Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice

Toxicology and Applied Pharmacology

Volumn 257, Issue 1, 2011, Pages 32-37

  Kasprzak, Kazimierz S ^a   Diwan, Bhalchandra A ^a   Kaczmarek, Monika Z ^a   Logsdon, Daniel L ^a   Fivash, Mathew J ^a   Salnikow, Konstantin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Ascorbate; Gulo mice; Gulonolactone oxidase; Nickel carcinogenesis

Indexed keywords

ASCORBIC ACID; GULONOLACTONE OXIDASE; NICKEL SUBSULFIDE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GRAFT; CARCINOGENESIS; CONTROLLED STUDY; DRUG CARCINOGENICITY; DRUG TISSUE LEVEL; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; STRAIN DIFFERENCE; TUMOR GROWTH; VITAMIN SUPPLEMENTATION; WILD TYPE;

ANIMALS; ASCORBIC ACID; CARCINOGENS; DRUG INTERACTIONS; INJECTIONS, INTRAMUSCULAR; L-GULONOLACTONE OXIDASE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NICKEL;

GULO; MUS;

EID: 81255200577     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.08.015     Document Type: Article

References (29)

1. Arita A., Costa M. Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics 2009, 1:222-228.
2. Bal W., Protas A.M., Kasprzak K.S. Genotoxicity of metal ions: chemical insights. Met. Ions. Life Sci. 2011, 8:319-373.
3. Buettner G.R., Jurkiewicz B.A. Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat. Res. 1996, 145:532-541.
4. Cameron E., Pauling L., Leibovitz B. Ascorbic acid and cancer: a review. Cancer Res. 1979, 39:663-681.
5. Chen Q., Espey M.G., Sun A.Y., Pooput C., Kirk K.L., Krishna M.C., Khosh D.B., Drisko J., Levine M. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:11105-11109.
6. Enderlein G., Cox D.R., Oakes D. Analysis of survival data. Chapman and Hall, London-New York 1984, 201 S. Biom. J. 1987, 29:114.
7. Gimbrone M.A., Leapman S.B., Cotran R.S., Folkman J. Tumor dormancy in vivo by prevention of neovascularization. J. Exp. Med. 1972, 136:261-276.
8. Hochberg Y., Tamhane A.C. Multiple Comparison Procedures 1987, John Wiley & Sons, New York, NY, USA.
9. Hogg R.V., Ledolter J. Applied Statistics for Engineers and Physical Scientists 1987, Macmillan Publishing Company, New York.
10. Hollander M., Wolfe D.A. Nonparametric Statistical Methods 1999, John Wiley & Sons Inc, New York.
11. Kaczmarek M., Timofeeva O.A., Karaczyn A., Malyguine A., Kasprzak K.S., Salnikow K. The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). Free Radic. Biol. Med. 2007, 42:1246-1257.
12. Kasprzak K.S. Role of oxidative damage in metal-induced carcinogenesis. Cellular Effects of Heavy Metals 2011, 237-259. Springer, London, UK. K. Banfalvi (Ed.).
13. Kasprzak K.S., Hernandez L. Enhancement of hydroxylation and deglycosylation of 2'-deoxyguanosine by carcinogenic nickel compounds. Cancer Res. 1989, 49:5964-5968.
14. Kasprzak K.S., Sunderman F.W. Mechanisms of dissolution of nickel subsulfide in rat serum. Res. Commun. Chem. Pathol. Pharmacol. 1977, 16:95-108.
15. Kasprzak K.S., Sunderman F.W., Salnikow K. Nickel carcinogenesis. Mutat. Res. 2003, 533:67-97.
16. Lykkesfeldt J. Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride. Anal. Biochem. 2000, 282:89-93.
17. Maeda N., Hagihara H., Nakata Y., Hiller S., Wilder J., Reddick R. Aortic wall damage in mice unable to synthesize ascorbic acid. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:841-846.
18. Misra M., Rodriguez R.E., North S.L., Kasprzak K.S. Nickel-induced renal lipid peroxidation in different strains of mice: concurrence with nickel effect on antioxidant defense systems. Toxicol. Lett. 1991, 58:121-133.
19. Naidu K.A. Vitamin C in human health and disease is still a mystery? An overview. Nutr. J. 2003, 2:7.
20. Rodriguez R.E., Misra M., Diwan B.A., Riggs C.W., Kasprzak K.S. Relative susceptibilities of C57BL/6, (C57BL/6×C3H/He)F1, and C3H/He mice to acute toxicity and carcinogenicity of nickel subsulfide. Toxicology 1996, 107:131-140.
21. Salnikow K., Kasprzak K.S. Ascorbate depletion: a critical step in nickel carcinogenesis?. Environ. Health Perspect. 2005, 113:577-584.
22. Salnikow K., Donald S.P., Bruick R.K., Zhitkovich A., Phang J.M., Kasprzak K.S. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J. Biol. Chem. 2004, 279:40337-40344.
23. Seber G.A., Wild C.J. Nonlinear Regression 1989, John Wiley & Sons, New York.
24. Sunderman F.W. Organ and species specificity in nickel subsulfide carcinogenesis. Basic Life Sci. 1983, 24:107-127.
25. Sunderman F.W., Selin C.E. The metabolism of nickel-63 carbonyl. Toxicol. Appl. Pharmacol. 1968, 12:207-218.
26. Telang S., Clem A.L., Eaton J.W., Chesney J. Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model. Neoplasia 2007, 9:47-56.
27. Vissers M.C., Wilkie R.P. Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha. J. Leukoc. Biol. 2007, 81:1236-1244.
28. Waalkes M.P., Kasprzak K.S., Ohshima M., Poirier L.A. Protective effects of zinc acetate toward the toxicity of nickelous acetate in rats. Toxicology 1985, 34:29-41.
29. Wald A. Sequential tests of statistical hypotheses. Ann. Math. Stat. 1945, 16:117-186.