Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 675-684

  Kathrotiya, Harshad G ^a   Patel, Manish P ^a  

^a SARDAR PATEL UNIVERSITY   (India)

Author keywords

Aryloxyquinoline; Antimicrobial activity; Antituberculosis activity; Cytotoxicity; FRAP assay; Multicomponent reaction; N Aryl quinolone

Indexed keywords

2' AMINO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 6 METHOXY 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 6 METHOXY 7'7' DIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 6 METHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 6,7',7' TRIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 7',7' DIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 6 METHOXY 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 6 METHOXY 7'7' DIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 6 METHYL 5' OXO 1' [3 (TRIFLUOROMETHYL)PHENYL] 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 6 METHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 6,7',7' TRIMETHYL 5' OXO 1' [3 (TRIFLUOROMETHYL)PHENYL] 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 6,7',7' TRIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 7',7' DIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 5' OXO 1' [3 (TRIFLUOROMETHYL)PHENYL] 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 6 METHOXY 5' OXO 1' [3 5'(TRIFLUOROMETHYL)PHENYL] OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 6 METHOXY 7'7' DIMETHYL 5' OXO 1' [3 5'(TRIFLUOROMETHYL)PHENYL] OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 2 (4 CYANOPHENOXY) 7',7' DIMETHYL 5' OXO 1' [3 (TRIFLUOROMETHYL)PHENYL] 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 6 CHLORO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 6 CHLORO 2 (4 CYANOPHENOXY) 1' (2,5 DIFLUOROPHENYL) 7'7' DIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 6 CHLORO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 6 CHLORO 2 (4 CYANOPHENOXY) 1' (3,4 DIFLUOROPHENYL) 7'7' DIMETHYL 5' OXO 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 6 CHLORO 2 (4 CYANOPHENOXY) 5' OXO 1' [3 (TRIFLUOROMETHYL)PHENYL] 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; 2' AMINO 6 CHLORO 2 (4 CYANOPHENOXY) 7'7' DIMETHYL 5' OXO 1' [3 (TRIFLUOROMETHYL)PHENYL] 1',4',5',6',7',8' HEXAHYDRO 3,4' BIQUINOLINE 3' CARBONITRILE; BETA ARYLOXYQUINOLINE; QUINOLINE DERIVATIVE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTITUBERCULOSIS ACTIVITY; ARTICLE; BIOASSAY; BRINE SHRIMP BIOASSAY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ONE POT SYNTHESIS;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIOXIDANTS; ANTITUBERCULAR AGENTS; ARTEMIA; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORINE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OVUM; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875952662     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.017     Document Type: Article

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