A single amino acid mutation contributes to adaptive beach mouse color pattern

Science

Volumn 313, Issue 5783, 2006, Pages 101-104

  Hoekstra, Hopi E ^a   Hirschmann, Rachel J ^a   Bundey, Richard A ^b   Insel, Paul A ^b   Crossland, Janet P ^c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; GENETIC ENGINEERING; MOLECULAR ORIENTATION; MUTAGENESIS; PATTERN RECOGNITION; PIGMENTS;

CHARGE-CHANGING AMINO ACID; LIGHT COLORATION; MELANOCORTIN-1 RECEPTOR (MC1R); NATURAL POPULATIONS;

AMINO ACIDS;

AMINO ACID; MELATONIN 1 RECEPTOR;

ALLELE; AMINO ACID; BEACH; CRYPSIS; MUTATION; NATURAL SELECTION; PIGMENT; POPULATION SIZE; RODENT;

ADAPTATION; ARTICLE; GENE; GENE MUTATION; GENETIC VARIABILITY; HAIR COLOR; MOLECULAR EVOLUTION; MOUSE; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PIGMENTATION; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SEASHORE;

ADAPTATION, BIOLOGICAL; ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CROSSES, GENETIC; CYCLIC AMP; FEMALE; FLORIDA; GENE FREQUENCY; GENOTYPE; HAIR; HAIR COLOR; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; PEROMYSCUS; PHENOTYPE; PIGMENTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PRINCIPAL COMPONENT ANALYSIS; RECEPTOR, MELANOCORTIN, TYPE 1; SEQUENCE ANALYSIS, DNA;

FLORIDA [UNITED STATES]; GULF COAST [UNITED STATES]; NORTH AMERICA; UNITED STATES;

EID: 33745911143     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1126121     Document Type: Article

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22. We thank M. Dewey for help maintaining mice, and L. Mullen, L. Turner, and C. Yamada for contributions to the molecular work. Natural population samples were provided by M. Ashley, C. Parkinson, A. Suazo, and M. Wooten. Comments by the Hoekstra Lab, M. Hofreiter, J. Kohn, K. Peichel, T. Price, H. Roempler, J. Stinchcombe, and anonymous reviewers improved this manuscript. J.P.C. is supported by NIH-P40-RR14279 and NSF-DBI-0444165. This research is funded by NSF-DEB-0344710 to H.E.H. GenBank Accession Numbers: DQ482848, DQ482850.