Synthesis and biological activity of new donepezil-hydrazinonicotinamide hybrids

Drug Research

Volumn 63, Issue 3, 2013, Pages 137-144

  Zurek, E ^a   Szymanski P ^a   Mikiciuk Olasik, E ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Alzheimer's disease; donepezil; inhibitors of acetylcholinesterase

Indexed keywords

6 HYDRAZINO N [2 (1 OXO 2 PIPERIDIN 1 YLMETHYLINDAN 5 YLOXY) ETHYL] NICOTINAMIDE; 6 HYDRAZINO N [3 (1 OXO 2 PIPERIDIN 1 YLMETHYLINDAN 5 YLOXY) PROPYL] NICOTINAMIDE; 6 HYDRAZINO N [5 (1 OXO 2 PIPERIDIN 1 YLMETHYLINDAN 5 YLOXY) PENTYL] NICOTINAMIDE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; HYDRAZINE; INDANONE DERIVATIVE; N [2 [2 (4 BENZYLPIPERIDIN 1 YLMETHYL) 1 OXOINDAN 5 YLOXY] ETHYL] 6 HYDRAZINONICOTINAMIDE; N [3 [2 (4 BENZYLPIPERIDIN 1 YLMETHYL) 1 OXOINDAN 5 YLOXY] PROPYL] 6 HYDRAZINONICOTINAMIDE; N [5 [2 (4 BENZYLPIPERIDIN 1 YLMETHYL) 1 OXOINDAN 5 YLOXY] PENTYL] 6 HYDRAZINONICOTINAMIDE; NICOTINAMIDE DERIVATIVE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; HYDRAZINONICTINAMIDE; INDAN DERIVATIVE; NICOTINAMIDE; PIPERIDINE DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; CHOLINESTERASE INHIBITION; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MOLECULAR DOCKING; ALZHEIMER DISEASE; CHEMISTRY; COLORIMETRY; COMPARATIVE STUDY; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; SYNTHESIS;

ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COLORIMETRY; INDANS; INHIBITORY CONCENTRATION 50; NIACINAMIDE; PIPERIDINES;

MLCS; MLOWN;

EID: 84878986551     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0033-1333735     Document Type: Article

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