메뉴 건너뛰기




Volumn 4, Issue , 2014, Pages

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TUMOR PROTEIN;

EID: 84894768842     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04186     Document Type: Article
Times cited : (35)

References (60)
  • 1
    • 19544379515 scopus 로고    scopus 로고
    • BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer
    • Taron, M. et al. BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer. Hum Mol Genet 13, 2443-9 (2004).
    • (2004) Hum Mol Genet , vol.13 , pp. 2443-2529
    • Taron, M.1
  • 2
    • 67649431893 scopus 로고    scopus 로고
    • Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
    • Rosell, R. et al. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS One 4, e5133 (2009).
    • (2009) PLoS One , vol.4
    • Rosell, R.1
  • 3
    • 84858785336 scopus 로고    scopus 로고
    • ERCC1 and BRAC1 mRNA expression levels in the primary tumor could predict the effectiveness of the second-line cisplatin-based chemotherapy in pretreated patients with metastatic non-small cell lung cancer
    • Papadaki, C. et al. ERCC1 and BRAC1 mRNA expression levels in the primary tumor could predict the effectiveness of the second-line cisplatin-based chemotherapy in pretreated patients with metastatic non-small cell lung cancer. J Thorac Oncol 7, 663-71 (2012).
    • (2012) J Thorac Oncol , vol.7 , pp. 663-671
    • Papadaki, C.1
  • 4
    • 78751584929 scopus 로고    scopus 로고
    • Correlation of BRCA1, TXR1 and TSP1mRNAexpression with treatment outcome to docetaxel-based first-line chemotherapy in patients with advanced/metastatic non-small-cell lung cancer
    • Papadaki, C. et al. Correlation of BRCA1, TXR1 and TSP1mRNAexpression with treatment outcome to docetaxel-based first-line chemotherapy in patients with advanced/metastatic non-small-cell lung cancer. Br J Cancer 104, 316-23 (2011).
    • (2011) Br J Cancer , vol.104 , pp. 316-323
    • Papadaki, C.1
  • 5
    • 58149177773 scopus 로고    scopus 로고
    • Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non- small-cell lung cancer patients
    • Boukovinas, I. et al. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non- small-cell lung cancer patients. PLoS One 3, e3695 (2008).
    • (2008) PLoS One , vol.3
    • Boukovinas, I.1
  • 6
    • 42549088992 scopus 로고    scopus 로고
    • BRCA1: A novel prognostic factor in resected non-small-cell lung cancer
    • Rosell, R. et al. BRCA1: a novel prognostic factor in resected non-small-cell lung cancer. PLoS One 2, e1129 (2007).
    • (2007) PLoS One , vol.2
    • Rosell, R.1
  • 7
    • 78650376422 scopus 로고    scopus 로고
    • BRCA1 mRNA expression and outcome to neoadjuvant cisplatinbased chemotherapy in bladder cancer
    • Font, A. et al. BRCA1 mRNA expression and outcome to neoadjuvant cisplatinbased chemotherapy in bladder cancer. Ann Oncol 22, 139-44 (2011).
    • (2011) Ann Oncol , vol.22 , pp. 139-144
    • Font, A.1
  • 8
    • 58149460399 scopus 로고    scopus 로고
    • The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer
    • Weberpals, J. et al. The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer. Int J Cancer 124, 806-15 (2009).
    • (2009) Int J Cancer , vol.124 , pp. 806-815
    • Weberpals, J.1
  • 9
    • 0026648940 scopus 로고
    • ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients
    • Dabholkar, M. et al. ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. J Natl Cancer Inst 84, 1512-7 (1992).
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1512-1517
    • Dabholkar, M.1
  • 10
    • 0037243405 scopus 로고    scopus 로고
    • Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway
    • DOI 10.1016/S1470-2045(03)00959-8
    • Middleton, M. R. & Margison, G. P. Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway. Lancet Oncol 4, 37-44 (2003). (Pubitemid 36124189)
    • (2003) Lancet Oncology , vol.4 , Issue.1 , pp. 37-44
    • Middleton, M.R.1    Margison, G.P.2
  • 11
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343, 1350-4 (2000).
    • (2000) N Engl J Med , vol.343 , pp. 1350-1414
    • Esteller, M.1
  • 12
  • 13
    • 84862535291 scopus 로고    scopus 로고
    • DNA methylation biomarkers in cancer: Progress towards clinical implementation
    • Mikeska, T., Bock, C., Do, H. & Dobrovic, A. DNA methylation biomarkers in cancer: progress towards clinical implementation. Expert Rev Mol Diagn 12, 473-87 (2012).
    • (2012) Expert Rev Mol Diagn , vol.12 , pp. 473-487
    • Mikeska, T.1    Bock, C.2    Do, H.3    Dobrovic, A.4
  • 14
    • 84870218588 scopus 로고    scopus 로고
    • DNA repair dysregulation from cancer driver to therapeutic target
    • Curtin, N. J. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer 12, 801-17 (2012).
    • (2012) Nat Rev Cancer , vol.12 , pp. 801-817
    • Curtin, N.J.1
  • 15
    • 77955450160 scopus 로고    scopus 로고
    • The implications of heterogeneousDNA methylation for the accurate quantification of methylation
    • Mikeska, T.,Candiloro, I.&Dobrovic, A. The implications of heterogeneousDNA methylation for the accurate quantification of methylation. Epigenomics 2, 561-573 (2010).
    • (2010) Epigenomics , vol.2 , pp. 561-573
    • Mikeska, T.1    Candiloro, I.2    Dobrovic, A.3
  • 17
    • 34548668191 scopus 로고    scopus 로고
    • Optimal primer design using the novel primer design program: MSPprimer provides accurate methylation analysis of the ATM promoter
    • DOI 10.1038/sj.onc.1210433, PII 1210433
    • Brandes, J. C., Carraway, H. & Herman, J. G. Optimal primer design using the novel primer design program:MSPprimer provides accurate methylation analysis of the ATM promoter. Oncogene 26, 6229-37 (2007). (Pubitemid 47414370)
    • (2007) Oncogene , vol.26 , Issue.42 , pp. 6229-6237
    • Brandes, J.C.1    Carraway, H.2    Herman, J.G.3
  • 18
    • 34247849498 scopus 로고    scopus 로고
    • Methylation-sensitive high resolution melting (MS-HRM): A new approach for sensitive and high-throughput assessment of methylation
    • Wojdacz, T. K. & Dobrovic, A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res 35, e41 (2007).
    • (2007) Nucleic Acids Res , vol.35
    • Wojdacz, T.K.1    Dobrovic, A.2
  • 20
    • 78649317775 scopus 로고    scopus 로고
    • DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast
    • Huang, K. T. et al. DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast. Breast Cancer Res Treat 124, 555-65 (2010).
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 555-565
    • Huang, K.T.1
  • 21
    • 78650803552 scopus 로고    scopus 로고
    • Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early- onset breast cancer
    • Wong, E. M. et al. Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early- onset breast cancer. Cancer Prev Res (Phila) 4, 23-33 (2011).
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 23-33
    • Wong, E.M.1
  • 22
    • 84862735041 scopus 로고    scopus 로고
    • No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia
    • Mikeska, T., Carney, D. A., Seymour, J. F. & Dobrovic, A. No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia. Leuk Lymphoma 53, 1420-2 (2012).
    • (2012) Leuk Lymphoma , vol.53 , pp. 1420-1422
    • Mikeska, T.1    Carney, D.A.2    Seymour, J.F.3    Dobrovic, A.4
  • 23
    • 34447640345 scopus 로고    scopus 로고
    • Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers
    • Wu, Y. H. et al. Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers. Oncogene 26, 4761-73 (2007).
    • (2007) Oncogene , vol.26 , pp. 4761-4773
    • Wu, Y.H.1
  • 24
    • 84870790796 scopus 로고    scopus 로고
    • Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma
    • Chaisaingmongkol, J. et al. Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma. Oncogene 31, 5108-16 (2012).
    • (2012) Oncogene , vol.31 , pp. 5108-5116
    • Chaisaingmongkol, J.1
  • 25
    • 77949895970 scopus 로고    scopus 로고
    • Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas
    • Chen, H. Y., Shao, C. J., Chen, F. R., Kwan, A. L. & Chen, Z. P. Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas. Int J Cancer 126, 1944-54 (2010).
    • (2010) Int J Cancer , vol.126 , pp. 1944-1954
    • Chen, H.Y.1    Shao, C.J.2    Chen, F.R.3    Kwan, A.L.4    Chen, Z.P.5
  • 26
    • 14244259066 scopus 로고    scopus 로고
    • Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells
    • Peng, B. et al. Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells. J Biol Chem 280, 4182-7 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 4182-4247
    • Peng, B.1
  • 29
    • 58249098396 scopus 로고    scopus 로고
    • Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
    • Vaissiere, T. et al. Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Res 69, 243-52 (2009).
    • (2009) Cancer Res , vol.69 , pp. 243-252
    • Vaissiere, T.1
  • 31
    • 69349091324 scopus 로고    scopus 로고
    • Epigenetic deregulation of DNA repair and its potential for therapy
    • Hegi, M. E., Sciuscio, D., Murat, A., Levivier, M. & Stupp, R. Epigenetic deregulation of DNA repair and its potential for therapy. Clin Cancer Res 15, 5026-31 (2009).
    • (2009) Clin Cancer Res , vol.15 , pp. 5026-5031
    • Hegi, M.E.1    Sciuscio, D.2    Murat, A.3    Levivier, M.4    Stupp, R.5
  • 33
    • 33747359590 scopus 로고    scopus 로고
    • Methylation mediated silencing of TMS1/ASC gene in prostate cancer
    • Das, P. M. et al. Methylation mediated silencing of TMS1/ASC gene in prostate cancer. Mol Cancer 5, 28 (2006).
    • (2006) Mol Cancer , vol.5 , pp. 28
    • Das, P.M.1
  • 36
    • 33646574585 scopus 로고    scopus 로고
    • BRCA1 promoter methylation predicts adverse ovarian cancer prognosis
    • DOI 10.1016/j.ygyno.2005.10.034, PII S0090825805009741
    • Chiang, J. W., Karlan, B. Y., Cass, L. & Baldwin, R. L. BRCA1 promoter methylation predicts adverse ovarian cancer prognosis. Gynecol Oncol 101, 403-10 (2006). (Pubitemid 43729975)
    • (2006) Gynecologic Oncology , vol.101 , Issue.3 , pp. 403-410
    • Chiang, J.W.1    Karlan, B.Y.2    Cass, L.3    Baldwin, R.L.4
  • 37
    • 0030843274 scopus 로고    scopus 로고
    • Methylation of the BRCA1 gene in sporadic breast cancer
    • Dobrovic, A. & Simpfendorfer, D. Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 57, 3347-50 (1997). (Pubitemid 27355472)
    • (1997) Cancer Research , vol.57 , Issue.16 , pp. 3347-3350
    • Dobrovic, A.1    Simpfendorfer, D.2
  • 38
    • 1342301467 scopus 로고    scopus 로고
    • Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: Implications for treatment and survival
    • Marsit, C. J. et al. Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 23, 1000-4 (2004).
    • (2004) Oncogene , vol.23 , pp. 1000-1014
    • Marsit, C.J.1
  • 39
    • 33847355994 scopus 로고    scopus 로고
    • Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer
    • Lee, M. N. et al. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin Cancer Res 13, 832-8 (2007).
    • (2007) Clin Cancer Res , vol.13 , pp. 832-838
    • Lee, M.N.1
  • 41
    • 0030659641 scopus 로고    scopus 로고
    • Reliable detection of DNA CpG methylation profiles by the isoschizomers MspI/HpaII using oligonucleotide stimulators
    • Kupper, D., Reuter, M.,Meisel, A.&Kruger, D. H. Reliable detection ofDNACpG methylation profiles by the isoschizomers MspI/HpaII using oligonucleotide stimulators. Biotechniques 23, 843-7 (1997). (Pubitemid 27476136)
    • (1997) BioTechniques , vol.23 , Issue.5 , pp. 843-847
    • Kupper, D.1    Reuter, M.2    Meisel, A.3    Kruger, D.H.4
  • 42
    • 62349131315 scopus 로고    scopus 로고
    • DNA repair in mammalian cells: Nucleotide excision repair: Variations on versatility
    • Nouspikel, T. DNA repair in mammalian cells: Nucleotide excision repair: variations on versatility. Cell Mol Life Sci 66, 994-1009 (2009).
    • (2009) Cell Mol Life Sci , vol.66 , pp. 994-1009
    • Nouspikel, T.1
  • 43
    • 77950877402 scopus 로고    scopus 로고
    • HR23B is a biomarker for tumor sensitivity to HDAC inhibitorbased therapy
    • Khan, O. et al. HR23B is a biomarker for tumor sensitivity to HDAC inhibitorbased therapy. Proc Natl Acad Sci U S A 107, 6532-7 (2010).
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6532-6537
    • Khan, O.1
  • 44
    • 51049090194 scopus 로고    scopus 로고
    • Antitumor activity of histone deacetylase inhibitors in nonsmall cell lung cancer cells: Development of a molecular predictive model
    • Miyanaga, A. et al. Antitumor activity of histone deacetylase inhibitors in nonsmall cell lung cancer cells: development of a molecular predictive model. Mol Cancer Ther 7, 1923-30 (2008).
    • (2008) Mol Cancer Ther , vol.7 , pp. 1923-1930
    • Miyanaga, A.1
  • 45
    • 0037125133 scopus 로고    scopus 로고
    • A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII
    • DOI 10.1016/S1568-7864(02)00036-8, PII S1568786402000368
    • Bandaru, V., Sunkara, S., Wallace, S. S. & Bond, J. P. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair (Amst) 1, 517-29 (2002). (Pubitemid 34655710)
    • (2002) DNA Repair , vol.1 , Issue.7 , pp. 517-529
    • Bandaru, V.1    Sunkara, S.2    Wallace, S.S.3    Bond, J.P.4
  • 46
    • 0037435402 scopus 로고    scopus 로고
    • The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death
    • DOI 10.1016/S1568-7864(03)00025-9
    • Rosenquist, T. A. et al. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. DNA Repair (Amst) 2, 581-91 (2003). (Pubitemid 36507126)
    • (2003) DNA Repair , vol.2 , Issue.5 , pp. 581-591
    • Rosenquist, T.A.1    Zaika, E.2    Fernandes, A.S.3    Zharkov, D.O.4    Miller, H.5    Grollman, A.P.6
  • 48
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research, N
    • Cancer Genome Atlas Research, N. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-25 (2012).
    • (2012) Nature , vol.489 , pp. 519-525
  • 49
    • 84856306090 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiling using Infinium(R) assay
    • Bibikova, M. et al. Genome-wide DNA methylation profiling using Infinium(R) assay. Epigenomics 1, 177-200 (2009).
    • (2009) Epigenomics , vol.1 , pp. 177-200
    • Bibikova, M.1
  • 50
    • 20444443120 scopus 로고    scopus 로고
    • Methylation profiling of archived non-small cell lung cancer: A promising prognostic system
    • Safar, A. M. et al. Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res 11, 4400-5 (2005).
    • (2005) Clin Cancer Res , vol.11 , pp. 4400-4445
    • Safar, A.M.1
  • 52
    • 41149143617 scopus 로고    scopus 로고
    • Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray
    • DOI 10.1002/cncr.23312
    • Wang, Y. et al.Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. Cancer 112, 1325-36 (2008). (Pubitemid 351429748)
    • (2008) Cancer , vol.112 , Issue.6 , pp. 1325-1336
    • Wang, Y.1    Zhang, D.2    Zheng, W.3    Luo, J.4    Bai, Y.5    Lu, Z.6
  • 53
    • 55149097901 scopus 로고    scopus 로고
    • Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status
    • Wu, J. Y. et al. Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status. Ann Surg Oncol 15, 3272-7 (2008).
    • (2008) Ann Surg Oncol , vol.15 , pp. 3272-3337
    • Wu, J.Y.1
  • 55
    • 33646427172 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    • Liu, Y., Lan, Q., Siegfried, J. M., Luketich, J. D. & Keohavong, P. Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 8, 46-51 (2006).
    • (2006) Neoplasia , vol.8 , pp. 46-51
    • Liu, Y.1    Lan, Q.2    Siegfried, J.M.3    Luketich, J.D.4    Keohavong, P.5
  • 56
    • 27544504703 scopus 로고    scopus 로고
    • Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung
    • Kim, Y. T. et al. Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung. J Thorac Cardiovasc Surg 130, 1378 (2005).
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 1378
    • Kim, Y.T.1
  • 57
    • 33750610873 scopus 로고    scopus 로고
    • Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung
    • Tang, M., Torres-Lanzas, J., Lopez-Rios, F., Esteller, M. & Sanchez-Cespedes, M. Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung. Int J Cancer 119, 2603-6 (2006).
    • (2006) Int J Cancer , vol.119 , pp. 2603-2626
    • Tang, M.1    Torres-Lanzas, J.2    Lopez-Rios, F.3    Esteller, M.4    Sanchez-Cespedes, M.5
  • 58
    • 48249117114 scopus 로고    scopus 로고
    • DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma
    • Seng, T. J. et al. DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Br J Cancer 99, 375-82 (2008).
    • (2008) Br J Cancer , vol.99 , pp. 375-382
    • Seng, T.J.1
  • 59
    • 85047688675 scopus 로고    scopus 로고
    • Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
    • Wang, Y. C. et al. Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. J Clin Invest 111, 887-95 (2003).
    • (2003) J Clin Invest , vol.111 , pp. 887-895
    • Wang, Y.C.1
  • 60
    • 70350061166 scopus 로고    scopus 로고
    • Loss of heterozygosity combined with promoter hypermethylation, the main mechanism of human MutL Homolog (hMLH1) gene inactivation in non-small cell lung cancer in a Chinese population
    • Geng, X., Wang, F., Zhang, L. & Zhang, W. M. Loss of heterozygosity combined with promoter hypermethylation, the main mechanism of human MutL Homolog (hMLH1) gene inactivation in non-small cell lung cancer in a Chinese population. Tumori 95, 488-94 (2009).
    • (2009) Tumori , vol.95 , pp. 488-494
    • Geng, X.1    Wang, F.2    Zhang, L.3    Zhang, W.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.