How protein kinase C activation protects nerve cells from oxidative stress-induced cell death

Journal of Neuroscience

Volumn 21, Issue 9, 2001, Pages 2929-2938

  Maher, P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

MAP kinases; Oxidative glutamate toxicity; Oxidative stress; Programmed cell death; Protein kinase C; Reactive oxygen species

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; HIPPOCAMPUS; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0035341268     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-09-02929.2001     Document Type: Article

References (82)

1. M EK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia
2. Oxidants, antioxidants, and the degenerative diseases of aging
3. Aging, energy, and oxidative stress in neurodegenerative diseases
4. Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: Blockade of p38 mitogen-activated protein kinase
5. Regulated expression of dual specificity protein phosphatases in rat brain
6. The search for physiological substrates of MAO and SAP kinases in mammalian cells
7. Viability measurements in mammalian cell systems
8. Protein kinase Cδ mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells
9. Oxidative stress, glutamate, and neurodegenerative disorders
10. Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival
11. Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell lines
12. Isoenzymes of protein kinase C: Differential involvement in apoptosis and pathogenesis
13. Ribosomal S6 kinase signaling and the control of translation
14. Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons
15. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
16. Involvement of protein kinase Cδ in phorbol ester-induced apoptosis in LNCaP prostate cancer cells
17. U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways
18. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis
19. Protein kinase Cδ
20. Overexpression of protein kinase C isoform ε but not δ in human interleukin-3-dependent cells suppresses apoptosis and induces Bcl-2 expression
21. Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or β-amyloid, is independent of jun kinase or p38 mitogen activated protein kinase activation
22. Suppression of ceramide-mediated programmed cell death by sphingosine-a-phosphate
23. 2
24. Mitogen-activated protein kinase phosphatase: A negative regulator of the mitogen-activated protein kinase cascade
25. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
26. Thyrotropin regulates c-Jun N-terminal kinase (JNK) activity through two distinct signal pathways in human thyroid cells
27. The potential for isoenzyme-selective modulation of protein kinase C
28. Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro
29. Protein kinase C isoenzymes: Divergence in signal transduction?
30. Protein kinase C isozymes and substrates
31. Multiple signaling pathways for the activation of JNK in mast cells: Involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7
32. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells
33. The role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases
34. 2-induced apoptosis in CHO cells
35. Emerging treatments for stroke in humans
36. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
37. Apoptosis induced by withdrawal of trophic factors in mediated by p38 mitogen-activated protein kinase
38. Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene
39. Protein kinase cascades activated by stress and inflammatory cytokines
40. Role of protein kinase activity in apoptosis
41. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
42. Protein kinase Cδ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
43. Requirement for cGMP in nerve cell death caused by glutathione depletion
44. A role of 12-lipoxygenase in nerve cell death caused by glutathione depletion
45. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion
46. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia
47. The role of monoamine metabolism in oxidative glutamate toxicity
48. Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord
49. Regulation of proliferation and apoptosis by epidermal growth factor and protein kinase C in human ovarian surface epithelial cells
50. A novel mitogen-activated protein kinase phosphatase
51. Modulating protein kinase C signal transduction
52. Induction and expression of long and short-term neurosecretory potentiation in a neural cell line
53. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
54. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
55. Atypical protein kinase C λ protects human leukemia cells against drug-induced apoptosis
56. Increased production of extracellular glutamate by the mitochondrial glutaminase following neuronal death
57. Protein kinase C and lipid signaling for sustained cellular responses
58. Activated Ki-Ras suppresses 12-0-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells
59. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate
60. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor α
61. Neuronal cell death: When, why and how
62. The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress
63. Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP
64. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
65. Glutathione, oxidative stress and neurodegeneration
66. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
67. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
68. Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis
69. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary neuron cultures
70. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
71. The regulation of reactive oxygen species production during programmed cell death
72. Oxidative stress in nerve cells induces a form of cell death with characteristics of both apoptosis and necrosis
73. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5
74. Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases
75. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
76. Loss of protein kinase C function induces an apoptotic response
77. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
78. MAP kinase phosphatase 1 is expressed and enhanced by FK506 in surviving mammillary, but not degenerating nigral neurons following axotomy
79. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
80. Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells
81. Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid