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Volumn 45, Issue 12, 2010, Pages 5887-5898
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Design, synthesis and structure-activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents
a
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Author keywords
1,3 Dipolar cycloaddition; 1,5 Diphenylpyrazoles; Anti estrogenic activity; Antitumor; Cytotoxic activity; Nitrilimines; Pyrazolo 3,4 d pyridazins; Structure activity relationship (SAR)
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Indexed keywords
3 (1 PHENYL 3 ETHOXYCARBONYL 4 CARBONYL) 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 (1,3 DIPHENYL 1H PYRAZOLE 4 CARBONYL) 1,5 PHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 (2,4 DIPHENYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 7 YL) 1,5 DIPHENYL 1H PYRAZOLE 4CARBONITRILE;
3 (3 ACETYL 1 PHENYL 1H PYRAZOLE 4 CARBONYL) 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 (3 MORPHOLIN 4 YL ACRYLOYL) 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 (7 HYDROXY 2 PHENYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 4 YL) 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 (7 METHYL 2 PHENYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 4 YL) 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [1 (4 CHLOROPHENYL) 3 ETHOXYCARBONYL 4 CARBONYL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [1 (4 METHYLPHENYL) 3 ETHOXYCARBONYL 4 CARBONYL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [2 (4 CHLOROPHENYL) 4 PHENYL 2H PYRAZOLO[3,4-D]PYRIDAZIN 7 YL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [2 (4 METHYLPHENYL) 2 PHENYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 7 YL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [3 (4 CYANO 1,5 DIPHENYL 1H PYRAZOLE 3 YL) 1 (4 METHYLPHENYL) 1H PYRAZOLE 4 CARBONYL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [3 (DIMETHYLAMINO)ACRYLOYL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [4 BENZOYL 1 (4 CHLOROPHENYL) 1H PYRAZOLE 3 CARBONYL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [4 BENZOYL 1 (4 METHYLPHENYL) 1H PYRAZOLE 3 CARBONYL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [7 (4 CYANO 1,5 DIPHENYL 1H PYRAZOLE 3 YL) 2 (4 CHLOROPHENYL) 2H PYRAZOLO[3,4 D]PYRIDAZIN 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 [7 (4 CYANO 1,5 DIPHENYL 1H PYRAZOLE 3 YL) 2 PHENYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 4 YL] 1,5 DIPHENYL 1H PYRAZOLE 4 CAR;
3 [7 HYDROXY 2 (4 CHLOROPHENYL) 2H PYRAZOLO[3,4 D]PYRIDAZIN 4 YL] 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
3 ACETYL 1,5 DIPHENYL 1H PYRAZOLE 4 CARBONITRILE;
4 (4 CYANO 1,5 DIPHENYL 1H PYRAZOLE 3 CARBONYL) 1 (4 CHLOROPHENYL) 1H PYRAZOLE 3 CARBOXYLIC ACID PHENYLAMID;
4 (4 CYANO 1,5 DIPHENYL 1H PYRAZOLE 3 CARBONYL) 1 PHENYL 1H PYRAZOLE 3 CARBOXYLIC ACID PHENYLAMID;
ANTINEOPLASTIC AGENT;
LETROZOLE;
PYRAZOLE DERIVATIVE;
UNCLASSIFIED DRUG;
ANIMAL EXPERIMENT;
ANIMAL TISSUE;
ARTICLE;
BREAST TUMOR;
CANCER CELL;
CONTROLLED STUDY;
CYCLOADDITION;
CYTOTOXICITY;
DRUG DESIGN;
DRUG SAFETY;
DRUG SYNTHESIS;
FEMALE;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
IN VIVO STUDY;
LD 50;
MALE;
MOUSE;
NONHUMAN;
OVARY TUMOR;
RAT;
SINGLE DRUG DOSE;
STRUCTURE ACTIVITY RELATION;
ANIMALS;
ANTINEOPLASTIC AGENTS;
BODY WEIGHT;
CELL LINE, TUMOR;
CELL PROLIFERATION;
CYCLIZATION;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG DESIGN;
DRUG SCREENING ASSAYS, ANTITUMOR;
FEMALE;
HETEROCYCLIC COMPOUNDS;
HUMANS;
MALE;
MICE;
MOLECULAR STRUCTURE;
PYRAZOLES;
RATS;
RATS, SPRAGUE-DAWLEY;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
UTERUS;
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EID: 78649335610
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2010.09.054 Document Type: Article |
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Times cited : (84)
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References (47)
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