Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance

Human Molecular Genetics

Volumn 17, Issue 16, 2008, Pages 2433-2440

  Akman, Hasan O ^a   Dorado, Beatriz ^a   López, Luis C ^a   García Cazorla, Ángeles ^a   Vilà, Maya R ^a   Tanabe, Lauren M ^b   Dauer, William T ^a,b   Bonilla, Eduardo ^a,c   Tanji, Kurenai ^c   Hirano, Michio ^a  

^a NewYork Presbyterian Hospital   (United States)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOTIDE; MITOCHONDRIAL DNA; MUTANT PROTEIN; THYMIDINE KINASE; THYMIDINE KINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEATH; DISEASE MODEL; DISEASE SEVERITY; ENCEPHALOMYELITIS; ENZYME DEFICIENCY; GENE LOCATION; GENE MUTATION; GENETIC CODE; HISTOPATHOLOGY; HOMOZYGOSITY; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL DNA DEPLETION SYNDROME; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SPINAL CORD VENTRAL HORN; WEAKNESS;

ANIMALS; DEOXYRIBONUCLEOTIDES; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MUTAGENESIS, INSERTIONAL; MUTATION, MISSENSE; ORGAN SPECIFICITY; THYMIDINE KINASE;

ANIMALIA; MUS;

EID: 48249149059     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn143     Document Type: Article

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