, Seyfried TN (1990) Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice. Behav Genet 20:307-323.
36. Olsen RW (1981) The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs. Mol Cell Biochem 39:261-279.
37. Ottman R, Annegers JF, Hauser WA, et al (1989) Seizure risk in offspring of parents with generalized vs. partial epilepsy. Epilepsia 30:157-161.
38. Pennachio LA, Lehesjoki AE, Stone NE, Willour VL, Virtaneva K, Miao J, D'Amato E, Ramirez L, Faham M, Koskikiemi M, Warrington JA, Norio R, de la Chapelle A, Cox DR, Myers RM (1996) Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1). Science 271:1731-1734.
39. Phillips HA, Scheffer IE, Berkovic SF, Hollway GE, Sutherland GR, Mulley JC (1995) Localization of a gene for autosomal dominant nocturnal frontal lobe epilepsy to chromosome 20q13.2. Nat Genet 10:117-118.
40. Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Scoville B, White BG (1984) Antiepileptic drug development program. Cleve Clin Q 51:293-305.
41. Ramanjaneyulu R, Ticku MK (1984) Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. Eur J Pharmacol 98:337-345.
42. Risch N, Ghosh S, Todd JA (1993) Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies:application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet S3:702-714.
43. Schlesinger K, Boggan WO, Griek BJ (1968) Pharmacogenetic correlates of pentylenetetrazole and electroconvulsive seizure thresholds in mice. Psychopharmacology (Berl) 13:181-188.
44. Schork NJ, Krieger JE, Trolliet MR, Franchini KG, Koike G, Krieger EM, Lander ES, Dzau VJ, Jacob HJ (1995) A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Res 5:164-172.
45. Simon JR, Contrera JF, Kuhar MJ (1976) Binding of 3H-kainic acid, an analogue of L-glutamate to brain membranes. J Neurochem 26:141-147.
46. Smart SL, Lopantsev V, Zhang CL, Robbins CA, Wang H, Chiu SY, Schwartzkroin PA, Messing A, Tempel BL (1998) Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron 20:809-819.
47. Steinlein OK, Mulley JC, Propping P, Wallace RH, Phillips HA, Sutherland GR, Scheffer IE, Berkovic SE (1995) A missense mutation in the neuronal nicotinic acetylcholine receptor a4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 11:201-203.
48. Taylor BA (1976) Genetic analysis of susceptibility to isoniazid-induced seizures in mice. Genetics 83:373-377.