Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo

Molecular Biology of the Cell

Volumn 22, Issue 2, 2011, Pages 256-265

  Qi, Xin ^a   Disatnik, Marie Helene ^a   Shen, Ning ^b   Sobel, Raymond A ^a   Mochly Rosen, Daria ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN I; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN DISEASE; BRAIN INJURY; CELL CULTURE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; GENE TRANSLOCATION; HYPERTENSION; IMMUNOPRECIPITATION; IN VIVO STUDY; MALE; MITOCHONDRION; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CELL DEATH; DYNAMINS; HUMANS; HYPERTENSION; MALE; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; NEURONS; OLIGOPEPTIDES; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-DELTA; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RATS, INBRED DAHL; SEQUENCE ALIGNMENT; TUMOR CELLS, CULTURED;

RATTUS;

EID: 78751470559     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-06-0551     Document Type: Article

References (53)

1. Barsoum MJ et al. (2006). Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 25, 3900-3911.
2. Brooks C, Wei Q, Cho SG, Dong Z (2009). Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 119, 1275-1285.
3. Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L (2008). Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 105, 15803-15808.
4. Chan DC (2006). Mitochondrial fusion and fission in mammals. Annu Rev Cell Dev Biol 22, 79-99.
5. Chen H, Chan DC (2005). Emerging functions of mammalian mitochondrial fusion and fission. Human Mole Genet 14 (spec no. 2), R283-289.
6. Chen H, Chan DC (2009). Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases. Human Mole Genet 18, R169-176.
7. Chen L, Gong Q, Stice JP, Knowlton AA (2009). Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res 84, 91-99.
8. Chen L et al. (2001a). Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci USA 98, 11114-11119.
9. Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D (2001b). Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem Biol 8, 1123-1129.
10. Cheung EC, McBride HM, Slack RS (2007). Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis 12, 979-992.
11. Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA (2009). S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324, 102-105.
12. Cieslak D, Lazou A (2007). Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress. Mol Cells 24, 224-231.
13. Cribbs JT, Strack S (2007). Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO Rep 8, 939-944.
14. Deng H, Dodson MW, Huang H, Guo M (2008). The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci USA 105, 14503-14508.
15. Denning MF, Wang Y, Tibudan S, Alkan S, Nickoloff BJ, Qin JZ (2002). Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ 9, 40-52.
16. DiMauro S, Schon EA, (2008). Mitochondrial disorders in the nervous system. Annu Rev Neurosci 31, 91-123.
17. Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, Smith CL, Youle RJ (2001). The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1, 515-525.
18. Gompel M, Soulie C, Ceballos-Picot I, Meijer L (2004). Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation. Neurosignals 13, 134-143.
19. Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, Tomizawa K, Nairn AC, Takei K, Matsui H, Matsushita M (2008). CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology. J Cell Biol 182, 573-585.
20. He Y, Liu J, Grossman D, Durrant D, Sweatman T, Lothstein L, Epand RF, Epand RM, Lee RM (2007). Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid. J Cell Biochem 101, 1210-1221.
21. Iadecola C, Davisson RL (2008). Hypertension and cerebrovascular dysfunction. Cell Metab 7, 476-484.
22. Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D (2003). Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108, 2304-2307.
23. Ishihara N et al. (2009). Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nature Cell Biol 11, 958-966.
24. Jagasia R, Grote P, Westermann B, Conradt B (2005). DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 433, 754-760.
25. James DI, Parone PA, Mattenberger Y, Martinou JC (2003). hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 278, 36373-36379.
26. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E (2008). Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9, 505-518.
27. Labrousse AM, Zappaterra MD, Rube DA, Van Der Bliek AM (1999). C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 4, 815-826.
28. Lee K, Song K (2008). Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylation. Cell Cycle 7, 216-221.
29. Li L, Lorenzo PS, Bogi K, Blumberg PM, Yuspa SH (1999). Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol 19, 8547-8558.
30. Li Z, Okamoto K, Hayashi Y, Sheng M (2004). The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119, 873-887.
31. Liot G, Bossy B, Lubitz S, Kushnareva Y, Sejbuk N, Bossy-Wetzel E (2009). Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 16, 899-909.
32. Majumder PK, Pandey P, Sun X, Cheng K, Datta R, Saxena S, Kharbanda S, Kufe D (2000). Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis. J Biol Chem 275, 21793-21796.
33. Moretti R, Torre P, Antonello RM, Manganaro D, Vilotti C, Pizzolato G (2008). Risk factors for vascular dementia: hypotension as a key point. Vasc Health Risk Manag 4, 395-402.
34. Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D (2004). Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem 279, 47985-47991.
35. Nguyen T, Ogbi M, Johnson JA (2008). Delta protein kinase C interacts with the d subunit of the F1F0 ATPase in neonatal cardiac myocytes exposed to hypoxia or phorbol ester. Implications for F1F0 ATPase regulation. J Biol Chem 283, 29831-29840.
36. Payne GW, Smeda JS (2002). Cerebrovascular alterations in pressure and protein kinase C-mediated constriction in Dahl salt-sensitive rats. J Hypertens 20, 1355-1363.
37. Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ (2008). The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 105, 1638-1643.
38. Qi X, Inagaki K, Sobel RA, Mochly-Rosen D (2008). Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest 118, 173-182.
39. Qi X, Mochly-Rosen D (2008). The PKCä-Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. J Cell Sci 121, 804-813.
40. Reddy PH, Mao P, Manczak M (2009). Mitochondrial structural and functional dynamics in Huntington's disease. Brain Res Rev 61, 33-48.
41. Schwartz RB (2002). Hyperperfusion encephalopathies: hypertensive encephalopathy and related conditions. Neurologist 8, 22-34.
42. Shen X, Zheng S, Thongboonkerd V, Xu M, Pierce WM Jr, Klein JB, Epstein PN (2004). Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes. Am J Physiol 287, E896-905.
43. Smirnova E, Griparic L, Shurland DL, Van Der Bliek AM (2001). Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 12, 2245-2256.
44. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K (2007). Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282, 11521-11529.
45. Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H (2009). The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol 186, 805-816.
46. Wang X, Su B, Fujioka H, Zhu X (2008a). Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am J Pathol 173, 470-482.
47. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008b). Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 105, 19318-19323.
48. Waterham HR, Koster J, van Roermund CW, Mooyer PA, Wanders RJ, Leonard JV (2007). A lethal defect of mitochondrial and peroxisomal fission. New Engl J Med 356, 1736-1741.
49. Wu S, Skolnick J, Zhang Y (2007). Ab initio modeling of small proteins by iterative TASSER simulations. BMC Biol 5, 17.
50. Yoon Y, Krueger EW, Oswald BJ, McNiven MA (2003). The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol 23, 5409-5420.
51. Youle RJ, Karbowski M (2005). Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol 6, 657-663.
52. Zhang Y (2007). Template-based modeling and free modeling by I-TASSER in CASP7. Proteins 69, (suppl 8) , 108-117.
53. Zhang Y (2008). I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 9, 40.