Flavonoids on allergy

Current Pharmaceutical Design

Volumn 20, Issue 6, 2014, Pages 973-987

  Castell, Margarida ^a,b   Pérez Cano, Francisco J ^a,b   Abril Gil, Mar ^a,b   Franch, Àngels ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Institut de Recerca en Nutricio i Seguretat Alimentaria INSA UB   (Spain)

Author keywords

Asthma; Flavanol; Flavanone; Flavone; Flavonol; IgE; Mast cell; Rhinitis

Indexed keywords

ANTHOCYANIN; BAICALIN; BIOCHANIN A; CALCIUM; CATECHIN; CHRYSIN; EPICATECHIN; FISETIN; FLAVONOID; HESPERIDIN; ICOSANOID; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; ISOQUERCITRIN; KAEMPFEROL; LUTEOLIN; MEMBRANE RECEPTOR; MYRICETIN; NARINGENIN; NARIRUTIN; PROCYANIDIN; PROTEIN TYROSINE KINASE; PROVINOL; PYCNOGENOL; QUERCETIN; QUERCITRIN; RUTOSIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIMANG; VITEXIN;

ALLERGIC ASTHMA; ALLERGIC DISEASE; ALLERGIC RHINITIS; ALLERGY; ARTICLE; CALCIUM TRANSPORT; CYTOKINE PRODUCTION; DEGRANULATION; DRUG EFFECT; DRUG EFFICACY; EFFECTOR CELL; HUMAN; INTERVENTION STUDY; MAST CELL; MEDIATOR RELEASE; NONHUMAN; OBSERVATIONAL STUDY; PASSIVE SKIN ANAPHYLAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT ALLERGY; SIGNAL TRANSDUCTION; SYSTEMIC ANAPHYLAXIS;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; FLAVONOIDS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; RECEPTORS, IGE;

EID: 84895118579     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990041     Document Type: Article

References (139)

1. Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000; 63: 1035-42.
2. Grassi D, Desideri G, Croce G, Tiberti S, Aggio A, Ferri C. Flavonoids, vascular function and cardiovascular protection. Curr Pharm Des 2009; 15: 1072-84.
3. González R, Ballester I, López-Posadas R, et al. Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr 2011; 51: 331-62.
4. García-Tirado J, Rieger-Reyes C, Saz-Peiró P. Effect of flavonoids in the prevention of lung cancer: systematic review. Med Clin (Barc) 2012; 139: 358-63.
5. Kawai M, Hirano T, Higa S, et al. Flavonoids and related compounds as anti-allergic substances. Allergol Int 2007; 56: 113-23.
6. Corradini E, Foglia P, Giansanti P, Gubbiotti R, Samperi R, Lagana A. Flavonoids: chemical properties and analytical methodologies of identification and quantitation in foods and plants. Nat Prod Res 2011; 25: 469-95.
7. Crozier A, Del Rio D, Clifford MN. Bioavailability of dietary flavonoids and phenolic compounds. Mol Aspects Med 2010; 31: 446-67.
8. Yano S, Umeda D, Maeda N, Fujimura Y, Yamada K, Tachibana H. Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice. J Agric Food Chem 2006; 54: 5203-7.
9. Yano S, Umeda D, Yamashita T, et al. Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice. Eur J Nutr 2007; 46: 257-63.
10. Cruz EA, Da-Silva SAG, Muzitano MF, Silva PMR, Costa SS, Rossi-Bergmann B. Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol 2008; 8: 1616-21.
11. Horiuchi M, Seyama Y. Antiinflammatory and antiallergic activity of Bidens pilosa L. var. radiata Scherff. J Health Sci 2006; 52: 711-7.
12. Horiuchi M, Seyama Y. Improvement of the antiinflammatory and antiallergic activity of Bidens pilosa L. var. radiata SCHERFF treated with enzyme (Cellulosine). J Health Sci 2008; 54: 294-301.
13. Shimosaki S, Tsurunaga Y, Itamura H, Nakamura M. Anti-allergic effect of the flavonoid myricitrin from Myrica rubra leaf extracts in vitro and in vivo. Nat Prod Res 2011; 25: 374-80.
14. Abril-Gil M, Massot-Cladera M, Pérez-Cano FJ, Castellote C, Franch A, Castell M. A diet enriched with cocoa prevents IgE synthesis in a rat allergy model. Pharmacol Res 2012; 65: 603-8.
15. Sakai T, Furoku S, Nakamoto M, et al. The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice. J Nutr Sci Vitaminol (Tokyo) 2010; 56: 72-6.
16. Bae Y, Lee S, Kim SH. Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-B. Toxicol Appl Pharmacol 2011; 254: 56-64.
17. Shin YW, Bae EA, Lee B, et al. Antiallergic effect of two variants of Artemisia princeps Pampanini. Nat Prod Sci 2006; 12: 67-73.
18. Lee SH, Bae EA, Park EK, et al. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. Int Immunopharmacol 2007; 7: 1678-84.
19. Lee NK, Choi SH, Park SH, Park EK, Kim DH. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 2004; 71: 174-80.
20. Park SH, Park EK, Kim DH. Passive cutaneous anaphylaxisinhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliate. Planta Med 2005; 71: 24-7.
21. Yoo JM, Kim JH, Park SJ, Kang YJ, Kim TJ. Inhibitory effect of eriodictyol on IgE/Ag-induced type I hypersensitivity. Biosci Biotechnol Biochem 2012; 76: 1285-90.
22. Itoh T, Hori Y, Atsumi T, et al. Hot water extract of adzuki (Vigna angularis) suppresses antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. Phytother Res 2012; 26: 1003-11.
23. Maeda-Yamamoto M, Inagaki N, Kitaura J, et al. O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells. J Immunol 2004; 172: 4486-92.
24. Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 2002; 40: 158-68.
25. Sharma SC, Sharma S, Gulati OP. Pycnogenol inhibits the release of histamine from mast cells. Phytother Res 2003; 17: 66-9.
26. Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin Emediated allergic response in mast cells. Phytother Res 2009; 23: 1691-5.
27. Kim JW, Lee JH, Hwang BY, et al. Morin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo. Biochem Pharmacol 2009; 77: 1506-12.
28. Lee JH, Kim JW, Ko NY, et al. Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells. Clin Exp Allergy 2008; 38: 794-804.
29. Shin TY, Kim SH, Kim DK, Leem KH, Park JS. Phlomis umbrosa root inhibits mast cell-dependent allergic reactions and inflammatory cytokine secretion. Phytother Res 2008; 22: 153-8.
30. Kim CD, Lee WK, No KO, et al. Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract. Int Immunopharmacol 2003; 3: 129-36.
31. Ueda Y, Oku H, Iinuma M, Ishiguro K. Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. Biol Pharm Bull 2005; 28: 1786-90.
32. Won Jung H, Jung JK, Weon Cho C, Kang JS, Park YK. Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells. J Ethnopharmacol 2012; 142: 684-93.
33. Medeiros KCP, Figueiredo CAV, Figueredo TB, et al. Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbuminsensitized mice. J Ethnopharmacol 2008; 119: 41-6.
34. Venkatesh P, Mukherjee PK, Kumar NS, et al. Anti-allergic activity of standardized extract of Albizia lebbeck with reference to catechin as a phytomarker. Immunopharmacol Immunotoxicol 2010; 32: 272-6.
35. Frieri M. Asthma concepts in the new millennium: update in asthma pathophysiology. Allergy Asthma Proc 2005; 26: 83-8.
36. Jacobsen EA, Ochkur SI, Lee NA, Lee JJ. Eosinophils and asthma. Curr Allergy Asthma Rep 2007; 7: 18-26.
37. Lukacs NW. Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol 2001; 1: 108-16.
38. Mattes J, Foster PS. Regulation of eosinophil migration and Th2 cell function by IL-5 and eotaxin. Curr Drug Targets Inflamm Allergy 2003; 2: 169-74.
39. O'Byrne PM. Cytokines or their antagonists for the treatment of asthma. Chest 2006; 130: 244-50.
40. Kips JC. Cytokines in asthma. Eur Respir J 2001; 18: 24-33.
41. Renauld JC. New insights into the role of cytokines in asthma. J Clin Pathol 2001; 54: 577-89.
42. Boyce JA, Broide D, Matsumoto K, Bochner BS. Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol 2009; 123: 569-74.
43. Van Oosterhout JM, Bloksma N. Regulatory T-lymphocytes in asthma. Eur Respir J 2005; 26: 918-32.
44. Du Q, Gu X, Cai J, Huang M, Su M. Chrysin attenuates allergic airway inflammation by modulating the transcription factors T-bet and GATA-3 in mice. Molec Med Reports 2012; 6: 100-4.
45. Das M, Ram A, Ghosh B. Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice. Inflammation Res 2003; 52: 101-6.
46. Ko WC, Lin LH, Shen HY, Lai CY, Chen CM, Shih CH. Biochanin A, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Alternat Med, 2011; 2011: 635058.
47. Park HJ, Lee CM, Jung ID, et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol 2009; 9: 261-7.
48. Chandrakant NC, Joshi AA. Anti-asthmatic and anti-anaphylactic activity of Helicanthus elastica Desr. Pharmacologyonline 2010: 2: 14-31.
49. Cruz EA, Reuter S, Martin H, et al. Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease. Phytomedicine 2012, 19: 115-21.
50. Rogerio AP, Kanashiro A, Fontanari C, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res 2007; 56: 402-8.
51. Joskova M, Franova S, Sadlonova V. Acute bronchodilator effect of quercetin in experimental allergic asthma. Bratisl Lek Listy 2011; 112: 9-12.
52. Rogerio AP, Dora CL, Andrade EL, et al. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res 2010; 61: 288-97.
53. Medeiros KC, Faustino L, Borduchi E, et al. Preventive and curative glycoside kaempferol treatments attenuate the TH2-driven allergic airway disease. Int Immunopharmacol 2009; 9: 1540-8.
54. Wu MY, Hung SK, Fu SL. Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF- B activity. J Agric Food Chem 2011; 59: 10496-504.
55. Shin IS, Lee MY, Lim HS, et al. An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma. PLoS ONE 2012; 7: e45734.
56. Kim JJ, Jiang J, Shim DW, et al. Anti-inflammatory and antiallergic effects of Agrimonia pilosa Ledeb extract on murine cell lines and OVA-induced airway inflammation. J Ethnopharmacol 2012; 140: 213-21.
57. Franova S, Joskova M, Sutovska M, et al. The efficiency of polyphenolic compounds on allergen induced hyperreactivity of the airways. Biomed Prev Nutr 2011; 1: 232-5.
58. Funaguchi N, Ohno Y, La BLB, et al. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol Physiol 2007; 34: 766-70.
59. Kim SH, Kim BK, Lee YC. Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma. Mediators Inflamm 2011; 2011: 485402.
60. Wei D, Ci X, Chu X, Wei M, Hua S, Deng X. Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model. Inflammation 2012; 35: 114-21.
61. Ok IS, Kim SH, Kim BK, Lee JC, Lee YC. Pinellia ternata, Citrus reticulata, and their combinational prescription inhibit eosinophil infiltration and airway hyperresponsiveness by suppressing CCR3+ and Th2 cytokines production in the ovalbumin-induced asthma model. Mediators Inflamm, 2009; 2009: 413270.
62. Oh HA, Kim HM, Jeong HJ. Alleviation of allergic rhinitis symptoms with Pyeongwee-San extract (KMP6). Immunopharmacol Immunotoxicol 2012; 34: 135-42.
63. Shi Y, Dai J, Liu H, et al. Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF- B activity in a murine model of asthma. Can J Physiol Pharmacol 2009; 87: 729-35.
64. Abdureyim S, Amat N, Umar A, Upur H, Berke B, Moore N. Antiinflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of Ravan Napas, a formulation of Uighur traditional medicine, in a rat model of allergic asthma. Evid Based Complement Alternat Med. 2011; 2011: 725926.
65. Hosseini S, Pishnamazi S, Sadrzadeh SMH, Farid F, Farid R, Watson RR. Pycnogenol in the management of asthma. J Med Food 2001; 4: 201-9.
66. Lau BHS, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma 2004; 41: 825-32.
67. Belcaro G, Luzzi R, Cesinaro Di Rocco P, et al. Pycnogenol® improvements in asthma management. Panminerva Med 2011; 53: 57-64.
68. Alvarez A, Sanchez C, García D, et al. Treatment of bronchial asthma with an aqueous extract of Mangifera indica L. (VIMANG®): Two cases report. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 2009; 8: 63-6.
69. Watson RR, Zibadi S, Rafatpanah H, et al. Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma. Nutr Res 2008; 28: 166-71.
70. Laekeman G, Simoens S, Buffels J, et al. Continuous versus ondemand pharmacotherapy of allergic rhinitis: evidence and practice. Respir Med 2010; 104: 615-25.
71. Kawai, M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: A randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol 2009; 149: 359-68.
72. Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int 2009; 58: 373-82.
73. Segawa S, Takata Y, Wakita Y, et al. Clinical effects of a hop water extract on Japanese cedar pollinosis during the pollen season: a double-blind, placebo-controlled trial. Biosci Biotechnol Biochem 2007; 71: 1955-62.
74. Enomoto T, Nagasako-Akazome Y, Kanda T, Ikeda M, Dake Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol 2006; 16: 283-9.
75. Wilson D, Evans M, Guthrie N, et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of Pycnogenol® for improving allergic rhinitis symptoms. Phytother Res 2010; 24: 1115-9.
76. Yoshimura M, Enomoto T, Dake Y, et al. An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int 2007; 56: 225-30.
77. Ryu Y, Fukuwatari Y, Sato N, et al. Scientific approach to preventive medicine-basic and clinical studies of anti-allergy activity and efficacy for prevention of allergy to cedar pollen of tomato skin extracts. Eastern Med 2003; 18: 39-54.
78. Hu G, Walls RS, Bass D, et al. The Chinese herbal formulation Biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trial. Ann Allergy Asthma Immunol 2002; 88: 478-87.
79. Shaheen SO, Sterne JAC, Thompson RL, Songhurst CE, Margetts BM, Burney PGJ. Dietary antioxidants and asthma in adults: population-based case-control study. Am J Respir Crit Care Med 2001; 164: 1823-8.
80. Garcia V, Arts ICW, Sterne JAC, Thompson RL, Shaheen SO. Dietary intake of flavonoids and asthma in adults. Eur Respir J 2005; 26: 449-52.
81. Knekt P, Kumpulainen J, Järvinen R, et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002; 76: 560-8.
82. Butland BK, Fehily AM, Elwood PC. Diet, lung function, and lung function decline in a cohort of 2512 middle aged men. Thorax 2000; 55: 102-8.
83. Magrone T, Jirillo E. Influence of polyphenols on allergic immune reactions: mechanisms of action. Proc Nutr Soc 2012; 71: 316-21.
84. Cheong H, Ryu SY, Oak MH, Cheon SH, Yoo GS, Kim KM. Studies of structure activity relationship of flavonoids for the antiallergic actions. Arch Pharm Res 1998; 21: 478-80.
85. Kawasaki M, Toyoda M, Teshima R, et al. In vitro antiallergic activity of flavonoids in histamine release assay using rat basophilic leukemia (RBL-2H3) cells. J Food Hyg Soc Japan 1994; 35: 497-503.
86. Mastuda H, Morikawa T, Ueda K, Managi H, Yoshikawa M. Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF- and IL-4 production from RBL-2H3 cells. Bioorg Med Chem 2002; 10: 3123-8.
87. Choi YH, Yan GH. Ellagic acid attenuates immunoglobulin Emediated allergic response in mast cells. Biol Pharm Bull 2009; 32: 1118-21.
88. Li GZ, Chai OH, Song CH. Inhibitory effects of epigallocatechin gallate on compound 48/80-induced mast cell activation and passive cutaneous anaphylaxis. Exp Mol Med. 2005; 37: 290-6.
89. Nakano N, Nishiyama C, Tokura T, et al. Procyanidin C1 from apple extracts inhibits Fc RI-mediated mast cell activation. Int Arch Allergy Immunol 2008; 147: 213-21.
90. Middleton E, Drzewiecki G. Flavonoid inhibition of human basophil histamine release stimulated by various agents. Biochem Pharmacol 1984; 33: 3333-8.
91. Huber R, Stintzing FC, Briemle D, Beckmann C, Meyer U, Gründemann C. In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits. Planta Med 2012; 78: 334-40.
92. Lim BO. Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator production of peritoneal exudate cells and immunoglobulin E level of mesenteric lymph node lymphocytes in Sprague-Dawley rats. Phytother Res 2002; 16: 166-70.
93. Park EK, Shin YW, Lee HU, Lee CS, Kim DH. Passive cutaneous anaphylaxis-inhibitory action of tectorigenin, a metabolite of tectoridin by intestinal microflora. Biol Pharm Bull 2004; 27: 1099-102.
94. Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin Emediated mediator release from human cultured mast cells. Clin Exp Allergy 2000; 30: 501-8.
95. Castellani ML, Kempuraj D, Frydas S, et al. Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Neuroimmunomodulation 2006; 13: 179-86.
96. Kimata M, Inagaki N, Nagai H. Effects of luteolin and other flavonoids on IgE-mediated allergic reactions. Planta Med 2000; 66: 25-9.
97. Haggag EG, Abou-Moustafa MA, Boucher W, Theoharides TC. The effect of a herbal water-extract on histamine release from mast cells and on allergic asthma. J Herbal Pharmacother 2003; 3: 41-54.
98. Kaneko M, Kanesaka M, Yoneyama M, Tominaga T, Jirillo E, Kumazawa Y. Inhibitory effects of fermented grape marc from Vitis vinifera Negroamaro on antigen-induced degranulation. Immunopharmacol Immunotoxicol 2010; 32: 454-61.
99. Chen S, Gong J, Liu F, Mohammed U. Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation. Immunology 2000; 100: 471-80.
100. Park HH, Lee S, Son HY, et al. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res 2008; 31: 1303-11.
101. Kempuraj D, Madhappan B, Christodoulou S, et al. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol 2005; 145: 934-44.
102. Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y. Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. Bioorg Med Chem 2008; 16: 4500-8.
103. Isoda H, Motojima H, Margout D, et al. Antiallergic effect of Picholine olive oil-in-water emulsions through -hexosaminidase release inhibition and characterization of their physicochemical properties. J Agric Food Chem 2012; 60: 7851-8.
104. Ogasawara H, Fujitani T, Drzewiecki G, Middleton E. The role of hydrogen peroxide in basophil histamine release and the effect of selected flavonoids. J Allergy Clin Immunol 1986; 78: 321-8.
105. Kaneko H, Kawamura H, Kumagai T, et al. Inhibitory effect of rice (Oryza sativa) polyphenols on degranulation of rat basophilic leukemia cell line RBL-2H3. Nippon Shokuhin Kagaku Kogaku Kaishi 2006; 53: 416-22.
106. Weng Z, Zhang B, Asadi S, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS ONE 2012; 7: 33805
107. Sun-Yup S, Park JR, Byun DS. 6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of Fc RI chain expression. J Microbiol Biotechnol 2012; 22: 622-7.
108. Murata K, Takano S, Masuda M, Iinuma M, Matsuda H. Antidegranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits. J Nat Med 2012 (in press).
109. Vafeiadou K, Vauzour D, Spencer JPE. Neuroinflammation and its modulation by flavonoids. Endocr Metab Immune Disord Drug Targets 2007; 7: 211-24.
110. Higa S, Hirano T, Kotani M, et al. Fisetin, a flavonol, inhibits TH2- type cytokine production by activated human basophils. J Allergy Clin Immunol 2003; 111: 1299-306.
111. Hirano T, Higa S, Arimitsu J, et al. Luteolin, a flavonoid, inhibits AP-1 activation by basophils. Biochem Biophys Res Commun 2006; 340: 1-7.
112. Hirano T, Higa S, Arimitsu J, et al. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin13 production by activated human basophils. Int Arch Allergy Immunol 2004; 134: 135-40.
113. Kandere-Grzybowska K, Kempuraj D, Cao J, Cetrulo CL, Theoharides TC. Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol 2006; 148: 208-15
114. Nauta AJ, Engels F, Knippels LM, Garssen J, Nijkamp FP, Redegeld FA. Mechanisms of allergy and asthma. Eur J Pharmacol 2008; 585: 354-60.
115. Kwak WJ, Moon TC, Lin CX, et al. Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. Biol Pharm Bul 2003; 26: 299-302.
116. Lim BO. Effects of wogonin, wogonoside, and 3,5,7,2',6'- pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes. J Ethnopharmacol 2003; 84: 23-9.
117. Ott VL, Cambier JC. Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention? J Allergy Clin Immunol 2000; 106: 429-40.
118. Blank U, Ra C, Miller L, White K, Metzger H, Kinet JP. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 1989; 337: 187-9.
119. Eiseman E, Bolen JB. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 1992; 355: 78-80.
120. Schneider E, Thieblemont N, De Moraes ML, Dy M. Basophils: New players in the cytokine network. Eur Cytokine Network 2010; 21: 142-53
121. Yano S, Tachibana H, Yamada K. Flavones suppress the expression of the high-affinity IgE receptor FC RI in human basophilic KU812 cells. J Agric Food Chem 2005; 53: 1812-7.
122. Shim SY, Choi JS, Byun DS. Kaempferol isolated from Nelumbo nucifera stamens negatively regulates Fc RI expression in human basophilic KU812F cells. J Microbiol Biotechnol 2009; 19: 155-60.
123. Tamura S, Yoshihira K, Fujiwara K, Murakami N. New inhibitors for expression of IgE receptor on human mast cell. Bioorg Med Chem Lett 2010; 20: 2299-302.
124. Tamura S, Yoshihira K, Tokumaru M, Zisheng X, Murakami N. Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos. Bioorg Med Chem Lett 2010; 20: 3872-5.
125. Yamashita S, Tsukamoto S, Kumazoe M, Kim YH, Yamada K, Tachibana H. Isoflavones suppress the expression of the Fc RI high-affinity immunoglobulin E receptor independent of the estrogen receptor. J Agric Food Chem 2012 (in press)
126. Fujimura Y, Yamada K, Tachibana H. A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on Fc RI expression. Biochem Biophys Res Commun 2005; 336: 674-81.
127. Fujimura Y, Umeda D, Kiyohara Y, Sunada Y, Yamada K, Tachibana H. The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate. Biochem Biophys Res Commun 2006; 348: 524-31.
128. Gauchat JF, Henchoz S, Mazzei G, et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 1993; 365: 340-3.
129. Nüsslein HG, Frosch KH, Woith W, Lane P, Kalden JR, Manger B. Increase of intracellular calcium is the essential signal for the expression of CD40 ligand. Eur J Immunol 1996; 26: 846-50.
130. Lee EJ, Ji GE, Sung MK. Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells. Inflamm Res 2010; 59: 847-54.
131. Chirumbolo S, Conforti A, Ortolani R, Vella A, Marzotto M, Bellavite P. Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin. Int Immunopharmacol 2010; 10: 183-92.
132. Wong BR, Grossbard EB, Payan DG, Masuda ES. Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opin Investig Drugs 2004; 13: 743-62.
133. Shichijo M, Yamamoto N, Tsujishita H, Kimata M, Nagai H, Kokubo T. Inhibition of Syk activity and degranulation of human mast cells by flavonoids. Biol Pharm Bul 2003; 26: 1685-90.
134. Park DK, Choi WS, Park HJ. Antiallergic activity of novel isoflavone methyl-glycosides from Cordyceps militaris grown on germinated soybeans in antigen-stimulated mast cells. J Agric Food Chem 2012; 60: 2309-15.
135. Oh JY, Choi WS, Lee CH, Park HJ. The ethyl acetate extract of Cordyceps militaris inhibits IgE-mediated allergic responses in mast cells and passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol 2011; 135: 422-9.
136. Agullo G, Gamet-Payrastre L, Manenti S, et al. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 1997; 53: 1649-57.
137. Lee JH, Kim JW, Ko NY, et al. Mast cell-mediated allergic response is suppressed by Sophorae flos: inhibition of SRC-family kinase. Exp Biol Med (Maywood) 2008; 233: 1271-9.
138. Kim SH, Kwon TK, Shin TY. Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model. Exp Biol Med (Maywood) 2008; 233: 192-9.
139. Rasheed Z, Akhtar N, Anbazhagan AN, Ramamurthy S, Shukla M, Haqqi TM. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cells. J Inflamm (Lond) 2009; 6: 1.