Protein kinase Cε: Function in neurons

FEBS Journal

Volumn 275, Issue 16, 2008, Pages 3988-3994

  Shirai, Yasuhito ^a   Adachi, Naoko ^a   Saito, Naoaki ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Alcohol; Ischemia; LTP; Neurite outgrowth; Pain

Indexed keywords

PROTEIN KINASE C EPSILON; ALCOHOL;

BRAIN NERVE CELL; DRINKING BEHAVIOR; ISCHEMIC PRECONDITIONING; NERVE FIBER GROWTH; NONHUMAN; PAIN; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; ANIMAL; BRAIN; CYTOLOGY; ENZYMOLOGY; LONG TERM POTENTIATION; MOUSE; NERVE CELL; NEURITE; PHYSIOLOGY; RAT; REVIEW;

MUS;

ANIMALS; BRAIN; ETHANOL; ISCHEMIC PRECONDITIONING; LONG-TERM POTENTIATION; MICE; NEURITES; NEURONS; PAIN; PROTEIN KINASE C-EPSILON; RATS;

EID: 48249144457     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06556.x     Document Type: Short Survey

References (49)

1. Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K Nishizuka Y (1988) The structure, expression, and properties of additional members of the protein kinase C family. J Biol Chem 263, 6927 6932.
2. Westel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, Negro-Vilar A Hannun YA (1992) Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol 117, 121 133.
3. Koide H, Ogita K, Kikkawa U Nishizuka Y (1992) Isolation and characterization of the ε subspecies of protein kinase C from rat brain. Proc Natl Acad Sci USA 89, 1149 1153.
4. Saito N, Itouji A, Totani Y, Osawa I, Koide H, Fujisawa N, Ogita K Tanaka C (1993) Cellular and intracellular localization of e-subspecies of protein kinase C in the rat brain; presynaptic localization of the e-subspecies. Brain Res 607, 241 248.
5. Tanaka C Nishizuka Y (1994) The protein kinase C family for neural signaling. Annu Rev Neurosci 17, 551 567.
6. Hundle B, McMahon T, Dagar J Messing RO (1995) Overexpression of ε-protein kinase C enhances nerve growth factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth. J Biol Chem 270, 30134 30140.
7. Zeidman R, Lofgren B, Pahlman S Larsson C (1999) PKCε, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells. J Cell Biol 145, 713 726.
8. Zeidman R, Troller U, Raghunath A, Pahlman S Larsson C (2002) Protein kinase Cε actin-binding site is important for neurite outgrowth during neuronal differentiation. Mol Biol Cell 13, 12 24.
9. Lingm M, Troller U, Zeidman R, Lundberg C Larsson C (2004) Induction of neurites by the regulatory domains of PKCδ and ε is counteracted by PKC catalytic activity and by the RhoA pathway. Exp Cell Res 292, 135 150.
10. Troller U Larsson C (2006) Cdc42 is involved in PKCε- and δ-induced neurite outgrowth and stress fibre dismantling. Biochem Biophys Res Commun 349, 91 98.
11. 2 binding of εPKC and its contribution to the nerutite induction ability. J Neurochem 102, 1635 1644.
12. Faure J, Vignais PV Dagher MC (1999) Phosphoinositide-dependent activation involves partial opening of the RhoA/Rho-GDI complex. Eur J Biochem 262, 879 889.
13. Troller U Larsson C (2004) A possible role for p190RhoGAP in PKCε-induced morphological effects. Cellular Sigmal 16, 245 252.
14. Lingm M, Troller U, Zeidman R, Stensman H, Schultz A Larssonm C (2005) Identification of conserved amino acids N-terminal of the PKCεC1b domain crucial for protein kinase Ce-mediated induction of neurite outgrowth. J Cell Biol 280, 17910 17919.
15. Hussain RJ Carpenter DO (2005) A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3. Cell Mol Neurobiol 25, 649 661.
16. Saito N Shirai Y (2002) Protein kinase Cγ (PKCγ): function of neuron specific isotype. J Biochem 132, 683 687.
17. Saitoh N, Hori T Takahashi T (2001) Activation of the epsilon isoform of protein kinase C in the mammalian nerve terminal. Proc Natl Acad Sci USA 98, 14017 14021.
18. Prekeris R, Mayhew MW, Cooper JB Terrian DM (1996) Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and paraticipates in the regulation of synapitic function. J Cell Biol 132, 77 90.
19. Dumus A, Sebben M Haynes L (1988) NMDA receptors activate the arachidnic acid cascade system in striatal neurons. Nature 336, 68 70.
20. Kasahara K Kikkawa U (1995) Distinct effects of saturated fatty acids on protein kinase C subspecies. J Biochem 117, 648 653.
21. Hama H, Hara Chikako, Kazuhiko Yamaguchi Miyawaki A (2004) PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggers by local contact with astrocytes. Neuron 41, 405 415.
22. Gordon AS, Yao L, Wu Z, Coe IR Diamond I (1997) Ethanol alters the subcellular localization of δ- and ε-protein kinase C in NG108-15 cells. Mol Pharmacol 52, 554 559.
23. Messing RO, Petersen PJ Henrich CJ (1991) Chronic ethanol exposure increases level of protein kinase Cδ and ε and protein kinase mediated phosphorylation in cultured neural cells. J Biol Chem 266, 23428 23432.
24. Coe IR, Yao L, Diamond I Gordon AS (1996) The role of protein kinase C in cellular tolerance to ethanol. J Biol Chem 271, 29468 29472.
25. A receptor modulators and alcohol in mice lacking PKCε. Nat Neurosci 2, 997 1002.
26. Choi DS, Jahan DW, Dadgar J, Chang WS Messing RO (2002) Conditional rescue of protein kinase Cε regulates ethanol preference and hypnotic sensitivity in adult mice. J Neurosci 22, 9905 9911.
27. A receptor sensitivity to ethanol and bendodiazepines through phosphorylation of γ2 subunits. J Biol Chem 282, 33052 33063.
28. Mcmahon T, Andersen R, Metten P, Crabbe JC Messing RO (2000) Protein kinase Cε mediates up-regulation of N-type calcium channels by ethanol. Mol Pharmacol 57, 53 58.
29. Armstrong SC (2004) Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiov Res 61, 427 436.
30. Chou WH Messing RO (2005) Protein kinase C isozymes in stroke. TCM 15, 47 51.
31. Murriel CL Mochly-Rosen D (2003) Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Arc Biochem Biophys 420, 246 254.
32. Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ Marber M (2002) Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischemic preconditioning of isolated buffer-perfusion mouse hearts. Cardiov Res 55, 672 680.
33. Raval AP, Dave KR, Mochly-Rosen D, Sick TJ Perez-Pinzon MA (2003) εPKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. J Neuroscience 23, 384 391.
34. Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ Perez-Pinzon MA (2004) Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the orgonotypic hippocampal slice. J Cereb Blood Flow Metab 24, 636 645.
35. Wang J, Bright R, Mochly-Rosen D Giffard RG (2004) Cell-specific role for ε- and βI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology 47, 136 145.
36. Di-Capua N, Sperling O Zoref-Shani E (2003) Protein kinase C-ε is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures. J Neurochem 84, 409 412.
37. Shimomura T, Zhao H Steinberg GK (2007) εPKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. Stroke 38, 375 380.
38. Davis J, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K et al. (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183 187.
39. Premkumar LS Ahern GP (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature 408, 985 990.
40. Tominaga M, Wada M Masu M (2001) Poteintiation of capsaicin receptor activity by metanotropic ATP receptor as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98, 6951 6956.
41. Numazaki M, Tominaga T, Toyooka H Tominaga M (2002) Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cε and identification of two target serine residues. J Biol Chem 277, 13375 13378.
42. Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, Armati PJ, Roufogails B Tominaga M (2006) Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCε-mediated phosphorylation at S800. Pain 123, 106 116.
43. Dai Y, Moriyama T, Higashi T, Togashi K, Kobayashi K, Yamanaka H, Tominaga M Noguchi K (2004) Proteinase-activated receptor2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci 24, 4298 4299.
44. + channels in hippocampal neurons by protein kinase Cε. J Neurosci 25, 507 513.
45. Zhu G, Wang D, Lin YH, McMahon T, Koo EH Messing RO (2001) Protein kinase C ε suppresses Aβ production and promotes activation of α-secretase. Biochem Bioohys Res Commun 285, 997 1006.
46. Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L Messing RO (2006) PKCe increases endothelin convertinbg enzyme activity and reuduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci USA 103, 8215 8220.
47. Steinhart R, Kazimirsky G, Okhrimenko H, Ben-Hur T Broudei C (2007) PKCε induces astrocytes differentiation of multipotential neural precursor cells. Glia 55, 224 232.
48. Akita Y (2002) Protein kinase Cε (PKC-ε): its unique structure and function. J Biochem 132, 847 852.
49. A receptor mediated responses in protein kinase Cγ (PKCγ) ans PKCε null mice. J Pharmacol Exp Ther 305, 264 270.