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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4707-4712

Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: Application to a pyrimidine-2,4-diamine template

(5) Mohamed, Tarek a Yeung, Jacky C K a Vasefi, Maryam S a Beazely, Michael A a Rao, Praveen P N a

a UNIVERSITY OF WATERLOO (Canada)

Author keywords

3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyl tetrazolium bromide; 5,5 dithiobis(2 nitrobenzoic acid); AD; Alzheimer's disease; amyloid ; A ; BACE 1; ChEIs; cholinesterase inhibitors; DTNB; eqBuChE; equinebutyrylcholinesterase; hAChE; hBuChE; human acetylcholinesterase; human butyrylcholinesterase; MTT; SAR; structure activity relationship; thioflavin T; ThT; secretase or beta site amyloid precursor protein cleaving enzyme

Indexed keywords

2 N (1 BENZYLPIPERIDIN 4 YL) 4 N (3,4 DIMETHOXYBENZYL)PYRIMIDINE 2,4 DIAMINE; AMYLOID BETA PROTEIN; BENZYLAMINE DERIVATIVE; BETA SECRETASE 1; CHOLINESTERASE INHIBITOR; DIAMINE DERIVATIVE; DONEPEZIL; GALANTAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CELL VIABILITY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; NEUROBLASTOMA CELL; PROTEIN AGGREGATION; REVIEW;

EID: 84863434077 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.077 Document Type: Article

Times cited : (57)

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