메뉴 건너뛰기




Volumn 48, Issue 4, 2010, Pages 746-756

δPKC inhibition or e{open}PKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification

Author keywords

Coronary endothelial cells; Nitric Oxide Synthase; Protein kinase C; Reactive oxygen species

Indexed keywords

CASPASE 3; CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; PROTEIN KINASE B; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; CYCLIC GMP; OXYGEN;

EID: 77649275766     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.11.002     Document Type: Article
Times cited : (46)

References (27)
  • 1
    • 33751525147 scopus 로고    scopus 로고
    • Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal
    • Forstermann U. Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal. Biol. Chem. 387 12 (2006) 1521-1533
    • (2006) Biol. Chem. , vol.387 , Issue.12 , pp. 1521-1533
    • Forstermann, U.1
  • 2
    • 1942468123 scopus 로고    scopus 로고
    • Novel NAD(P)H oxidases in the cardiovascular system
    • Griendling K.K. Novel NAD(P)H oxidases in the cardiovascular system. Heart 90 5 (2004) 491-493
    • (2004) Heart , vol.90 , Issue.5 , pp. 491-493
    • Griendling, K.K.1
  • 4
    • 34250731849 scopus 로고    scopus 로고
    • Life history of eNOS: partners and pathways
    • Dudzinski D.M., and Michel T. Life history of eNOS: partners and pathways. Cardiovasc. Res. 75 2 (2007) 247-260
    • (2007) Cardiovasc. Res. , vol.75 , Issue.2 , pp. 247-260
    • Dudzinski, D.M.1    Michel, T.2
  • 5
    • 33846392950 scopus 로고    scopus 로고
    • Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    • Mount P.F., Kemp B.E., and Power D.A. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J. Mol. Cell. Cardiol. 42 2 (2007) 271-279
    • (2007) J. Mol. Cell. Cardiol. , vol.42 , Issue.2 , pp. 271-279
    • Mount, P.F.1    Kemp, B.E.2    Power, D.A.3
  • 6
    • 0242690438 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
    • Fleming I., Schulz C., Fichtlscherer B., Kemp B.E., Fisslthaler B., and Busse R. AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb. Haemost. 90 5 (2003) 863-871
    • (2003) Thromb. Haemost. , vol.90 , Issue.5 , pp. 863-871
    • Fleming, I.1    Schulz, C.2    Fichtlscherer, B.3    Kemp, B.E.4    Fisslthaler, B.5    Busse, R.6
  • 7
    • 33947315308 scopus 로고    scopus 로고
    • DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo
    • Bright R., Steinberg G.K., and Mochly-Rosen D. DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res. 1144 (2007) 146-155
    • (2007) Brain Res. , vol.1144 , pp. 146-155
    • Bright, R.1    Steinberg, G.K.2    Mochly-Rosen, D.3
  • 8
    • 0033624056 scopus 로고    scopus 로고
    • Ischemic preconditioning: from basic mechanisms to clinical applications
    • Nakano A., Cohen M.V., and Downey J.M. Ischemic preconditioning: from basic mechanisms to clinical applications. Pharmacol. Ther. 86 3 (2000) 263-275
    • (2000) Pharmacol. Ther. , vol.86 , Issue.3 , pp. 263-275
    • Nakano, A.1    Cohen, M.V.2    Downey, J.M.3
  • 9
    • 33646048801 scopus 로고    scopus 로고
    • Epsilon protein kinase C as a potential therapeutic target for the ischemic heart
    • Inagaki K., Churchill E., and Mochly-Rosen D. Epsilon protein kinase C as a potential therapeutic target for the ischemic heart. Cardiovasc. Res. 70 2 (2006) 222-230
    • (2006) Cardiovasc. Res. , vol.70 , Issue.2 , pp. 222-230
    • Inagaki, K.1    Churchill, E.2    Mochly-Rosen, D.3
  • 10
    • 0028938152 scopus 로고
    • Localization of protein kinases by anchoring proteins: a theme in signal transduction
    • Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 268 5208 (1995) 247-251
    • (1995) Science , vol.268 , Issue.5208 , pp. 247-251
    • Mochly-Rosen, D.1
  • 11
    • 0031761325 scopus 로고    scopus 로고
    • Peptide modulators of protein-protein interactions in intracellular signaling
    • Souroujon M.C., and Mochly-Rosen D. Peptide modulators of protein-protein interactions in intracellular signaling. Nat. Biotechnol. 16 10 (1998) 919-924
    • (1998) Nat. Biotechnol. , vol.16 , Issue.10 , pp. 919-924
    • Souroujon, M.C.1    Mochly-Rosen, D.2
  • 13
    • 0041932511 scopus 로고    scopus 로고
    • Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator
    • Inagaki K., Hahn H.S., Dorn G.W., and Mochly-Rosen D. Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator. Circulation 108 7 (2003) 869-875
    • (2003) Circulation , vol.108 , Issue.7 , pp. 869-875
    • Inagaki, K.1    Hahn, H.S.2    Dorn, G.W.3    Mochly-Rosen, D.4
  • 14
    • 33846855571 scopus 로고    scopus 로고
    • Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage
    • Ikeno F., Inagaki K., Rezaee M., and Mochly-Rosen D. Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovasc. Res. 73 4 (2007) 699-709
    • (2007) Cardiovasc. Res. , vol.73 , Issue.4 , pp. 699-709
    • Ikeno, F.1    Inagaki, K.2    Rezaee, M.3    Mochly-Rosen, D.4
  • 16
    • 0030918007 scopus 로고    scopus 로고
    • Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF
    • Ziche M., Parenti A., Ledda F., Dell'Era P., Granger H.J., Maggi C.A., and Presta M. Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. Circ. Res. 80 6 (1997) 845-852
    • (1997) Circ. Res. , vol.80 , Issue.6 , pp. 845-852
    • Ziche, M.1    Parenti, A.2    Ledda, F.3    Dell'Era, P.4    Granger, H.J.5    Maggi, C.A.6    Presta, M.7
  • 17
    • 58149168842 scopus 로고    scopus 로고
    • HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements
    • Zielonka J., Hardy M., and Kalyanaraman B. HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. Free Radic. Biol. Med. 46 3 (2009) 329-338
    • (2009) Free Radic. Biol. Med. , vol.46 , Issue.3 , pp. 329-338
    • Zielonka, J.1    Hardy, M.2    Kalyanaraman, B.3
  • 18
    • 33751184940 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 mediates angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium
    • Donnini S., Solito R., Giachetti A., Granger H.J., Ziche M., and Morbidelli L. Fibroblast growth factor-2 mediates angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium. J. Pharmacol. Exp. Ther. 319 2 (2006) 515-522
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , Issue.2 , pp. 515-522
    • Donnini, S.1    Solito, R.2    Giachetti, A.3    Granger, H.J.4    Ziche, M.5    Morbidelli, L.6
  • 19
    • 33745212227 scopus 로고    scopus 로고
    • FGF-2 overexpression opposes the beta amyloid toxic injuries to the vascular endothelium
    • Donnini S., Cantara S., Morbidelli L., Giachetti A., and Ziche M. FGF-2 overexpression opposes the beta amyloid toxic injuries to the vascular endothelium. Cell Death Differ. 13 7 (2006) 1088-1096
    • (2006) Cell Death Differ. , vol.13 , Issue.7 , pp. 1088-1096
    • Donnini, S.1    Cantara, S.2    Morbidelli, L.3    Giachetti, A.4    Ziche, M.5
  • 20
    • 0035542854 scopus 로고    scopus 로고
    • Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7)
    • Chen L., Wright L.R., Chen C.H., Oliver S.F., Wender P.A., and Mochly-Rosen D. Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem. Biol. 8 12 (2001) 1123-1129
    • (2001) Chem. Biol. , vol.8 , Issue.12 , pp. 1123-1129
    • Chen, L.1    Wright, L.R.2    Chen, C.H.3    Oliver, S.F.4    Wender, P.A.5    Mochly-Rosen, D.6
  • 21
    • 0020698115 scopus 로고
    • Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane
    • Kraft A.S., and Anderson W.B. Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane. Nature 301 5901 (1983) 621-623
    • (1983) Nature , vol.301 , Issue.5901 , pp. 621-623
    • Kraft, A.S.1    Anderson, W.B.2
  • 23
    • 0037031892 scopus 로고    scopus 로고
    • Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    • Zou M.H., Hou X.Y., Shi C.M., Nagata D., Walsh K., and Cohen R.A. Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. J. Biol. Chem. 277 36 (2002) 32552-32557
    • (2002) J. Biol. Chem. , vol.277 , Issue.36 , pp. 32552-32557
    • Zou, M.H.1    Hou, X.Y.2    Shi, C.M.3    Nagata, D.4    Walsh, K.5    Cohen, R.A.6
  • 24
    • 42149116966 scopus 로고    scopus 로고
    • Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells
    • Rask-Madsen C., and King G.L. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 28 5 (2008) 919-924
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.5 , pp. 919-924
    • Rask-Madsen, C.1    King, G.L.2
  • 25
    • 0033529650 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity
    • Shizukuda Y., Tang S., Yokota R., and Ware J.A. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circ. Res. 85 3 (1999) 247-256
    • (1999) Circ. Res. , vol.85 , Issue.3 , pp. 247-256
    • Shizukuda, Y.1    Tang, S.2    Yokota, R.3    Ware, J.A.4
  • 26
    • 41549163846 scopus 로고    scopus 로고
    • Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation
    • Sud N., Wedgwood S., and Black S.M. Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. Am. J. Physiol., Lung Cell Mol. Physiol. 294 3 (2008) L582-591
    • (2008) Am. J. Physiol., Lung Cell Mol. Physiol. , vol.294 , Issue.3
    • Sud, N.1    Wedgwood, S.2    Black, S.M.3
  • 27
    • 4644262241 scopus 로고    scopus 로고
    • Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts
    • Tanaka M., Terry R.D., Mokhtari G.K., Inagaki K., Koyanagi T., Kofidis T., Mochly-Rosen D., and Robbins R.C. Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. Circulation 110 11 Suppl 1 (2004) II194-II199
    • (2004) Circulation , vol.110 , Issue.11 SUPPL. 1
    • Tanaka, M.1    Terry, R.D.2    Mokhtari, G.K.3    Inagaki, K.4    Koyanagi, T.5    Kofidis, T.6    Mochly-Rosen, D.7    Robbins, R.C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.