δPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo

Brain Research

Volumn 1144, Issue 1, 2007, Pages 146-155

  Bright, Rachel ^a   Steinberg, Gary K ^a   Mochly Rosen, Daria ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebral blood flow; Hypertension; Microvasculature; Protein kinase C; Stroke; Vasculature

Indexed keywords

PEPTIDE DERIVATIVE; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; OLIGOPEPTIDE; SER PHE ASN SER TYR GLU LEU GLY GLU SER LEU; SER-PHE-ASN-SER-TYR-GLU-LEU-GLY-GLU-SER-LEU; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; CHRONIC STRESS; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; HYPERTENSION; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN CIRCULATION; BRAIN EDEMA; BRAIN INFARCTION; CEREBRAL ARTERY DISEASE; DRUG EFFECT; LASER DOPPLER FLOWMETRY; MALE; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALIA; RATTUS;

ANIMALS; BRAIN EDEMA; BRAIN ISCHEMIA; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; HYPERTENSION; INFARCTION, MIDDLE CEREBRAL ARTERY; LASER-DOPPLER FLOWMETRY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; OLIGOPEPTIDES; PROTEIN KINASE C-DELTA; RATS; RATS, INBRED DAHL; RATS, SPRAGUE-DAWLEY;

EID: 33947315308     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.01.113     Document Type: Article

References (47)

1. Akopov S.E., Sercombe R., and Seylaz J. Endothelial dysfunction in cerebral vessels following carotid artery infusion of phorbol ester in rabbits: the role of polymorphonuclear leukocytes. J. Cereb. Blood Flow Metab. 14 (1994) 1078-1087
2. Arboix A., Roig H., Rossich R., Martinez E.M., and Garcia-Eroles L. Differences between hypertensive and non-hypertensive ischemic stroke. Eur. J. Neurol. 11 (2004) 687-692
3. Armstead W.M. Superoxide generation links protein kinase C activation to impaired ATP-sensitive K+ channel function after brain injury. Stroke 30 (1999) 153-159
4. Ay H., Koroshetz W.J., Vangel M., Benner T., Melinosky C., Zhu M., Menezes N., Lopez C.J., and Sorensen A.G. Conversion of ischemic brain tissue into infarction increases with age. Stroke 36 (2005) 2632-2636
5. Beg S.S., Hansen-Schwartz J.A., Vikman P.J., Xu C.B., and Edvinsson L.I. Protein kinase C inhibition prevents upregulation of vascular ET(B) and 5-HT(1B) receptors and reverses cerebral blood flow reduction after subarachnoid haemorrhage in rats. J. Cereb. Blood Flow Metab. 27 (2007) 21-32
6. Begley R., Liron T., Baryza J., and Mochly-Rosen D. Biodistribution of intracellularly acting peptides conjugated reversibly to TAT. Biochem. Biophys. Res. Commun. 318 (2004) 949-954
7. Bright R., Raval A.P., Dembner J.M., Perez-Pinzon M.A., Steinberg G.K., Yenari M.A., and Mochly-Rosen D. Protein kinase C delta mediates cerebral reperfusion injury in vivo. J. Neurosci. 24 (2004) 6880-6888
8. Brodie C., and Blumberg P.M. Regulation of apoptosis by protein kinase C delta. Apoptosis 8 (2003) 19-27
9. Chen L., Hahn H., Wu G., Chen C.H., Liron T., Schechtman D., Cavallaro G., Banci L., Guo Y., Bolli R., Dorn II G.W., and Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 11114-11119
10. Chou W.H., Choi D.S., Zhang H., Mu D., McMahon T., Kharazia V.N., Lowell C.A., Ferriero D.M., and Messing R.O. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J. Clin. Invest. 114 (2004) 49-56
11. Churchill E.N., and Szweda L.I. Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function. Arch. Biochem. Biophys. 439 (2005) 194-199
12. del Zoppo G.J., and Mabuchi T. Cerebral microvessel responses to focal ischemia. J. Cereb. Blood Flow Metab. 23 (2003) 879-894
13. Faraci F.M. Vascular protection. Stroke 34 (2003) 327-329
14. Fukunaga K., Soderling T.R., and Miyamoto E. Activation of Ca2+/calmodulin-dependent protein kinase II and protein kinase C by glutamate in cultured rat hippocampal neurons. J. Biol. Chem. 267 (1992) 22527-22533
15. Gursoy-Ozdemir Y., Can A., and Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 35 (2004) 1449-1453
16. Henrion D., and Laher I. Effects of staurosporine and calphostin C, two structurally unrelated inhibitors of protein kinase C, on vascular tone. Can. J. Physiol. Pharmacol. 71 (1993) 521-524
17. Inagaki K., Iwanaga Y., Sarai N., Onozawa Y., Takenaka H., Mochly-Rosen D., and Kihara Y. Tissue angiotensin II during progression of ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. J. Mol. Cell Cardiol. 34 (2002) 1377-1385
18. Inagaki K., Chen L., Ikeno F., Lee F.H., Imahashi K., Bouley D.M., Rezaee M., Yock P.G., Murphy E., and Mochly-Rosen D. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108 (2003) 2304-2307
19. Inagaki K., Begley R., Ikeno F., and Mochly-Rosen D. Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. Circulation 111 (2005) 44-50
20. Iwai J., and Heine M. Dahl salt-sensitive rats and human essential hypertension. J. Hypertens. Suppl. 3 (1986) S29-S31
21. Jin Y., Sagher O., Thai Q.A., Kassell N.F., and Lee K.S. The effects of papaverine on phorbol dibutyrate-induced vasoconstriction in brain slice microvessels. J. Neurosurg. 81 (1994) 574-578
22. Johnson J.A., and Mochly-Rosen D. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme. Circ. Res. 76 (1995) 654-663
23. Kaasinen S.K., Goldsteins G., Alhonen L., Janne J., and Koistinaho J. Induction and activation of protein kinase C delta in hippocampus and cortex after kainic acid treatment. Exp. Neurol. 176 (2002) 203-212
24. Kheifets V., Bright R., Inagaki K., Schechtman D., and Mochly-Rosen D. Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. J. Biol. Chem. 281 (2006) 23218-23226
25. Kraft A.S., and Anderson W.B. Phorbol esters increase the amount of Ca+2, phospholipid-dependent protein kinase associated with plasma membrane. Nature 301 (1983) 621-623
26. Laher I., and Zhang J.H. Protein kinase C and cerebral vasospasm. J. Cereb. Blood Flow Metab. 21 (2001) 887-906
27. La Porta C.A., and Comolli R. Biochemical and immunological characterization of calcium-dependent and -independent PKC isoenzymes in renal ischemia. Biochem. Biophys. Res. Commun. 191 (1993) 1124-1130
28. Majumder P.K., Mishra N.C., Sun X., Bharti A., Kharbanda S., Saxena S., and Kufe D. Targeting of protein kinase C delta to mitochondria in the oxidative stress response. Cell Growth Differ. 12 (2001) 465-470
29. Melgar M.A., Rafols J., Gloss D., and Diaz F.G. Postischemic reperfusion: ultrastructural blood-brain barrier and hemodynamic correlative changes in an awake model of transient forebrain ischemia. Neurosurgery 56 (2005) 571-581
30. Miettinen S., Roivainen R., Keinanen R., Hokfelt T., and Koistinaho J. Specific induction of protein kinase C delta subspecies after transient middle cerebral artery occlusion in the rat brain: inhibition by MK-801. J. Neurosci. 16 (1996) 6236-6245
31. Murray M.A., Faraci F.M., and Heistad D.D. Role of protein kinase C in constrictor responses of the rat basilar artery in vivo. J. Physiol. 445 (1992) 169-179
32. Murriel C.L., Churchill E., Inagaki K., Szweda L.I., and Mochly-Rosen D. Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J. Biol. Chem. 279 (2004) 47985-47992
33. Nakane H., Yao H., Ibayashi S., Kitazono T., Ooboshi H., Uchimura H., and Fujishima M. Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats. Brain Res. 782 (1998) 290-296
34. Rasool A.H., Rahman A.R., Choudhury S.R., and Singh R.B. Blood pressure in acute intracerebral haemorrhage. J. Hum. Hypertens. 18 (2004) 187-192
35. Raval A.P., Dave K.R., Prado R., Katz L.M., Busto R., Sick T.J., Ginsberg M.D., Mochly-Rosen D., and Perez-Pinzon M.A. Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. J. Cereb. Blood Flow Metab. 25 (2005) 730-741
36. Ramzy D., Rao V., Tumiati L.C., Xu N., Sheshgiri R., Miriuka S., Delgado D.H., and Ross H.J. Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. Circulation 114 (2006) I319-I326
37. Rosendorff C. Endothelin, vascular hypertrophy and hypertension. Cardiovasc. Drugs Ther. 10 (1997) 795-802
38. Schwarze S.R., Ho A., Vocero-Akbani A., and Dowdy S.F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285 (1999) 1569-1572
39. Smeda J.S., and Payne G.W. Alterations in autoregulatory and myogenic function in the cerebrovasculature of Dahl salt-sensitive rats. Stroke 34 (2003) 1484-1490
40. Strandgaard S. Autoregulation of cerebral circulation in hypertension. Acta Neurol. Scand. Suppl. 66 (1978) 1-82
41. Takahashi M., and Macdonald R.L. Vascular aspects of neuroprotection. Neurol. Res. 26 (2004) 862-869
42. Uhl M.W., Kochanek P.M., Schiding J.K., and Nemoto E.M. Effect of phorbol myristate acetate on cerebral blood flow in normal and neutrophil-depleted rats. Stroke 24 (1993) 1977-1982
43. Vaccarino F.M., Liljequist S., and Tallman J.F. Modulation of protein kinase C translocation by excitatory and inhibitory amino acids in primary cultures of neurons. J. Neurochem. 57 (1991) 391-396
44. Vanden Hoek T., Becker L.B., Shhao Z.H., Li C.Q., and Schumacker P.T. Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ. Res. 86 (2000) 541-548
45. Yang G.Y., and Betz A.L. Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 25 (1994) 1658-1664
46. Yoshida K., Mizukami Y., and Kitakaze M. Nitric oxide mediates protein kinase C isoform translocation in rat heart during postischemic reperfusion. Biochem. Biophys. Acta 1453 (1999) 230-238
47. Zheng Z., and Yenari M.A. Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol. Res. 26 (2004) 884-892