Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: Consequences in aging muscle and therapeutic strategies for muscular dystrophies

Aging Cell

Volumn 6, Issue 4, 2007, Pages 515-523

  Zhu, Chun Hong ^a   Mouly, Vincent ^b   Cooper, Racquel N ^b   Mamchaoui, Kamel ^b   Bigot, Anne ^b   Shay, Jerry W ^a   Di Santo, James P ^c   Butler Browne, Gillian S ^b   Wright, Woodring E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SORBONNE UNIVERSITÉ   (France)

^c INSTITUT PASTEUR   (France)

Author keywords

HTERT; Muscular dystrophy; Myopathies; P16; Replicative lifespan; Replicative senescence; Satellite stem cell; Telomerase

Indexed keywords

CYCLIN DEPENDENT KINASE 4; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL COUNT; CELL DEATH; CELL DIVISION; CELL IMMORTALIZATION; CELL MIGRATION; CELL PROLIFERATION; CELL THERAPY; CHRONIC DISEASE; CONTROLLED STUDY; DNA MODIFICATION; ENZYME ACTIVITY; GENE INSERTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNE DEFICIENCY; MALE; MOUSE; MUSCLE INJURY; MUSCLE REGENERATION; MUSCULAR DYSTROPHY; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SITE DIRECTED MUTAGENESIS; XENOGRAFT;

AGING; ANIMALS; CELL AGING; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE 4; GENES, CDC; HUMANS; MICE; MUSCLE DEVELOPMENT; MUSCLES; MUSCULAR DYSTROPHIES; MYOBLASTS; REGENERATION; SATELLITE CELLS, SKELETAL MUSCLE; TELOMERASE; TELOMERE; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 34447647096     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2007.00306.x     Document Type: Article

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