-
1
-
-
79952232216
-
Global cancer statistics
-
10.3322/caac.20107, 21296855
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90. 10.3322/caac.20107, 21296855.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
10.1038/nrc2069, 17251915
-
Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer 2007, 7:79-94. 10.1038/nrc2069, 17251915.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
3
-
-
35848943698
-
Mitogenic signaling pathways induced by G protein-coupled receptors
-
10.1002/jcp.21246, 17786953
-
Rozengurt E. Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol 2007, 213:589-602. 10.1002/jcp.21246, 17786953.
-
(2007)
J Cell Physiol
, vol.213
, pp. 589-602
-
-
Rozengurt, E.1
-
4
-
-
77649179672
-
Eicosanoids and cancer
-
10.1038/nrc2809, 2898136, 20168319
-
Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer 2010, 10:181-93. 10.1038/nrc2809, 2898136, 20168319.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 181-193
-
-
Wang, D.1
Dubois, R.N.2
-
5
-
-
0037205055
-
G protein pathways
-
10.1126/science.1071550, 12040175
-
Neves SR, Ram PT, Iyengar R. G protein pathways. Science 2002, 296:1636-9. 10.1126/science.1071550, 12040175.
-
(2002)
Science
, vol.296
, pp. 1636-1639
-
-
Neves, S.R.1
Ram, P.T.2
Iyengar, R.3
-
6
-
-
14644426000
-
Receptors coupled to heterotrimeric G proteins of the G12 family
-
10.1016/j.tips.2005.01.007, 15749160
-
Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends Pharmacol Sci 2005, 26:146-54. 10.1016/j.tips.2005.01.007, 15749160.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 146-154
-
-
Riobo, N.A.1
Manning, D.R.2
-
7
-
-
33947603008
-
Protein kinase C and other diacylglycerol effectors in cancer
-
10.1038/nrc2110, 17384583
-
Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007, 7:281-94. 10.1038/nrc2110, 17384583.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 281-294
-
-
Griner, E.M.1
Kazanietz, M.G.2
-
8
-
-
0035866371
-
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis
-
Gokmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Res 2001, 61:1375-81.
-
(2001)
Cancer Res
, vol.61
, pp. 1375-1381
-
-
Gokmen-Polar, Y.1
Murray, N.R.2
Velasco, M.A.3
Gatalica, Z.4
Fields, A.P.5
-
9
-
-
23844521568
-
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
10.1158/0008-5472.CAN-05-0071, 16103100
-
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005, 65:7462-9. 10.1158/0008-5472.CAN-05-0071, 16103100.
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
Konicek, B.W.4
Lynch, R.L.5
Bailey, S.N.6
-
10
-
-
33748940753
-
Neurotensin and growth of normal and neoplastic tissues
-
10.1016/j.peptides.2006.01.028, 16904238
-
Evers BM. Neurotensin and growth of normal and neoplastic tissues. Peptides 2006, 27:2424-33. 10.1016/j.peptides.2006.01.028, 16904238.
-
(2006)
Peptides
, vol.27
, pp. 2424-2433
-
-
Evers, B.M.1
-
11
-
-
33748756339
-
Involvement of neurotensin in cancer growth: evidence, mechanisms and development of diagnostic tools
-
10.1016/j.peptides.2006.04.030, 16887236
-
Carraway RE, Plona AM. Involvement of neurotensin in cancer growth: evidence, mechanisms and development of diagnostic tools. Peptides 2006, 27:2445-60. 10.1016/j.peptides.2006.04.030, 16887236.
-
(2006)
Peptides
, vol.27
, pp. 2445-2460
-
-
Carraway, R.E.1
Plona, A.M.2
-
12
-
-
0025162343
-
Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethane
-
10.1038/bjc.1990.299, 1971434, 2206944
-
Tasuta M, Iishi H, Baba M, Taniguchi H. Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethane. Br J Cancer 1990, 62:368-71. 10.1038/bjc.1990.299, 1971434, 2206944.
-
(1990)
Br J Cancer
, vol.62
, pp. 368-371
-
-
Tasuta, M.1
Iishi, H.2
Baba, M.3
Taniguchi, H.4
-
13
-
-
84884963660
-
The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer
-
Bugni JM, Al-Rabadi L, Jubbal K, Karagiannides I, Lawson G, Pothoulakis C. The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer. Int J Cancer 2011,
-
(2011)
Int J Cancer
-
-
Bugni, J.M.1
Al-Rabadi, L.2
Jubbal, K.3
Karagiannides, I.4
Lawson, G.5
Pothoulakis, C.6
-
14
-
-
79960847184
-
The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers
-
10.1016/j.biochi.2011.04.024, 21605619
-
Dupouy S, Mourra N, Doan VK, Gompel A, Alifano M, Forgez P. The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers. Biochimie 2011, 93:1369-78. 10.1016/j.biochi.2011.04.024, 21605619.
-
(2011)
Biochimie
, vol.93
, pp. 1369-1378
-
-
Dupouy, S.1
Mourra, N.2
Doan, V.K.3
Gompel, A.4
Alifano, M.5
Forgez, P.6
-
15
-
-
0001246577
-
Neurotensin and neurotensin receptors
-
10.1016/S0165-6147(99)01357-7, 10390649
-
Vincent JP, Mazella J, Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol Sci 1999, 20:302-9. 10.1016/S0165-6147(99)01357-7, 10390649.
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 302-309
-
-
Vincent, J.P.1
Mazella, J.2
Kitabgi, P.3
-
16
-
-
33748916428
-
Functional roles of the NTS2 and NTS3 receptors
-
10.1016/j.peptides.2006.04.026, 16872720
-
Mazella J, Vincent JP. Functional roles of the NTS2 and NTS3 receptors. Peptides 2006, 27:2469-75. 10.1016/j.peptides.2006.04.026, 16872720.
-
(2006)
Peptides
, vol.27
, pp. 2469-2475
-
-
Mazella, J.1
Vincent, J.P.2
-
17
-
-
73949109143
-
Differential expression of new splice variants of the neurotensin receptor 1 gene in human prostate cancer cell lines
-
10.1016/j.peptides.2009.12.007, 20018219
-
Almeida TA, Rodriguez Y, Hernandez M, Reyes R, Bello AR. Differential expression of new splice variants of the neurotensin receptor 1 gene in human prostate cancer cell lines. Peptides 2010, 31:242-7. 10.1016/j.peptides.2009.12.007, 20018219.
-
(2010)
Peptides
, vol.31
, pp. 242-247
-
-
Almeida, T.A.1
Rodriguez, Y.2
Hernandez, M.3
Reyes, R.4
Bello, A.R.5
-
18
-
-
33645279248
-
Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas
-
Souaze F, Viardot-Foucault V, Roullet N, Toy-Miou-Leong M, Gompel A, Bruyneel E, et al. Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas. Carcinogenesis 2006, 27:708-16.
-
(2006)
Carcinogenesis
, vol.27
, pp. 708-716
-
-
Souaze, F.1
Viardot-Foucault, V.2
Roullet, N.3
Toy-Miou-Leong, M.4
Gompel, A.5
Bruyneel, E.6
-
19
-
-
77955498516
-
Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers
-
10.1158/1535-7163.MCT-09-1080, 2932703, 20663927
-
Wang X, Jackson LN, Johnson SM, Wang Q, Evers BM. Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers. Mol Cancer Ther 2010, 9:2389-98. 10.1158/1535-7163.MCT-09-1080, 2932703, 20663927.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2389-2398
-
-
Wang, X.1
Jackson, L.N.2
Johnson, S.M.3
Wang, Q.4
Evers, B.M.5
-
20
-
-
34548665706
-
Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis
-
10.1016/j.peptides.2007.06.030, 17870207
-
Bossard C, Souaze F, Jarry A, Bezieau S, Mosnier JF, Forgez P, et al. Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis. Peptides 2007, 28:2030-5. 10.1016/j.peptides.2007.06.030, 17870207.
-
(2007)
Peptides
, vol.28
, pp. 2030-2035
-
-
Bossard, C.1
Souaze, F.2
Jarry, A.3
Bezieau, S.4
Mosnier, J.F.5
Forgez, P.6
-
21
-
-
49049110032
-
Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma
-
10.1016/j.peptides.2008.04.014, 18541341
-
Gui X, Guzman G, Dobner PR, Kadkol SS. Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. Peptides 2008, 29:1609-15. 10.1016/j.peptides.2008.04.014, 18541341.
-
(2008)
Peptides
, vol.29
, pp. 1609-1615
-
-
Gui, X.1
Guzman, G.2
Dobner, P.R.3
Kadkol, S.S.4
-
22
-
-
0032961942
-
Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice
-
10.1002/(SICI)1097-0215(19990129)80:3<448::AID-IJC19>3.0.CO;2-N, 9935189
-
Maoret JJ, Anini Y, Rouyer-Fessard C, Gully D, Laburthe M. Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice. Int J Cancer 1999, 80:448-54. 10.1002/(SICI)1097-0215(19990129)80:3<448::AID-IJC19>3.0.CO;2-N, 9935189.
-
(1999)
Int J Cancer
, vol.80
, pp. 448-454
-
-
Maoret, J.J.1
Anini, Y.2
Rouyer-Fessard, C.3
Gully, D.4
Laburthe, M.5
-
23
-
-
0038520185
-
Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1
-
Guha S, Lunn JA, Santiskulvong C, Rozengurt E. Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1. Cancer Res 2003, 63:2379-87.
-
(2003)
Cancer Res
, vol.63
, pp. 2379-2387
-
-
Guha, S.1
Lunn, J.A.2
Santiskulvong, C.3
Rozengurt, E.4
-
24
-
-
2642535866
-
Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells
-
10.1016/j.regpep.2004.03.004, 15177934
-
Hassan S, Dobner PR, Carraway RE. Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. Regul Pept 2004, 120:155-66. 10.1016/j.regpep.2004.03.004, 15177934.
-
(2004)
Regul Pept
, vol.120
, pp. 155-166
-
-
Hassan, S.1
Dobner, P.R.2
Carraway, R.E.3
-
25
-
-
12944288130
-
Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells
-
10.1002/jcp.20187, 15389644
-
Kisfalvi K, Guha S, Rozengurt E. Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells. J Cell Physiol 2005, 202:880-90. 10.1002/jcp.20187, 15389644.
-
(2005)
J Cell Physiol
, vol.202
, pp. 880-890
-
-
Kisfalvi, K.1
Guha, S.2
Rozengurt, E.3
-
26
-
-
0037086167
-
Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1
-
Guha S, Rey O, Rozengurt E. Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1. Cancer Res 2002, 62:1632-40.
-
(2002)
Cancer Res
, vol.62
, pp. 1632-1640
-
-
Guha, S.1
Rey, O.2
Rozengurt, E.3
-
27
-
-
77950787442
-
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells
-
2888293, 20082306
-
Kisfalvi K, Hurd C, Guha S, Rozengurt E. Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells. J Cell Physiol 2010, 223:309-16. 2888293, 20082306.
-
(2010)
J Cell Physiol
, vol.223
, pp. 309-316
-
-
Kisfalvi, K.1
Hurd, C.2
Guha, S.3
Rozengurt, E.4
-
28
-
-
0031858241
-
Signal transduction mechanisms in neurotensin-mediated cellular regulation
-
10.1016/S0039-6060(98)70126-6, 9706144
-
Ehlers RA, Bonnor RM, Wang X, Hellmich MR, Evers BM. Signal transduction mechanisms in neurotensin-mediated cellular regulation. Surgery 1998, 124:239-46. 10.1016/S0039-6060(98)70126-6, 9706144.
-
(1998)
Surgery
, vol.124
, pp. 239-246
-
-
Ehlers, R.A.1
Bonnor, R.M.2
Wang, X.3
Hellmich, M.R.4
Evers, B.M.5
-
29
-
-
33749076514
-
Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells
-
10.1593/neo.06259, 1584301, 16984735
-
Wang Q, Zhou Y, Evers BM. Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells. Neoplasia 2006, 8:781-7. 10.1593/neo.06259, 1584301, 16984735.
-
(2006)
Neoplasia
, vol.8
, pp. 781-787
-
-
Wang, Q.1
Zhou, Y.2
Evers, B.M.3
-
30
-
-
0029795988
-
Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24
-
1217909, 8947479
-
Poinot-Chazel C, Portier M, Bouaboula M, Vita N, Pecceu F, Gully D, et al. Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24. Biochem J 1996, 320(Pt 1):145-51. 1217909, 8947479.
-
(1996)
Biochem J
, vol.320
, Issue.PART 1
, pp. 145-151
-
-
Poinot-Chazel, C.1
Portier, M.2
Bouaboula, M.3
Vita, N.4
Pecceu, F.5
Gully, D.6
-
31
-
-
33749349876
-
Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells
-
10.1158/1078-0432.CCR-06-0968, 2613866, 17000667
-
Wang X, Wang Q, Ives KL, Evers BM. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res 2006, 12:5346-55. 10.1158/1078-0432.CCR-06-0968, 2613866, 17000667.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5346-5355
-
-
Wang, X.1
Wang, Q.2
Ives, K.L.3
Evers, B.M.4
-
32
-
-
67349094072
-
Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells
-
Olszewski U, Hamilton G. Neurotensin signaling induces intracellular alkalinization and interleukin-8 expression in human pancreatic cancer cells. Mol Oncol 2009,
-
(2009)
Mol Oncol
-
-
Olszewski, U.1
Hamilton, G.2
-
33
-
-
77949273925
-
Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines
-
10.1016/j.bbrc.2010.02.009, 20138826
-
Olszewski U, Hlozek M, Hamilton G. Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines. Biochem Biophys Res Commun 2010, 393:414-9. 10.1016/j.bbrc.2010.02.009, 20138826.
-
(2010)
Biochem Biophys Res Commun
, vol.393
, pp. 414-419
-
-
Olszewski, U.1
Hlozek, M.2
Hamilton, G.3
-
34
-
-
0027936456
-
Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factor
-
10.1002/jcp.1041590106, 8138589
-
Refsnes M, Thoresen GH, Dajani OF, Christoffersen T. Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factor. J Cell Physiol 1994, 159:35-40. 10.1002/jcp.1041590106, 8138589.
-
(1994)
J Cell Physiol
, vol.159
, pp. 35-40
-
-
Refsnes, M.1
Thoresen, G.H.2
Dajani, O.F.3
Christoffersen, T.4
-
35
-
-
0028927510
-
Regulation of autocrine gastrin expression by the TGF alpha autocrine loop
-
10.1002/jcp.1041620211, 7822434
-
Howell GM, Ziober BL, Humphrey LE, Willson JK, Sun L, Lynch M, et al. Regulation of autocrine gastrin expression by the TGF alpha autocrine loop. J Cell Physiol 1995, 162:256-65. 10.1002/jcp.1041620211, 7822434.
-
(1995)
J Cell Physiol
, vol.162
, pp. 256-265
-
-
Howell, G.M.1
Ziober, B.L.2
Humphrey, L.E.3
Willson, J.K.4
Sun, L.5
Lynch, M.6
-
36
-
-
0024323242
-
Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly differentiated and well differentiated human colon carcinoma cells
-
10.1210/mend-3-8-1215, 2674694
-
Mulder KM, Brattain MG. Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly differentiated and well differentiated human colon carcinoma cells. Mol Endocrinol 1989, 3:1215-22. 10.1210/mend-3-8-1215, 2674694.
-
(1989)
Mol Endocrinol
, vol.3
, pp. 1215-1222
-
-
Mulder, K.M.1
Brattain, M.G.2
-
37
-
-
0037016733
-
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands
-
Sawhney RS, Zhou GH, Humphrey LE, Ghosh P, Kreisberg JI, Brattain MG. Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands. J Biol Chem 2002, 277:75-86.
-
(2002)
J Biol Chem
, vol.277
, pp. 75-86
-
-
Sawhney, R.S.1
Zhou, G.H.2
Humphrey, L.E.3
Ghosh, P.4
Kreisberg, J.I.5
Brattain, M.G.6
-
38
-
-
0026806170
-
Neurotensin expression and release in human colon cancers
-
10.1097/00000658-199210000-00005, 1242644, 1329682
-
Evers BM, Ishizuka J, Chung DH, Townsend CM, Thompson JC. Neurotensin expression and release in human colon cancers. Ann Surg 1992, 216:423-30. 10.1097/00000658-199210000-00005, 1242644, 1329682.
-
(1992)
Ann Surg
, vol.216
, pp. 423-430
-
-
Evers, B.M.1
Ishizuka, J.2
Chung, D.H.3
Townsend, C.M.4
Thompson, J.C.5
-
39
-
-
0026777369
-
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
-
10.1016/0092-8674(92)90536-L, 1623525
-
Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 1992, 70:93-104. 10.1016/0092-8674(92)90536-L, 1623525.
-
(1992)
Cell
, vol.70
, pp. 93-104
-
-
Pelicci, G.1
Lanfrancone, L.2
Grignani, F.3
McGlade, J.4
Cavallo, F.5
Forni, G.6
-
40
-
-
0035474473
-
Signaling via Shc family adapter proteins
-
10.1038/sj.onc.1204776, 11607835
-
Ravichandran KS. Signaling via Shc family adapter proteins. Oncogene 2001, 20:6322-30. 10.1038/sj.onc.1204776, 11607835.
-
(2001)
Oncogene
, vol.20
, pp. 6322-6330
-
-
Ravichandran, K.S.1
-
41
-
-
0033599039
-
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
-
Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999, 402:884-8.
-
(1999)
Nature
, vol.402
, pp. 884-888
-
-
Prenzel, N.1
Zwick, E.2
Daub, H.3
Leserer, M.4
Abraham, R.5
Wallasch, C.6
-
42
-
-
33745714456
-
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
-
10.1152/ajpcell.00620.2005, 16769815
-
Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 2006, 291:C1-10. 10.1152/ajpcell.00620.2005, 16769815.
-
(2006)
Am J Physiol Cell Physiol
, vol.291
-
-
Ohtsu, H.1
Dempsey, P.J.2
Eguchi, S.3
-
43
-
-
0035827528
-
Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade
-
10.1074/jbc.M102307200, 11274221
-
Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, et al. Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 2001, 276:20130-5. 10.1074/jbc.M102307200, 11274221.
-
(2001)
J Biol Chem
, vol.276
, pp. 20130-20135
-
-
Andreev, J.1
Galisteo, M.L.2
Kranenburg, O.3
Logan, S.K.4
Chiu, E.S.5
Okigaki, M.6
-
44
-
-
0034724860
-
Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src)
-
10.1074/jbc.275.17.12619, 10777553
-
Keely SJ, Calandrella SO, Barrett KE. Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular ca(2+), PYK-2, and p60(src). J Biol Chem 2000, 275:12619-25. 10.1074/jbc.275.17.12619, 10777553.
-
(2000)
J Biol Chem
, vol.275
, pp. 12619-12625
-
-
Keely, S.J.1
Calandrella, S.O.2
Barrett, K.E.3
-
45
-
-
0025332577
-
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase
-
10.1073/pnas.87.7.2466, 53710, 2138778
-
Thastrup O, Cullen PJ, Drobak BK, Hanley MR, Dawson AP. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Proc Natl Acad Sci USA 1990, 87:2466-70. 10.1073/pnas.87.7.2466, 53710, 2138778.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 2466-2470
-
-
Thastrup, O.1
Cullen, P.J.2
Drobak, B.K.3
Hanley, M.R.4
Dawson, A.P.5
-
46
-
-
21044454703
-
PI 3-kinase p110beta: a new target for antithrombotic therapy
-
10.1038/nm1232, 15834429
-
Jackson SP, Schoenwaelder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE, et al. PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med 2005, 11:507-14. 10.1038/nm1232, 15834429.
-
(2005)
Nat Med
, vol.11
, pp. 507-514
-
-
Jackson, S.P.1
Schoenwaelder, S.M.2
Goncalves, I.3
Nesbitt, W.S.4
Yap, C.L.5
Wright, C.E.6
-
47
-
-
0042635764
-
The role of transforming growth factor alpha in determining growth factor independence
-
Awwad RA, Sergina N, Yang H, Ziober B, Willson JK, Zborowska E, et al. The role of transforming growth factor alpha in determining growth factor independence. Cancer Res 2003, 63:4731-8.
-
(2003)
Cancer Res
, vol.63
, pp. 4731-4738
-
-
Awwad, R.A.1
Sergina, N.2
Yang, H.3
Ziober, B.4
Willson, J.K.5
Zborowska, E.6
-
48
-
-
17144464934
-
Regulation of transforming growth factor alpha expression in a growth factor-independent cell line
-
121495, 9418877
-
Howell GM, Humphrey LE, Ziober BL, Awwad R, Periyasamy B, Koterba A, et al. Regulation of transforming growth factor alpha expression in a growth factor-independent cell line. Mol Cell Biol 1998, 18:303-13. 121495, 9418877.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 303-313
-
-
Howell, G.M.1
Humphrey, L.E.2
Ziober, B.L.3
Awwad, R.4
Periyasamy, B.5
Koterba, A.6
-
49
-
-
0027167739
-
Growth control in a human colon carcinoma cell line mediated by cell-associated transforming growth factor-alpha (TGF alpha)
-
10.1006/excr.1993.1119, 8482359
-
Zorbas MA, Yeoman LC. Growth control in a human colon carcinoma cell line mediated by cell-associated transforming growth factor-alpha (TGF alpha). Exp Cell Res 1993, 206:49-57. 10.1006/excr.1993.1119, 8482359.
-
(1993)
Exp Cell Res
, vol.206
, pp. 49-57
-
-
Zorbas, M.A.1
Yeoman, L.C.2
-
50
-
-
2442692682
-
Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation
-
10.1074/jbc.M401430200, 15010475
-
Darmoul D, Gratio V, Devaud H, Laburthe M. Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. J Biol Chem 2004, 279:20927-34. 10.1074/jbc.M401430200, 15010475.
-
(2004)
J Biol Chem
, vol.279
, pp. 20927-20934
-
-
Darmoul, D.1
Gratio, V.2
Devaud, H.3
Laburthe, M.4
-
51
-
-
4644340883
-
Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation
-
Darmoul D, Gratio V, Devaud H, Peiretti F, Laburthe M. Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. Mol Cancer Res 2004, 2:514-22.
-
(2004)
Mol Cancer Res
, vol.2
, pp. 514-522
-
-
Darmoul, D.1
Gratio, V.2
Devaud, H.3
Peiretti, F.4
Laburthe, M.5
-
52
-
-
0034687278
-
A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
-
10.1038/sj.onc.1203871, 11042696
-
Benistant C, Chapuis H, Roche S. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells. Oncogene 2000, 19:5083-90. 10.1038/sj.onc.1203871, 11042696.
-
(2000)
Oncogene
, vol.19
, pp. 5083-5090
-
-
Benistant, C.1
Chapuis, H.2
Roche, S.3
-
53
-
-
40949135397
-
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
10.1158/0008-5472.CAN-07-5659, 18339877
-
Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS, et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 2008, 68:1953-61. 10.1158/0008-5472.CAN-07-5659, 18339877.
-
(2008)
Cancer Res
, vol.68
, pp. 1953-1961
-
-
Jhawer, M.1
Goel, S.2
Wilson, A.J.3
Montagna, C.4
Ling, Y.H.5
Byun, D.S.6
-
54
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
10.1126/science.296.5573.1655, 12040186
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-7. 10.1126/science.296.5573.1655, 12040186.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
55
-
-
58149175555
-
The life of a cell: apoptosis regulation by the PI3K/PKB pathway
-
10.1042/BJ20081056, 18842113
-
Duronio V. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 2008, 415:333-44. 10.1042/BJ20081056, 18842113.
-
(2008)
Biochem J
, vol.415
, pp. 333-344
-
-
Duronio, V.1
-
56
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
10.1038/nrc839, 12094235
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2:489-501. 10.1038/nrc839, 12094235.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
57
-
-
77955288855
-
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
-
10.1172/JCI37539, 2912177, 20664172
-
Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, et al. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J Clin Invest 2010, 120:2858-66. 10.1172/JCI37539, 2912177, 20664172.
-
(2010)
J Clin Invest
, vol.120
, pp. 2858-2866
-
-
Di Nicolantonio, F.1
Arena, S.2
Tabernero, J.3
Grosso, S.4
Molinari, F.5
Macarulla, T.6
-
58
-
-
77956280407
-
PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling
-
10.1158/0008-5472.CAN-10-0409, 3178450, 20699365
-
Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, et al. PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Res 2010, 70:6804-14. 10.1158/0008-5472.CAN-10-0409, 3178450, 20699365.
-
(2010)
Cancer Res
, vol.70
, pp. 6804-6814
-
-
Halilovic, E.1
She, Q.B.2
Ye, Q.3
Pagliarini, R.4
Sellers, W.R.5
Solit, D.B.6
-
59
-
-
16544370387
-
Neurotensin negatively modulates Akt activity in neurotensin receptor-1-transfected AV12 cells
-
10.1002/jcb.20098, 15156571
-
Liu F, Yang P, Baez M, Ni B. Neurotensin negatively modulates Akt activity in neurotensin receptor-1-transfected AV12 cells. J Cell Biochem 2004, 92:603-11. 10.1002/jcb.20098, 15156571.
-
(2004)
J Cell Biochem
, vol.92
, pp. 603-611
-
-
Liu, F.1
Yang, P.2
Baez, M.3
Ni, B.4
-
60
-
-
34147192985
-
Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists
-
10.1016/j.cellsig.2007.01.006, 17307332
-
Santiskulvong C, Rozengurt E. Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists. Cell Signal 2007, 19:1348-57. 10.1016/j.cellsig.2007.01.006, 17307332.
-
(2007)
Cell Signal
, vol.19
, pp. 1348-1357
-
-
Santiskulvong, C.1
Rozengurt, E.2
-
61
-
-
8544251332
-
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
-
10.1074/jbc.M407701200, 15322124
-
Liu Y, Su W, Thompson EA, Leitges M, Murray NR, Fields AP. Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. J Biol Chem 2004, 279:45556-63. 10.1074/jbc.M407701200, 15322124.
-
(2004)
J Biol Chem
, vol.279
, pp. 45556-45563
-
-
Liu, Y.1
Su, W.2
Thompson, E.A.3
Leitges, M.4
Murray, N.R.5
Fields, A.P.6
-
62
-
-
0034671497
-
Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells
-
Baba I, Shirasawa S, Iwamoto R, Okumura K, Tsunoda T, Nishioka M, et al. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. Cancer Res 2000, 60:6886-9.
-
(2000)
Cancer Res
, vol.60
, pp. 6886-6889
-
-
Baba, I.1
Shirasawa, S.2
Iwamoto, R.3
Okumura, K.4
Tsunoda, T.5
Nishioka, M.6
-
63
-
-
20044363654
-
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent
-
Caron RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, et al. H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. Mol Cancer Ther 2005, 4:243-55.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 243-255
-
-
Caron, R.W.1
Yacoub, A.2
Zhu, X.3
Mitchell, C.4
Han, S.I.5
Sasazuki, T.6
-
64
-
-
36549072385
-
Validation of HB-EGF and amphiregulin as targets for human cancer therapy
-
10.1016/j.bbrc.2007.11.015, 18023415
-
Yotsumoto F, Yagi H, Suzuki SO, Oki E, Tsujioka H, Hachisuga T, et al. Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem Biophys Res Commun 2008, 365:555-61. 10.1016/j.bbrc.2007.11.015, 18023415.
-
(2008)
Biochem Biophys Res Commun
, vol.365
, pp. 555-561
-
-
Yotsumoto, F.1
Yagi, H.2
Suzuki, S.O.3
Oki, E.4
Tsujioka, H.5
Hachisuga, T.6
-
65
-
-
79953181287
-
Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells
-
10.1074/jbc.M110.192534, 21212273
-
Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. J Biol Chem 2011, 286:6092-9. 10.1074/jbc.M110.192534, 21212273.
-
(2011)
J Biol Chem
, vol.286
, pp. 6092-6099
-
-
Zhao, D.1
Bakirtzi, K.2
Zhan, Y.3
Zeng, H.4
Koon, H.W.5
Pothoulakis, C.6
-
66
-
-
46149106818
-
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
-
10.1073/pnas.0707761105, 2448830, 18544649
-
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci USA 2008, 105:8292-7. 10.1073/pnas.0707761105, 2448830, 18544649.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
Bjorklof, K.2
Salpekar, A.3
Gonella, C.4
Ramadani, F.5
Bilancio, A.6
-
67
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
10.1126/science.7624799, 7624799
-
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 1995, 269:690-3. 10.1126/science.7624799, 7624799.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
|