Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice

European Journal of Nutrition

Volumn 46, Issue 5, 2007, Pages 257-263

  Yano, Satomi ^a   Umeda, Daisuke ^a   Yamashita, Tatsunori ^a   Ninomiya, Yu ^a   Sumida, Mami ^a   Fujimura, Yoshinori ^a   Yamada, Koji ^a   Tachibana, Hirofumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Apigenin; BALB c mice; Chrysin; Th2 cytokines

Indexed keywords

APIGENIN; CHRYSIN; CYTOKINE; FLAVONE DERIVATIVE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 13; INTERLEUKIN 4; MESSENGER RNA; OVALBUMIN;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; DOWN REGULATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDING; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; IN VIVO STUDY; LYMPHOCYTE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; SPLEEN; TH2 CELL; UPREGULATION;

ANIMALS; APIGENIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONES; FLAVONOIDS; FRUIT; IMMUNITY, CELLULAR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; TH2 CELLS; VEGETABLES;

MUS;

EID: 34547173554     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-007-0658-7     Document Type: Article

References (20)

1. Avila MA, Velasco JA, Cansado J, Notario V (1994) Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Cancer Res 54:2424-2428
2. Gerritsen ME, Carley WW, Ranges GE, Shen CP, Phan SA, Ligon GF, Perry CA (1995) Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am J Pathol 147:278-292
3. Yano S, Tachibana H, Yamada K (2005) Flavones suppress the expression of the high-affinity IgE receptor FcεRI in human basophilic KU812 cells. J Agric Food Chem 53:1812-1817
4. Yano S, Umeda D, Maeda N, Fujimura Y, Yamada K, Tachibana H (2006) Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice. J Agric Food Chem 54:5203-5207
5. Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY, Lin JK (2001) Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-γ by flavonoids in mouse macrophages. FEBS Lett 496:2-18
6. Fujimura Y, Tachibana H, Yamada K (2002) Peroxisome proliferator- activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor FcεRI in human basophilic KU812 cells. Biochem Biophys Res Commun 297:193-201
7. Miyazaki Y, Tachibana H, Yamada K (2002) Inhibitory effect of peroxisome proliferator-activated receptor-γ ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. Biochem Biophys Res Commun 295:547-552
8. Reeves PG, Nielsen FH, Fahey GC Jr (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951
9. Fujimura Y, Tachibana H, Eto N, Yamada K (2000) Antigen binding of an ovomucoid-specific antibody is affected by a carbohydrate chain located on the light chain variable region. Biosci Biotechnol Biochem 64:2298-2305
10. H1 clones. J Immunol 138:3688-3694
11. Mosmann TR, Coffman RL (1989) Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 46:111-147
12. Fiorentino DF, Bond MW, Mosmann TR (1989) Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170:2081-2095
13. Gieni RS, Yang X, HayGlass KT (1993) Allergen-specific modulation of cytokine synthesis patterns and IgE responses in vivo with chemically modified allergen. J Immunol 150:302-310
14. Holgate ST (1999) The allergy and asthma. Nature 402:B2-B4
15. Corry DB, Kheradmand F (1999) Induction and regulation of the IgE response. Nature 402:B18-B23
16. Kotani M, Matsumoto M, Fujita A, Higa S, Wang W, Suemura M, Kishimoto T, Tanaka T (2000) Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol 106:159-166
17. Quelle FW, Shimoda K, Thierfelder W (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 15:3336-3343
18. Schindler U, Wu P, Rothe M, Brasseur M, McKnight SL (1995) Components of a Stat recognition code: Evidence for two layers of molecular selectivity. Immunity 2:689-697
19. Tachibana H, Kubo T, Miyase T, Tanino S, Yoshimoto M, Sano M, Yamamoto-Maeda M, Yamada K (2001) Identification of an inhibitor for interleukin 4-induced ε germline transcription and antigen-specific IgE production in vivo. Biochem Biophys Res Commun 280:53-60
20. Gangur V, Oppenheim JJ (2000) Are chemokines essential or secondary participants in allergic responses? Ann Allergy Asthma Immunol 84:569-581