Pycnogenol® inhibits the release of histamine from mast cells

Phytotherapy Research

Volumn 17, Issue 1, 2003, Pages 66-69

  Sharma, S C ^a   Sharma, S ^b   Gulati, O P ^c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ADELAIDE AND MEATH HOSPITAL   (Ireland)

^c Horphag Research   (Switzerland)

Author keywords

Bioflavonoids; Free radicals; Histamine; Mast cell; Pinus pinaster; Pycnogenol ; Sodium cromoglycate

Indexed keywords

BIOFLAVONOID; CALCIMYCIN; CALCIUM IONOPHORE; CROMOGLYCATE DISODIUM; HISTAMINE; PLANT EXTRACT; PYCNOGENOL; SCAVENGER; 4 METHOXY N METHYLPHENETHYLAMINE; DIAGNOSTIC AGENT; FLAVONOID; HISTAMINE H1 RECEPTOR ANTAGONIST; PYCNOGENOLS;

ANIMAL CELL; ARTICLE; BARK; CELL ISOLATION; CONTROLLED STUDY; DRUG POTENCY; EXTRACTION; FLUOROMETRY; HISTAMINE RELEASE; MALE; MAST CELL; NONHUMAN; PERITONEUM CELL; PINE; RAT STRAIN; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; IC 50; PHYTOTHERAPY; RAT; WISTAR RAT;

ANIMALIA; PINUS PINASTER;

ANIMALS; CALCIMYCIN; CROMOLYN SODIUM; FLAVONOIDS; HISTAMINE; HISTAMINE H1 ANTAGONISTS; INHIBITORY CONCENTRATION 50; MALE; MAST CELLS; P-METHOXY-N-METHYLPHENETHYLAMINE; PHYTOTHERAPY; PINUS; PLANT BARK; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 0037208250     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1240     Document Type: Article

References (47)

1. Akagi M, Fukuishi N, Sakaguchi M, Matsui N, Takahashi H. 1998. Role of superoxide generation and degradation of mast cells in allergic inflammation. Nippon Yakaurigaku Zasshi 112(Suppl 1): 73-77.
2. Al-Shabanah OA, Mansour MA, Elmazar MM. 1999. Enhanced generation of leukotriene B4 and superoxide radical from calcium ionophore (A23187) stimulated human neutrophils after priming with interferon-alpha. Res Commun Mol Pathol Pharmacol 106: 115-128.
3. Babe KS jr, Serafin WE. 1995. Histamine, bradykinin and their antagonists. In The Pharmacological Basis of Therapeutics Hardman JC, Limbird LE, Molinoff PB, Rudden RW, Gilman AG (eds) McGraw-Hill: New York, 581-600.
4. Bito T, Roy S, Sen CK, Packer L. 2000. Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression. Free Rad Biol Med 28: 219-227.
5. Blazso G, Gabor M, Sibbel R, Rohdewald P. 1994. Antiinflammatory and superoxide radical scavenging activities of procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol 3: 217-220.
6. Blazso G, Gabor M, Rohdewald P. 1997. Antiinflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application. Pharmazie 52: 380-382.
7. Blazso G, Gaspar R, Gabor M. 1996. Procyanidins containing extract from the bark of Pinus pinaster. Sol. Pharm Pharmacol Lett 6: 8-11.
8. Broad LM, Armstrong DL, Puteny JW. 1999. Role of the inositol 1,4,5-trisphosphate receptor in Ca(2+) feedback inhibition of calcium release-activated calcium current (l(crac)). J Biol Chem 274: 32881-32888.
9. Cho KJ, Yun CH, Yoon DY et al. 2000. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide stimulated RAW 264.7. Toxicol Appl Pharmacol 168: 64-71.
10. Cockcroft S, Gomperts BD. 1979. Evidence for a role of phosphatidylinositol turnover in stimulus secretion coupling. Biochem J 178: 681-687.
11. Di Bello MG, Masini E, Ioannides C et al. 1998. Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals. Inflamm Res 47: 122-130.
12. Di Lorenzo G, Drago A, Esposito Pelliteri G et al. 2001. Measurement of inflammatory mediators of mast cells in eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol 125: 164-175.
13. Elstner FE, Kleber E. 1990. Radical scavenger properties of leucocyanidin. In Flavonoids in Biology and Medicine III: Current Issues in Flavonoid Research, Das MP (ed.) Natural University of Singapore Press: Singapore 227-235.
14. Ezeamuzi CI, Al-Hage M. 1998. Effect of some anti-asthma drugs on human eosinophils superoxide anions release and degranulation. Int Arch Allergy Immunol 115: 162-168.
15. Foreman JC, Monge JL, Gomperts BD. 1973. Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature 245:249-251.
16. Franzius D, Hoth M, Penner R. 1994. Non-specific effects of calcium entry antagonists in mast cells. Pflugers Arch 428: 433-438.
17. Fukuishi N, Matsuura S, Nakagawa C, Akagi R, Akagi M. 1997. The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells. Biochem Mol Med 61: 107-113.
18. Goldhaber JI, Qayyum MS. 2001. Oxygen free radicals and excitation-contraction coupling. Antioxid Redox signal 2: 55-64.
19. Hoth M, Perner R. 1992. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 23: 353-356.
20. Johnson AR, Moran NC. 1969. The selective release of histamine from rat mast cells by compound 48/80 and antigen. Amr J Physiol 216: 453-459.
21. Josephson RA, Silverman HS, Lakatta EG, Stern MD, Zweier JL. 1991. Study of the mechanism of hydrogen peroxide and hydroxyl free-radical induced cellular injury and calcium overload in cardiac muscles. J Biol Chem 266: 2354-2362.
22. Kassel O, Amrani Y, Landry Y, Bronner C. 1995. Mast cell activation involves membrane potential- and thapsigargin-sensitive intracellular calcium pools. Fundam Clin Pharmacol 9: 531-539.
23. Kilpatrick LE, Jakazbovics E, McCawley LJ, Kane LH, Korchak HM. 1995. Cromolyn inhibits assembly of the NADPH oxidase and superoxide anion generation by human neutrophils. J Immunol. 154: 3429-3436.
24. Knol EE, Mul FP, Lie WJ, Verhoeven AJ, Roos D. 1996. The role of basophils in allergic disease. Eur Respir J Suppl 126S-131S.
25. +-pump in rat peritoneal mast cells: some aspects of regulation of activity and cellular function. Dan Med Bull 42: 441-454.
26. Kuno M, Kawaguchi J, Nakamura F. 1990. PT pretreatment inhibits compound 48/80 activation of Ca(+)-permeable channels in rat peritoneal mast cells. Am J Physiol. 259(5 Pt 1): C715-722.
27. Lagunoff D, Chi EY. 1978. Mast cell secretion: membrane events. J Invest Dermatol 71: 81-84.
28. Masini E, Giannella E, Palmerani B, Pistelli A, Gambassi F, Mannaioni PF. 1989. Prostaglandin H synthetase activates xenobiotics into free radicals: histamine release and biochemical characteristics. Int Arch Allergy Appl Immunol 88: 134-135.
29. Masini E, Palmerani B, Gambassi F et al. 1990. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. Biochem Pharmacol 39: 879-889.
30. Murphy S, Kelly HW. 1987. Cromolyn sodium: a review of mechanisms and clinical use in asthma. Drugs Intell Clin Pharm 21:22-35.
31. Okabe E, Odajima C, Taga R, Kukreja RC, Hess ML, Ito H. 1988. The effect of oxygen free radicals on calcium permeability and calcium loading at steady state in cardiac sarcoplasmic reticulum. Mol Pharmacol 34: 388-394.
32. Packer L, Rimbach G, Virgili F. 1999. Antioxidant activity and biological properties of a procyanidine rich extract from the pine (Pinus maritime) bark, Pycnogenol. Free Rad Biol Med 27: 704-724.
33. Pearce FL, Atkinson G, Madeleine E, Truneh A, Weston PM, White JR. 1979. Effect of antiallergic compounds on histamine release induced by basic agents, antigen and the calcium ionophore A23187. In The Mast Cell. Its Role in Health and Disease, (Pepys J, Edward AM (eds). Pitman Medical: UK, 69-75.
34. Poch B, Gansauge F, Gansauge S et al. 1996. Release of histamine in whole blood by oxygen radicals: division between specific and unspecific processes. Inflamm Res 45: 428-433.
35. Rihn B, Saliou C, Bottin MC, Keith G, Parker L. 2001. From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited. Phytother Res 15: 76-79.
36. Rohdewald P. 1998. In Flavonoids in Health and Disease, Rice Evans CA, Packer L (eds). Dekker Inc: New York 405-419.
37. Rohdewald P. 1999. Bioavailability and metabolism of Pycnogenol®. Eur Bull Drug Res 7: 5-7.
38. Saliou C, Valacchi G, Rimbach G. 2001. Assessing bioflavonoids as regulators of NF-kappa β activity and inflammatory gene expression in mammalian cells. Methods Enzymol 335: 380-387.
39. Shapiro GG, Konig P 1985. Cromolyn sodium: a review. Pharmacotherapy 5: 281-288.
40. Sharma SC, Jande MB. 1989. Inhibition of mast cell histamine release by copper. Arch Int Pharmacodyn Ther 299: 254-268.
41. Sharma SC. 2001. Effect of pycnogenol on mast cell histamine release. Br Pharmacol Soc Meeting Dublin, Ireland. 2-5 July, P 44 abstract.
42. Suzuki T, Mori K, Uchida M. 1982. Inhibition by calcium antagonists of histamine release by concanavalin A and compound 48/80. Eur J Pharmacol 85: 155-161.
43. Taniguchi K, Urakami M, Takanaka K. 1987. Effect of antiallergic agents on polymorphonuclear leukocytes. The inhibition of arachidonic acid release and superoxide production. Nippon Yakurigaku Zasshi 90: 97-103.
44. Virgili F, Kobuchi H, Packer L. 1998. Procyanidins extracted from Pinus maritima (Pycnogenol): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine Raw 264.7 macrophages. Free Rad Biol Med 24: 1120-1129.
45. Wakelin SH. 2001. Contact urticaria. Clin Exp Dermatol 26: 132-134.
46. Wang DY, Clement P. 2000. Pathogenic mechanisms underlying the clinical symptoms of allergic rhinitis. Am J Rhinol 14: 325-333.
47. Xu JH, Wu HS, Li L. 1994. 4-Aminopyridine induced histamine release and its antagonism by certain drugs. Yao Xue Bao 29: 176-179.