Minimization of MC1R selectivity by modification of the core structure of α-MSH-ND

Chemistry and Biology

Volumn 8, Issue 9, 2001, Pages 857-870

  Lim, Sung Kil ^a   Li, Song Zhe ^a   Lee, Chang Hun ^a   Yoon, Chang Ju ^b   Baik, Ja Hyun ^a   Lee, Weontae ^a  

^a Yonsei University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Binding affinity; cAMP generating activity; Homology modeling; Melanocortin receptor; Nuclear magnetic resonance; Type I turn

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN RECEPTOR; CYCLIC AMP; DRUG DERIVATIVE; LIGAND; MELANOCORTIN RECEPTOR;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; COMPARATIVE STUDY; ENZYME SPECIFICITY; HAMSTER; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ALPHA-MSH; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0034820198     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00057-6     Document Type: Article

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