Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 549-557

  Sangani, Chetan B ^a   Makawana, Jigar A ^a   Zhang, Xin ^a   Teraiya, Shashikant B ^a   Lin, Lin ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

1H Pyrazole 4 carbaldehyde; 4H Quinoline; Antibacterial activity; Anticancer activity; Molecular modeling; One pot reaction; Pyridine

Indexed keywords

2 AMINO 4 (5 CHLORO 1 (4 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 4 YL) 5 OXO 1 (PYRAZOL 4 YL) 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (5 CHLORO 1 (4 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 4 YL) 7,7 DIMETHYL 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (5 CHLORO 3 METHYL 1 4 TOLYL 1H PYRAZOL 4 YL) 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (5 CHLORO 3 METHYL 1 4 TOLYL 1H PYRAZOL 4 YL) 7,7 DIMETHYL 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (5 CHLORO 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (5 CHLORO 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 7,7 DIMETHYL 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ETHYL 2 AMINO 4 (5 CHLORO 1 (4 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 4 YL) 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 2 AMINO 4 (5 CHLORO 1 (4 CHLOROPHENYL) 3 METHYL 1H PYRAZOL 4 YL) 7,7 DIMETHYL 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 2 AMINO 4 (5 CHLORO 3 METHYL 1 4 TOLYL 1H PYRAZOL 4 YL) 7,7 DIMETHYL 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 2 AMINO 4 (5 CHLORO 3 METHYL 1 4 TOLYL 1H PYRAZOL 4YL) 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 2 AMINO 4 (5 CHLORO 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 7,7 DIMETHYL 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 2 AMINO 4 (5 CHLORO 3 METHYL 1 PHENYL 1H PYRAZOL 4YL) 5 OXO 1 (PYRIDIN 3 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION ASSAY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR HYBRIDIZATION; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; HUMAN; IC50; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PYRAZOLES; PYRIDINES; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896744566     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.018     Document Type: Article

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