-
1
-
-
37649011777
-
A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC
-
Hongpaisan J., and Alkon D.L. A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 19571-19576
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 19571-19576
-
-
Hongpaisan, J.1
Alkon, D.L.2
-
2
-
-
16244401633
-
Dual effects of bryostatin-1 on spatial memory and depression
-
Sun M.K., and Alkon D.L. Dual effects of bryostatin-1 on spatial memory and depression. Eur. J. Pharmacol. 512 (2005) 43-51
-
(2005)
Eur. J. Pharmacol.
, vol.512
, pp. 43-51
-
-
Sun, M.K.1
Alkon, D.L.2
-
3
-
-
35248870218
-
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies
-
Podar K., et al. The therapeutic role of targeting protein kinase C in solid and hematologic malignancies. Expert Opin. Investig. Drugs 16 (2007) 1693-1697
-
(2007)
Expert Opin. Investig. Drugs
, vol.16
, pp. 1693-1697
-
-
Podar, K.1
-
4
-
-
0030894069
-
Bryostatin 1 and phorbol ester down-modulate protein kinase C-α and -ε via the ubiquitin/proteasome pathway in human fibroblasts
-
Lee H.W., et al. Bryostatin 1 and phorbol ester down-modulate protein kinase C-α and -ε via the ubiquitin/proteasome pathway in human fibroblasts. Mol. Pharmacol. 51 (1997) 439-447
-
(1997)
Mol. Pharmacol.
, vol.51
, pp. 439-447
-
-
Lee, H.W.1
-
5
-
-
15844395343
-
Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC
-
Seki T., et al. Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes Cells 10 (2005) 225-239
-
(2005)
Genes Cells
, vol.10
, pp. 225-239
-
-
Seki, T.1
-
6
-
-
0035413601
-
Protein kinase C: Structural and spatial regulation by phosphorylation, cofactor, and macromolecular interactions
-
Newton A.C. Protein kinase C: Structural and spatial regulation by phosphorylation, cofactor, and macromolecular interactions. Chem. Rev. 101 (2001) 2353-2364
-
(2001)
Chem. Rev.
, vol.101
, pp. 2353-2364
-
-
Newton, A.C.1
-
7
-
-
0035474310
-
Adaptor proteins in protein kinase C-mediated signal transduction
-
Schechtman D., and Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20 (2001) 6339-6347
-
(2001)
Oncogene
, vol.20
, pp. 6339-6347
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
8
-
-
0034634651
-
Phosphorylation of protein kinase Cδ on distinct tyrosine residues regulates specific cellular functions
-
Kronfeld I., et al. Phosphorylation of protein kinase Cδ on distinct tyrosine residues regulates specific cellular functions. J. Biol. Chem. 275 (2000) 35491-35498
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35491-35498
-
-
Kronfeld, I.1
-
9
-
-
1242339601
-
Identification of two distinct pathways of protein kinase Cα down-regulation in intestinal epithelial cells
-
Leontieva O.V., and Black J.D. Identification of two distinct pathways of protein kinase Cα down-regulation in intestinal epithelial cells. J. Biol. Chem. 279 (2004) 5788-5801
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5788-5801
-
-
Leontieva, O.V.1
Black, J.D.2
-
10
-
-
0033858056
-
Protein kinase Cα actively downregulates through caveolae-dependent traffic to an endosomal compartment
-
Prevostel C., et al. Protein kinase Cα actively downregulates through caveolae-dependent traffic to an endosomal compartment. J. Cell Sci. 113 (2000) 2575-2584
-
(2000)
J. Cell Sci.
, vol.113
, pp. 2575-2584
-
-
Prevostel, C.1
-
11
-
-
0028979464
-
Crystal structure of the cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester
-
Zhang G., et al. Crystal structure of the cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester. Cell 81 (1995) 917-924
-
(1995)
Cell
, vol.81
, pp. 917-924
-
-
Zhang, G.1
-
12
-
-
0000018373
-
Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin
-
Jeffrey A.M., and Liskamp R.M. Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin. Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 241-245
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 241-245
-
-
Jeffrey, A.M.1
Liskamp, R.M.2
-
13
-
-
0000852678
-
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C
-
Wender P.A., et al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7197-7201
-
(1988)
Proc. Natl. Acad. Sci. U. S. A.
, vol.85
, pp. 7197-7201
-
-
Wender, P.A.1
-
14
-
-
0026612631
-
3H]bryostatin 4 to protein kinase C
-
3H]bryostatin 4 to protein kinase C. Biochem. Pharmacol. 43 (1992) 2007-2014
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 2007-2014
-
-
Lewin, N.E.1
-
15
-
-
0343819883
-
Differential roles of the tandem C1 domains of protein kinase Cδ in the biphasic down-regulation induced by bryostatin 1
-
Lorenzo P.S., et al. Differential roles of the tandem C1 domains of protein kinase Cδ in the biphasic down-regulation induced by bryostatin 1. Cancer Res. 59 (1999) 6137-6144
-
(1999)
Cancer Res.
, vol.59
, pp. 6137-6144
-
-
Lorenzo, P.S.1
-
16
-
-
33748764383
-
C1 domains exposed: from diacylglycerol binding to protein-protein interactions
-
Colón-González F., and Kazanietz M.G. C1 domains exposed: from diacylglycerol binding to protein-protein interactions. Biochim. Biophys. Acta 1761 (2006) 827-837
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 827-837
-
-
Colón-González, F.1
Kazanietz, M.G.2
-
17
-
-
0035990921
-
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity
-
Irie K., et al. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol. Ther. 93 (2002) 271-281
-
(2002)
Pharmacol. Ther.
, vol.93
, pp. 271-281
-
-
Irie, K.1
-
18
-
-
0141679354
-
Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C
-
Giorgione J., et al. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C. Biochemistry 42 (2003) 11194-11202
-
(2003)
Biochemistry
, vol.42
, pp. 11194-11202
-
-
Giorgione, J.1
-
19
-
-
0033538433
-
Interplay of C1 and C2 domains of protein kinase C-α in its membrane binding and activation
-
Medkova M., and Cho W. Interplay of C1 and C2 domains of protein kinase C-α in its membrane binding and activation. J. Biol. Chem. 274 (1999) 19852-19861
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 19852-19861
-
-
Medkova, M.1
Cho, W.2
-
20
-
-
0344443708
-
Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains
-
Ananthanarayanan B., et al. Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains. J. Biol. Chem. 278 (2003) 46886-46894
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46886-46894
-
-
Ananthanarayanan, B.1
-
21
-
-
21244504606
-
Diacylglycerol-induced membrane targeting and activation of protein kinase Cε: mechanistic differences between protein kinases Cδ and Cε
-
Stahelin R.V., et al. Diacylglycerol-induced membrane targeting and activation of protein kinase Cε: mechanistic differences between protein kinases Cδ and Cε. J. Biol. Chem. 280 (2005) 19784-19793
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19784-19793
-
-
Stahelin, R.V.1
-
22
-
-
33745728984
-
Bryostatin enhancement of memory in Hermissenda
-
Kuzirian A.M., et al. Bryostatin enhancement of memory in Hermissenda. Biol. Bull. 210 (2006) 201-214
-
(2006)
Biol. Bull.
, vol.210
, pp. 201-214
-
-
Kuzirian, A.M.1
-
23
-
-
0345459958
-
Phase I study of prolonged infusion bryostatin-1 in patients with advanced malignancies
-
Marshall J.L., et al. Phase I study of prolonged infusion bryostatin-1 in patients with advanced malignancies. Cancer Biol. Ther. 1 (2002) 409-416
-
(2002)
Cancer Biol. Ther.
, vol.1
, pp. 409-416
-
-
Marshall, J.L.1
-
24
-
-
51649126750
-
Post-stroke neuronal rescue and synaptogenesis mediated in vivo by PKC in adult brains
-
Sun M.K., et al. Post-stroke neuronal rescue and synaptogenesis mediated in vivo by PKC in adult brains. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 13620-13625
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 13620-13625
-
-
Sun, M.K.1
-
25
-
-
0033571223
-
2+ bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine
-
2+ bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine. EMBO J. 18 (1999) 6329-6388
-
(1999)
EMBO J.
, vol.18
, pp. 6329-6388
-
-
Verdaguer, N.1
-
26
-
-
0030955354
-
Late memory-related genes in the hippocampus revealed by RNA fingerprinting
-
Cavallaro S., et al. Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9669-9673
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 9669-9673
-
-
Cavallaro, S.1
-
27
-
-
0033521130
-
Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
-
Zhao W., et al. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J. Biol. Chem. 274 (1999) 34893-34902
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34893-34902
-
-
Zhao, W.1
-
28
-
-
0141742631
-
Fibroblast growth factors and their receptors in the central nervous system
-
Reuss B., et al. Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res. 313 (2003) 139-157
-
(2003)
Cell Tissue Res.
, vol.313
, pp. 139-157
-
-
Reuss, B.1
-
29
-
-
0036667947
-
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells
-
Meinhardt G., et al. Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. Anticancer Drugs 13 (2002) 725-733
-
(2002)
Anticancer Drugs
, vol.13
, pp. 725-733
-
-
Meinhardt, G.1
-
30
-
-
0034535535
-
Cell death or synaptic loss in Alzheimer disease
-
Terry R.D. Cell death or synaptic loss in Alzheimer disease. J. Neuropathol. Exp. Neurol. 59 (2000) 1118-1119
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 1118-1119
-
-
Terry, R.D.1
-
31
-
-
33747760358
-
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
-
Scheff S.W., et al. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol. Aging 27 (2006) 1372-1384
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1372-1384
-
-
Scheff, S.W.1
-
32
-
-
44649161175
-
Protein kinase C-mediated protection of motoneurons from excitotoxicity
-
Tomimatsu N., and Arakawa Y. Protein kinase C-mediated protection of motoneurons from excitotoxicity. Neurosci. Lett. 439 (2008) 143-146
-
(2008)
Neurosci. Lett.
, vol.439
, pp. 143-146
-
-
Tomimatsu, N.1
Arakawa, Y.2
-
33
-
-
20044393676
-
Activation of protein kinase C-δ attenuates kainate-induced cell death of cortical neurons
-
Jung Y.S., et al. Activation of protein kinase C-δ attenuates kainate-induced cell death of cortical neurons. Neuroreport 16 (2005) 741-744
-
(2005)
Neuroreport
, vol.16
, pp. 741-744
-
-
Jung, Y.S.1
-
34
-
-
0033830726
-
A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C
-
Noh K.M., et al. A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C. Neurobiol. Dis. 7 (2000) 375-383
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 375-383
-
-
Noh, K.M.1
-
35
-
-
33846528583
-
PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease
-
Alkon D.L., et al. PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease. Trends Pharmacol. Sci. 28 (2007) 51-60
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 51-60
-
-
Alkon, D.L.1
-
36
-
-
3342934646
-
Therapeutic effect of PKC activators on Alzheimer's disease transgenic mice
-
Etcheberrigaray R., et al. Therapeutic effect of PKC activators on Alzheimer's disease transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 11141-11146
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 11141-11146
-
-
Etcheberrigaray, R.1
-
37
-
-
14444272986
-
Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum J.D., et al. Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273 (1998) 27765-27767
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
-
38
-
-
34447634320
-
New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing α-secretase activity
-
Yang H.Q., et al. New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing α-secretase activity. Eur. J. Neurosci. 26 (2007) 381-391
-
(2007)
Eur. J. Neurosci.
, vol.26
, pp. 381-391
-
-
Yang, H.Q.1
-
39
-
-
33744465230
-
PKCε increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
-
Choi D.S., et al. PKCε increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 8215-8220
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 8215-8220
-
-
Choi, D.S.1
-
41
-
-
0028859466
-
Regulated formation of Golgi secretory vesicles containing Alzheimer β-amyloid precursor protein
-
Xu H., et al. Regulated formation of Golgi secretory vesicles containing Alzheimer β-amyloid precursor protein. J. Biol. Chem. 270 (1995) 23243-23245
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23243-23245
-
-
Xu, H.1
-
42
-
-
0032829387
-
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase
-
Behrens M.M., et al. Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase. Neuroscience 94 (1999) 917-927
-
(1999)
Neuroscience
, vol.94
, pp. 917-927
-
-
Behrens, M.M.1
-
43
-
-
0028106342
-
A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's β-amyloid precursor protein gene
-
Trejo J., et al. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's β-amyloid precursor protein gene. J. Biol. Chem. 269 (1994) 21682-21690
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 21682-21690
-
-
Trejo, J.1
-
44
-
-
57549101895
-
Enhanced generation of Alzheimer's amyloid-β following chronic exposure to phorbol ester correlates with differential effects on α and ε isozymes of protein kinase C
-
da Cruz E., et al. Enhanced generation of Alzheimer's amyloid-β following chronic exposure to phorbol ester correlates with differential effects on α and ε isozymes of protein kinase C. J. Neurochem. 108 (2009) 319-330
-
(2009)
J. Neurochem.
, vol.108
, pp. 319-330
-
-
da Cruz, E.1
-
45
-
-
0037710311
-
The isoform-specific regulation of apoptosis by protein kinase C
-
Gutcher I., et al. The isoform-specific regulation of apoptosis by protein kinase C. Cell. Mol. Life Sci. 60 (2003) 1061-1070
-
(2003)
Cell. Mol. Life Sci.
, vol.60
, pp. 1061-1070
-
-
Gutcher, I.1
-
46
-
-
27644472331
-
Activation of protein kinase CßI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons
-
Lallemend F., et al. Activation of protein kinase CßI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons. J. Cell Sci. 118 (2005) 4511-4525
-
(2005)
J. Cell Sci.
, vol.118
, pp. 4511-4525
-
-
Lallemend, F.1
-
47
-
-
20444365447
-
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth
-
Domeniconi M., et al. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 46 (2005) 849-855
-
(2005)
Neuron
, vol.46
, pp. 849-855
-
-
Domeniconi, M.1
-
48
-
-
33845567392
-
TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
-
Ahmed Z., et al. TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin. FASEB J. 20 (2006) 1939-1941
-
(2006)
FASEB J.
, vol.20
, pp. 1939-1941
-
-
Ahmed, Z.1
-
49
-
-
34249944425
-
On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of spatial memory
-
Bonini J.S., et al. On the participation of hippocampal PKC in acquisition, consolidation and reconsolidation of spatial memory. Neuroscience 147 (2007) 37-45
-
(2007)
Neuroscience
, vol.147
, pp. 37-45
-
-
Bonini, J.S.1
-
50
-
-
15444345629
-
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCδ and discovery of an ILV analogue of improved isozyme selectivity
-
Kozikowski A.P., et al. Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCδ and discovery of an ILV analogue of improved isozyme selectivity. J. Med. Chem. 40 (1997) 1316-1326
-
(1997)
J. Med. Chem.
, vol.40
, pp. 1316-1326
-
-
Kozikowski, A.P.1
-
51
-
-
2342626503
-
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay
-
Saraiva L., et al. Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay. Eur. J. Pharmacol. 491 (2004) 101-110
-
(2004)
Eur. J. Pharmacol.
, vol.491
, pp. 101-110
-
-
Saraiva, L.1
-
52
-
-
0030987327
-
Tumor promotion by depleting cells of protein kinase Cδ
-
Lu Z., et al. Tumor promotion by depleting cells of protein kinase Cδ. Mol. Cell. Biol. 17 (1997) 3418-3428
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 3418-3428
-
-
Lu, Z.1
-
53
-
-
0032031093
-
Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells
-
Scaglione-Sewell B., et al. Decreased PKC-α expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. Cancer Res. 58 (1998) 1074-1081
-
(1998)
Cancer Res.
, vol.58
, pp. 1074-1081
-
-
Scaglione-Sewell, B.1
-
54
-
-
0035354188
-
Protein kinase Cα and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells
-
Mandil R., et al. Protein kinase Cα and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res. 61 (2001) 4612-4619
-
(2001)
Cancer Res.
, vol.61
, pp. 4612-4619
-
-
Mandil, R.1
-
55
-
-
27444433826
-
Protein kinase Cδ induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms
-
Ryer E.J., et al. Protein kinase Cδ induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. J. Biol. Chem. 280 (2005) 35310-35317
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35310-35317
-
-
Ryer, E.J.1
-
56
-
-
33947603008
-
Protein kinase C and other diacylglycerol effectors in cancer
-
Griner E.M., and Kazanietz M.G. Protein kinase C and other diacylglycerol effectors in cancer. Nat. Rev. Cancer 7 (2007) 281-294
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 281-294
-
-
Griner, E.M.1
Kazanietz, M.G.2
-
57
-
-
1842454982
-
The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival
-
Jackson D.N., and Foster D.A. The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival. FASEB J. 18 (2004) 627-636
-
(2004)
FASEB J.
, vol.18
, pp. 627-636
-
-
Jackson, D.N.1
Foster, D.A.2
-
58
-
-
0242414715
-
Protein kinase C modulates tumor necrosis factor-related apoptosis- inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling
-
Harper N., et al. Protein kinase C modulates tumor necrosis factor-related apoptosis- inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling. J. Biol. Chem. 278 (2003) 44338-44347
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44338-44347
-
-
Harper, N.1
-
59
-
-
33747626309
-
Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C
-
Byun H.S., et al. Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. Mol. Pharmacol. 70 (2006) 1099-1108
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1099-1108
-
-
Byun, H.S.1
-
60
-
-
4143073538
-
Selective regulation by δ-PKC and PI3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils
-
Kilpatrick L.E., et al. Selective regulation by δ-PKC and PI3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. Am. J. Physiol. Cell Physiol. 287 (2004) C633-C642
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.287
-
-
Kilpatrick, L.E.1
-
61
-
-
36749025313
-
Protein kinase Cδ and apoptosis
-
Reyland M.E. Protein kinase Cδ and apoptosis. Biochem. Soc. Trans. 35 (2007) 1001-1004
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1001-1004
-
-
Reyland, M.E.1
-
62
-
-
0642378446
-
Cell cycle deregulation: a common motif in cancer
-
Malumbres M., and Carnero A. Cell cycle deregulation: a common motif in cancer. Prog. Cell Cycle Res. 5 (2003) 5-18
-
(2003)
Prog. Cell Cycle Res.
, vol.5
, pp. 5-18
-
-
Malumbres, M.1
Carnero, A.2
-
63
-
-
0034168037
-
Protein kinase C-mediated regulation of the cell cycle
-
Black J.D. Protein kinase C-mediated regulation of the cell cycle. Front. Biosci. 5 (2000) D406-D423
-
(2000)
Front. Biosci.
, vol.5
-
-
Black, J.D.1
-
64
-
-
0036855463
-
Protein kinase Cα (PKCα): regulation and biological function
-
Nakashima S. Protein kinase Cα (PKCα): regulation and biological function. J. Biochem. 132 (2002) 669-675
-
(2002)
J. Biochem.
, vol.132
, pp. 669-675
-
-
Nakashima, S.1
-
65
-
-
0030795939
-
Linking protein kinase C to cell-cycle control
-
Livneh E., and Fishman D. Linking protein kinase C to cell-cycle control. Eur. J. Biochem. 248 (1997) 1-9
-
(1997)
Eur. J. Biochem.
, vol.248
, pp. 1-9
-
-
Livneh, E.1
Fishman, D.2
-
66
-
-
3042647350
-
Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms
-
Gavrielides M.V., et al. Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms. Curr. Drug Targets 5 (2004) 431-443
-
(2004)
Curr. Drug Targets
, vol.5
, pp. 431-443
-
-
Gavrielides, M.V.1
-
67
-
-
2342613651
-
Characterization of the interaction of ingenol 3-angelate with protein kinase C
-
Kedei N., et al. Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Res. 64 (2004) 3243-3255
-
(2004)
Cancer Res.
, vol.64
, pp. 3243-3255
-
-
Kedei, N.1
-
68
-
-
0033136715
-
Tumor promoting diterpenes from Euphorbia leuconeura L
-
Vogg G., et al. Tumor promoting diterpenes from Euphorbia leuconeura L. Phytochemistry 51 (1999) 289-295
-
(1999)
Phytochemistry
, vol.51
, pp. 289-295
-
-
Vogg, G.1
-
69
-
-
0023084369
-
New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin
-
Fujiki H., and Sugimura T. New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin. Adv. Cancer Res. 49 (1987) 223-264
-
(1987)
Adv. Cancer Res.
, vol.49
, pp. 223-264
-
-
Fujiki, H.1
Sugimura, T.2
-
70
-
-
2342439577
-
Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes
-
Irie K., et al. Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Curr. Pharm. Des. 10 (2004) 1371-1385
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1371-1385
-
-
Irie, K.1
-
71
-
-
0031835782
-
Mechanism of antitumor action of PKC activator, gnidimacrin
-
Yoshida M., et al. Mechanism of antitumor action of PKC activator, gnidimacrin. Int. J. Cancer 77 (1998) 243-250
-
(1998)
Int. J. Cancer
, vol.77
, pp. 243-250
-
-
Yoshida, M.1
-
72
-
-
0035829436
-
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily
-
Shao L., et al. Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily. J. Med. Chem. 44 (2001) 3872-3880
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3872-3880
-
-
Shao, L.1
-
73
-
-
0028903813
-
Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C
-
Gilbert B.A., et al. Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. Biochemistry 34 (1995) 3916-3920
-
(1995)
Biochemistry
, vol.34
, pp. 3916-3920
-
-
Gilbert, B.A.1
-
74
-
-
33645389928
-
Branched diacylglycerol-lactones as potent protein kinase C ligands and α-secretase activators
-
Lee J., et al. Branched diacylglycerol-lactones as potent protein kinase C ligands and α-secretase activators. J. Med. Chem. 49 (2006) 2028-2036
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2028-2036
-
-
Lee, J.1
-
76
-
-
33744828259
-
The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site
-
Kanno T., et al. The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J. Lipid Res. 47 (2006) 1146-1150
-
(2006)
J. Lipid Res.
, vol.47
, pp. 1146-1150
-
-
Kanno, T.1
-
77
-
-
0024543387
-
Selective activation of the γ-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites
-
Shearman M.S., et al. Selective activation of the γ-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites. FEBS Lett. 243 (1989) 177-182
-
(1989)
FEBS Lett.
, vol.243
, pp. 177-182
-
-
Shearman, M.S.1
-
78
-
-
0022499282
-
N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C
-
Ito M., et al. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Biochemistry 25 (1986) 4179-4184
-
(1986)
Biochemistry
, vol.25
, pp. 4179-4184
-
-
Ito, M.1
-
79
-
-
0029623148
-
Activation of protein kinase C by oxidized diacylglycerols
-
Takekoshi S., et al. Activation of protein kinase C by oxidized diacylglycerols. Biochem. Biophys. Res. Commun. 217 (1995) 654-660
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.217
, pp. 654-660
-
-
Takekoshi, S.1
-
80
-
-
0022602044
-
Activation of protein kinase C by the action of 9,11-epithio-11,12- methano-thromboxane A2 (STA2), a stable analogue of thromboxane A2, in human platelets
-
Kawahara Y., et al. Activation of protein kinase C by the action of 9,11-epithio-11,12- methano-thromboxane A2 (STA2), a stable analogue of thromboxane A2, in human platelets. Thromb. Res. 41 (1986) 811-818
-
(1986)
Thromb. Res.
, vol.41
, pp. 811-818
-
-
Kawahara, Y.1
-
81
-
-
2442643936
-
Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells
-
Mitra J., and Enders G.H. Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells. Oncogene 23 (2004) 3361-3367
-
(2004)
Oncogene
, vol.23
, pp. 3361-3367
-
-
Mitra, J.1
Enders, G.H.2
|