DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast

Breast Cancer Research and Treatment

Volumn 124, Issue 2, 2010, Pages 555-565

  Huang, Katie T ^a,b   Dobrovic, Alexander ^a,b   Yan, Max ^a   Karim, Rooshdiya Z ^c   Lee, C Soon ^c,f,g   Lakhani, Sunil R ^d,e   Fox, Stephen B ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^f UNIVERSITY OF WESTERN SYDNEY   (Australia)

^g UNIVERSITY OF SYDNEY   (Australia)

Author keywords

DNA methylation; Fibroadenoma; Phyllodes breast; RASSF1A; TWIST1

Indexed keywords

APC PROTEIN; BISULFITE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MAL; PROTEIN MLH1; PROTEIN RAR BETA; PROTEIN TP73; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST 1; TUMOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; WNT INHIBITORY FACTOR 1; WNT PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BREAST FIBROADENOMA; CANCER GRADING; CONTROLLED STUDY; CYSTOSARCOMA PHYLLOIDES; DNA DENATURATION; DNA METHYLATION; FEMALE; GENE AMPLIFICATION; HIGH THROUGHPUT SCREENING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; METHYLATION SENSETIVE HIGH RESOLUTION MELTING; MITOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; AUSTRALIA; BREAST NEOPLASMS; CHI-SQUARE DISTRIBUTION; DNA METHYLATION; FEMALE; FIBROADENOMA; GENE EXPRESSION PROFILING; GENETIC MARKERS; HUMANS; LOGISTIC MODELS; MIDDLE AGED; NUCLEAR PROTEINS; PHYLLODES TUMOR; PROMOTER REGIONS, GENETIC; RISK ASSESSMENT; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; TWIST TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 78649317775     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0970-4     Document Type: Article

References (50)

1. AM McKenna M Pintilie B Youngson SJ Done 2007 Quantification of the morphologic features of fibroepithelial tumors of the breast Arch Pathol Lab Med 131 10 1568 1573 17922594
2. MA Guerrero BR Ballard AM Grau 2003 Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth Surg Oncol 12 1 27 37 10.1016/S0960-7404(03)00005-7 12689668 (Pubitemid 36411667)
3. RZ Karim RA Scolyer GM Tse PH Tan TC Putti CS Lee 2009 Pathogenic mechanisms in the initiation and progression of mammary phyllodes tumours Pathology 41 2 105 117 1:CAS:528:DC%2BD1MXotlOjsg%3D%3D 10.1080/ 00313020802579342 19152185
4. RZ Karim SK Gerega YH Yang A Spillane H Carmalt RA Scolyer CS Lee 2009 Phyllodes tumours of the breast: a clinicopathological analysis of 65 cases from a single institution Breast 18 3 165 170 1:STN:280:DC%2BD1MvhsF2ntA%3D%3D 10.1016/j.breast.2009.03.001 19329316
5. RK Jacklin PF Ridgway P Ziprin V Healy D Hadjiminas A Darzi 2006 Optimising preoperative diagnosis in phyllodes tumour of the breast J Clin Pathol 59 5 454 459 1:STN:280:DC%2BD283jslGjsA%3D%3D 10.1136/jcp.2005.025866 16461806
6. S Krishnamurthy R Ashfaq HJ Shin N Sneige 2000 Distinction of phyllodes tumor from fibroadenoma: a reappraisal of an old problem Cancer 90 6 342 349 1:STN:280:DC%2BD3M%2Fpt1Ohsg%3D%3D 10.1002/1097-0142(20001225)90:6<342::AID- CNCR4>3.0.CO;2-I 11156517 (Pubitemid 32011845)
7. M Esteller 2008 Molecular origins of cancer: epigenetics in cancer N Engl J Med 358 11 1148 1159 1:CAS:528:DC%2BD1cXjt1ahs7Y%3D 10.1056/NEJMra072067 18337604 (Pubitemid 351398489)
8. JG Herman SB Baylin 2003 Mechanisms of disease: gene silencing in cancer in association with promoter hypermethylation N Engl J Med 349 21 2042 2054 1:CAS:528:DC%2BD3sXptFKmu7s%3D 10.1056/NEJMra023075 14627790 (Pubitemid 37448928)
9. VV Levenson 2007 Biomarkers for early detection of breast cancer: what, when, and where? Biochim Biophys Acta 1770 6 847 856 1:CAS:528: DC%2BD2sXkslChtbk%3D 17368950
10. MG House M Guo DT Efron KD Lillemoe JL Cameron JE Syphard CM Hooker SC Abraham EA Montgomery JG Herman MV Brock 2003 Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior J Gastrointest Surg 7 8 1004 1014 10.1016/j.gassur.2003.08.002 14675710 discussion 1014 (Pubitemid 37524068)
11. K Kawaguchi Y Oda T Saito H Yamamoto T Takahira C Kobayashi S Tamiya N Tateishi Y Iwamoto M Tsuneyoshi 2006 DNA hypermethylation status of multiple genes in soft tissue sarcomas Mod Pathol 19 1 106 114 1:CAS:528: DC%2BD2MXhtlSqu7zJ 10.1038/modpathol.3800502 16258501 (Pubitemid 43250985)
12. K Saito S Sakurai T Sano K Sakamoto T Asao Y Hosoya T Nakajima H Kuwano 2008 Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy Cancer Sci 99 2 253 259 1:CAS:528:DC%2BD1MXjs1ygtLk%3D 10.1111/j.1349-7006.2007.00682.x 18271923 (Pubitemid 351228477)
13. C Seidel F Bartel M Rastetter K Bluemke P Wurl H Taubert R Dammann 2005 Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma Int J Cancer 114 3 442 447 1:CAS:528:DC%2BD2MXhvFKksLk%3D 10.1002/ijc.20707 15551306 (Pubitemid 40279967)
14. LM McShane DG Altman W Sauerbrei SE Taube M Gion GM Clark 2006 REporting recommendations for tumor MARKer prognostic studies (REMARK) Breast Cancer Res Treat 100 2 229 235 10.1007/s10549-006-9242-8 16932852 (Pubitemid 44631925)
15. LS Kristensen T Mikeska M Krypuy A Dobrovic 2008 Sensitive melting analysis after real time-methylation specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection Nucleic Acids Res 36 7 e42 10.1093/nar/gkn113 18344521 (Pubitemid 351567020)
16. TK Wojdacz A Dobrovic 2007 Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation Nucleic Acids Res 35 6 e41 10.1093/nar/gkm013 17289753 (Pubitemid 47061680)
17. Candiloro IL, Mikeska T, Hokland P, Dobrovic A (2008) Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene. Epigenetics Chromatin 1(1):7
18. T Wojdacz L Hansen A Dobrovic 2008 A new approach to primer design for the control of PCR bias in methylation studies BMC Res Notes 1 1 54 10.1186/1756-0500-1-54 18710507
19. MF Paz MF Fraga S Avila M Guo M Pollan JG Herman M Esteller 2003 A systematic profile of DNA methylation in human cancer cell lines Cancer Res 63 5 1114 1121 1:CAS:528:DC%2BD3sXhs1agtLo%3D 12615730 (Pubitemid 36278446)
20. IL Candiloro A Dobrovic 2009 Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism Cancer Prev Res (Phila Pa) 2 10 862 867 1:CAS:528:DC%2BC3cXptVyrsL8%3D
21. M Esteller PG Corn SB Baylin JG Herman 2001 A gene hypermethylation profile of human cancer Cancer Res 61 8 3225 3229 1:CAS:528:DC%2BD3MXjtFSjt7g%3D 11309270
22. W Feng L Shen S Wen DG Rosen J Jelinek X Hu S Huan M Huang J Liu AA Sahin KK Hunt RC Bast Jr Y Shen JP Issa Y Yu 2007 Correlation between CpG methylation profiles and hormone receptor status in breast cancers Breast Cancer Res 9 4 R57 10.1186/bcr1762 17764565 (Pubitemid 350187466)
23. T Moribe N Iizuka T Miura N Kimura S Tamatsukuri H Ishitsuka Y Hamamoto K Sakamoto T Tamesa M Oka 2009 Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma Int J Cancer 125 2 388 397 1:CAS:528:DC%2BD1MXms1amu7k%3D 10.1002/ijc.24394 19384946
24. S Mulero-Navarro M Esteller 2008 Epigenetic biomarkers for human cancer: the time is now Crit Rev Oncol Hematol 68 1 1 11 10.1016/j.critrevonc.2008.03. 001 18430583
25. JH Kim YD Choi JS Lee JH Lee JH Nam C Choi MH Park JH Yoon 2009 Borderline and malignant phyllodes tumors display similar promoter methylation profiles Virchows Arch 455 6 469 475 1:CAS:528:DC%2BD1MXhsV2jt73L 10.1007/s00428-009-0858-z 19924440
26. K Harvey N Tapon 2007 The Salvador-Warts-Hippo pathway-an emerging tumour-suppressor network Nat Rev Cancer 7 3 182 191 1:CAS:528: DC%2BD2sXitVGrsLc%3D 10.1038/nrc2070 17318211
27. E Mathe 2004 RASSF1A, the new guardian of mitosis Nat Genet 36 2 117 118 1:CAS:528:DC%2BD2cXntlChtA%3D%3D 10.1038/ng0204-117 14752520 (Pubitemid 38174368)
28. L Shivakumar J Minna T Sakamaki R Pestell MA White 2002 The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation Mol Cell Biol 22 12 4309 4318 1:CAS:528:DC%2BD38XktlSlsrw%3D 10.1128/MCB.22.12.4309-4318.2002 12024041 (Pubitemid 34556598)
29. FJ Reu DW Leaman RR Maitra SI Bae L Cherkassky MW Fox DR Rempinski N Beaulieu AR MacLeod EC Borden 2006 Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons Cancer Res 66 5 2785 2793 1:CAS:528:DC%2BD28XhvV2gtrs%3D 10.1158/0008-5472.CAN-05-2303 16510600
30. HJ Oh KK Lee SJ Song MS Jin MS Song JH Lee CR Im JO Lee S Yonehara DS Lim 2006 Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis Cancer Res 66 5 2562 2569 1:CAS:528:DC%2BD28XhvV2htb0%3D 10.1158/0008-5472.CAN-05-2951 16510573
31. PS Yan H Shi F Rahmatpanah TH Hsiau AH Hsiau YW Leu JC Liu TH Huang 2003 Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer Cancer Res 63 19 6178 6186 1:CAS:528:DC%2BD3sXotV2jtbk%3D 14559801
32. JP Issa YL Ottaviano P Celano SR Hamilton NE Davidson SB Baylin 1994 Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon Nat Genet 7 4 536 540 1:CAS:528:DyaK2cXlsFSntb0%3D 10.1038/ng0894-536 7951326 (Pubitemid 24308343)
33. PA Jones PW Laird 1999 Cancer epigenetics comes of age Nat Genet 21 2 163 167 1:CAS:528:DyaK1MXpsVClug%3D%3D 10.1038/5947 9988266 (Pubitemid 29070360)
34. I Peters B Vaske K Albrecht MA Kuczyk U Jonas J Serth 2007 Adiposity and age are statistically related to enhanced RASSF1A tumor suppressor gene promoter methylation in normal autopsy kidney tissue Cancer Epidemiol Biomarkers Prev 16 12 2526 2532 1:CAS:528:DC%2BD2sXhsVenurzM 10.1158/1055-9965.EPI-07-0203 18086755 (Pubitemid 351196306)
35. MS Lee GN Lowe DD Strong JE Wergedal CA Glackin 1999 TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage J Cell Biochem 75 4 566 577 1:CAS:528:DyaK1MXnt1Cjt74%3D 10.1002/(SICI)1097- 4644(19991215)75:4<566::AID-JCB3>3.0.CO;2-0 10572240 (Pubitemid 29529912)
36. R Maestro AP Dei Tos Y Hamamori S Krasnokutsky V Sartorelli L Kedes C Doglioni DH Beach GJ Hannon 1999 Twist is a potential oncogene that inhibits apoptosis Genes Dev 13 17 2207 2217 1:CAS:528:DyaK1MXlvFSjtbg%3D 10.1101/gad.13.17.2207 10485844 (Pubitemid 29426726)
37. EH Gort KP Suijkerbuijk SM Roothaan V Raman M Vooijs E van der Wall PJ van Diest 2008 Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer Cancer Epidemiol Biomarkers Prev 17 12 3325 3330 1:CAS:528:DC%2BD1cXhsVOgtLzI 10.1158/1055-9965.EPI-08-0472 19064546
38. AA Mangi BL Smith MA Gadd KK Tanabe MJ Ott WW Souba 1999 Surgical management of phyllodes tumors Arch Surg 134 5 487 492 1:STN:280: DyaK1M3lsV2quw%3D%3D 10.1001/archsurg.134.5.487 10323420 discussion 492-483 (Pubitemid 29218119)
39. S Noguchi H Yokouchi T Aihara K Motomura H Inaji S Imaoka H Koyama 1995 Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis Cancer 76 10 1779 1785 1:STN:280:DyaK283itlamsw%3D%3D 10.1002/1097- 0142(19951115)76:10<1779::AID-CNCR2820761015>3.0.CO;2-0 8625047
40. GJ Klarmann A Decker WL Farrar 2008 Epigenetic gene silencing in the Wnt pathway in breast cancer Epigenetics 3 2 59 63 10.4161/epi.3.2.5899 18398311
41. AM Brown 2001 Wnt signaling in breast cancer: have we come full circle? Breast Cancer Res 3 6 351 355 1:CAS:528:DC%2BD38Xjs1amsg%3D%3D 10.1186/bcr321 11737884 (Pubitemid 34196359)
42. EJ Sawyer AM Hanby AJ Rowan CE Gillett RE Thomas R Poulsom SR Lakhani IO Ellis P Ellis IP Tomlinson 2002 The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours J Pathol 196 4 437 444 1:CAS:528:DC%2BD38XjtVCgsLY%3D 10.1002/path.1067 11920740 (Pubitemid 34262856)
43. H Suzuki M Toyota H Carraway E Gabrielson T Ohmura T Fujikane N Nishikawa Y Sogabe M Nojima T Sonoda M Mori K Hirata K Imai Y Shinomura SB Baylin T Tokino 2008 Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer Br J Cancer 98 6 1147 1156 1:CAS:528:DC%2BD1cXjtlGktb0%3D 10.1038/sj.bjc.6604259 18283316 (Pubitemid 351399804)
44. L Ai Q Tao S Zhong CR Fields WJ Kim MW Lee Y Cui KD Brown KD Robertson 2006 Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer Carcinogenesis 27 7 1341 1348 1:CAS:528:DC%2BD28XmsVegurc%3D 10.1093/carcin/bgi379 16501252 (Pubitemid 43985409)
45. H Taniguchi H Yamamoto T Hirata N Miyamoto M Oki K Nosho Y Adachi T Endo K Imai Y Shinomura 2005 Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers Oncogene 24 53 7946 7952 1:CAS:528:DC%2BD2MXht1GisL3L 10.1038/sj.onc.1208910 16007117 (Pubitemid 41715201)
46. J Mazieres B He L You Z Xu AY Lee I Mikami N Reguart R Rosell F McCormick DM Jablons 2004 Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer Cancer Res 64 14 4717 4720 1:CAS:528:DC%2BD2cXls1OmsL4%3D 10.1158/0008-5472.CAN-04-1389 15256437 (Pubitemid 38924512)
47. M Kansara M Tsang L Kodjabachian NA Sims MK Trivett M Ehrich A Dobrovic J Slavin PF Choong PJ Simmons IB Dawid DM Thomas 2009 Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice J Clin Invest 119 4 837 851 1:CAS:528:DC%2BD1MXktlSntrY%3D 10.1172/JCI37175 19307728
48. M Esteller SR Hamilton PC Burger SB Baylin JG Herman 1999 Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res 59 4 793 797 1:CAS:528:DyaK1MXht1Sjurk%3D 10029064
49. AM Jones R Mitter R Springall T Graham E Winter C Gillett AM Hanby IP Tomlinson EJ Sawyer 2008 A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence J Pathol 214 5 533 544 1:CAS:528: DC%2BD1cXmtFKitL8%3D 10.1002/path.2320 18288784 (Pubitemid 351482269)
50. A Di Vinci L Perdelli B Banelli S Salvi I Casciano I Gelvi G Allemanni E Margallo B Gatteschi M Romani 2005 p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma Int J Cancer 114 3 414 421 1:CAS:528:DC%2BD2MXhvFKksLw%3D 10.1002/ijc.20771 15578730 (Pubitemid 40279962)