Synergistic effects of chronic bryostatin-1 and α-tocopherol on spatial learning and memory in rats

European Journal of Pharmacology

Volumn 584, Issue 2-3, 2008, Pages 328-337

  Sun, Miao Kun ^a   Alkon, Daniel L ^a  

^a Blanchette Rockefeller Neurosciences Institute   (United States)

Author keywords

tocopherol; (Rat); Cognition; Learning and memory; Protein kinase C; Spatial memory; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; BRYOSTATIN 1; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; LEARNING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; TASK PERFORMANCE;

ADMINISTRATION, ORAL; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BRAIN; BRYOSTATINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME ACTIVATORS; INJECTIONS, INTRAVENOUS; LEARNING; MALE; MAZE LEARNING; MEMORY; NOOTROPIC AGENTS; PROTEIN KINASE C; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 41249090722     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.014     Document Type: Article

References (40)

1. Ahi J., Radulovic J., and Spiess J. The role of hippocampal signaling cascades in consolidation of fear memory. Behav. Brain Res. 149 (2004) 17-31
2. Alkon D.L., and Rasmussen H. A spatial-temporal model of cell activation. Science 239 (1988) 998-1005
3. Alkon D.L., Epstein H., Kuzirian A., Bennett M.C., and Nelson T.J. Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 16432-16437
4. Alkon D.L., Sun M.-K., and Nelson T.J. PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease. Trends Pharmacol. Sci. 28 (2007) 51-60
5. Bonini J.S., Da Silva W.C., Bevilaqua L.R., Medina J.H., Izquierdo I., and Cammarota M. On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of spatial memory. Neuroscience 147 (2007) 37-45
6. Clamp A.R., Blackhall F.H., Vasey P., Soukop M., Coleman R., Halbert G., Robson L., and Jayson G.C. A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma. Br. J. Cancer 89 (2003) 1152-1154
7. Cole G., Dobkins K.R., Hansen L.A., Terry R.D., and Saitoh T. Decreased levels of protein kinase C in Alzheimer brain. Brain Res. 452 (1988) 165-174
8. Colombo P.J., Wetsel W.C., and Gallagher M. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 14195-14199
9. Cuppini R., Ciaroni S., Cecchini T., Ambrogini P., Ferri P., Cuppini C., Ninfali P., and Del Grande P. Tocopherols enhance neurogenesis in dentate gyrus of adult rats. Int. J. Vitam. Nutr. Res. 72 (2002) 170-176
10. Ekstrand-Hammarstrom B., Osterlund C., Lilliehook B., and Bucht A. Vitamin E down-regulates nitrogen-activated protein kinases, nuclear factor-kappB and inflammatory responses in lung epithelial cells. Clin. Exp. Immunol. 147 (2007) 359-369
11. Etcheberrigaray R., Tan M., Dewachter I., Kuiperi C., Van der Auwera I., Wera S., Qiao L., Bank B., Nelson T.J., Kozikowski A.P., Van Leuven F., and Alkon D.L. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 11141-11146
12. Favit A., Grimaldi M., Nelson T.J., and Alkon D.L. Alzheimer's-specific effects of soluble b-amyloid on protein kinase C-a and -g degradation in human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 10 (1998) 5562-5567
13. Ferri P., Cecchini T., Ciaroni S., Ambrogini P., Cuppini R., Santi S., Benedetti S.A., Pagliarani S., Del Grande P., and Papa S. Vitamin E affect cell death in adult rat dentate gyrus. J. Neurocytol. 32 (2003) 1155-1164
14. Ferri P., Cecchini T., Ambroqini P., Betti M., Cuppini R., Del Grande P., and Ciaroni S. alpha-tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta. J. Neurobiol. 66 (2006) 793-810
15. Freedman J.E., and Keaney Jr. J.F. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. J. Nutrit. 131 (2001) 374S-377S
16. Frey R.S., Gao X., Javaid K., Siddiqui S.S., Rahman A., and Malik A.B. Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. J. Biol. Chem. 281 (2006) 16128-16138
17. Fukui K., Takatsu H., Shinkai T., Suzuki S., Abe K., and Urano S. Appearance of amyloid b-like substances and delayed-type apoptosis in rats hippocampus CA1 region through aging and oxidative stress. J. Alzh. Dis. 8 (2005) 299-309
18. Gohil K., Schock B.C., Chakraborty A.A., Terasawa Y., Raber J., Farese Jr. R.V., Packer L., Cross C.E., and Traber M.G. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in a-tocopherol transfer protein. Free Rad. Biol. Med. 35 (2003) 1343-1354
19. Gutterman D.D. Vascular dysfunction in hyperglycemia: is protein kinase C the culprit?. Circ. Res. 90 (2002) 5-7
20. Hennings H., Blumberg P.M., Pettit G.R., Herald C.L., Shores R., and Yuspa S.H. Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis 8 (1987) 1343-1346
21. Hickman P.F., Kemp G.J., Thompson C.H., Thompson C.H., Salisbury A.J., Wade K., Harris A.L., and Radda G.K. Bryostatin-1, a novel antineoplastic agent and protein kinase C activator, induces human myalgia and muscle metabolic defects: a 31P magnetic resonance spectroscopic study. Br. J. Cancer 72 (1995) 998-1003
22. Jerusalinsky D., Quillfeldt J.A., Walz R., Da Silva R.C., Medina J.H., and Izquierdo I. Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats. Behav. Neural. Biol. 61 (1994) 107-109
23. Joseph J.A., Shukitt-Hale B., Denisova N.A., Prior R.L., Cao G., Martin A., Taglialatela G., and Bickford P.C. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J. Neurosci. 18 (1998) 8047-8055
24. Jung Y.-S., Ryu B.R., Lee B.K., Mook-Jung I., Kim S.U., Lee S.H., Baik E.J., and Moon C.H. Role for PKC-e in neuronal death induced by oxidative stress. Biochem. Biophys. Res. Comm. 320 (2004) 789-794
25. Kogure K., Hama S., Goto S., Munakata T., Tokumura A., and Fukuzawa K. Alpha-Tocopheryl succinate activates protein kinase C in cellular and cell-free systems. J. Nutr. Sci. Vitaminol. (Tokyo) 49 (2003) 310-314
26. Li H., Wojciechowski W., Dell'Agnola C., Lopez N.E., and Espinoza-Delgado I. IFN-gamma and T-bet expression in human dendritic cells from normal donors and cancer patients is controlled through mechanisms involving ERK-1/2-dependent and IL-12-independent pathways. J. Immunol. 177 (2007) 3554-3563
27. Olds J.L., Anderson M.L., McPhie D.L., and Alkon D.L. Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus. Science 245 (1989) 866-869
28. Olds J.L., Bhalla U.S., McPhie D.L., Lester D.S., Bower J.M., and Alkon D.L. Lateralization of membrane-associated protein kinase C in rat piriform cortex: specific to operant training cues in the olfactory modality. Behav. Brain Res. 61 (1994) 37-46
29. Pappert E.J., Tangney C.C., Goetz C.G., Ling Z.D., Lipton J.W., Stebbins G.T., and Carvey P.M. Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: Dose-response study and correlations with plasma levels. Neurology 47 (1996) 1037-1042
30. Pinton P., Rimessi A., Marchi S., Orsini F., Migliaccio E., Giorgio M., Contursi C., Minucci S., Mantovani F., Wieckowski M.R., Del Sal G., Pelicci P.G., and Rizzuto R. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science 315 (2007) 659-663
31. Saito N., Kikkawa U., Nishizuka Y., and Tanaka C. Distribution of protein kinase C-like immunoreactive neurons in rat brain. J. Neurosci. 8 (1988) 369-382
32. Schneider C. Chemistry and biology of vitamin E. Mol. Nutr. Food Res. 49 (2005) 7-30
33. Schreurs B.G., Oh M.M., and Alkon D.L. Pairing-specific long-term depression of Purkinje cell excitatory postsynaptic potentials results from a classical conditioning procedure in the rabbit cerebellar slice. J. Neurophysiol. 75 (1996) 1051-1060
34. Singh V.K., Shafran R.L., Jackson III W.E., Seed T.M., and Kumar K.S. Induction of cytokines by radioprotective tocopherol analogs. Exp. Mol. Pathol. 81 (2006) 55-61
35. Sun M.-K., and Alkon D.L. Dual effects of bryostatin-1 on spatial memory and depression. Eur. J. Pharmacol. 512 (2005) 43-51
36. Van der Zee E.A., Kronforst-Collins M.A., Maizels E.T., Hunzicker-Dunn M., and Disterhoft J.F. Gamma isoform-selective changes in PKC immunoreactivity after trace eyeblink conditioning in the rabbit hippocampus. Hippocampus 7 (1997) 271-285
37. Weeber E.J., Atkins C.M., Selcher J.C., Varga A.W., Mirnikjoo B., Paylor R., Leitges M., and Sweatt J.D. A role for the b isoform of protein kinase C in fear conditioning. J. Neurosci. 20 (2000) 5906-5914
38. Yasoshima Y., and Yamamoto T. Rat gustatory memory requires protein kinase C activity in the amygdale and cortical gustatory area. NeuroReport 8 (1997) 1363-1367
39. Zhang X.H., Zhang R.W., Zhao H., Cai H.Y., Gush K.A., Kerr R.G., Pettit G.R., and Kraft A.S. Preclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C. Cancer Res. 56 (1996) 802-808
40. Zhang B., Tanaka J., Yang L., Yang L., Sakanaka M., Hata R., Maeda N., and Mitsuda N. Protective effect of vitamin E against focal brain ischemia and neuronal death through induction of target genes of hypoxia-inducible factor-1. Neuroscience 126 (2004) 433-440