Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5283-5292

  Thomas, K D ^a,b   Adhikari, Airody Vasudeva ^b   Telkar, Sandeep ^e   Chowdhury, Imran H ^c   Mahmood, Riaz ^e   Pal, Nishith K ^c   Row, Guru ^d   Sumesh, E ^a  

^a Anthem Biosciences Pvt Ltd   (India)

^b NATIONAL INSTITUTE OF TECHNOLOGY KARNATAKA   (India)

^c Dr B C Roy Post Graduate Institute of Basic Medical Education and Research (IPGME and R)   (India)

^d INDIAN INSTITUTE OF SCIENCE   (India)

^e KUVEMPU UNIVERSITY   (India)

Author keywords

Antibacterial; Antimycobacterial; Docking study; Quinoline; X ray crystallography

Indexed keywords

2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL N (4 METHOXYPHENYL)HYDRAZINECARBOXAMIDE; 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL] N (4 METHYLPHENYL)HYDRAZINECARBOTHIOAMIDE; 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL] N (4 METHYLPHENYL)HYDRAZINECARBOXAMIDE; 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL] N (PYRIDIN 3 YL)HYDRAZINECARBOTHIOAMIDE; 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)UINOLINE 3 YL]CARBONYL] N (4 METHOXYPHENYL)HYDRAZINECARBOTHIOAMIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (1 METHYL 1H BENZOTRIAZOL 5 YLMETHYLENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (1 METHYL 1H PYRROL 2 YLMETHYLENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (2 FLUORO 4 METHOXY BENZYLIDENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (2 METHYLSULFANYL BENZYLIDENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (3 HYDROXY 4 METHOXY BENZYLIDENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (3H IMIDAZOL 4 YLMETHYLENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (4 METHOXY BENZYLIDENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (5 FLUORO 2 HYDROXY BENZYLIDENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (5 METHOXY 1H INDOL 3 YLMETHYLENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (5 METHYL 3H IMIDAZOL 4 YLMETHYLENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID (7 METHYL 1H INDOL 3 YLMETHYLENE)HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID [4 (1,1,2,2 TETRAFLUORO ETHOXY) BENZYLIDENE]HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID BENZO[1,2,5]OXADIAZOL 5 YLMETHYLENE HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID BENZOFURAN 5 YLMETHYLENE HYDRAZIDE; 4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBOXYLIC ACID PYRIDIN 4 YLMETHYLENE HYDRAZIDE; 4 HYDROXY N' [(E) (4 METHYLPHENYL)METHYLIDENE] 8 (TRIFLUOROMETHYL)QUINOLINE 3 CARBOHYDRAZIDE; ACETIC ACID 4 [(4 HYDROXY 8 TRIFLUOROMETHYL QUINOLINE 3 CARBONYL)HYDRAZONOMETHYL] FURAN 2 YLMETHYLESTER; HYDRAZIDE DERIVATIVE; N (2 FLUOROPHENYL) 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL]HYDRAZINECARBOTHIOAMIDE; N (3 CHLOROPHENYL) 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL]HYDRAZINECARBOTHIOAMIDE; N (3 CHLOROPHENYL) 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL]HYDRAZINECARBOXAMIDE; N (3,5 DIMETHYLPHENYL) 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL]HYDRAZINECARBOXAMIDE; N (4 ETHYLPHENYL) 2 [[4 HYDROXY 8 (TRIFLUOROMETHYL)QUINOLIN 3 YL]CARBONYL]HYDRAZINECARBOXAMIDE; QUINOLINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; BACTERIA; DRUG DESIGN; HYDRAZINES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINOLINES;

EID: 80054938834     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.033     Document Type: Article

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