Investigation of the novel lead of melanocortin 1 receptor for pigmentary disorders

Evidence-based Complementary and Alternative Medicine

Volumn 2014, Issue , 2014, Pages

  Tang, Hsin Chieh ^a   Chen, Calvin Yu Chian ^a,b,c,d  

^a ASIA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^d Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN 1 RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; MOLECULAR DYNAMICS; PEPTIDE LIBRARY; PIGMENT DISORDER; PRIORITY JOURNAL; PROTEIN STABILITY; RECEPTOR AFFINITY;

EID: 84896071801     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2014/254678     Document Type: Article

References (81)

1. Johnson B. E., Mandell G., Daniels F. Jr., Melanin and cellular reactions to ultraviolet radiation. Nature 1972 235 57 147 149 2-s2.0-0015491602
2. Cui R., Widlund H. R., Feige E., Lin J. Y., Wilensky D. L., Igras V. E., D'Orazio J., Fung C. Y., Schanbacher C. F., Granter S. R., Fisher D. E., Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 2007 128 5 853 864 2-s2.0-33847422145 10.1016/j.cell.2006.12.045 (Pubitemid 46341415)
3. Lin J. Y., Fisher D. E., Melanocyte biology and skin pigmentation. Nature 2007 445 7130 843 850 2-s2.0-33847188116 10.1038/nature05660
4. Fisher D. E., James W. D., Indoor tanning-science, behavior, and policy. The New England Journal of Medicine 2010 363 10 901 903 2-s2.0-77956275516 10.1056/NEJMp1005999
5. Schally A. V., Arimura A., Kastin A. J., Hypothalamic regulatory hormones. Science 1973 179 4071 341 350 2-s2.0-0015936081
6. Proulx-Ferland L., Labrie F., Dumont D., Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary. Science 1982 217 4554 62 63 2-s2.0-0019962499 (Pubitemid 12019246)
7. Lugcr T. A., Scholzen T., Grabbe S., The role of a-melanocyte-stimulating hormone in cutaneous biology. Journal of Investigative Dermatology Symposium Proceedings 1997 2 1 87 93 2-s2.0-0030843370
8. Lerner A. B., McGuire J. S., Melanocyte-stimulating hormone and adrenocorticotrophic hormone. Their relation to pigmentation. The The New England Journal of Medicine 1964 270 539 546 2-s2.0-0000094045
9. Harris J. I., Lerner A. B., Amino-acid sequence of the α -melanocyte-stimulating hormone. Nature 1957 179 4574 1346 1347 2-s2.0-0000902061 10.1038/1791346a0
10. Singh A., Wilczynski A., Holder J. R., Witek R. M., Dirain M. L., Xiang Z., Edison A. S., Haskell-Luevano C., Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D1H NMR. Journal of Medicinal Chemistry 2011 54 5 1379 1390 2-s2.0-79952275654 10.1021/jm101425m
11. Barkey N. M., Tafreshi N. K., Josan J. S., de Silva C. R., Sill K. N., Hruby V. J., Gillies R. J., Morse D. L., Vagner J., Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. Journal of Medicinal Chemistry 2011 54 23 8078 8084 2-s2.0-82555204257 10.1021/jm201226w
12. Jayawickreme C. K., Quillan J. M., Graminski G. F., Lerner M. R., Discovery and structure-function analysis of α -melanocyte-stimulating hormone antagonists. Journal of Biological Chemistry 1994 269 47 29846 29854 2-s2.0-0027986476 (Pubitemid 24365149)
13. Lim S., Li S., Lee C., Yoon C., Baik J., Lee W., Minimization of MC1R selectivity by modification of the core structure of α -MSH-ND. Chemistry and Biology 2001 8 9 857 870 2-s2.0-0034820198 10.1016/S1074-5521(01)00057-6 (Pubitemid 32863203)
14. Brabez N., Lynch R. M., Xu L., Gillies R. J., Chassaing G., Lavielle S., Hruby V. J., Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. Journal of Medicinal Chemistry 2011 54 20 7375 7384 2-s2.0-80054935311 10.1021/jm2009937
15. Bourne H. R., Meng E. C., Rhodopsin sees the light. Science 2000 289 5480 733 734 2-s2.0-0034604351 10.1126/science.289.5480.733 (Pubitemid 30650182)
16. Palczewski K., Kumasaka T., Hori T., Behnke C. A., Motoshima H., Fox B. A., Le Trong I., Teller D. C., Okada T., Stenkamp R. E., Yamamoto M., Miyano M., Crystal structure of rhodopsin: a G protein-coupled receptor. Science 2000 289 5480 739 745 2-s2.0-0034604451 10.1126/science.289.5480.739 (Pubitemid 30650186)
17. Vinós J., Jalink K., Hardy R. W., Britt S. G., Zuker C. S., A G protein-coupled receptor phosphatase required for rhodopsin function. Science 1997 277 5326 687 690 2-s2.0-0030820848 10.1126/science.277.5326.687 (Pubitemid 27373914)
18. Venkatakrishnan A. J., Deupi X., Lebon G., Molecular signatures of G-protein-coupled receptors. Nature 2013 494 7436 185 194
19. Mountjoy K. G., Robbins L. S., Mortrud M. T., Cone R. D., The cloning of a family of genes that encode the melanocortin receptors. Science 1992 257 5074 1248 1251 2-s2.0-0026800892
20. Lembo P. M. C., Grazzini E., Cao J., Hubatsch D. A., Pelletier M., Hoffert C., St-Onge S., Pou C., Labrecque J., Groblewski T., O'Donnell D., Payza K., Ahmad S., Walker P., The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nature Cell Biology 1999 1 5 267 271 2-s2.0-0033194242 (Pubitemid 129495776)
21. Borowsky B., Durkin M. M., Ogozalek K., Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nature Medicine 2002 8 8 825 830
22. Lalueza-Fox C., Römpler H., Caramelli D., Stäubert C., Catalano G., Hughes D., Rohland N., Pilli E., Longo L., Condemi S., de la Rasilla M., Fortea J., Rosas A., Stoneking M., Schöneberg T., Bertranpetit J., Hofreiter M., A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals. Science 2007 318 5855 1453 1455 2-s2.0-36749025107 10.1126/science.1147417 (Pubitemid 350208956)
23. Mundy N. I., Badcock N. S., Hart T., Scribner K., Janssen K., Nadeau N. J., Conserved genetic basis of a quantitative plumage trait involved in mate choice. Science 2004 303 5665 1870 1873 2-s2.0-1642300825 10.1126/science. 1093834 (Pubitemid 38374879)
24. Hoekstra H. E., Hirschmann R. J., Bundey R. A., Insel P. A., Crossland J. P., A single amino acid mutation contributes to adaptive beach mouse color pattern. Science 2006 313 5783 101 104 2-s2.0-33745911143 10.1126/science. 1126121 (Pubitemid 44051263)
25. Saito Y., Nothacker H.-P., Wang Z., Lin S. H. S., Leslie F., Civelli O., Molecular characterization of the melanin-concentrating-hormone receptor. Nature 1999 400 6741 265 269 2-s2.0-0033566084 10.1038/22321 (Pubitemid 29334141)
26. Sotomayor M., Schulten K., Single-molecule experiments in vitro and in silico. Science 2007 316 5828 1144 1148 2-s2.0-34249930159 10.1126/science. 1137591 (Pubitemid 46877468)
27. Levitt M., Warshel A., Computer simulation of protein folding. Nature 1975 253 5494 694 698 2-s2.0-0016610491
28. Palsson B., The challenges of in silico biology. Nature Biotechnology 2000 18 11 1147 1150 2-s2.0-0033764285 10.1038/81125
29. von Mering C., Krause R., Snel B., Cornell M., Oliver S. G., Fields S., Bork P., Comparative assessment of large-scale data sets of protein-protein interactions. Nature 2002 417 6887 399 403 2-s2.0-0037161731 (Pubitemid 34563526)
30. Palsson B., In silico biology through 'omics'. Nature Biotechnology 2002 20 7 649 650 2-s2.0-0035989610 10.1038/nbt0702-649 (Pubitemid 34734124)
31. Kitano H., Computational systems biology. Nature 2002 420 6912 206 210 2-s2.0-0037079054 10.1038/nature01254 (Pubitemid 35340131)
32. di Ventura B., Lemerle C., Michalodimitrakis K., Serrano L., From in vivo to in silico biology and back. Nature 2006 443 7111 527 533 2-s2.0-33749506763 10.1038/nature05127 (Pubitemid 44527283)
33. van de Waterbeemd H., Gifford E., ADMET in silico modelling: towards prediction paradise? Nature Reviews Drug Discovery 2003 2 3 192 204 2-s2.0-0037364162 10.1038/nrd1032 (Pubitemid 37361664)
34. Puzyn T., Rasulev B., Gajewicz A., Hu X., Dasari T. P., Michalkova A., Hwang H.-M., Toropov A., Leszczynska D., Leszczynski J., Using nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles. Nature Nanotechnology 2011 6 3 175 178 2-s2.0-79952372146 10.1038/nnano.2011.10
35. Liao G., Wang J., Guo J., Allard J., Cheng J., Ng A., Shafer S., Puech A., McPherson J. D., Foernzler D., Peltz G., Usuka J., In silico genetics: identification of a functional elements regulating HZ-E α gene expression. Science 2004 306 5696 690 695 2-s2.0-7444225272 10.1126/science.1100636 (Pubitemid 39440918)
36. Pellecchia M., Fragment-based drug discovery takes a virtual turn. Nature Chemical Biology 2009 5 5 274 275 2-s2.0-65349083135 10.1038/nchembio0509-274
37. Bajorath J., Integration of virtual and high-throughput screening. Nature Reviews Drug Discovery 2002 1 11 882 894 2-s2.0-0036835460 10.1038/nrd941 (Pubitemid 37361583)
38. Shoichet B. K., Virtual screening of chemical libraries. Nature 2004 432 7019 862 865 2-s2.0-11144323163 10.1038/nature03197 (Pubitemid 40037142)
39. Naylor E., Arredouani A., Vasudevan S. R., Lewis A. M., Parkesh R., Mizote A., Rosen D., Thomas J. M., Izumi M., Ganesan A., Galione A., Churchill G. C., Identification of a chemical probe for NAADP by virtual screening. Nature Chemical Biology 2009 5 4 220 226 2-s2.0-62649161780 10.1038/nchembio.150
40. Duan Y., Kollman P. A., Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution. Science 1998 282 5389 740 744 2-s2.0-0032561237 10.1126/science.282.5389.740 (Pubitemid 28489385)
41. Karplus M., Petsko G. A., Molecular dynamics simulations in biology. Nature 1990 347 6294 631 639 2-s2.0-0025048105 10.1038/347631a0 (Pubitemid 20356240)
42. Bash P. A., Singh U. C., Langridge R., Kollman P. A., Free energy calculations by computer simulation. Science 1987 236 4801 564 568 2-s2.0-0023346161 (Pubitemid 17069921)
43. Huelsenbeck J. P., Ronquist F., Nielsen R., Bollback J. P., Bayesian inference of phylogeny and its impact on evolutionary biology. Science 2001 294 5550 2310 2314 2-s2.0-0035861456 10.1126/science.1065889 (Pubitemid 33140548)
44. Karplus M., McCammon J. A., Molecular dynamics simulations of biomolecules. Nature Structural Biology 2002 9 9 646 652 2-s2.0-0036725277 10.1038/nsb0902-646 (Pubitemid 34977295)
45. D'Orazio J. A., Nobuhisa T., Cui R., Arya M., Spry M., Wakamatsu K., Igras V., Kunisada T., Granter S. R., Nishimura E. K., Ito S., Fisher D. E., Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 2006 443 7109 340 344 2-s2.0-33748920021 10.1038/nature05098 (Pubitemid 44435153)
46. Harms J., Lautenschlager S., Minder C. E., Minder E. I., An α -melanocyte-stimulating hormone analogue in erythropoietic protoporphyria. The New England Journal of Medicine 2009 360 3 306 307 2-s2.0-58349109469 10.1056/NEJMc0805682
47. Chen C. Y., Weighted equation and rules-a novel concept for evaluating protein-ligand interaction. Journal of Biomolecular Structure and Dynamics 2009 27 3 271 282 2-s2.0-70349903395
48. Chang K. W., Tsai T. Y., Chen K. C., Yang S. C., Huang H. J., Chang T. T., Sun M. F., Chen H. Y., Tsai F. J., Chen C. Y., iSMART: an integrated cloud computing web server for traditional Chinese medicine for online virtual screening, de novo evolution and drug design. Journal of Biomolecular Structure and Dynamics 2011 29 1 243 250 2-s2.0-79959444251
49. Tsai T. Y., Chang K. W., Chen C. Y., IScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan. Journal of Computer-Aided Molecular Design 2011 25 6 525 531 2-s2.0-80051545693 10.1007/s10822-011-9438-9
50. Chen C. Y., A novel integrated framework and improved methodology of computer-aided drug design. Current Topics in Medicinal Chemistry 2013 13 9 965 988
51. Tou W. I., Chang S. S., Lee C. C., Chen C. Y., Drug design for neuropathic pain regulation from traditional Chinese medicine. Scientific Reports 2013 3 844
52. Chen K. C., Chang S. S., Huang H. J., Three-in-one agonists for PPAR-alpha, PPAR-gamma, and PPAR-delta from traditional Chinese medicine. Journal of Biomolecular Structure and Dynamics 2012 30 6 662 683
53. Chen K. C., Sun M. F., Yang S. C., Chang S. S., Chen H. Y., Tsai F. J., Chen C. Y., Investigation into potent inflammation inhibitors from traditional Chinese medicine. Chemical Biology and Drug Design 2011 78 4 679 688 2-s2.0-80052619174 10.1111/j.1747-0285.2011.01202.x
54. Chang S. S., Huang H. J., Chen C. Y., Two birds with one stone? Possible dual-targeting H1N1 inhibitors from traditional Chinese medicine. PLoS Computational Biology 2011 7 12 2-s2.0-84855282742 10.1371/journal.pcbi.1002315 e1002315
55. Chang T. T., Sun M. F., Chen H. Y., Tsai F. J., Fisher M., Lin J. G., Chen C. Y., Screening from the world's largest TCM database against H1N1 virus. Journal of Biomolecular Structure and Dynamics 2011 28 5 773 786 2-s2.0-79952209193
56. Yang S. C., Chang S. S., Chen H. Y., Chen C. Y. C., Identification of potent EGFR inhibitors from TCM database@Taiwan. PLoS Computational Biology 2011 7 10 2-s2.0-80055077153 10.1371/journal.pcbi.1002189 e1002189
57. Fjell C. D., Hiss J. A., Hancock R. E. W., Schneider G., Designing antimicrobial peptides: form follows function. Nature Reviews 2012 11 1 37 51 2-s2.0-84857411069
58. Shoichet B. K., Kobilka B. K., Structure-based drug screening for G-protein-coupled receptors. Trends in Pharmacological Sciences 2012 33 5 268 272 2-s2.0-84860513814 10.1016/j.tips.2012.03.007
59. Mooney C., Haslam N. J., Holton T. A., PeptideLocator: prediction of bioactive peptides in protein sequences. Bioinformatics 2013 29 9 1120 1126
60. Hruby V. J., Designing peptide receptor agonists and antagonists. Nature Reviews 2002 1 11 847 858 2-s2.0-0036834372 10.1038/nrd939 (Pubitemid 37361580)
61. Lam K. S., Salmon S. E., Hersh E. M., Hruby V. J., Kazmierski W. M., Knapp R. J., A new type of synthetic peptide library for identifying ligand-binding activity. Nature 1991 353 6348 82 84 2-s2.0-0026419328 (Pubitemid 21896787)
62. Houghten R. A., Pinilla C., Blondelle S. E., Appel J. R., Dooley T., Cuervo J. H., Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 1991 353 6348 84 86 2-s2.0-0026419319 (Pubitemid 21896788)
63. Chen C. Y. C., TCM database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in Silico. PLoS ONE 2011 6 1 2-s2.0-79251561193 10.1371/journal.pone.0015939 e15939
64. Duchrow T., Shtatland T., Guettler D., Pivovarov M., Kramer S., Weissleder R., Enhancing navigation in biomedical databases by community voting and database-driven text classification. BMC Bioinformatics 2009 10, article 1471 317 2-s2.0-70449719005 10.1186/1471-2105-10-317
65. Doedens L., Opperer F., Cai M., Beck J. G., Dedek M., Palmer E., Hruby V. J., Kessler H., Multiple N -methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. Journal of the American Chemical Society 2010 132 23 8115 8128 2-s2.0-77953304018 10.1021/ja101428m
66. Baker D., Sali A., Protein structure prediction and structural genomics. Science 2001 294 5540 93 96 2-s2.0-0035812694 10.1126/science.1065659 (Pubitemid 32952955)
67. Brooks B. R., Brooks C. L. III, Mackerell A. D. Jr., Nilsson L., Petrella R. J., Roux B., Won Y., Archontis G., Bartels C., Boresch S., Caflisch A., Caves L., Cui Q., Dinner A. R., Feig M., Fischer S., Gao J., Hodoscek M., Im W., Kuczera K., Lazaridis T., Ma J., Ovchinnikov V., Paci E., Pastor R. W., Post C. B., Pu J. Z., Schaefer M., Tidor B., Venable R. M., Woodcock H. L., Wu X., Yang W., York D. M., Karplus M., CHARMM: the biomolecular simulation program. Journal of Computational Chemistry 2009 30 10 1545 1614 2-s2.0-67650500988 10.1002/jcc.21287
68. Friedman N., Linial M., Nachman I., Pe'er D., Using Bayesian networks to analyze expression data. Journal of Computational Biology 2000 7 3-4 601 620 2-s2.0-0033707946 10.1089/106652700750050961
69. Yu J., Smith V. A., Wang P. P., Hartemink A. J., Jarvis E. D., Advances to Bayesian network inference for generating causal networks from observational biological data. Bioinformatics 2004 20 18 3594 3603 2-s2.0-12344259602 10.1093/bioinformatics/bth448 (Pubitemid 40136795)
70. Chen C. Y., Tou W. I., How to design a drug for the disordered proteins? Drug Discovery Today 2013 18 19-20 910 915
71. Tou W. I., Chen C. Y., May disordered protein cause serious drug side effect? Drug Discovery Today 2013 10.1016/j.drudis.2013.10.020
72. Liao W. L., Tsai F. j., Personalized medicine: a paradigm shift in healthcare. BioMedicine 2013 3 2 66 72
73. Tsai F. J., Biomedicine brings the future nearer. BioMedicine 2011 1 1 1
74. Tsai F. J., Rare diseases: a mysterious puzzle. BioMedicine 2013 3 2 65
75. Chou I. C., Lin W. D., Wang C. H., Möbius syndrome in a male with XX/XY mosaicism. BioMedicine 2013 3 2 102 104
76. Lee C. C., Tsai C. H., Wan L., Increased incidence of Parkinsonism among Chinese with β -glucosidase mutation in central Taiwan. BioMedicine 2013 3 2 92 94
77. Lin D. Y., Tsai F. J., Tsai C. H., Huang C. Y., Mechanisms governing the protective effect of 17 β -estradiol and estrogen receptors against cardiomyocyte injury. BioMedicine 2011 1 1 21 28
78. Wang C. H., Lin W. D., Bau D. T., Appearance of acanthosis nigricans may precede obesity: an involvement of the insulin/IGF receptor signaling pathway. BioMedicine 2013 3 2 82 87
79. Chang Y. M., Velmurugan B. K., Kuo W. W., Inhibitory effect of alpinate Oxyphyllae fructus extracts on Ang II-induced cardiac pathological remodeling-related pathways in H9c2 cardiomyoblast cells. BioMedicine 2013 3 4 148 152
80. Chou I. C., Lin W. D., Wang C. H., Association analysis between Tourette's syndrome and two dopamine genes (DAT1, DBH) in Taiwanese children. BioMedicine 2013 3 2 88 91
81. Lin W. Y., Liu H. P., Chang J. S., Genetic variations within the PSORS1 region affect Kawasaki disease development and coronary artery aneurysm formation. BioMedicine 2013 3 2 73 81