Donepezil: An important prototype to the design of new drug candidates for Alzheimer's disease

Mini-Reviews in Medicinal Chemistry

Volumn 14, Issue 1, 2014, Pages 2-19

  Simões, Maria Cecília Rodrigues ^a,b   Viegas, Flávia Pereira Dias ^a,b   Moreira, Marcella Soares ^a   Silva, Matheus de Freitas ^a   Riquiel, Mariana Máximo ^a   da Rosa, Patrícia Mattos ^a   Castelli, Maísa Rosa ^a   dos Santos, Marcelo Henrique ^a,b   Soares, Marisi Gomes ^a   Viegas Jr , Claudio ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF ALFENAS   (Brazil)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Donepezil; Molecular hybridization; Neurodegenerative disorders; Rational drug design

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CHOLINESTERASE INHIBITOR; COUMARIN; DONEPEZIL; GALANTAMINE; HUPERZINE A; HYDRAZINE; MINAPRINE; NICOTINAMIDE; PLACEBO; RIVASTIGMINE; TACRINE DERIVATIVE;

ALZHEIMER DISEASE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; DEGENERATIVE DISEASE; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; IC 50; MOLECULAR DOCKING; MOLECULAR HYBRIDIZATION; MOLECULAR MODEL; NAUSEA AND VOMITING; NEUROPATHOLOGY; PHARMACODYNAMICS; REVIEW; STRUCTURE ACTIVITY RELATION; TREMOR;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; INDANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES;

EID: 84896737802     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557513666131119201353     Document Type: Review

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