Nuclear localization of de Novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 44015-44022

  MacFarlane, Amanda J ^a,c   Anderson, Donald D ^a   Flodby, Per ^a,d   Perry, Cheryll A ^a   Allen, Robert H ^b   Stabler, Sally P ^b   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS PATHWAYS; COFACTORS; DIHYDROFOLATE REDUCTASE; DNA INTEGRITY; HOMOCYSTEINES; IN-VIVO; LIMITING STEP; NUCLEAR DNA; NUCLEAR LOCALIZATION; OVER-EXPRESSION; PROTEIN LEVEL; S-PHASE; SERINE HYDROXYMETHYLTRANSFERASE; THYMIDYLATE SYNTHASE; UBIQUITIN-LIKE; WILD TYPES;

AMINO ACIDS; BIOSYNTHESIS; CELL CULTURE; CELLS; DNA; MAMMALS; TISSUE;

BIOCHEMISTRY;

DNA; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; URACIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA INTEGRATION; ENZYME LOCALIZATION; FOLATE METABOLISM; GENE OVEREXPRESSION; LIVER; METHYLATION; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; SHMT1 GENE; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; DNA; GLYCINE HYDROXYMETHYLTRANSFERASE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PYRIDOXAL PHOSPHATE; PYRIMIDINES; S PHASE; THYMIDYLATE SYNTHASE; TISSUE DISTRIBUTION; TRANSGENES; URACIL;

EID: 83755181500     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.307629     Document Type: Article

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