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Volumn , Issue , 2012, Pages 171-190

Modulation of protein kinase C isoforms: A potential therapeutic for ischemic stroke?

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EID: 84895216883     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (1)

References (86)
  • 1
    • 33644685637 scopus 로고    scopus 로고
    • The role of protein kinase c in cerebral ischemic and reperfusion injury
    • Bright R, Mochly-Rosen D. The role of protein kinase c in cerebral ischemic and reperfusion injury. Stroke. 2005;36:2781-2790.
    • (2005) Stroke. , vol.36 , pp. 2781-2790
    • Bright, R.1    Mochly-Rosen, D.2
  • 2
    • 0037214308 scopus 로고    scopus 로고
    • Protein kinase c activity, translocation, and selective isoform subcellular redistribution in the rat cerebral cortex after in vitro ischemia
    • Selvatici R, Marino S, Piubello C, Rodi D, Beani L, Gandini E, Siniscalchi A. Protein kinase c activity, translocation, and selective isoform subcellular redistribution in the rat cerebral cortex after in vitro ischemia. J. Neurosci. Res., 2003;71:64-71.
    • (2003) J. Neurosci. Res. , vol.71 , pp. 64-71
    • Selvatici, R.1    Marino, S.2    Piubello, C.3    Rodi, D.4    Beani, L.5    Gandini, E.6    Siniscalchi, A.7
  • 3
    • 0027486480 scopus 로고
    • Alterations of protein kinase c in rat hippocampus following traumatic brain injury
    • Yang K, Taft WC, Dixon CE, Todaro CA, Yu RK, Hayes RL. Alterations of protein kinase c in rat hippocampus following traumatic brain injury. J. Neurotrauma., 1993;10:287-295.
    • (1993) J. Neurotrauma. , vol.10 , pp. 287-295
    • Yang, K.1    Taft, W.C.2    Dixon, C.E.3    Todaro, C.A.4    Yu, R.K.5    Hayes, R.L.6
  • 4
    • 0035204621 scopus 로고    scopus 로고
    • Protein kinase c isoforms as therapeutic targets in nervous system disease states
    • Battaini F. Protein kinase c isoforms as therapeutic targets in nervous system disease states. Pharmacol. Res., 2001;44:353-361.
    • (2001) Pharmacol. Res. , vol.44 , pp. 353-361
    • Battaini, F.1
  • 6
  • 7
    • 0036177115 scopus 로고    scopus 로고
    • Targeting protein kinase c: New therapeutic opportunities against high-grade malignant gliomas?
    • da Rocha AB, Mans DR, Regner A, Schwartsmann G. Targeting protein kinase c: New therapeutic opportunities against high-grade malignant gliomas? Oncologist. 2002;7:17-33.
    • (2002) Oncologist. , vol.7 , pp. 17-33
    • da Rocha, A.B.1    Mans, D.R.2    Regner, A.3    Schwartsmann, G.4
  • 8
    • 0037178897 scopus 로고    scopus 로고
    • Activation of protein kinase czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation
    • Hussain S, Assender JW, Bond M, Wong LF, Murphy D, Newby AC. Activation of protein kinase czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation. J. Biol. Chem., 2002;277:27345-27352.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27345-27352
    • Hussain, S.1    Assender, J.W.2    Bond, M.3    Wong, L.F.4    Murphy, D.5    Newby, A.C.6
  • 9
    • 33947315308 scopus 로고    scopus 로고
    • Deltapkc mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo
    • Bright R, Steinberg GK, Mochly-Rosen D. Deltapkc mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res., 2007;1144:146-155.
    • (2007) Brain Res. , vol.1144 , pp. 146-155
    • Bright, R.1    Steinberg, G.K.2    Mochly-Rosen, D.3
  • 10
    • 48249144457 scopus 로고    scopus 로고
    • Protein kinase cepsilon: Function in neurons
    • Shirai Y, Adachi N, Saito N. Protein kinase cepsilon: Function in neurons. FEBS J., 2008;275:3988-3994.
    • (2008) FEBS J. , vol.275 , pp. 3988-3994
    • Shirai, Y.1    Adachi, N.2    Saito, N.3
  • 13
    • 0031853418 scopus 로고    scopus 로고
    • Age-related alteration of pkc, a key enzyme in memory processes: Physiological and pathological examples
    • Pascale A, Govoni S, Battaini F. Age-related alteration of pkc, a key enzyme in memory processes: Physiological and pathological examples. Mol. Neurobiol., 1998;16:49-62.
    • (1998) Mol. Neurobiol. , vol.16 , pp. 49-62
    • Pascale, A.1    Govoni, S.2    Battaini, F.3
  • 14
    • 78649275318 scopus 로고    scopus 로고
    • Highly specific modulators of protein kinase c localization: Applications to heart failure
    • Qvit N, Mochly-Rosen D. Highly specific modulators of protein kinase c localization: Applications to heart failure. Drug Discov Today Dis Mech. 2010;7:e87-e93.
    • (2010) Drug Discov Today Dis Mech. , vol.7
    • Qvit, N.1    Mochly-Rosen, D.2
  • 15
    • 0347986633 scopus 로고    scopus 로고
    • Emerging and diverse roles of protein kinase c in immune cell signalling
    • Tan SL, Parker PJ. Emerging and diverse roles of protein kinase c in immune cell signalling. Biochem, J., 2003;376:545-552.
    • (2003) Biochem, J. , vol.376 , pp. 545-552
    • Tan, S.L.1    Parker, P.J.2
  • 16
    • 0033567932 scopus 로고    scopus 로고
    • A defective protein kinase c anchoring system underlying age-associated impairment in tnf-alpha production in rat macrophages
    • Corsini E, Battaini F, Lucchi L, Marinovich M, Racchi M, Govoni S, Galli CL. A defective protein kinase c anchoring system underlying age-associated impairment in tnf-alpha production in rat macrophages. J. Immunol., 1999;163:3468-3473.
    • (1999) J. Immunol. , vol.163 , pp. 3468-3473
    • Corsini, E.1    Battaini, F.2    Lucchi, L.3    Marinovich, M.4    Racchi, M.5    Govoni, S.6    Galli, C.L.7
  • 18
    • 0347627362 scopus 로고    scopus 로고
    • The role of protein kinase c-alpha (pkc-alpha) in malignancies of the gastrointestinal tract
    • Lahn M, Paterson BM, Sundell K, Ma D. The role of protein kinase c-alpha (pkc-alpha) in malignancies of the gastrointestinal tract. Eur. J. Cancer, 2004;40:10-20.
    • (2004) Eur. J. Cancer , vol.40 , pp. 10-20
    • Lahn, M.1    Paterson, B.M.2    Sundell, K.3    Ma, D.4
  • 19
    • 0036196195 scopus 로고    scopus 로고
    • Intracellular transport mechanisms of signal transducers
    • Dorn GW, 2nd, Mochly-Rosen D. Intracellular transport mechanisms of signal transducers. Annu. Rev. Physiol., 2002;64:407-429.
    • (2002) Annu. Rev. Physiol. , vol.64 , pp. 407-429
    • Dorn II, G.W.1    Mochly-Rosen, D.2
  • 20
    • 0035474310 scopus 로고    scopus 로고
    • Adaptor proteins in protein kinase c-mediated signal transduction
    • Schechtman D, Mochly-Rosen D. Adaptor proteins in protein kinase c-mediated signal transduction. Oncogene. 2001;20:6339-6347.
    • (2001) Oncogene. , vol.20 , pp. 6339-6347
    • Schechtman, D.1    Mochly-Rosen, D.2
  • 21
    • 80053268287 scopus 로고    scopus 로고
    • Pkc-delta and pkc-epsilon: Foes of the same family or strangers? J
    • Duquesnes N, Lezoualc'h F, Crozatier B. Pkc-delta and pkc-epsilon: Foes of the same family or strangers? J. Mol. Cell Cardiol., 2011;51:665-673.
    • (2011) Mol. Cell Cardiol. , vol.51 , pp. 665-673
    • Duquesnes, N.1    Lezoualc'h, F.2    Crozatier, B.3
  • 22
    • 32544433631 scopus 로고    scopus 로고
    • Protein kinase c family members as a target for regulation of blood-brain barrier na,k,2cl-cotransporter during in vitro stroke conditions and nicotine exposure
    • Yang T, Roder KE, Bhat GJ, Thekkumkara TJ, Abbruscato TJ. Protein kinase c family members as a target for regulation of blood-brain barrier na,k,2cl-cotransporter during in vitro stroke conditions and nicotine exposure. Pharm. Res., 2006;23:291-302.
    • (2006) Pharm. Res. , vol.23 , pp. 291-302
    • Yang, T.1    Roder, K.E.2    Bhat, G.J.3    Thekkumkara, T.J.4    Abbruscato, T.J.5
  • 23
    • 2542478893 scopus 로고    scopus 로고
    • Cell-specific role for epsilon- and betai-protein kinase c isozymes in protecting cortical neurons and astrocytes from ischemia-like injury
    • Wang J, Bright R, Mochly-Rosen D, Giffard RG. Cell-specific role for epsilon- and betai-protein kinase c isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology, 2004;47:136-145.
    • (2004) Neuropharmacology , vol.47 , pp. 136-145
    • Wang, J.1    Bright, R.2    Mochly-Rosen, D.3    Giffard, R.G.4
  • 24
    • 0033006973 scopus 로고    scopus 로고
    • Cerebrovascular alterations in protein kinase c-mediated constriction in stroke-prone rats
    • Smeda JS, King S, Harder DR. Cerebrovascular alterations in protein kinase c-mediated constriction in stroke-prone rats. Stroke, 1999;30:656-661.
    • (1999) Stroke , vol.30 , pp. 656-661
    • Smeda, J.S.1    King, S.2    Harder, D.R.3
  • 25
    • 27144446361 scopus 로고    scopus 로고
    • Activation of pkc modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation
    • Fleegal MA, Hom S, Borg LK, Davis TP. Activation of pkc modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation. Am. J. Physiol. Heart Circ. Physiol., 2005;289:H2012-2019.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289
    • Fleegal, M.A.1    Hom, S.2    Borg, L.K.3    Davis, T.P.4
  • 28
    • 80855132749 scopus 로고    scopus 로고
    • Dopaminergic neurotoxicant 6-ohda induces oxidative damage through proteolytic activation of pkcdelta in cell culture and animal models of parkinson's disease
    • Latchoumycandane C, Anantharam V, Jin H, Kanthasamy A. Dopaminergic neurotoxicant 6-ohda induces oxidative damage through proteolytic activation of pkcdelta in cell culture and animal models of parkinson's disease. Toxicol. Appl. Pharmacol., 2011;256:314-323.
    • (2011) Toxicol. Appl. Pharmacol. , vol.256 , pp. 314-323
    • Latchoumycandane, C.1    Anantharam, V.2    Jin, H.3    Kanthasamy, A.4
  • 30
    • 78751470559 scopus 로고    scopus 로고
    • Aberrant mitochondrial fission in neurons induced by protein kinase c{delta} under oxidative stress conditions in vivo
    • Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D. Aberrant mitochondrial fission in neurons induced by protein kinase c{delta} under oxidative stress conditions in vivo. Mol. Biol. Cell, 2011;22:256-265.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 256-265
    • Qi, X.1    Disatnik, M.H.2    Shen, N.3    Sobel, R.A.4    Mochly-Rosen, D.5
  • 31
    • 77956596656 scopus 로고    scopus 로고
    • Mitochondrial import of pkcepsilon is mediated by hsp90: A role in cardioprotection from ischaemia and reperfusion injury
    • Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D. Mitochondrial import of pkcepsilon is mediated by hsp90: A role in cardioprotection from ischaemia and reperfusion injury. Cardiovasc. Res., 2010;88:83-92.
    • (2010) Cardiovasc. Res. , vol.88 , pp. 83-92
    • Budas, G.R.1    Churchill, E.N.2    Disatnik, M.H.3    Sun, L.4    Mochly-Rosen, D.5
  • 34
    • 72949117855 scopus 로고    scopus 로고
    • Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltapkc during reperfusion
    • Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltapkc during reperfusion. Cardiovasc. Res., 2010;85:385-394.
    • (2010) Cardiovasc. Res. , vol.85 , pp. 385-394
    • Churchill, E.N.1    Ferreira, J.C.2    Brum, P.C.3    Szweda, L.I.4    Mochly-Rosen, D.5
  • 35
    • 0032890011 scopus 로고    scopus 로고
    • Effect of ageing on the expression of protein kinase c and its activation by 1,25(oh)2-vitamin d3 in rat skeletal muscle
    • Facchinetti MM, de Boland AR. Effect of ageing on the expression of protein kinase c and its activation by 1,25(oh)2-vitamin d3 in rat skeletal muscle. Cell Signal., 1999;11:39-44.
    • (1999) Cell Signal. , vol.11 , pp. 39-44
    • Facchinetti, M.M.1    de Boland, A.R.2
  • 36
    • 80052818491 scopus 로고    scopus 로고
    • Betaiipkc and epsilonpkc isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure
    • Ferreira JC, Brum PC, Mochly-Rosen D. Betaiipkc and epsilonpkc isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. J. Mol. Cell Cardiol., 2011;51:479-484.
    • (2011) J. Mol. Cell Cardiol. , vol.51 , pp. 479-484
    • Ferreira, J.C.1    Brum, P.C.2    Mochly-Rosen, D.3
  • 37
    • 77953543762 scopus 로고    scopus 로고
    • Pharmacology of protein kinase c activators: Cognition-enhancing and antidementic therapeutics
    • Sun MK, Alkon DL. Pharmacology of protein kinase c activators: Cognition-enhancing and antidementic therapeutics. Pharmacol. Ther., 2010;127:66-77.
    • (2010) Pharmacol. Ther. , vol.127 , pp. 66-77
    • Sun, M.K.1    Alkon, D.L.2
  • 38
    • 33746555648 scopus 로고    scopus 로고
    • Bryostatin-1: Pharmacology and therapeutic potential as a cns drug
    • Sun MK, Alkon DL. Bryostatin-1: Pharmacology and therapeutic potential as a cns drug. CNS Drug Rev., 2006;12:1-8.
    • (2006) CNS Drug Rev. , vol.12 , pp. 1-8
    • Sun, M.K.1    Alkon, D.L.2
  • 39
    • 78651483724 scopus 로고    scopus 로고
    • Pkc epsilon activation prevents synaptic loss, abeta elevation, and cognitive deficits in alzheimer's disease transgenic mice
    • Hongpaisan J, Sun MK, Alkon DL. Pkc epsilon activation prevents synaptic loss, abeta elevation, and cognitive deficits in alzheimer's disease transgenic mice. J. Neurosci., 2011;31:630-643.
    • (2011) J. Neurosci. , vol.31 , pp. 630-643
    • Hongpaisan, J.1    Sun, M.K.2    Alkon, D.L.3
  • 40
    • 62849107572 scopus 로고    scopus 로고
    • Neuroprotective versus tumorigenic protein kinase c activators
    • Nelson TJ, Alkon DL. Neuroprotective versus tumorigenic protein kinase c activators. Trends Biochem. Sci., 2009;34:136-145.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 136-145
    • Nelson, T.J.1    Alkon, D.L.2
  • 41
    • 34547111785 scopus 로고    scopus 로고
    • Suppression of deltapkc activation after focal cerebral ischemia contributes to the protective effect of hypothermia
    • Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK. Suppression of deltapkc activation after focal cerebral ischemia contributes to the protective effect of hypothermia. J. Cereb. Blood Flow. Metab., 2007;27:1463-1475.
    • (2007) J. Cereb. Blood Flow. Metab. , vol.27 , pp. 1463-1475
    • Shimohata, T.1    Zhao, H.2    Sung, J.H.3    Sun, G.4    Mochly-Rosen, D.5    Steinberg, G.K.6
  • 42
    • 0031807666 scopus 로고    scopus 로고
    • Protein kinase c expression and activity after global incomplete cerebral ischemia in dogs
    • discussion 1452-1443
    • Sieber FE, Traystman RJ, Brown PR, Martin LJ. Protein kinase c expression and activity after global incomplete cerebral ischemia in dogs. Stroke, 1998;29:1445-1452; discussion 1452-1443.
    • (1998) Stroke , vol.29 , pp. 1445-1452
    • Sieber, F.E.1    Traystman, R.J.2    Brown, P.R.3    Martin, L.J.4
  • 43
    • 0347363880 scopus 로고    scopus 로고
    • Protein kinase c-gamma and calcium/calmodulin-dependent protein kinase ii-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion
    • Matsumoto S, Shamloo M, Matsumoto E, Isshiki A, Wieloch T. Protein kinase c-gamma and calcium/calmodulin-dependent protein kinase ii-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion. J. Cereb. Blood Flow. Metab., 2004;24:54-61.
    • (2004) J. Cereb. Blood Flow. Metab. , vol.24 , pp. 54-61
    • Matsumoto, S.1    Shamloo, M.2    Matsumoto, E.3    Isshiki, A.4    Wieloch, T.5
  • 45
    • 70149093189 scopus 로고    scopus 로고
    • Postischemic pkc activation rescues retrograde and anterograde long-term memory
    • Sun MK, Hongpaisan J, Alkon DL. Postischemic pkc activation rescues retrograde and anterograde long-term memory. Proc. Natl. Acad. Sci. USA, 2009;106:14676-14680.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14676-14680
    • Sun, M.K.1    Hongpaisan, J.2    Alkon, D.L.3
  • 46
    • 51649126750 scopus 로고    scopus 로고
    • Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase c in adult brains
    • Sun MK, Hongpaisan J, Nelson TJ, Alkon DL. Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase c in adult brains. Proc. Natl. Acad. Sci. USA, 2008;105:13620-13625.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13620-13625
    • Sun, M.K.1    Hongpaisan, J.2    Nelson, T.J.3    Alkon, D.L.4
  • 47
    • 26944484048 scopus 로고    scopus 로고
    • Identification of protein kinase c isoforms involved in cerebral hypoxic preconditioning of mice
    • Li J, Niu C, Han S, Zu P, Li H, Xu Q, Fang L. Identification of protein kinase c isoforms involved in cerebral hypoxic preconditioning of mice. Brain Res., 2005;1060:62-72.
    • (2005) Brain Res. , vol.1060 , pp. 62-72
    • Li, J.1    Niu, C.2    Han, S.3    Zu, P.4    Li, H.5    Xu, Q.6    Fang, L.7
  • 48
    • 79953686223 scopus 로고    scopus 로고
    • Proteomic analysis of cpkcbetaii-interacting proteins involved in hpc-induced neuroprotection against cerebral ischemia of mice
    • Bu X, Zhang N, Yang X, Liu Y, Du J, Liang J, Xu Q, Li J. Proteomic analysis of cpkcbetaii-interacting proteins involved in hpc-induced neuroprotection against cerebral ischemia of mice. J. Neurochem., 2011;117:346-356.
    • (2011) J. Neurochem. , vol.117 , pp. 346-356
    • Bu, X.1    Zhang, N.2    Yang, X.3    Liu, Y.4    Du, J.5    Liang, J.6    Xu, Q.7    Li, J.8
  • 49
    • 33846243745 scopus 로고    scopus 로고
    • An integrated view of oxidative stress in aging: Basic mechanisms, functional effects, and pathological considerations
    • Kregel KC, Zhang HJ. An integrated view of oxidative stress in aging: Basic mechanisms, functional effects, and pathological considerations. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007;292:R18-36.
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.292
    • Kregel, K.C.1    Zhang, H.J.2
  • 51
    • 0142200985 scopus 로고    scopus 로고
    • Role of proteolytic activation of protein kinase cdelta in oxidative stress-induced apoptosis
    • Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Role of proteolytic activation of protein kinase cdelta in oxidative stress-induced apoptosis. Antioxid. Redox. Signal., 2003;5:609-620.
    • (2003) Antioxid. Redox. Signal. , vol.5 , pp. 609-620
    • Kanthasamy, A.G.1    Kitazawa, M.2    Kanthasamy, A.3    Anantharam, V.4
  • 52
    • 0035341268 scopus 로고    scopus 로고
    • How protein kinase c activation protects nerve cells from oxidative stress-induced cell death
    • Maher P. How protein kinase c activation protects nerve cells from oxidative stress-induced cell death. J. Neurosci., 2001;21:2929-2938.
    • (2001) J. Neurosci. , vol.21 , pp. 2929-2938
    • Maher, P.1
  • 53
    • 70350733634 scopus 로고    scopus 로고
    • Oxalate-induced activation of pkc-alpha and -delta regulates nadph oxidase-mediated oxidative injury in renal tubular epithelial cells
    • Thamilselvan V, Menon M, Thamilselvan S. Oxalate-induced activation of pkc-alpha and -delta regulates nadph oxidase-mediated oxidative injury in renal tubular epithelial cells. Am. J. Physiol. Renal. Physiol., 2009;297:F1399-1410.
    • (2009) Am. J. Physiol. Renal. Physiol. , vol.297
    • Thamilselvan, V.1    Menon, M.2    Thamilselvan, S.3
  • 54
    • 77950678652 scopus 로고    scopus 로고
    • Protein kinase c-delta is involved in induction of nox1 gene expression by aldosterone in rat vascular smooth muscle cells
    • Wei H, Mi X, Ji L, Yang L, Xia Q, Wei Y, Miyamori I, Fan C. Protein kinase c-delta is involved in induction of nox1 gene expression by aldosterone in rat vascular smooth muscle cells. Biochemistry (Mosc). 2010;75:304-309.
    • (2010) Biochemistry (Mosc). , vol.75 , pp. 304-309
    • Wei, H.1    Mi, X.2    Ji, L.3    Yang, L.4    Xia, Q.5    Wei, Y.6    Miyamori, I.7    Fan, C.8
  • 56
    • 0031444147 scopus 로고    scopus 로고
    • Activation and inhibition of protein kinase c protect rat neuronal cultures against ischemia-reperfusion insult
    • Reshef A, Sperling O, Zoref-Shani E. Activation and inhibition of protein kinase c protect rat neuronal cultures against ischemia-reperfusion insult. Neurosci. Lett., 1997;238:37-40.
    • (1997) Neurosci. Lett. , vol.238 , pp. 37-40
    • Reshef, A.1    Sperling, O.2    Zoref-Shani, E.3
  • 57
    • 33646034941 scopus 로고    scopus 로고
    • Acute pkcdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: Role of gsk-3beta
    • Kostyak JC, Hunter JC, Korzick DH. Acute pkcdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: Role of gsk-3beta. Cardiovasc. Res., 2006;70:325-334.
    • (2006) Cardiovasc. Res. , vol.70 , pp. 325-334
    • Kostyak, J.C.1    Hunter, J.C.2    Korzick, D.H.3
  • 59
    • 38149091885 scopus 로고    scopus 로고
    • Sustained pharmacological inhibition of deltapkc protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
    • Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. Sustained pharmacological inhibition of deltapkc protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J. Clin. Invest., 2008;118:173-182.
    • (2008) J. Clin. Invest. , vol.118 , pp. 173-182
    • Qi, X.1    Inagaki, K.2    Sobel, R.A.3    Mochly-Rosen, D.4
  • 61
    • 77649275766 scopus 로고    scopus 로고
    • Deltapkc inhibition or varepsilonpkc activation repairs endothelial vascular dysfunction by regulating enos post-translational modification
    • Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M. Deltapkc inhibition or varepsilonpkc activation repairs endothelial vascular dysfunction by regulating enos post-translational modification. J. Mol. Cell Cardiol., 2010;48:746-756.
    • (2010) J. Mol. Cell Cardiol. , vol.48 , pp. 746-756
    • Monti, M.1    Donnini, S.2    Giachetti, A.3    Mochly-Rosen, D.4    Ziche, M.5
  • 63
    • 78049452265 scopus 로고    scopus 로고
    • Protein kinase c activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation
    • Willis CL, Meske DS, Davis TP. Protein kinase c activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation. J. Cereb. Blood Flow Metab., 2010;30:1847-1859.
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , pp. 1847-1859
    • Willis, C.L.1    Meske, D.S.2    Davis, T.P.3
  • 64
    • 79953024917 scopus 로고    scopus 로고
    • Matrix metalloproteinases modulated by protein kinase cepsilon mediate resistin-induced migration of human coronary artery smooth muscle cells
    • Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W. Matrix metalloproteinases modulated by protein kinase cepsilon mediate resistin-induced migration of human coronary artery smooth muscle cells. J. Vasc. Surg., 2011;53:1044-1051.
    • (2011) J. Vasc. Surg. , vol.53 , pp. 1044-1051
    • Ding, Q.1    Chai, H.2    Mahmood, N.3    Tsao, J.4    Mochly-Rosen, D.5    Zhou, W.6
  • 65
    • 70450233404 scopus 로고    scopus 로고
    • Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase cepsilon-dependent manner
    • Sonobe Y, Takeuchi H, Kataoka K, Li H, Jin S, Mimuro M, Hashizume Y, Sano Y, Kanda T, Mizuno T, Suzumura A. Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase cepsilon-dependent manner. J. Biol. Chem., 2009;284:31834-31842.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31834-31842
    • Sonobe, Y.1    Takeuchi, H.2    Kataoka, K.3    Li, H.4    Jin, S.5    Mimuro, M.6    Hashizume, Y.7    Sano, Y.8    Kanda, T.9    Mizuno, T.10    Suzumura, A.11
  • 66
    • 84859733885 scopus 로고    scopus 로고
    • Doxycycline-mediated protective effect against focal cerebral ischemia-reperfusion injury through the modulation of tight junctions and pkcdelta signaling in rats
    • Wang Z, Xue Y, Jiao H, Liu Y, Wang P. Doxycycline-mediated protective effect against focal cerebral ischemia-reperfusion injury through the modulation of tight junctions and pkcdelta signaling in rats. J. Mol. Neurosci., 2012;47:89-100.
    • (2012) J. Mol. Neurosci. , vol.47 , pp. 89-100
    • Wang, Z.1    Xue, Y.2    Jiao, H.3    Liu, Y.4    Wang, P.5
  • 67
    • 0041363324 scopus 로고    scopus 로고
    • Essential role for erk mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes
    • Arai K, Lee SR, Lo EH. Essential role for erk mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia. 2003;43:254-264.
    • (2003) Glia. , vol.43 , pp. 254-264
    • Arai, K.1    Lee, S.R.2    Lo, E.H.3
  • 68
    • 0033863013 scopus 로고    scopus 로고
    • Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: Possible role in diabetic nephropathy
    • McLennan SV, Fisher E, Martell SY, Death AK, Williams PF, Lyons JG, Yue DK. Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: Possible role in diabetic nephropathy. Kidney Int. Suppl., 2000;77:S81-87.
    • (2000) Kidney Int. Suppl. , vol.77
    • McLennan, S.V.1    Fisher, E.2    Martell, S.Y.3    Death, A.K.4    Williams, P.F.5    Lyons, J.G.6    Yue, D.K.7
  • 69
    • 0034760892 scopus 로고    scopus 로고
    • Involvement of protein kinase c in tnfalpha regulation of trabecular matrix metalloproteinases and timps
    • Alexander JP, Acott TS. Involvement of protein kinase c in tnfalpha regulation of trabecular matrix metalloproteinases and timps. Invest. Ophthalmol. Vis. Sci., 2001;42:2831-2838.
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 2831-2838
    • Alexander, J.P.1    Acott, T.S.2
  • 70
    • 0037144496 scopus 로고    scopus 로고
    • Protein kinase c-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by il-1 and tnf-alpha in glioma cells via nf-kappa b
    • Esteve PO, Chicoine E, Robledo O, Aoudjit F, Descoteaux A, Potworowski EF, St-Pierre Y. Protein kinase c-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by il-1 and tnf-alpha in glioma cells via nf-kappa b. J. Biol. Chem., 2002;277:35150-35155.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35150-35155
    • Esteve, P.O.1    Chicoine, E.2    Robledo, O.3    Aoudjit, F.4    Descoteaux, A.5    Potworowski, E.F.6    St-Pierre, Y.7
  • 72
    • 46449112466 scopus 로고    scopus 로고
    • Endothelial pkc delta activation attenuates neutrophil transendothelial migration
    • Carpenter AC, Alexander JS. Endothelial pkc delta activation attenuates neutrophil transendothelial migration. Inflamm. Res., 2008;57:216-229.
    • (2008) Inflamm. Res. , vol.57 , pp. 216-229
    • Carpenter, A.C.1    Alexander, J.S.2
  • 73
    • 62049083667 scopus 로고    scopus 로고
    • Preserved coronary endothelial function by inhibition of delta protein kinase c in a porcine acute myocardial infarction model
    • Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. Preserved coronary endothelial function by inhibition of delta protein kinase c in a porcine acute myocardial infarction model. Int. J. Cardiol., 2009;133:256-259.
    • (2009) Int. J. Cardiol. , vol.133 , pp. 256-259
    • Kaneda, H.1    Ikeno, F.2    Inagaki, K.3    Mochly-Rosen, D.4
  • 75
    • 37649011777 scopus 로고    scopus 로고
    • A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by pkc
    • Hongpaisan J, Alkon DL. A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by pkc. Proc. Natl. Acad. Sci. USA, 2007;104:19571-19576.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19571-19576
    • Hongpaisan, J.1    Alkon, D.L.2
  • 76
    • 79955603001 scopus 로고    scopus 로고
    • Pkcdelta activation mediates angiogenesis via nadph oxidase activity in pc-3 prostate cancer cells
    • Kim J, Koyanagi T, Mochly-Rosen D. Pkcdelta activation mediates angiogenesis via nadph oxidase activity in pc-3 prostate cancer cells. Prostate, 2011;71:946-954.
    • (2011) Prostate , vol.71 , pp. 946-954
    • Kim, J.1    Koyanagi, T.2    Mochly-Rosen, D.3
  • 79
    • 41249090722 scopus 로고    scopus 로고
    • Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats
    • Sun MK, Alkon DL. Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats. Eur. J. Pharmacol., 2008;584:328-337.
    • (2008) Eur. J. Pharmacol. , vol.584 , pp. 328-337
    • Sun, M.K.1    Alkon, D.L.2
  • 81
    • 0032739628 scopus 로고    scopus 로고
    • Age-dependent modulation of pkc isoforms and nos activity and expression in rat cortex, striatum, and hippocampus
    • La Porta CA, Comolli R. Age-dependent modulation of pkc isoforms and nos activity and expression in rat cortex, striatum, and hippocampus. Exp. Gerontol., 1999;34:863-874.
    • (1999) Exp. Gerontol. , vol.34 , pp. 863-874
    • La Porta, C.A.1    Comolli, R.2
  • 83
    • 67649658224 scopus 로고    scopus 로고
    • Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, na+, k+ atpase and protein kinase c in adult and old rat brain regions
    • Sharma D, Sethi P, Hussain E, Singh R. Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, na+, k+ atpase and protein kinase c in adult and old rat brain regions. Biogerontology, 2009;10:489-502.
    • (2009) Biogerontology , vol.10 , pp. 489-502
    • Sharma, D.1    Sethi, P.2    Hussain, E.3    Singh, R.4
  • 84
    • 0036522981 scopus 로고    scopus 로고
    • Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase c-dependent activation of the alpha6beta1 integrin
    • Milner R, Campbell IL. Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase c-dependent activation of the alpha6beta1 integrin. J. Neurosci., 2002;22:1562-1572.
    • (2002) J. Neurosci. , vol.22 , pp. 1562-1572
    • Milner, R.1    Campbell, I.L.2
  • 85
    • 38149037346 scopus 로고    scopus 로고
    • Subtype activation and interaction of protein kinase c and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage
    • Ansar S, Edvinsson L. Subtype activation and interaction of protein kinase c and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Stroke, 2008;39:185-190.
    • (2008) Stroke , vol.39 , pp. 185-190
    • Ansar, S.1    Edvinsson, L.2
  • 86
    • 0033781544 scopus 로고    scopus 로고
    • Protein kinase c activation and its pharmacological inhibition in vascular disease
    • Meier M, King GL. Protein kinase c activation and its pharmacological inhibition in vascular disease. Vasc. Med., 2000;5:173-18.
    • (2000) Vasc. Med. , vol.5 , pp. 173-118
    • Meier, M.1    King, G.L.2


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