Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease

Toxicology and Applied Pharmacology

Volumn 256, Issue 3, 2011, Pages 314-323

  Latchoumycandane, Calivarathan ^a   Anantharam, Vellareddy ^a   Jin, Huajun ^a   Kanthasamy, Anumantha ^a   Kanthasamy, Arthi ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

6 OHDA; Animal model; Apoptosis; Oxidative stress; Parkinson's disease; PKC delta

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; LENTIVIRUS VECTOR; OXIDOPAMINE; PROTEIN KINASE C DELTA; SCAVENGER; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA FRAGMENTATION; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; LOSS OF FUNCTION MUTATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN DEGRADATION; RAT; SUBSTANTIA NIGRA; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE; CELLS, CULTURED; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATIVE STRESS; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PROTEIN KINASE C-DELTA; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; MUS;

EID: 80855132749     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.07.021     Document Type: Article

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