Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 365-378

  Starčević, Kristina ^a,c   Pešić, Dijana ^a,e   Toplak, Ana ^a,d   Landek, Goran ^a,e   Alihodžić, Sulejman ^a,e   Herreros, Esperanza ^b   Ferrer, Santiago ^b   Spaventi, Radan ^a,e   Perić, Mihaela ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (Spain)

^c UNIVERSITY OF ZAGREB   (Croatia)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e Galapagos Istraživački Centar Doo ^*  (Croatia)

Author keywords

Antimalarial; Azalide; Hybrid molecules; Malaria; Plasmodium falciparum; Quinoline; Synthesis

Indexed keywords

3' N (DEMETHYL) 3' N [3 ({4 [(7 CHLORO 4 QUINOLINYL)AMINO]BUTANOYL}AMINO)PROPYL]3 O DECLADINOSYL 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 3' N (DEMETHYL) 3' N [4 (7 CHLORO QUINOLIN 4 YLAMINO)ACETYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 3' N (DEMETHYL) 3' N [4 (7 CHLOROQUINOLIN 4 YLAMINO)BUTANOYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN; 3' N (DEMETHYL) 3' N {3 [(7 CHLORO 4 QUINOLINYL)AMINO]PROPYL} 3 O DECLADINOSYL 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 3' N (DEMETHYL) 3' N {3 [(7 CHLORO 4 QUINOLINYL)AMINO]PROPYL} 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 3' N (DEMETHYL)3' N [3 ({4 [(7 CHLORO 4 QUINOLINYL)AMINO]BUTANOYL}AMINO)PROPYL] 9 DEOXO 9A METHYL 9A AZA 9A HOMOERYTHROMYCIN A; 4 AMINOQUINOLINE; ANTIMALARIAL AGENT; AZITHROMYCIN; CHLOROQUINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYBRID; IN VITRO STUDY; MOLECULE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

AMINOQUINOLINES; ANTIMALARIALS; AZITHROMYCIN; CELL LINE; CHLOROQUINE; HUMANS; MACROLIDES; MALARIA; PLASMODIUM FALCIPARUM;

EID: 84857239463     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.039     Document Type: Article

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