Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 67, Issue , 2013, Pages 64-74

  Samadi, Abdelouahid ^a   Revenga, Mario De La Fuente ^b   Pérez, Concepción ^b   Iriepa, Isabel ^c   Moraleda, Ignacio ^c   Rodríguez Franco, María Isabel ^b   Marco Contelles, José ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

6 Chloro pyridonepezils; ADME; Alzheimer's disease; Dual AChE inhibitors; hAChE; hBuChE; In vitro blood brain barrier; Molecular modeling

Indexed keywords

2 [(1 BENZYLPIPERIDIN 4 YL)AMINO] 6 CHLORO 4 PHENYLPYRIDINE 3,5 DICARBONITRILE; 2 [(1 BENZYLPIPERIDIN 4 YL)AMINO] 6 CHLOROPYRIDINE 3,5 DICARBONITRILE; 2 [[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL]AMINO] 6 CHLORO 4 PHENYLPYRIDINE 3,5 DICARBONITRILE; 2 [[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL]AMINO] 6 CHLOROPYRIDINE 3,5 DICARBONITRILE; 2 [[3 (1 BENZYLPIPERIDIN 4 YL)PROPYL]AMINO] 6 CHLORO 4 PHENYLPYRIDINE 3,5 DICARBONITRILE; 2 [[3 (1 BENZYLPIPERIDIN 4 YL)PROPYL]AMINO] 6 CHLOROPYRIDINE 3,5 DICARBONITRILE; 2 [[4 (1 BENZYLPIPERIDIN 4 YL)BUTYL]AMINO] 6 CHLORO 4 PHENYLPYRIDINE 3,5 DICARBONITRILE; 2 [[4 (1 BENZYLPIPERIDIN 4 YL)BUTYL]AMINO] 6 CHLOROPYRIDINE 3,5 DICARBONITRILE; 2,6 BIS[(1 BENZYLPIPERIDIN 4 YL)AMINO]PYRIDINE 3,5 DICARBONITRILE; 2,6 BIS[[2 (1 BENZYLPIPERIDIN 4 YL)ETHYL]AMINO] 4 PHENYLPYRIDINE 3,5 DICARBONITRILE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CHOLINESTERASE INHIBITION; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; HYDROGEN BOND; IC 50; IN VITRO STUDY; LIPID BRAIN LEVEL; MEMBRANE TRANSPORT; MOLECULAR MODEL;

6-CHLORO-PYRIDONEPEZILS; ADME; ALZHEIMER'S DISEASE; DUAL ACHE INHIBITORS; HACHE; HBUCHE; IN VITRO BLOOD BRAIN BARRIER; MOLECULAR MODELING;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882514623     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.021     Document Type: Article

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