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Volumn 19, Issue 7, 2011, Pages 2269-2281

Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: Dual activity as cholinesterase and Aβ-aggregation inhibitors

(5) Mohamed, Tarek a Zhao, Xiaobei b Habib, Lila K c Yang, Jerry b Rao, Praveen P N a

a UNIVERSITY OF WATERLOO (Canada)

b UNIVERSITY OF CALIFORNIA (United States)

c UNIVERSITY OF CALIFORNIA SAN DIEGO (United States)

Author keywords

3 (4,5 Dimethylthiazol 2 yl) 2,5 diphenyl tetrazolium bromide (MTT); 5,5 Dithiobis(2 nitrobenzoic acid) (DTNB); Acetylcholinesterase (AChE); Amyloid (A ); Butyrylcholinesterase (BuChE); Cholinesterase inhibitors (ChEIs); Human acetylcholinesterase (hAChE); Structure activity relationship (SAR); Thioflavin T (ThT)

Indexed keywords

1 [4 [4 (BENZYLAMINO)PYRIMIDIN 2 YL]PIPERAZIN 1 YL]ETHANONE; 2 (4 METHYLPIPERIDIN 1 YL) N (NAPHTH 1 YLMETHYL)PYRIMIDIN 4 AMINE; 2 [4 [4 (BENZYLAMINO)PYRIMIDIN 2 YL]PIPERAZIN 1 YL]ETHANOL; 2 CHLORO N (NAPHTH 1 YLMETHYL)PYRIMIDIN 4 AMINE; 2 CHLORO N PHENETHYLPYRIMIDIN 4 AMINE; 2 MORPHOLINO N PHENETHYLPYRIMIDIN 4 AMINE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; N (NAPHTH 1 YLMETHYL) 2 (PYRROLIDIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (4 CYCLOHEXYLPIPERAZIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (4 ISOPROPYLPIPERAZIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (4 ISOPROPYLPIPERIDIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (4 METHYLPIPERAZIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (4 METHYLPIPERIDIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (4 PROPYLPIPERAZIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 (PYRROLIDIN 1 YL)PYRIMIDIN 4 AMINE; N BENZYL 2 [4 (2 METHOXYETHYL)PIPERAZIN 1 YL]PYRIMIDIN 4 AMINE; N BENZYL 2 CHLOROPYRIMIDIN 4 AMINE; N BENZYL 2 MORPHOLINOPYRIMIDIN 4 AMINE; N BENZYL 2 THIOMORPHOLINOPYRIMIDIN 4 AMINE; PROPIDIUM IODIDE; PROTEIN INHIBITOR; PYRIMIDINE DERIVATIVE; TACRINE; TERT BUTYL 4 [4 (BENZYLAMINO)PYRIMIDIN 2 YL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PROTEIN AGGREGATION; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PEPTIDES; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953226962 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2011.02.030 Document Type: Article

Times cited : (50)

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