-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
G.L. Semenza Targeting HIF-1 for cancer therapy Nat. Rev. Cancer 3 2003 721 732 (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
2
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts
-
D.R. Mole, C. Blancher, R.R. Copley, P.J. Pollard, J.M. Gleadle, J. Ragoussis, and P.J. Ratcliffe Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts J. Biol. Chem. 284 2009 16767 16775
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16767-16775
-
-
Mole, D.R.1
Blancher, C.2
Copley, R.R.3
Pollard, P.J.4
Gleadle, J.M.5
Ragoussis, J.6
Ratcliffe, P.J.7
-
3
-
-
84866940088
-
The role of hypoxia-inducible factor 1 in atherosclerosis
-
L. Gao, Q. Chen, X. Zhou, and L. Fan The role of hypoxia-inducible factor 1 in atherosclerosis J. Clin. Pathol. 65 2012 872 876
-
(2012)
J. Clin. Pathol.
, vol.65
, pp. 872-876
-
-
Gao, L.1
Chen, Q.2
Zhou, X.3
Fan, L.4
-
4
-
-
84861845402
-
The updated biology of hypoxia-inducible factor
-
S.N. Greer, J.L. Metcalf, Y. Wang, and M. Ohh The updated biology of hypoxia-inducible factor EMBO J. 31 2012 2448 2460
-
(2012)
EMBO J.
, vol.31
, pp. 2448-2460
-
-
Greer, S.N.1
Metcalf, J.L.2
Wang, Y.3
Ohh, M.4
-
5
-
-
79958191830
-
Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
-
N. Rohwer, and T. Cramer Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways Drug Resist Updates 14 2011 191 201
-
(2011)
Drug Resist Updates
, vol.14
, pp. 191-201
-
-
Rohwer, N.1
Cramer, T.2
-
6
-
-
80053645045
-
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
-
C.C.-L. Wong, D.M. Gilkes, H. Zhang, J. Chen, H. Wei, P. Chaturvedi, S.I. Fraley, C.-M. Wong, U.-S. Khoo, I.O.-L. Ng, D. Wirtz, and G.L. Semenza Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation Proc. Natl. Acad. Sci. USA 108 2011 16369 16374
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 16369-16374
-
-
Wong, C.C.-L.1
Gilkes, D.M.2
Zhang, H.3
Chen, J.4
Wei, H.5
Chaturvedi, P.6
Fraley, S.I.7
Wong, C.-M.8
Khoo, U.-S.9
Ng, I.O.-L.10
Wirtz, D.11
Semenza, G.L.12
-
7
-
-
46949094778
-
Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer
-
Y. Yamamoto, M. Ibusuki, Y. Okumura, T. Kawasoe, K. Kai, K. Iyama, and H. Iwase Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer Breast Cancer Res. Treat. 110 2007 465 475
-
(2007)
Breast Cancer Res. Treat.
, vol.110
, pp. 465-475
-
-
Yamamoto, Y.1
Ibusuki, M.2
Okumura, Y.3
Kawasoe, T.4
Kai, K.5
Iyama, K.6
Iwase, H.7
-
8
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation Science 292 2001 468 472 (Pubitemid 32335942)
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.-M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
9
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
DOI 10.1101/gad.991402
-
D. Lando, D.J. Peet, J.J. Gorman, D.A. Whelan, M.L. Whitelaw, and R.K. Bruick FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev. 16 2002 1466 1471 (Pubitemid 34686328)
-
(2002)
Genes and Development
, vol.16
, Issue.12
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
10
-
-
78650864017
-
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
-
C. Loenarz, and C.J. Schofield Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases Trends Biochem. Sci. 36 2011 7 18
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 7-18
-
-
Loenarz, C.1
Schofield, C.J.2
-
13
-
-
33847051180
-
Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate
-
DOI 10.1016/j.freeradbiomed.2006.11.023, PII S0891584906007611
-
M.C.M. Vissers, S.P. Gunningham, M.J. Morrison, G.U. Dachs, and M.J. Currie Modulation of hypoxia-inducible factor-1α in cultured primary cells by intracellular ascorbate Free Radic. Biol. Med. 42 2007 765 772 (Pubitemid 46274164)
-
(2007)
Free Radical Biology and Medicine
, vol.42
, Issue.6
, pp. 765-772
-
-
Vissers, M.C.M.1
Gunningham, S.P.2
Morrison, M.J.3
Dachs, G.U.4
Currie, M.J.5
-
14
-
-
33847050240
-
Non-heme dioxygenases: Cellular sensors and regulators jelly rolled into one? Nat. Chem
-
A. Ozer, and R.K. Bruick Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat. Chem Biol 3 2007 144 153
-
(2007)
Biol
, vol.3
, pp. 144-153
-
-
Ozer, A.1
Bruick, R.K.2
-
15
-
-
1642315195
-
Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases
-
DOI 10.1074/jbc.M312254200
-
P. Koivunen, M. Hirsilä, V. Günzler, K.I. Kivirikko, and J. Myllyharju Catalytic properties of the asparagine hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases J. Biol. Chem 279 2004 9899 9904 (Pubitemid 38372589)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.11
, pp. 9899-9904
-
-
Koivunen, P.1
Hirsila, M.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
16
-
-
0016562984
-
A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture
-
R.F. Kletzien, M.W. Pariza, J.E. Becker, and V.R. Potter A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture Anal. Biochem 68 1975 537 544
-
(1975)
Anal. Biochem
, vol.68
, pp. 537-544
-
-
Kletzien, R.F.1
Pariza, M.W.2
Becker, J.E.3
Potter, V.R.4
-
17
-
-
0028890292
-
Analysis of water-soluble antioxidants by high-pressure liquid chromatography
-
R.C. Rose, and A.M. Bode Analysis of water-soluble antioxidants by high-pressure liquid chromatography Biochem. J. 306 1995 101 105
-
(1995)
Biochem. J.
, vol.306
, pp. 101-105
-
-
Rose, R.C.1
Bode, A.M.2
-
18
-
-
0036773458
-
Novel chimeric gene promoters responsive to hypoxia and ionizing radiation
-
DOI 10.1038/sj.gt.3301823
-
O. Greco, B. Marples, G.U. Dachs, K.J. Williams, A.V. Patterson, and S.D. Scott Novel chimeric gene promoters responsive to hypoxia and ionizing radiation Gene Ther 9 2002 1403 1411 (Pubitemid 35244166)
-
(2002)
Gene Therapy
, vol.9
, Issue.20
, pp. 1403-1411
-
-
Greco, O.1
Marples, B.2
Dachs, G.U.3
Williams, K.J.4
Patterson, A.V.5
Scott, S.D.6
-
19
-
-
84857405506
-
Wnt signalling pathway parameters for mammalian cells
-
C.W. Tan, B.S. Gardiner, Y. Hirokawa, M.J. Layton, D.W. Smith, and A.W. Burgess Wnt signalling pathway parameters for mammalian cells PLoS One 7 2012 e31882
-
(2012)
PLoS One
, vol.7
, pp. 31882
-
-
Tan, C.W.1
Gardiner, B.S.2
Hirokawa, Y.3
Layton, M.J.4
Smith, D.W.5
Burgess, A.W.6
-
21
-
-
33646195654
-
Force microscopy of nonadherent cells: A comparison of leukemia cell deformability
-
M.J. Rosenbluth, W.A. Lam, and D.A. Fletcher Force microscopy of nonadherent cells: a comparison of leukemia cell deformability Biophys. J. 90 2006 2994 3003
-
(2006)
Biophys. J.
, vol.90
, pp. 2994-3003
-
-
Rosenbluth, M.J.1
Lam, W.A.2
Fletcher, D.A.3
-
22
-
-
84880447472
-
Hypoxia modulates fibroblastic architecture, adhesion and migration: A role for HIF-1α in cofilin regulation and cytoplasmic actin distribution
-
M. Vogler, S. Vogel, S. Krull, K. Farhat, P. Leisering, S. Lutz, C.M. Wuertz, D.M. Katschinski, and A. Zieseniss Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution PLoS One 8 2013 e69128
-
(2013)
PLoS One
, vol.8
, pp. 69128
-
-
Vogler, M.1
Vogel, S.2
Krull, S.3
Farhat, K.4
Leisering, P.5
Lutz, S.6
Wuertz, C.M.7
Katschinski, D.M.8
Zieseniss, A.9
-
23
-
-
0019945384
-
The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration
-
DOI 10.1079/BJN19820059
-
R.M. Evans, L. Currie, and A. Campbell The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration Br. J. Nutr 47 1982 473 482 (Pubitemid 12016758)
-
(1982)
British Journal of Nutrition
, vol.47
, Issue.3
, pp. 473-482
-
-
Evans, R.M.1
Currie, L.2
Campbell, A.3
-
24
-
-
64249111126
-
Ascorbic acid efflux and re-uptake in endothelial cells: Maintenance of intracellular ascorbate
-
J.M. May, and Z.-c. Qu Ascorbic acid efflux and re-uptake in endothelial cells: maintenance of intracellular ascorbate Mol. Cell. Biochem. 325 2009 79 88
-
(2009)
Mol. Cell. Biochem.
, vol.325
, pp. 79-88
-
-
May, J.M.1
Qu, Z.-C.2
-
25
-
-
84890461711
-
Myths, artifacts and fatal flaws: Identifying limitations and opportunities in vitamin C research
-
A.J. Michels, and B. Frei Myths, artifacts and fatal flaws: identifying limitations and opportunities in vitamin C research Nutrients 5 2013 5161 5192
-
(2013)
Nutrients
, vol.5
, pp. 5161-5192
-
-
Michels, A.J.1
Frei, B.2
-
26
-
-
0035083741
-
Monitoring of ascorbate at a constant rate in cell culture: Effect on cell growth
-
DOI 10.1290/1071-2690(2001)037<0026:MOAAAC>2.0.CO;2
-
T. Chepda, M. Cadau, G.J. Frey, and A. Chamson Monitoring of ascorbate at a constant rate in cell culture: effect on cell growth In Vitro Cell Dev. Biol. Anim. 37 2001 26 30 (Pubitemid 32245951)
-
(2001)
In Vitro Cellular and Developmental Biology - Animal
, vol.37
, Issue.1
, pp. 26-30
-
-
Chepda, T.1
Cadau, M.2
Girin, Ph.3
Frey, J.4
Chamson, A.5
-
27
-
-
0015396218
-
The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts
-
B. Peterkofsky The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts Arch. Biochem. Biophys 152 1972 318 328
-
(1972)
Arch. Biochem. Biophys
, vol.152
, pp. 318-328
-
-
Peterkofsky, B.1
-
28
-
-
0022938999
-
Ascorbate autoxidation in the presence of iron and copper chelates
-
G.R. Buettner Ascorbate autoxidation in the presence of iron and copper chelates Free Radic. Res. Commun 1 1986 349 353
-
(1986)
Free Radic. Res. Commun
, vol.1
, pp. 349-353
-
-
Buettner, G.R.1
-
29
-
-
36148954660
-
The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer
-
DOI 10.1007/s10555-007-9080-0, Forty Years of Metastasis Research: A Tribute to Dr. Isaiah J. Fidler
-
H.R. Mellor, and A.L. Harris The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer Cancer Metastasis Rev 26 2007 553 566 (Pubitemid 350115110)
-
(2007)
Cancer and Metastasis Reviews
, vol.26
, Issue.3-4
, pp. 553-566
-
-
Mellor, H.R.1
Harris, A.L.2
-
30
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
G. Bellot, R. Garcia-Medina, P. Gounon, J. Chiche, D. Roux, J. Pouysségur, and N.M. Mazure Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains Mol. Cell. Biol. 29 2009 2570 2581
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouysségur, J.6
Mazure, N.M.7
-
31
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
H. Zhang, M. Bosch-Marce, L.A. Shimoda, Y.S. Tan, J.H. Baek, J.B. Wesley, F.J. Gonzalez, and G.L. Semenza Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia J. Biol. Chem. 283 2008 10892 10903
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
Gonzalez, F.J.7
Semenza, G.L.8
-
32
-
-
84896729677
-
Ascorbic acid: Properties and determination
-
B. Caballero, Academic Press Oxford
-
M.A. Kall Ascorbic acid: properties and determination B. Caballero, Encyclopedia of Food Sciences and Nutrition 2003 Academic Press Oxford 316 324
-
(2003)
Encyclopedia of Food Sciences and Nutrition
, pp. 316-324
-
-
Kall, M.A.1
-
33
-
-
0019905709
-
Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron: The role of ascorbate in peptidyl proline hydroxylation
-
L. De Jong, S.P.J. Albracht, and A. Kemp Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron: the role of ascorbate in peptidyl proline hydroxylation Biochim. Biophys. Acta 704 326-332 1982
-
(1982)
Biochim. Biophys. Acta
, vol.704
, pp. 326-332
-
-
De Jong, L.1
Albracht, S.P.J.2
Kemp, A.3
-
34
-
-
77950906905
-
Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents
-
E. Flashman, S.L. Davies, K.K. Yeoh, and C.J. Schofield Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents Biochem. J 427 2010 135 142
-
(2010)
Biochem. J
, vol.427
, pp. 135-142
-
-
Flashman, E.1
Davies, S.L.2
Yeoh, K.K.3
Schofield, C.J.4
-
35
-
-
80053211441
-
Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation
-
R.S. Singleton, D.C. Trudgian, R. Fischer, B.M. Kessler, P.J. Ratcliffe, and M.E. Cockman Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation J. Biol. Chem. 286 2011 33784 33794
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 33784-33794
-
-
Singleton, R.S.1
Trudgian, D.C.2
Fischer, R.3
Kessler, B.M.4
Ratcliffe, P.J.5
Cockman, M.E.6
-
36
-
-
34548257176
-
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
-
DOI 10.1016/j.ccr.2007.08.004, PII S1535610807002334
-
P. Gao, H. Zhang, R. Dinavahi, F. Li, Y. Xiang, V. Raman, Z.M. Bhujwalla, D.W. Felsher, L. Cheng, J. Pevsner, L.A. Lee, and G.L. Semenza HIF-dependent antitumorigenic effects of antioxidants in vivo Cancer Cell 12 2007 230 238 (Pubitemid 47333417)
-
(2007)
Cancer Cell
, vol.12
, Issue.3
, pp. 230-238
-
-
Gao, P.1
Zhang, H.2
Dinavahi, R.3
Li, F.4
Xiang, Y.5
Raman, V.6
Bhujwalla, Z.M.7
Felsher, D.W.8
Cheng, L.9
Pevsner, J.10
Lee, L.A.11
Semenza, G.L.12
Dang, C.V.13
-
37
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
DOI 10.1074/jbc.C200273200
-
K.S. Hewitson, L.A. McNeill, M.V. Riordan, Y.-M. Tian, A.N. Bullock, R.W. Welford, J.M. Elkins, N.J. Oldham, S. Bhattacharya, J.M. Gleadle, P.J. Ratcliffe, C.W. Pugh, and C.J. Schofield Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J. Biol. Chem. 277 2002 26351 26355 (Pubitemid 34967127)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.29
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.-M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
Ratcliffe, P.J.11
Pugh, C.W.12
Schofield, C.J.13
-
38
-
-
23444447955
-
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
-
DOI 10.1096/fj.04-3399je
-
M. Hirsilä, P. Koivunen, L. Xu, T. Seeley, K.I. Kivirikko, and J. Myllyharju Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway FASEB J. 19 2005 1308 1310 (Pubitemid 41113732)
-
(2005)
FASEB Journal
, vol.19
, Issue.10
, pp. 1308-1310
-
-
Hirsila, M.1
Koivunen, P.2
Xu, L.3
Seeley, T.4
Kivirikko, K.I.5
Myllyharju, J.6
-
39
-
-
59149091875
-
Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1α protein
-
M. Kaczmarek, R.E. Cachau, I.A. Topol, K.S. Kasprzak, A. Ghio, and K. Salnikow Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1α protein Toxicol. Sci. 107 2009 394 403
-
(2009)
Toxicol. Sci.
, vol.107
, pp. 394-403
-
-
Kaczmarek, M.1
Cachau, R.E.2
Topol, I.A.3
Kasprzak, K.S.4
Ghio, A.5
Salnikow, K.6
-
40
-
-
47249114860
-
ESI-MS studies on prolyl-hydroxylase domain 2 reveal a new metal binding site
-
J. Mecinović, R. Chowdhury, B.M.R. Liénard, E. Flashman, M.R.G. Buck, N.J. Oldham, and C.J. Schofield ESI-MS studies on prolyl-hydroxylase domain 2 reveal a new metal binding site Chem. Med. Chem. 3 2008 569 572
-
(2008)
Chem. Med. Chem.
, vol.3
, pp. 569-572
-
-
Mecinović, J.1
Chowdhury, R.2
Liénard, B.M.R.3
Flashman, E.4
Buck, M.R.G.5
Oldham, N.J.6
Schofield, C.J.7
-
41
-
-
77951235773
-
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers
-
H. Chen, N.C. Giri, R. Zhang, K. Yamane, Y. Zhang, M. Maroney, and M. Costa Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers J. Biol. Chem. 285 2010 7374 7383
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7374-7383
-
-
Chen, H.1
Giri, N.C.2
Zhang, R.3
Yamane, K.4
Zhang, Y.5
Maroney, M.6
Costa, M.7
-
42
-
-
33645891676
-
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
-
I.J. Clifton, M.A. McDonough, D. Ehrismann, N.J. Kershaw, N. Granatino, and C.J. Schofield Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins J. Inorg. Biochem. 100 2006 644 669
-
(2006)
J. Inorg. Biochem.
, vol.100
, pp. 644-669
-
-
Clifton, I.J.1
McDonough, M.A.2
Ehrismann, D.3
Kershaw, N.J.4
Granatino, N.5
Schofield, C.J.6
-
43
-
-
0001101920
-
Chelation of ferrous sulphate solutions by desferrioxamine B
-
J.F. Goodwin, and C.F. Whitten Chelation of ferrous sulphate solutions by desferrioxamine B Nature 205 1965 281 283
-
(1965)
Nature
, vol.205
, pp. 281-283
-
-
Goodwin, J.F.1
Whitten, C.F.2
-
44
-
-
77954623393
-
Chelation of intracellular iron enhances endothelial barrier function: A role for vitamin C?
-
J.M. May, and Z.-c. Qu Chelation of intracellular iron enhances endothelial barrier function: a role for vitamin C? Arch. Biochem. Biophys. 500 2010 162 168
-
(2010)
Arch. Biochem. Biophys.
, vol.500
, pp. 162-168
-
-
May, J.M.1
Qu, Z.-C.2
-
45
-
-
29644442625
-
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
-
DOI 10.1074/jbc.M508718200
-
H. Lu, C.L. Dalgard, A. Mohyeldin, T. McFate, A.S. Tait, and A. Verma Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1 J. Biol. Chem. 280 2005 41928 41939 (Pubitemid 43023162)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.51
, pp. 41928-41939
-
-
Lu, H.1
Dalgard, C.L.2
Mohyeldin, A.3
McFate, T.4
Tait, A.S.5
Verma, A.6
-
46
-
-
84876325985
-
Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer
-
P.J. Ratcliffe Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer J. Physiol 591 2013 2027 2042
-
(2013)
J. Physiol
, vol.591
, pp. 2027-2042
-
-
Ratcliffe, P.J.1
-
47
-
-
0037446983
-
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells
-
H.J. Knowles, R.R. Raval, A.L. Harris, and P.J. Ratcliffe Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells Cancer Res. 63 2003 1764 1768 (Pubitemid 36460834)
-
(2003)
Cancer Research
, vol.63
, Issue.8
, pp. 1764-1768
-
-
Knowles, H.J.1
Raval, R.R.2
Harris, A.L.3
Ratcliffe, P.J.4
-
48
-
-
58149102376
-
Current insights on the biology and clinical aspects of VEGF regulation
-
D.M. Birk, J. Barbato, L. Mureebe, and R.A. Chaer Current insights on the biology and clinical aspects of VEGF regulation Vasc. Endovasc. Surg 42 2009 517 530
-
(2009)
Vasc. Endovasc. Surg
, vol.42
, pp. 517-530
-
-
Birk, D.M.1
Barbato, J.2
Mureebe, L.3
Chaer, R.A.4
-
49
-
-
33745614894
-
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
-
DOI 10.1073/pnas.0601283103
-
M.A. McDonough, V. Li, E. Flashman, R. Chowdhury, C. Mohr, B.M.R. Liénard, J. Zondlo, N.J. Oldham, I.J. Clifton, J. Lewis, L.A. McNeill, R.J.M. Kurzeja, K.S. Hewitson, E. Yang, S. Jordan, R.S. Syed, and C.J. Schofield Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl-hydroxylase (PHD2) Proc. Natl. Acad. Sci. USA 103 2006 9814 9819 (Pubitemid 43993580)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.26
, pp. 9814-9819
-
-
McDonough, M.A.1
Li, V.2
Flashman, E.3
Chowdhury, R.4
Mohr, C.5
Lienard, B.M.R.6
Zondlo, J.7
Oldham, N.J.8
Clifton, I.J.9
Lewis, J.10
McNeill, L.A.11
Kurzeja, R.J.M.12
Hewitson, K.S.13
Yang, E.14
Jordan, S.15
Syed, R.S.16
Schofield, C.J.17
-
50
-
-
78649658053
-
Structural studies on human 2-oxoglutarate dependent oxygenases
-
M.A. McDonough, C. Loenarz, R. Chowdhury, I.J. Clifton, and C.J. Schofield Structural studies on human 2-oxoglutarate dependent oxygenases Curr. Opin. Struct. Biol. 20 2010 659 672
-
(2010)
Curr. Opin. Struct. Biol.
, vol.20
, pp. 659-672
-
-
McDonough, M.A.1
Loenarz, C.2
Chowdhury, R.3
Clifton, I.J.4
Schofield, C.J.5
-
51
-
-
9244219627
-
Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance
-
DOI 10.1073/pnas.93.8.3704
-
M. Levine, C. Conry-Cantilena, Y. Wang, R.W. Welch, P.W. Washko, K.R. Dhariwal, J.B. Park, A. Lazarev, J.F. Graumlich, J. King, and L.R. Cantilena Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance Proc. Natl. Acad. Sci. USA 93 1996 3704 3709 (Pubitemid 26125678)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.8
, pp. 3704-3709
-
-
Levine, M.1
Conry-Cantilena, C.2
Wang, Y.3
Welch, R.W.4
Washko, P.W.5
Dhariwal, K.R.6
Park, J.B.7
Lazarev, A.8
Graumlich, J.F.9
King, J.10
Cantilena, L.R.11
-
53
-
-
26444521256
-
Pharamacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissuse
-
DOI 10.1073/pnas.0506390102
-
Q. Chen, M.G. Espey, M.C. Krishna, J.B. Mitchell, C.P. Corpe, G.R. Buettner, E. Shacter, and M. Levine Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues Proc. Natl. Acad. Sci. USA 102 2005 13604 13609 (Pubitemid 41420895)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.38
, pp. 13604-13609
-
-
Chen, Q.1
Espey, M.G.2
Krishna, M.C.3
Mitchell, J.B.4
Corpe, C.P.5
Buettner, G.R.6
Shaded, E.7
Levine, M.8
-
54
-
-
13444301515
-
Vitamin C deficiency in cancer patients
-
DOI 10.1191/0269216305pm970oa
-
C.R. Mayland, M.I. Bennett, and K. Allan Vitamin C deficiency in cancer patients Palliative Med. 19 2005 17 20 (Pubitemid 40202054)
-
(2005)
Palliative Medicine
, vol.19
, Issue.1
, pp. 17-20
-
-
Mayland, C.R.1
Bennett, M.I.2
Allan, K.3
-
55
-
-
33645066360
-
Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate
-
D.T. Jones, I.S. Trowbridge, and A.L. Harris Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate Cancer Res 66 2006 2749 2756
-
(2006)
Cancer Res
, vol.66
, pp. 2749-2756
-
-
Jones, D.T.1
Trowbridge, I.S.2
Harris, A.L.3
-
56
-
-
67749086874
-
Effect of small interference RNA targeting HIF-1α mediated by rAAV combined L-ascorbate on pancreatic tumours in athymic mice
-
C. Chen, J. Sun, G. Liu, and J. Chen Effect of small interference RNA targeting HIF-1α mediated by rAAV combined L-ascorbate on pancreatic tumours in athymic mice Pathol. Oncol. Res. 15 2008 109 114
-
(2008)
Pathol. Oncol. Res.
, vol.15
, pp. 109-114
-
-
Chen, C.1
Sun, J.2
Liu, G.3
Chen, J.4
-
57
-
-
3042628499
-
Evaluation of antioxidant enzymes activity and concentration of non-enzymatic antioxidants in human brain tumours
-
H. Dudek, R. Farbiszewski, M. Rydzewska, T. Michno, and A. Kozłowksi Evaluation of antioxidant enzymes activity and concentration of non-enzymatic antioxidants in human brain tumours Wiad. Lek. 57 2004 16 19
-
(2004)
Wiad. Lek.
, vol.57
, pp. 16-19
-
-
Dudek, H.1
Farbiszewski, R.2
Rydzewska, M.3
Michno, T.4
Kozłowksi, A.5
-
58
-
-
0024399787
-
Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and non-neoplastic human breast tissue
-
DOI 10.1002/ijc.2910430634
-
H. Langemann, J. Torhorst, A. Kabiersch, W. Krenger, and C.G. Honegger Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and non-neoplastic human breast tissue Int. J. Cancer 43 1989 1169 1173 (Pubitemid 19158054)
-
(1989)
International Journal of Cancer
, vol.43
, Issue.6
, pp. 1169-1173
-
-
Langemann, H.1
Torhorst, J.2
Kabiersch, A.3
Krenger, W.4
Honegger, C.G.5
-
59
-
-
31844454246
-
Glutathione, ascorbic acid and antioxidant enzymes in the tumor tissue and blood of patients with oral squamous cell carcinoma
-
A.I. Fiaschi, A. Cozzolino, G. Ruggiero, and G. Giorgi Glutathione, ascorbic acid and antioxidant enzymes in the tumour tissue and blood of patients with oral squamous cell carcinoma Eur. Rev. Med. Pharmacol. Sci. 9 2005 361 367 (Pubitemid 43180326)
-
(2005)
European Review for Medical and Pharmacological Sciences
, vol.9
, Issue.6
, pp. 361-367
-
-
Fiaschi, A.I.1
Cozzolino, A.2
Ruggiero, G.3
Giorgi, G.4
-
60
-
-
77955037416
-
Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer
-
C. Kuiper, I.G.M. Molenaar, G.U. Dachs, M.J. Currie, P.H. Sykes, and M.C.M. Vissers Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer Cancer Res. 70 2010 5749 5758
-
(2010)
Cancer Res.
, vol.70
, pp. 5749-5758
-
-
Kuiper, C.1
Molenaar, I.G.M.2
Dachs, G.U.3
Currie, M.J.4
Sykes, P.H.5
Vissers, M.C.M.6
-
61
-
-
84896737068
-
Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer
-
C. Kuiper, G.U. Dachs, D. Munn, M.J. Currie, B. Robinson, J.F. Pearson, and M.C.M. Vissers Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer Front. Oncol. 4 2014 10.3389/fonc.2014.00010
-
(2014)
Front. Oncol.
, vol.4
-
-
Kuiper, C.1
Dachs, G.U.2
Munn, D.3
Currie, M.J.4
Robinson, B.5
Pearson, J.F.6
Vissers, M.C.M.7
-
62
-
-
0024396368
-
Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature
-
M.W. Dewhirst, C.Y. Tso, R. Oliver, C.S. Gustafson, T.W. Secomb, and J.F. Gross Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature Int. J. Radiat. Oncol. Biol. Phys. 17 1989 91 99 (Pubitemid 19173243)
-
(1989)
International Journal of Radiation Oncology Biology Physics
, vol.17
, Issue.1
, pp. 91-99
-
-
Dewhirst, M.W.1
Tso, C.Y.2
Oliver, R.3
Gustafson, C.S.4
Secomb, T.W.5
Gross, J.F.6
-
63
-
-
0033984256
-
Carcinogenic nickel induces genes involved with hypoxic stress
-
K. Salnikow, M.V. Blagosklonny, H. Ryan, R. Johnson, and M. Costa Carcinogenic nickel induces genes involved with hypoxic stress Cancer Res. 60 2000 38 41 (Pubitemid 30058726)
-
(2000)
Cancer Research
, vol.60
, Issue.1
, pp. 38-41
-
-
Salnikow, K.1
Blagosklonny, M.V.2
Ryan, H.3
Johnson, R.4
Costa, M.5
-
64
-
-
81255200577
-
Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice
-
K.S. Kasprzak, B.A. Diwan, M.Z. Kaczmarek, D.L. Logsdon, M.J. Fivash, and K. Salnikow Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice Toxicol. Appl. Pharmacol. 257 2011 32 37
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.257
, pp. 32-37
-
-
Kasprzak, K.S.1
Diwan, B.A.2
Kaczmarek, M.Z.3
Logsdon, D.L.4
Fivash, M.J.5
Salnikow, K.6
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