Synthesis and antimicrobial activity of some new N-substituted quinoline derivatives of 1H-pyrazole

Archiv der Pharmazie

Volumn 344, Issue 2, 2011, Pages 91-101

  Thumar, Nilesh J ^a   Patel, Manish P ^a  

^a SARDAR PATEL UNIVERSITY   (India)

Author keywords

Antimicrobial activity; MCR; MIC; Pyrazole 4 carbaldehyde; Quinoline

Indexed keywords

2 AMINO 1 (4 FLUOROPHENYL) 4 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 4 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 4 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 4 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 4 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 5 OXO 4 (1 PHENYL 3 4 TOLYL 1H PYRAZOL 4 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 5 OXO 4 [1 PHENYL 3 (THIOPHEN 2 YL) 1H PYRAZOL 4 YL] 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 7,7 DIMETHYL 4 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 7,7 DIMETHYL 5 OXO 4 (1 PHENYL 3 4 TOLYL 1H PYRAZOL 4 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 (4 FLUOROPHENYL) 7,7 DIMETHYL 5 OXO 4 [1 PHENYL 3 (THIOPHEN 2 YL) 1H PYRAZOL 4 YL] 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 4 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 4 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 5 OXO 4 (1 PHENYL 3 4 TOLYL 1H PYRAZOL 4 YL) 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 5 OXO 4 [1 PHENYL 3 (THIOPHEN 2 YL) 1H PYRAZOL 4 YL] 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 1 (4 FLUOROPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 1 (4 FLUOROPHENYL) 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 (1,3 DIPHENYL 1H PYRAZOL 4 YL) 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 (4 FLUOROPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 (4 FLUOROPHENYL) 7,7-DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 (4 FLUOROPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 (4 FLUOROPHENYL) 7,7-DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 4 [3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] 1 [4 (4 FLUOROPHENYL)THIAZOL 2 YL] 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBONITRILE; ALDEHYDE; CYCLOHEXANONE DERIVATIVE; MALONONITRILE; PYRAZOLE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACILLUS SUBTILIS; BROTH DILUTION; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CLOSTRIDIUM TETANI; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SALMONELLA TYPHI; STREPTOCOCCUS PNEUMONIAE; VIBRIO CHOLERAE;

ANTI-INFECTIVE AGENTS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRAZOLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79551711842     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000010     Document Type: Article

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